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1
المؤلفون: Gaurang P Bhide, Natalie E Bohrer, Danying Song, Jeanne Cabel, Marc R Lake, John E Harlan, Laura J Miesbauer
المصدر: Glycobiology.
مصطلحات موضوعية: Biochemistry
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2Academic Journal
المؤلفون: A Kelekar, B S Chang, J E Harlan, S W Fesik, C B Thompson, Mol Cell Biol, Inactivating Dimer Bcl-x L, Ameeta Kelekar, Brian S. Chang, John E. Harlan, Stephen W. Fesik, Craig, B. Thompson
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.7895; http://mcb.asm.org/content/17/12/7040.full.pdf
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3
المؤلفون: Kerren K. Swinger, Magdalena Przytulinska, Yunsong Tong, Alan S. Florjancic, Eric F. Johnson, Philip J. Merta, Kent D. Stewart, Thomas D. Penning, Nirupama B. Soni, Alexander R. Shoemaker, John E. Harlan, Haizhong Zhu
المصدر: ACS Medicinal Chemistry Letters. 4:211-215
مصطلحات موضوعية: Hydrophobic effect, Hydrogen bond, Kinase, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Kinase inhibition, Biochemistry
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4
المصدر: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 68:601-605
مصطلحات موضوعية: Models, Molecular, Drug, On column, Stereochemistry, media_common.quotation_subject, Adamantane, Biophysics, Dehydrogenase, Crystallography, X-Ray, Ligands, Biochemistry, chemistry.chemical_compound, Protein structure, Structural Biology, 11β-hydroxysteroid dehydrogenase type 1, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Genetics, Humans, Enzyme Inhibitors, Protein Structure, Quaternary, media_common, biology, Ligand, Chemistry, Laboratory Communications, Condensed Matter Physics, Drug Design, biology.protein, Structure based
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5
المؤلفون: Allison J. Xu, David Maag, Melanie J. Schroeder Patterson, Paul Ellis, Uri S. Ladror, Damien B. Ready, Eric F. Johnson, Bruce W. Surber, Niru B. Soni, Ramesh Iyer, Yan Shi, Joann P. Palma, Larry R. Solomon, John E. Harlan, Thomas D. Penning, Cherrie K. Donawho, Xuesong Liu, Alexander R. Shoemaker
المصدر: Clinical Cancer Research. 18:510-523
مصطلحات موضوعية: Cancer Research, DNA Repair, Veliparib, Poly ADP ribose polymerase, Metabolite, Poly (ADP-Ribose) Polymerase-1, Antineoplastic Agents, Mice, SCID, Poly(ADP-ribose) Polymerase Inhibitors, Biology, Poly (ADP-Ribose) Polymerase Inhibitor, Mice, chemistry.chemical_compound, Cell Line, Tumor, Temozolomide, Animals, Humans, Cysteine, BRCA2 Protein, Drug Synergism, Neoplasms, Experimental, Xenograft Model Antitumor Assays, Molecular biology, Dacarbazine, Mice, Inbred C57BL, Cell killing, Oncology, chemistry, Benzamides, PARP inhibitor, Benzimidazoles, Female, NAD+ kinase, Poly(ADP-ribose) Polymerases, Iniparib
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6
المؤلفون: Peter Ansell, Evelyn McKeegan, Haiying Zhang, John Xue, Rick Lesniewski, Sevan Brodjian, Don J. Davidson, John E. Harlan
المصدر: European Journal of Cancer. 46:966-973
مصطلحات موضوعية: Cancer Research, Angiogenesis, Angiogenesis Inhibitors, Biology, Pichia, Receptor tyrosine kinase, Kringle domain, medicine, Animals, Humans, Protein kinase B, Angiostatin, Hepatocyte Growth Factor, Plasminogen, Proto-Oncogene Proteins c-met, Molecular biology, Peptide Fragments, Recombinant Proteins, Cell biology, Oncology, biology.protein, Phosphorylation, Hepatocyte growth factor, Rabbits, Signal transduction, Proto-Oncogene Proteins c-akt, medicine.drug
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7
المؤلفون: Philip J. Hajduk, John E. Harlan, Ulrich Ebert, Robert W. Johnson, Stefan Barghorn, Larry R. Solomon, Thomas F. Holzman, Boris Labkovsky, Heinz Hillen, Edward T. Olejniczak, Rohinton Edalji, Karl A. Walter, Liping Yu, Paul L. Richardson, Laura J. Miesbauer, Diane Bartley, Ana Pereda Lopez
