المؤلفون: Andreea Zubaș, Alina Ghinet, Amaury Farce, Joëlle Dubois, Elena Bîcu

المصدر: Pharmaceuticals, Vol 16, Iss 6, p 888 (2023)

مصطلحات موضوعية: tubulin, inhibitor, dual, farnesyltransferase, cancer, cyanochalcone, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/6/888; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/7a614bbe9e6449458fb251afebe52d6c

المؤلفون: Laure Peilleron, Tatyana D. Grayfer, Joëlle Dubois, Robert H. Dodd, Kevin Cariou

المصدر: Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1103-1111 (2018)

مصطلحات موضوعية: halogenation, hypervalent iodine, monoterpenes, Science, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1860-5397

URL الوصول: https://doaj.org/article/c3d87339091a4ae8ac16860f2df045e5

المؤلفون: Jacquie L. Harper, Iman M. Khalil, Lisa Shaw, Marie-Lise Bourguet-Kondracki, Joëlle Dubois, Alexis Valentin, David Barker, Brent R. Copp

المصدر: Marine Drugs, Vol 13, Iss 8, Pp 5102-5110 (2015)

مصطلحات موضوعية: thiaplidiaquinone, Aplidium, ascidian, thiazinoquinone, apoptosis, Jurkat, cytotoxicity, malaria, farnesyltransferase, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1660-3397/13/8/5102; https://doaj.org/toc/1660-3397

URL الوصول: https://doaj.org/article/25001f675d8446feb4fa4efc647d267e

المؤلفون: Aminata P Nacoulma, Veronique Megalizzi, Laurent R Pottier, Manuela De Lorenzi, Sylviane Thoret, Joëlle Dubois, Olivier M Vandeputte, Pierre Duez, Danny Vereecke, Mondher El Jaziri

المصدر: PLoS ONE, Vol 8, Iss 10, p e77529 (2013)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3805576?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/10879328f84349968207c39528cb8407

المؤلفون: Pierrick Dufrénoy, Marie Hechelski, Adam Daïch, Amaury Farce, Emmanuelle Lipka, Joëlle Dubois, Christophe Waterlot, Alina Ghinet

المصدر: Sustainable Chemistry and Pharmacy. 30:100894

مصطلحات موضوعية: Pharmaceutical Science, Environmental Chemistry, Management, Monitoring, Policy and Law, Pollution

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d7ff18ee389139d420e51176fa71e817
https://doi.org/10.1016/j.scp.2022.100894

المؤلفون: Shannon Pecnard, Joëlle Dubois, Jérôme Bignon, Guillaume Bernadat, Hélène Levaique, Mouad Alami, Olivier Provot, Ilhem Khelifi

المساهمون: Biomolécules : Conception, Isolement, Synthèse (BioCIS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

المصدر: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2020, ⟨10.1002/cmdc.202000197⟩

مصطلحات موضوعية: Models, Molecular, Cell Survival, Antineoplastic Agents, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Tubulin, Biological property, Drug Discovery, Tumor Cells, Cultured, Humans, [CHIM]Chemical Sciences, General Pharmacology, Toxicology and Pharmaceutics, Cytotoxicity, IC50, neoplasms, Cell Proliferation, Pharmacology, Aza Compounds, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Quinoline, Cell Cycle, Tubulin Modulators, 3. Good health, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Oxazepines, chemistry, Cell culture, Biophysics, Molecular Medicine, Oxazepine, Drug Screening Assays, Antitumor, Lead compound, K562 cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be24d4117e716337c37e8961b716b44
https://hal.archives-ouvertes.fr/hal-02910295/document

المؤلفون: Michael Knorr, Farce Amaury, Joëlle Dubois, Mohamed Othman, Carsten Strohmann, Anthony Pesquet, Hamid Marzag, Adam Daïch, Ata Martin Lawson, Alina Ghinet

