المؤلفون: Joaquín Miguel Pellegrini, Candela Martin, María Paula Morelli, Julieta Aylen Schander, Nancy Liliana Tateosian, Nicolás Oscar Amiano, Agustín Rollandelli, Domingo Juan Palmero, Alberto Levi, Lorena Ciallella, María Isabel Colombo, Verónica Edith García

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/e3730db0604c4b0fb9b9154b50e38f08

المؤلفون: María Paula Morelli, María Paula Del Medico Zajac, Joaquín Miguel Pellegrini, Nicolás Oscar Amiano, Nancy Liliana Tateosian, Gabriela Calamante, María Magdalena Gherardi, Verónica Edith García

المصدر: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

مصطلحات موضوعية: Ag85A, DNA vaccine, IL-12, MVA, tuberculosis, vaccine, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcimb.2020.581812/full; https://doaj.org/toc/2235-2988

URL الوصول: https://doaj.org/article/7553edbeb0a346fab78c0f7ff0d6f9ab

المؤلفون: Joaquín Miguel Pellegrini, Candela Martin, María Paula Morelli, Julieta Aylen Schander, Nancy Liliana Tateosian, Nicolás Oscar Amiano, Agustín Rolandelli, Domingo Juan Palmero, Alberto Levi, Lorena Ciallella, María Isabel Colombo, Verónica Edith García

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/34b86553194c465db3807a47a424f058

المؤلفون: Agustín Rolandelli, Joaquín Miguel Pellegrini, Rodrigo Emanuel Hernández Del Pino, Nancy Liliana Tateosian, Nicolás Oscar Amiano, María Paula Morelli, Florencia Andrea Castello, Nicolás Casco, Alberto Levi, Domingo Juan Palmero, Verónica Edith García

المصدر: Frontiers in Immunology, Vol 10 (2019)

مصطلحات موضوعية: tuberculosis, Th17, IL17F, single-nucleotide polymorphism, rs763780, immunogenetics, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02248/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/618ddf7308e843f5a3b6169fb90a4766

المؤلفون: Nancy Liliana Tateosian, María Paula Morelli, Joaquín Miguel Pellegrini, Verónica Edith García

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 5; Pages: 5033

مصطلحات موضوعية: tuberculosis, infection, immunology, endotype

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Microbiology; https://dx.doi.org/10.3390/ijms24055033

الاتاحة: https://doi.org/10.3390/ijms24055033

المؤلفون: Joaquin Miguel Pellegrini, Jean-Pierre Gorvel, Sylvie Mémet

المصدر: Microorganisms; Volume 10; Issue 7; Pages: 1260

مصطلحات موضوعية: Brucella, chronic infection, persistence, immunosuppression, intracellular bacteria

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medical Microbiology; https://dx.doi.org/10.3390/microorganisms10071260

الاتاحة: https://doi.org/10.3390/microorganisms10071260

المؤلفون: Joaquin Miguel Pellegrini, Nancy Liliana Tateosian, María Paula Morelli, Verónica Edith García

المصدر: Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)

مصطلحات موضوعية: autophagy, tuberculosis, human, host-directed therapy, immunology & infectious diseases, Microbiology, QR1-502

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2021.820095/full; https://doaj.org/toc/2235-2988; https://doaj.org/article/786f283f9d3b46318f36f7eaa682248c

الاتاحة: https://doi.org/10.3389/fcimb.2021.820095
https://doaj.org/article/786f283f9d3b46318f36f7eaa682248c

المؤلفون: Alberto Levi, María Paula Morelli, Julieta Aylen Schander, María Isabel Colombo, Nicolás Oscar Amiano, Domingo Palmero, Verónica E. García, Joaquín Miguel Pellegrini, Lorena Ciallella, Nancy Liliana Tateosian, Candela Martin, Agustín Rolandelli