المصدر: Biochemistry. 48:1870-1877
مصطلحات موضوعية: Models, Molecular, Amyloid, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Microscopy, Atomic Force, Antiparallel (biochemistry), Fibril, Biochemistry, Oligomer, Protein Structure, Secondary, chemistry.chemical_compound, Protein structure, Humans, Amino Acid Sequence, Protein Structure, Quaternary, Peptide sequence, Amyloid beta-Peptides, biology, Chemistry, Nuclear magnetic resonance spectroscopy, Peptide Fragments, In vitro, Solubility, biology.protein, Protein Multimerization, Antibody
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8
المؤلفون: Susan E. Lacy, David A. Egan, Robert L Simmer, Nancy Xie, Edward B. Reilly, Devries Peter J, Richard R. Lesniewski, Zhihong Liu, Clarissa G. Jakob, John E. Harlan, Vincent S. Stoll
المصدر: Blood. 110:2408-2413
مصطلحات موضوعية: Models, Molecular, Genetically modified mouse, Immunology, Pure red cell aplasia, Biology, Crystallography, X-Ray, Biochemistry, Antibodies, Cell Line, law.invention, Mice, law, hemic and lymphatic diseases, Receptors, Erythropoietin, medicine, Animals, Humans, Erythropoiesis, Binding site, Protein Structure, Quaternary, Erythropoietin, Mice, Knockout, Binding Sites, Activator (genetics), Molecular Mimicry, food and beverages, Cell Biology, Hematology, medicine.disease, Molecular biology, Protein Structure, Tertiary, Erythropoietin receptor, Hematocrit, Structural Homology, Protein, biology.protein, Recombinant DNA, Cancer research, Antibody, medicine.drug
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9
المؤلفون: Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
المصدر: Chemical Biology & Drug Design. 69:395-404
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Molecular Sequence Data, Plasma protein binding, Bacterial genome size, medicine.disease_cause, Biochemistry, Mass Spectrometry, Microbiology, Haemophilus influenzae, Structure-Activity Relationship, Bacterial Proteins, Drug Discovery, medicine, Animals, Amino Acid Sequence, Adenosine Triphosphatases, Pharmacology, B-Lymphocytes, biology, Drug discovery, Organic Chemistry, Genomics, biology.organism_classification, Anti-Bacterial Agents, Mechanism of action, Essential gene, Drug Design, Molecular Medicine, medicine.symptom, Antibacterial activity, Genome, Bacterial, Bacteria, Protein Binding
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10
المؤلفون: Kenton L. Longenecker, Karl A. Walter, Rohinton Edalji, John E. Harlan, Diane Bartley, Philip J. Hajduk, Larry R. Solomon, Thomas F. Holzman, Geoffrey F. Stamper, Yu Gui Gu, Vincent S. Stoll, Claude G. Lerner, Bruce A. Beutel, Elizabeth H. Fry, Clarissa G. Jakob
المصدر: Protein Science. 14:3039-3047
مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Sequence Homology, Sequence alignment, Biology, Crystallography, X-Ray, Ligands, Biochemistry, Article, Substrate Specificity, chemistry.chemical_compound, Amino Acid Sequence, Enzyme Inhibitors, Peptide Synthases, Binding site, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, Peptide sequence, chemistry.chemical_classification, DNA ligase, Binding Sites, Small molecule, Protein Structure, Tertiary, Streptococcus pneumoniae, Enzyme, chemistry, Essential gene, Peptidoglycan, Sequence Alignment
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11
المؤلفون: T. F. Holzman, Uri S. Ladror, Kenneth Jarvis, Hing L. Sham, Mark G. Anderson, Shi-Chung Ng, Le Wang, David Frost, Luis E. Rodriguez, Saul H. Rosenberg, Steven W. Muchmore, John E. Harlan, Jerry Cohen, Debra Ferguson, Yi-Chun Wang, Paul E. Kroeger, Vincent S. Stoll, Gerard M. Sullivan, Ingrid B J K Joseph, Nan-Horng Lin, Wen-Zhen Gu, Haiying Zhang, Clarissa G. Jakob, Kennan C. Marsh, Karl A. Walten