المساهمون: Unité de Recherche en Chimie Organique et Macromoléculaire (URCOM), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Technische Universität Dortmund [Dortmund] (TU), Institut de Chimie Pharmaceutique Albert Lespagnol (ICPAL), Université de Lille, Droit et Santé, Hautes Etudes d’Ingénieur [Lille] (HEI), JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), The authors gratefully acknowledge the 'Institut Normand de Chimie Moléculaire, Médicinale et Macromoléculaire, INC3M FR-CNRS 3038', the ‘Normand Crunch Network’, the URCOM laboratory and the University of Le Havre Normandy of Normandie-Université for their financial support and technical help and facilities., Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

المصدر: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2019, 17 (10), pp.2798-2808. ⟨10.1039/c8ob02612b⟩
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (10), pp.2798-2808. ⟨10.1039/c8ob02612b⟩

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Farnesyltransferase, Molecular Conformation, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Isoindoles, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Biochemistry, chemistry.chemical_compound, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Farnesyltranstransferase, [CHIM]Chemical Sciences, Spiro Compounds, Lewis acids and bases, Enzyme Inhibitors, Physical and Theoretical Chemistry, Imide, Olefin fiber, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, Organic Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, 0104 chemical sciences, chemistry, Intramolecular force, biology.protein, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Brønsted–Lowry acid–base theory, Isoindole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54af2f765622751ae1fff353b5b7c3ef
https://doi.org/10.1039/c8ob02612b

المؤلفون: Emilie Floquet, Joëlle Dubois, Alina Ghinet, Amaury Farce, Benoît Rigo, Xavier Thuru

المساهمون: Institut de Chimie Pharmaceutique Albert Lespagnol (ICPAL), Université de Lille, Droit et Santé, Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université catholique de Lille (UCL), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)

المصدر: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2020, 96, pp.103643. ⟨10.1016/j.bioorg.2020.103643⟩
Bioorganic Chemistry, 2020, 96, pp.103643. ⟨10.1016/j.bioorg.2020.103643⟩

مصطلحات موضوعية: Pyruvate dehydrogenase kinase, Thio, Antineoplastic Agents, Acetates, Ligands, 01 natural sciences, Biochemistry, Benzophenones, Tubulin, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Humans, [CHIM]Chemical Sciences, Binding site, Molecular Biology, Protein Kinase Inhibitors, ComputingMilieux_MISCELLANEOUS, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Cancer, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Cell cycle, medicine.disease, Pyruvate dehydrogenase complex, In vitro, Tubulin Modulators, 0104 chemical sciences, 3. Good health, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, biology.protein, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7faadf08e20c814a343cef30a29447df
https://hal.archives-ouvertes.fr/hal-02873632

المؤلفون: Sylviane Thoret, Joëlle Dubois, Marion Thévenin

المصدر: European Journal of Organic Chemistry. 2018:5843-5852

مصطلحات موضوعية: Chalcone, chemistry.chemical_compound, 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, Total synthesis, Physical and Theoretical Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2513bd8c27985bc5352f9c3791f21fbb
https://doi.org/10.1002/ejoc.201800338

المؤلفون: Joëlle Dubois, Marcel Kaiser, Brent R. Copp, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, David Barker, Melissa M. Cadelis

المساهمون: School of Chemical Sciences [Auckland], University of Auckland [Auckland], Laboratoire de chimie et biochimie des substances naturelles, Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), University of Basel (Unibas), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2017, 25 (16), pp.4433-4443. ⟨10.1016/j.bmc.2017.06.029⟩
Bioorganic and Medicinal Chemistry, 2017, 25 (16), pp.4433-4443. ⟨10.1016/j.bmc.2017.06.029⟩