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: 0301 basic medicine, Tuberculosis, Science, Immune receptor, Article, Proinflammatory cytokine, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, medicine, Multidisciplinary, biology, business.industry, Autophagy, Lipid signaling, Antimicrobial responses, medicine.disease, biology.organism_classification, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, Medicine, lipids (amino acids, peptides, and proteins), business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7ccc76fe122cf784016d832914df8f
http://europepmc.org/articles/PMC8245456

المؤلفون: Juan Palmero, Claudio Gallego, Juan Andrés Stupka, Graciela C. de Casado, Camila Martinena, Verónica E. García, Joaquín Miguel Pellegrini, Lorena Ciallella, Nancy Liliana Tateosian, María Paula Morelli, Nicolás Casco, Nicolás Oscar Amiano, Florencia Andrea Castello, Rita Armitano, Agustín Rolandelli

مصطلحات موضوعية: medicine.anatomical_structure, business.industry, Monocyte, Immunology, Myeloid-derived Suppressor Cell, medicine, Immunological status, Active tuberculosis, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::73c9d7ecc268d5348ffed2f0f000d25b
https://doi.org/10.21203/rs.3.rs-145332/v1

المؤلفون: Florencia Sabbione, Domingo Palmero, Alberto Levi, Florencia Andrea Castello, María Isabel Colombo, Nicolás Oscar Amiano, Lorena Ciallella, Nancy Liliana Tateosian, María Paula Morelli, Analía Silvina Trevani, Verónica E. García, Joaquín Miguel Pellegrini

المصدر: Autophagy
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

مصطلحات موضوعية: 0301 basic medicine, Tuberculosis, Neutrophils, Phagocytosis, Biology, TUBERCULOSIS, Microbiology, Mycobacterium tuberculosis, 03 medical and health sciences, Immune system, Signaling Lymphocytic Activation Molecule Family Member 1, IMMUNE RESPONSE, PATIENTS, medicine, Autophagy, Humans, Molecular Biology, Pathogen, Letter to the Editor, 030102 biochemistry & molecular biology, Mechanism (biology), Macrophages, purl.org/becyt/ford/3.1 [https], Cell Biology, respiratory system, Active tuberculosis, biology.organism_classification, medicine.disease, 030104 developmental biology, AUTOPHAGY, purl.org/becyt/ford/3 [https], NEUTROPHIL, SLAMF1

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6246cd41f96c03087f51a71ca85f620
https://pubmed.ncbi.nlm.nih.gov/32954947

المؤلفون: Nicolás Oscar Amiano, Domingo Palmero, Alberto Levi, Verónica E. García, Joaquín Miguel Pellegrini, Nancy Liliana Tateosian, María Paula Morelli, Lorena Ciallella, Agustín Rollandelli, María Isabel Colombo

مصطلحات موضوعية: Tuberculosis, business.industry, medicine.medical_treatment, Inflammation, Lipid signaling, Immune receptor, medicine.disease, Proinflammatory cytokine, Immune system, Cytokine, Immunopathology, Immunology, Medicine, lipids (amino acids, peptides, and proteins), medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8fdf6f2fc3733035193c1a056822099e
https://doi.org/10.1101/2020.08.04.236257

المؤلفون: Lorena Ciallella, Liliana Cusmano, Vanesa Seery, Domingo Palmero, Graciela C. de Casado, Agustín Rolandelli, Florencia Andrea Castello, Maria A. Erschen, Juan L. Iovanna, Juan Andrés Stupka, Rita Armitano, Nicolás Oscar Amiano, Claudio Gallego, Nancy Liliana Tateosian, María Paula Morelli, Verónica E. García, Joaquín Miguel Pellegrini

المساهمون: Universidad de Buenos Aires [Buenos Aires] (UBA), Hospital General de Agudos Parmenio Piñero [Buenos Aires, Argentine], Hospital Francisco Javier Muñiz, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) [PICT2015-0611 to V.E.G. and PICT Start Up 2016-0022 to N.O.A] and Universidad de Buenos Aires (UBACyT) [20020170100127BA to V.E.G. and 200201150200107BA to N.O.A.]., Bodescot, Myriam, Hospital Francisco Javier Muñiz [Buenos Aires, Argentine], Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU)