المصدر: Anti-Cancer Drugs. 16:1059-1069
مصطلحات موضوعية: Vascular Endothelial Growth Factor A, Cancer Research, Angiogenesis, Farnesyltransferase, Mice, Nude, Antineoplastic Agents, Crystallography, X-Ray, Mice, chemistry.chemical_compound, Cell Line, Tumor, Neoplasms, Animals, Farnesyltranstransferase, Humans, Potency, Corneal Neovascularization, Pharmacology (medical), Secretion, RNA, Messenger, Enzyme Inhibitors, Cell Proliferation, Pharmacology, Messenger RNA, biology, Farnesyltransferase inhibitor, Imidazoles, Xenograft Model Antitumor Assays, Vascular endothelial growth factor, Oncology, chemistry, ras Proteins, Cancer research, biology.protein, Function (biology)
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12
المؤلفون: Michael Bahr, Andreas Striebinger, Ulrich Ebert, John E. Harlan, Eve H. Barlow, Patrick Keller, Heinz Hillen, Carsten Krantz, Volker Nimmrich, Bodo Janson, Stefan Barghorn, Robert S. Bitner, Martin Schmidt
المصدر: Journal of Neurochemistry. 95:834-847
مصطلحات موضوعية: chemistry.chemical_classification, biology, Amyloid, Amyloid beta, Peptide, Fibril, Biochemistry, Oligomer, Epitope, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Protein structure, chemistry, biology.protein, Amyloid precursor protein, Neuroscience
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13
المؤلفون: Andrew Vogt, Richard S. Smith, T. F. Holzman, Jianwei Shen, Robert E. Johnson, Jieyi Wang, John E. Harlan, Tanveer F. Ahmed, Sally Dorwin, Jean M. Severin
المصدر: Analytical Biochemistry. 345:258-269
مصطلحات موضوعية: Nitrilotriacetic Acid, MALDI imaging, Chromatography, Protein mass spectrometry, Surface Properties, Chemistry, Biophysics, Nitrilotriacetic acid, Proteins, Self-assembled monolayer, Cell Biology, Mass spectrometry, Biochemistry, Recombinant Proteins, Sample preparation in mass spectrometry, chemistry.chemical_compound, Matrix-assisted laser desorption/ionization, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Histidine, Sample preparation, Gold, Peptides, Molecular Biology
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14
المؤلفون: Stephen F. Betz, Kevin Ronald Condroski, John E. Harlan, Bruce A. Beutel, Jean M. Severin, Sean M. Merrick, Vicki L. Nienaber, Susan J. Swanson, Rolf Wagner, Vincent S. Stoll, Karl A. Walter, J. Owen McCall, Peter Magdalinos, Claude G. Lerner, William J. Sanders, Geoffrey F. Stamper, Clarissa G. Jakob, Robert P. Meadows
المصدر: Journal of Medicinal Chemistry. 47:1709-1718
مصطلحات موضوعية: Models, Molecular, Guanine, Databases, Factual, Molecular model, Stereochemistry, Dihydroneopterin aldolase, Crystallography, X-Ray, Benzoates, Neopterin, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Aldehyde-Lyases, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Aldolase A, Active site, Triazoles, Lyase, Crystallography, Pyrimidines, Enzyme, Purines, Enzyme inhibitor, biology.protein, Molecular Medicine
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15
المؤلفون: Craig B. Thompson, John E. Harlan, Marian H. Harris, Stephen W. Fesik, Ameeta Kelekar, Brian S. Chang
المصدر: Molecular and Cellular Biology. 19:6673-6681
مصطلحات موضوعية: Programmed cell death, bcl-X Protein, Apoptosis, Plasma protein binding, medicine.disease_cause, Bcl-2-associated X protein, Proto-Oncogene Proteins, medicine, Humans, Cell Growth and Development, Molecular Biology, Gene, Sequence Deletion, bcl-2-Associated X Protein, Mutation, Binding Sites, biology, HEK 293 cells, Cell Biology, Transfection, Molecular biology, Protein Structure, Tertiary, Cell biology, Phenotype, Proto-Oncogene Proteins c-bcl-2, biology.protein, Dimerization, Protein Binding
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16