مصطلحات موضوعية: Cell Survival, Stereochemistry, Staphylococcus, [SDV]Life Sciences [q-bio], Farnesyltransferase, Plasmodium falciparum, Clinical Biochemistry, Thiaplidiaquinone, Pharmaceutical Science, FTase inhibitor, Microbial Sensitivity Tests, 01 natural sciences, Biochemistry, Natural product, Cell Line, Antimalarials, Structure-Activity Relationship, Prenylation, Drug Discovery, Structural isomer, Animals, Farnesyltranstransferase, Structure–activity relationship, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cytotoxicity, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Terpenes, 010405 organic chemistry, Chemistry, Organic Chemistry, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, biology.organism_classification, Anti-plasmodial, Anti-Bacterial Agents, Rats, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, biology.protein, Molecular Medicine, Biomimetic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91f3dac7c1a58c77f878e98fe61859c
https://doi.org/10.1016/j.bmc.2017.06.029

المؤلفون: Joëlle Dubois, Vida Terzic, Guillaume Pousse, Rachel Méallet-Renault, Philippe Grellier

المساهمون: Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires (PPSM), École normale supérieure - Cachan (ENS Cachan)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Molécules de Communication et Adaptation des Micro-organismes (MCAM), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (13), pp.8542-8551. ⟨10.1021/acs.joc.9b00895⟩

مصطلحات موضوعية: Azides, Stereochemistry, Plasmodium falciparum, Trypanosoma brucei brucei, Antiprotozoal Agents, Alkyne, Hydrocarbons, Cyclic, 010402 general chemistry, 01 natural sciences, Fluorescence, chemistry.chemical_compound, [CHIM]Chemical Sciences, Reactivity (chemistry), ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Strain (chemistry), Cycloaddition Reaction, Molecular Structure, 010405 organic chemistry, Aryl, Organic Chemistry, Substitution (logic), Cycloaddition, 0104 chemical sciences, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, chemistry, Azide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe001d250e3953cea85f8278fc8de08
https://pubmed.ncbi.nlm.nih.gov/31199143

المؤلفون: Liliana Lucescu, Sergiu Shova, Romain Magnez, Xavier Thuru, Amaury Farce, Alina Ghinet, Elena Bîcu, Joëlle Dubois, Dalila Belei, Benoît Rigo

المساهمون: Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Pharmaceutique Albert Lespagnol (ICPAL), Université de Lille, Droit et Santé, 'Petru Poni' Institute of Macromolecular Chemistry, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université catholique de Lille (UCL), Alexandru Ioan Cuza University of Iași [Romania], Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

المصدر: Archiv der Pharmazie / Chemistry in Life Sciences
Archiv der Pharmazie / Chemistry in Life Sciences, 2019, 352 (5), pp.1800227. ⟨10.1002/ardp.201800227⟩
Archiv der Pharmazie / Chemistry in Life Sciences, Wiley-VCH Verlag, 2019, 352 (5), pp.1800227. ⟨10.1002/ardp.201800227⟩

مصطلحات موضوعية: Nitrile, Farnesyltransferase, Pharmaceutical Science, CHO Cells, 01 natural sciences, chemistry.chemical_compound, Structure-Activity Relationship, Cricetulus, 1,3,5-Triazine, Drug Discovery, Animals, Farnesyltranstransferase, Humans, [CHIM]Chemical Sciences, Pyrrolidinones, Isoxazole, Enzyme Inhibitors, ComputingMilieux_MISCELLANEOUS, Triazine, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Triazines, Chinese hamster ovary cell, Isoxazoles, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, biology.protein, Protein farnesylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3eb1df977568acf9d2e4285742939d1
https://hal.science/hal-02873628

المؤلفون: Emmanuelle Lipka, Joëlle Dubois, Amaury Farce, Benoît Rigo, Alina Ghinet, Germain Homerin

المصدر: Organic & Biomolecular Chemistry. 15:8110-8118

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Stereochemistry, In silico, Farnesyltransferase, Context (language use), Models, Biological, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Farnesyltranstransferase, Humans, Computer Simulation, Enzyme Inhibitors, Physical and Theoretical Chemistry, Binding site, Binding Sites, Molecular Structure, biology, Bicyclic molecule, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, Combinatorial chemistry, Pyrrolidonecarboxylic Acid, 0104 chemical sciences, 030104 developmental biology, biology.protein, Pyroglutamic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2a35edddbbba753bd27884899bdca6
https://doi.org/10.1039/c7ob01489a