المصدر: Scientific Reports
Scientific Reports, 2020, 10 (1), pp.7472. ⟨10.1038/s41598-020-64428-z⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.7472. ⟨10.1038/s41598-020-64428-z⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, lcsh:Medicine, LATENCY ANTIGEN, Diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine, lcsh:Science, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Multidisciplinary, biology, Biological techniques, Middle Aged, Antibodies, Bacterial, 3. Good health, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, purl.org/becyt/ford/3 [https], Female, Biotechnology, Adult, Tuberculosis, Adolescent, IgG, 030106 microbiology, Immunology, Tuberculin, IFN gamma, TUBERCULOSIS, Article, QuantiFERON, Mycobacterium tuberculosis, purl.org/becyt/ford/3.3 [https], 03 medical and health sciences, Interferon-gamma, Immune system, Antigen, Latent Tuberculosis, Humans, Latency (engineering), [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Aged, Antigens, Bacterial, business.industry, lcsh:R, Plasma levels, biology.organism_classification, medicine.disease, bacterial infections and mycoses, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 030104 developmental biology, Immunoglobulin G, lcsh:Q, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business, Biomarkers

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8d96d59fef79c99acef464cb1a644a
https://www.hal.inserm.fr/inserm-02873029/file/s41598-020-64428-z.pdf

المؤلفون: Adali Pecci, Sol Yanel Nuñez, Luciana Rocha-Viegas, Guillermo P. Vicent, Maria Florencia Ogara, Verónica E. García, Joaquín Miguel Pellegrini, Micaela Silbermins

المساهمون: Agencia Nacional de Promoción Científica y Tecnológica (Argentina), Fundación Alberto J. Roemmers, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina)

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: 0301 basic medicine, Myeloid, bcl-X Protein, Biophysics, Down-Regulation, Apoptosis, Glucocorticoid receptor, Biology, Response Elements, Biochemistry, 03 medical and health sciences, Receptors, Glucocorticoid, 0302 clinical medicine, Downregulation and upregulation, Structural Biology, Genetics, medicine, Humans, BCL2L1 gene, Promoter Regions, Genetic, Glucocorticoids, Molecular Biology, Apoptosis Regulator, Nuclear Proteins, Myeloid leukemia, U937 Cells, medicine.disease, Chromatin, ASH2L, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Leukemia, Myeloid, Acute, Leukemia, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b046c24f91f274f3644dc9c11774f037
http://hdl.handle.net/10261/223065

المؤلفون: María Paula Morelli, María Paula Del Medico Zajac, Joaquín Miguel Pellegrini, Nicolás Oscar Amiano, Nancy Liliana Tateosian, Gabriela Calamante, María Magdalena Gherardi, Verónica Edith García

مصطلحات موضوعية: Clinical Microbiology, Medical Bacteriology, Medical Infection Agents (incl. Prions), Medical Virology, Ag85A, DNA vaccine, IL-12, MVA, tuberculosis, vaccine

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_IL-12_DNA_Displays_Efficient_Adjuvant_Effects_Improving_Immunogenicity_of_Ag85A_in_DNA_Prime_MVA_Boost_Immunizations_PDF/12992450

الاتاحة: https://doi.org/10.3389/fcimb.2020.581812.s001
https://figshare.com/articles/dataset/Data_Sheet_1_IL-12_DNA_Displays_Efficient_Adjuvant_Effects_Improving_Immunogenicity_of_Ag85A_in_DNA_Prime_MVA_Boost_Immunizations_PDF/12992450

المؤلفون: Agustín Rolandelli, Joaquín Miguel Pellegrini, Rodrigo Emanuel Hernández Del Pino, Nancy Liliana Tateosian, Nicolás Oscar Amiano, María Paula Morelli, Florencia Andrea Castello, Nicolás Casco, Alberto Levi, Domingo Juan Palmero, Verónica Edith García