المؤلفون: Jeff M Schkeryantz, Edward T. Olejniczak, Matthias Eberstadt, Edith A. S. Harris, Stephen W. Fesik, Hong Wang, Xiaohong Liu, Robert P. Meadows, David A. Janowick, Donald E. Staunton, Arndt Schnuchel, John E. Harlan
المصدر: Cell. 95:269-277
مصطلحات موضوعية: RhoGEF domain, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Rho family of GTPases, Protein Serine-Threonine Kinases, Biology, Protein Structure, Secondary, General Biochemistry, Genetics and Molecular Biology, Homology (biology), Nucleotide exchange factor, Protein structure, Proto-Oncogene Proteins, Guanine Nucleotide Exchange Factors, Nucleotide, chemistry.chemical_classification, Sequence Homology, Amino Acid, Nucleotides, Biochemistry, Genetics and Molecular Biology(all), Blood Proteins, Phosphoproteins, Protein Structure, Tertiary, Pleckstrin homology domain, Biochemistry, chemistry, Mutagenesis, biology.protein, Guanine nucleotide exchange factor
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17
المؤلفون: Stephen W. Fesik, Steven J. Burakoff, Seth D. Crosby, Warren S. Wade, Ming-Ming Zhou, John E. Harlan, Kodimangalam S. Ravichandran
المصدر: Journal of Biological Chemistry. 270:31119-31123
مصطلحات موضوعية: Phosphotyrosine binding, Binding Sites, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Signal transducing adaptor protein, Cell Biology, Biology, SH2 domain, environment and public health, Biochemistry, src Homology Domains, Growth factor receptor, Animals, Humans, Tyrosine, Amino Acid Sequence, Phosphorylation, Binding site, Peptides, Phosphotyrosine, Receptor, Phosphotyrosine-binding domain, Molecular Biology, Proto-oncogene tyrosine-protein kinase Src
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18
المؤلفون: Rohinton Edalji, Amy Greischar, Clarissa G. Jakob, Enrico L. Digiammarino, Uri S. Ladror, Karl A. Walter, Charles W. Hutchins, John E. Harlan, Tariq Ghayur, Liu Junjian, Marc R. Lake
المصدر: mAbs. 3(5)
مصطلحات موضوعية: Stereochemistry, Chemistry, Tumor Necrosis Factor-alpha, Immunology, Molecular Sequence Data, Immunoglobulin Variable Region, Antibodies, Monoclonal, Protein engineering, Plasma protein binding, Immunoglobulin domain, Ligands, Protein Engineering, Domain (software engineering), Protein Structure, Tertiary, Kinetics, Protein structure, Drug Design, Report, Immunology and Allergy, Humans, Amino Acid Sequence, Linker, Binding selectivity, Binding domain, Protein Binding
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19
المؤلفون: Zhen Wu, Alfred Hahn, Chung-Ming Hsieh, Eve H. Barlow, Gerard B. Fox, Feng Luo, Shaun McLoughlin, Karl A. Walter, Jijie Gu, Volker Nimmrich, Martin Schmidt, Leddy Mary R, Prasant Chandran, Hans Schoemaker, Terese Seifert, Mark L. Day, John E. Harlan, Ralf Loebbert, Enrico DiGianmarrino
المصدر: Alzheimer's & Dementia. 6
مصطلحات موضوعية: Epidemiology, medicine.drug_class, business.industry, Health Policy, Disease, Monoclonal antibody, RAGE (receptor), Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, medicine, Neurology (clinical), Geriatrics and Gerontology, business
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20
المؤلفون: Dale J. Kempf, Peggy P. Huang, Charles A. Flentge, John E. Harlan, Kennan C. Marsh, John T. Randolph, Larry L. Klein
المصدر: Bioorganicmedicinal chemistry letters. 19(18)
مصطلحات موضوعية: Tertiary amine, CYP3A, Clinical Biochemistry, Pharmaceutical Science, Pyrimidinones, Biochemistry, Lopinavir, Structure-Activity Relationship, Dogs, Pharmacokinetics, Drug Discovery, medicine, HIV Protease Inhibitor, Animals, Cytochrome P-450 CYP3A, Humans, Protease inhibitor (pharmacology), Drug Interactions, Molecular Biology, Ritonavir, biology, Chemistry, Organic Chemistry, virus diseases, HIV Protease Inhibitors, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Cytochrome P-450 CYP3A Inhibitors, medicine.drug