المؤلفون: Joëlle Dubois, David Barker, Alexis Valentin, Melissa M. Cadelis, Brent R. Copp, Marie-Lise Bourguet-Kondracki

المساهمون: University of Auckland [Auckland], Molécules de Communication et Adaptation des Micro-organismes (MCAM), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), University of Auckland, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut de Recherche pour le Développement (IRD)

المصدر: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2016, 24 (14), pp.3102-3107. ⟨10.1016/j.bmc.2016.05.024⟩

مصطلحات موضوعية: Stereochemistry, [SDV]Life Sciences [q-bio], Farnesyltransferase, Plasmodium falciparum, Clinical Biochemistry, Pharmaceutical Science, FTase inhibitor, Tecomaquinone I, Heterocyclic Compounds, 4 or More Rings, 01 natural sciences, Biochemistry, Natural product, Antimalarials, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Animals, Farnesyltranstransferase, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, IC50, Pyrans, biology, 010405 organic chemistry, Spectrum Analysis, Organic Chemistry, biology.organism_classification, Anti-plasmodial, 3. Good health, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, biology.protein, Molecular Medicine, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f29675c733ef38f9afa900bd9670f40
https://doi.org/10.1016/j.bmc.2016.05.024

المؤلفون: Alina Ghinet, Dalila Belei, Liliana Lucescu, Elena Bîcu, Joëlle Dubois

المصدر: Letters in Drug Design & Discovery. 13:479-488

مصطلحات موضوعية: Chemistry, Pharmaceutical Science, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030220 oncology & carcinogenesis, Drug Discovery, Molecular Medicine, Indolizine, Biological evaluation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f70cc60d2f52016fd487a807779d7f98
https://doi.org/10.2174/1570180812666151022221628

المؤلفون: Rama Ibrahim, Angélique Ferry, Camille Dejean, Françoise Dumas, Pascal Retailleau, Joëlle Dubois, Joël Raingeaud, Franck Le Bideau, Mohammad Kousara, Pierre-Etienne Venot

المصدر: Synthesis. 48:1637-1646

مصطلحات موضوعية: Natural product, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Enantioselective synthesis, Absolute configuration, Total synthesis, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Michael reaction, Chemoselectivity, Enone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::345d14517bf465d935fed3e08b129dbb
https://doi.org/10.1055/s-0035-1561430

المؤلفون: Iuliana-Monica Moise, Alina Ghinet, Joëlle Dubois, Elena Bîcu, Amaury Farce

المصدر: Bioorganic Chemistry. 103:104184

مصطلحات موضوعية: Farnesyltransferase, Antineoplastic Agents, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Phenothiazines, Tubulin, Cell Line, Tumor, Drug Discovery, medicine, Farnesyltranstransferase, Humans, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, Cell Proliferation, Binding Sites, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Cell growth, Organic Chemistry, Farnesyltransferase inhibitor, Indolizines, Cancer, medicine.disease, Tubulin Modulators, In vitro, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Drug Design, Cancer cell, Cancer research, biology.protein, Drug Screening Assays, Antitumor, Ovarian cancer, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd4c254498e6432aa78fc8c450362cc
https://doi.org/10.1016/j.bioorg.2020.104184

المؤلفون: Joëlle Dubois, Germain Homerin, Alina Ghinet, Adrian Sorin Nica, Amaury Farce

المساهمون: Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Yncréa Hauts-de-France, Université catholique de Lille (UCL), CHU Lille, Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Alexandru Ioan Cuza University of Iași [Romania]

المصدر: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2020, 30, pp.127149-. ⟨10.1016/j.bmcl.2020.127149⟩