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, tuberculosis, Th17, IL17F, single-nucleotide polymorphism, rs763780, immunogenetics

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_The_Non-synonymous_rs763780_Single-Nucleotide_Polymorphism_in_IL17F_Gene_Is_Associated_With_Susceptibility_to_Tuberculosis_and_Advanced_Disease_Severity_in_Argentina_PDF/9884762

الاتاحة: https://doi.org/10.3389/fimmu.2019.02248.s001
https://figshare.com/articles/dataset/Data_Sheet_1_The_Non-synonymous_rs763780_Single-Nucleotide_Polymorphism_in_IL17F_Gene_Is_Associated_With_Susceptibility_to_Tuberculosis_and_Advanced_Disease_Severity_in_Argentina_PDF/9884762

المؤلفون: María Magdalena Gherardi, Virginia Pasquinelli, Delfina Peña, H. Eduardo Chuluyan, Rodrigo Emanuel Hernández del Pino, Rosa M. Musella, Nicolás Oscar Amiano, Marisa Gutierrez, Verónica E. García, Joaquín Miguel Pellegrini, Juan L. Iovanna, Ana Inés Rovetta, Agustín Rolandelli, Nancy Liliana Tateosian, Domingo Palmero

المصدر: EBioMedicine, Vol 2, Iss 8, Pp 884-890 (2015)
EBioMedicine
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

مصطلحات موضوعية: Adult, Male, Tuberculosis, CIENCIAS MÉDICAS Y DE LA SALUD, Inmunología, Tuberculin, lcsh:Medicine, Peripheral blood mononuclear cell, General Biochemistry, Genetics and Molecular Biology, Mycobacterium tuberculosis, IFN-gamma, Interferon-gamma, Antigen, Latent Tuberculosis, Diagnosis, medicine, Humans, Antigens, Tuberculosis Vaccines, Ifn-Gamma, Mycobacterium bovis, Antigens, Bacterial, lcsh:R5-920, biology, Latent tuberculosis, lcsh:R, General Medicine, purl.org/becyt/ford/3.1 [https], Middle Aged, biology.organism_classification, medicine.disease, Active Tuberculosis, bacterial infections and mycoses, Virology, Active tuberculosis, Medicina Básica, Immunology, Leukocytes, Mononuclear, purl.org/becyt/ford/3 [https], Original Article, Female, Tuberculosis vaccines, lcsh:Medicine (General)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a804f3b6296f0986ea21177faed3649d

المؤلفون: Agustín Rolandelli, Maria Cecilia Santilli, Domingo Palmero, Nicolás Oscar Amiano, Verónica E. García, Joaquín Miguel Pellegrini, Nancy Liliana Tateosian, Florencia Andrea Castello, Nicolás Casco, María Alicia Morelli, Alberto Levi

المصدر: Genes; Volume 9; Issue 1; Pages: 46
Genes, Vol 9, Iss 1, p 46 (2018)
Genes
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

مصطلحات موضوعية: SINGLE NUCLEOTIDE POLYMORPHISM, 0301 basic medicine, Tuberculosis, lcsh:QH426-470, Population, Single-nucleotide polymorphism, Biology, TUBERCULOSIS, INTERFERON GAMMA, Peripheral blood mononuclear cell, Article, Ciencias Biológicas, purl.org/becyt/ford/1 [https], Mycobacterium tuberculosis, 03 medical and health sciences, single nucleotide polymorphism, Genotype, Genetics, medicine, SNP, Interferon gamma, purl.org/becyt/ford/1.6 [https], education, Genetics (clinical), mycobacterium tuberculosis, MYCOBACTERIUM TUBERCULOSIS, education.field_of_study, rs1861494, Bioquímica y Biología Molecular, tuberculosis, biology.organism_classification, medicine.disease, lcsh:Genetics, RS1861494, 030104 developmental biology, Immunology, CIENCIAS NATURALES Y EXACTAS, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3894f39b41bf739f9df4e08ff7fc64b8