مصطلحات موضوعية: Farnesyltransferase, Chalcone, Inhibitor, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, 01 natural sciences, Biochemistry, Lithium hydroxide, Catalysis, Ultrasounds, Sonication, Structure-Activity Relationship, chemistry.chemical_compound, Chalcones, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Farnesyltranstransferase, Humans, [CHIM]Chemical Sciences, Enzyme Inhibitors, Claisen-Schmidt, Molecular Biology, Binding Sites, biology, 010405 organic chemistry, Chemistry, Aryl, Organic Chemistry, Combinatorial chemistry, In vitro, 0104 chemical sciences, 3. Good health, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Cell culture, biology.protein, Molecular Medicine, Target protein, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f750912f37397af44112f6296382301
https://doi.org/10.1016/j.bmcl.2020.127149

المؤلفون: Mouad Alami, Timothée Naret, Ilhem Khelifi, Jérôme Bignon, Abdallah Hamze, Maria Concepcion Garcia Alvarez, Olivier Provot, Hélène Levaique, Joëlle Dubois

المساهمون: Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine, Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 168, pp.176-188. ⟨10.1016/j.ejmech.2019.02.038⟩

مصطلحات موضوعية: Mitosis, Antineoplastic Agents, Apoptosis, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Methylamines, Structure-Activity Relationship, quinoline, carbazole, Drug Discovery, Quinazoline, Tumor Cells, Cultured, Humans, isoCA-4, Cytotoxicity, 030304 developmental biology, Cell Proliferation, Cancer, Pharmacology, Indole test, 0303 health sciences, Matrigel, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Carbazole, Cytotoxins, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Quinoline, General Medicine, Cell Cycle Checkpoints, tubulin 2, HCT116 Cells, 3. Good health, 0104 chemical sciences, Tubulin, chemistry, Biochemistry, indole, biology.protein, cytotoxicity, Drug Screening Assays, Antitumor, quinazoline

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96fd498a8ee5906b61da1490555ad16
https://hal.archives-ouvertes.fr/hal-02394208/document

المؤلفون: Martin Souce, Mouad Alami, Timothée Naret, Olivier Provot, Paloma F. Varela, Athena Kasselouri, Hélène Levaique, Alain Deroussent, Ilhem Khelifi, Jérôme Bignon, Angelo Paci, Benoît Gigant, Joëlle Dubois, Abdallah Hamze

المساهمون: Molécules bioactives, conception, isolement et synthèse (MBCIS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Groupe de Chimie Analytique de Paris-Sud, Université Paris-Sud - Paris 11 (UP11), Vectorologie et thérapeutiques anti-cancéreuses [Villejuif] (UMR 8203), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Pharmacologie, Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Biochimie Structurale des Microtubules, des Kinésines et de leurs Cargos (MIKICA), Département Biochimie, Biophysique et Biologie Structurale (B3S), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (4), pp.1902-1916. ⟨10.1021/acs.jmedchem.8b01386⟩
Journal of Medicinal Chemistry, 2019, 62 (4), pp.1902-1916. ⟨10.1021/acs.jmedchem.8b01386⟩

مصطلحات موضوعية: Carbazoles, Antineoplastic Agents, Plasma protein binding, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Quinaldines, 01 natural sciences, Polymerization, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Tubulin, Cell Line, Tumor, Drug Discovery, Human Umbilical Vein Endothelial Cells, Colchicine, Structure–activity relationship, [CHIM]Chemical Sciences, Animals, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Molecular Structure, 010405 organic chemistry, Quinaldine, In vitro, Tubulin Modulators, 0104 chemical sciences, 3. Good health, Rats, G2 Phase Cell Cycle Checkpoints, chemistry, Biochemistry, Cell culture, 030220 oncology & carcinogenesis, biology.protein, Microsome, Microsomes, Liver, Molecular Medicine, Drug Screening Assays, Antitumor, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a2b78671b1af350b21d83a2fd97ebd
https://pubmed.ncbi.nlm.nih.gov/30525602