المؤلفون: Nicolás Casco, Agustín Rolandelli, María Isabel Colombo, Domingo Palmero, Nancy Liliana Tateosian, Nicolás Oscar Amiano, Verónica E. García, Joaquín Miguel Pellegrini

المصدر: Autophagy. 13(7)

مصطلحات موضوعية: 0301 basic medicine, Tuberculosis, Basic Research Papers, T cell, Biology, TUBERCULOSIS, Monocytes, Mycobacterium tuberculosis, Ciencias Biológicas, 03 medical and health sciences, Interferon-gamma, 0302 clinical medicine, Immune system, Tuberculosis diagnosis, Biología Celular, Microbiología, IMMUNE RESPONSE, medicine, PATIENTS, Autophagy, Humans, Molecular Biology, Pathogen, Cells, Cultured, MYCOBACTERIUM TUBERCULOSIS, CYTOKINES, Interleukin-17, Cell Biology, IFNG, biology.organism_classification, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Immunology, AUTOPHAGY, IL17A, CIENCIAS NATURALES Y EXACTAS, 030215 immunology, Signal Transduction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73d03995e35901b4980da86d46a7bdb
https://pubmed.ncbi.nlm.nih.gov/28581888

المؤلفون: Gabriela María Recalde, Fabiana Bigi, Ana Inés Rovetta, Delfina Peña, Verónica E. García, Joaquín Miguel Pellegrini, Rodrigo Emanuel Hernández del Pino, Rosa M. Musella, María Isabel Colombo, Domingo Palmero, Marisa Gutierrez

المصدر: Autophagy 10 (12) : 2109-2121 (November 2014)
INTA Digital (INTA)
Instituto Nacional de Tecnología Agropecuaria
instacron:INTA

مصطلحات موضوعية: Male, CIENCIAS MÉDICAS Y DE LA SALUD, Tuberculosis, Respuesta Inmunológica, DEFENSE, T cell, Inmunología, Autofagia, Virulence, chemical and pharmacologic phenomena, Biology, TUBERCULOSIS, Mycobacterium tuberculosis, Interferon-gamma, Citoquinas, Immune system, Antigen, IMMUNE RESPONSE, Autophagy, PATIENTS, medicine, Humans, Antigens, Molecular Biology, Pathogen, Antigens, Bacterial, Macrophages, Brief Report, CYTOKINES, Antígenos, Cell Biology, Th1 Cells, IFNG, respiratory system, bacterial infections and mycoses, biology.organism_classification, medicine.disease, Interferonas, Interferon Gamma, Medicina Básica, medicine.anatomical_structure, Immunology, Female, AUTOPHAGY, Interferons

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1247a8dba492ca95b5697e99a4f9a849
https://doi.org/10.4161/15548627.2014.981791

المؤلفون: Domingo Palmero, Virginia Pasquinelli, Nancy Liliana Tateosian, H. Eduardo Chuluyan, Rogelio Hernández-Pando, María Antonieta de Jesús Araujo-Solís, Rosa M. Musella, Rodrigo Emanuel Hernández del Pino, Diego Guerrieri, Natalia Santucci, Luciano D’Attilio, Sigifredo Pedraza-Sánchez, Verónica E. García, Joaquín Miguel Pellegrini, Nella Ambrosi

المصدر: The American Journal of Pathology. 184(5):1268-1273

مصطلحات موضوعية: Tuberculosis, biology, business.industry, biology.organism_classification, medicine.disease, Peripheral blood mononuclear cell, 3. Good health, Pathology and Forensic Medicine, Mycobacterium tuberculosis, Immune system, Antigen, Interferon, Immunology, Medicine, Interferon gamma, business, medicine.drug, SLPI

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ebe923286bdff34703f84ceea7beb6