المؤلفون: Yu Shee, Haote Li, Pengpeng Zhang, Andrea M. Nikolic, Wenxin Lu, H. Ray Kelly, Vidhyadhar Manee, Sanil Sreekumar, Frederic G. Buono, Jinhua J. Song, Timothy R. Newhouse, Victor S. Batista

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/e93efc9d82a34a26a2ffd7bfe5466d20

المؤلفون: Yvett Sosa, Bhav Kapur, Jessica Hurtak, Laura J. Kingsley, Hao Wu, Stefanie Gruber, Herbert Nar, Saad Khattabi, Jesus Seco Moral, Maria Fátima Lucas, Caterina Martin, Nikola Lončar, Frederic Buono, Noah Pefaur, Andrew E. Nixon, Jinhua J. Song

المصدر: Frontiers in Chemical Biology, Vol 3 (2024)

مصطلحات موضوعية: ketoreductase, kinetic resolution, in silico screening, asymmetric synthesis, BioMatchMaker, biocatalysis, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fchbi.2024.1425501/full; https://doaj.org/toc/2813-530X

URL الوصول: https://doaj.org/article/9cf8af4a995a453ca62582f81e558283

المؤلفون: Abbigayle E. Cuomo, Sebastian Ibarraran, Sanil Sreekumar, Haote Li, Jungmin Eun, Jan Paul Menzel, Pengpeng Zhang, Frederic Buono, Jinhua J. Song, Robert H. Crabtree, Victor S. Batista, Timothy R. Newhouse

المصدر: ACS Central Science, Vol 9, Iss 9, Pp 1768-1774 (2023)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2374-7951

URL الوصول: https://doaj.org/article/10372cf32c0d4552aff21780f51311e4

المؤلفون: Zhulin Tan, Xuan Ju, Hao Wu, Weitong Dong, Joyce C. Leung, Xiaowen Hou, Heewon Lee, Alice Granger, Joshua M. Paolillo, Susan V. DiMeo, Chengsheng Chen, Linglin Wu, Jon C. Lorenz, Max Sarvestani, Frederic Buono, Rogelio Frutos, Thomas G. Tampone, Xiaojun Huang, Gulin Zhang, Yuwen Wang, Earl Spinelli, Zhen Lei, Jinhua J. Song

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Ecology, Sociology, Developmental Biology, Hematology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, scalable synthesis toward, scalable asymmetric synthesis, catalyzed epoxide opening, carbon quaternary stereocenter, 1 , requisite ketone, rapid manufacturing, part 2, overall yield, high chemical, heterocyclic core, five steps, final assembly, enantiomeric purities, enabling robust, 300 kg

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_Scalable_Synthesis_toward_a_KRAS_G12C_Inhibitor_Building_Block_Bearing_an_All-Carbon_Quaternary_Stereocenter_Part_2_Asymmetric_Synthesis_via_Shi_Epoxidation/24947434

الاتاحة: https://doi.org/10.1021/acs.oprd.3c00363.s001
https://figshare.com/articles/journal_contribution/Development_of_a_Scalable_Synthesis_toward_a_KRAS_G12C_Inhibitor_Building_Block_Bearing_an_All-Carbon_Quaternary_Stereocenter_Part_2_Asymmetric_Synthesis_via_Shi_Epoxidation/24947434

المؤلفون: Joyce C. Leung, Yibo Xu, Suttipol Radomkit, Jaehee Lee, Wan Shin Kim, Jonathan T. Reeves, Weitong Dong, Hwanjong Jang, Xiaowen Hou, Jon C. Lorenz, Xiaole Shao, Denis Byrne, Joe Johnson, Anthony Brundage, Clement Valentin, Phouvieng Beyer, Susan V. DiMeo, Bo Qu, Ruoshi Li, Max Sarvestani, Jinhua J. Song

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, scale production synthesis, scalable synthesis toward, replacing processes involving, kras g12c inhibitor, key building block, extensive chromatographic purifications, enabling timely delivery, chiral building block, carbon quaternary stereocenters, carbon quaternary stereocenter, discovery oncology programs, 1 , part 1, discovery route, practical route, particular interest, organic chemistry, molecules containing

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_Scalable_Synthesis_toward_a_KRAS_G12C_Inhibitor_Building_Block_Bearing_an_All-Carbon_Quaternary_Stereocenter_Part_1_From_Discovery_Route_to_Kilogram-Scale_Production/24943851

الاتاحة: https://doi.org/10.1021/acs.oprd.3c00362.s001
https://figshare.com/articles/journal_contribution/Development_of_a_Scalable_Synthesis_toward_a_KRAS_G12C_Inhibitor_Building_Block_Bearing_an_All-Carbon_Quaternary_Stereocenter_Part_1_From_Discovery_Route_to_Kilogram-Scale_Production/24943851

المؤلفون: Bachir Latli, Matt J. Hrapchak, Lalith P. Samankumara, Daniel R. Fandrick, Scott Pennino, Heewon Lee, Jinhua J. Song

المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 66:155-168

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Radiology, Nuclear Medicine and imaging, Biochemistry, Spectroscopy, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::19d0d68360ee397b826084104e67cc5b
https://doi.org/10.1002/jlcr.4024

المؤلفون: Bachir Latli, Matt J. Hrapchak, Jonathan T. Reeves, Heewon Lee, Jinhua J. Song

المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 66:145-154

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Radiology, Nuclear Medicine and imaging, Biochemistry, Spectroscopy, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::57c80177e3d32838514b6afbf6a79e8c
https://doi.org/10.1002/jlcr.4022

المؤلفون: Rogelio Frutos, Thomas G. Tampone, Jason Mulder, Joe Gao, Joshua D. Sieber, Sonia Rodriguez, Nizar Haddad, Katrin Baer, Jack Brown, Bing-Shiou Yang, Riccardo Giovannini, Jinhua J. Song, Nelu Grinberg, Heewon Lee, Chris H. Senanayake

المصدر: Organic Process Research & Development. 27:505-512

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5417df0fc0c90acc8c027c01343024c7
https://doi.org/10.1021/acs.oprd.2c00373

المؤلفون: Bo Qu (150402), Xudong Wei (50612), Xingzhong Zeng (1676347), Bing-Shiou Yang (1777186), Jean-Nicolas Desrosiers (1392826), Jolaine Savoie (1479193), Jun Wang (5906), Maurice A. Marsini (1479196), Zhibin Li (129098), Nizar Haddad (1392799), Jon C. Lorenz (1434073), Patrick Tielmann (1763995), Nora Maier (11663719), Jinhua J. Song (1433575), Chris H. Senanayake (1392808)

مصطلحات موضوعية: Biochemistry, Pharmacology, Sociology, Infectious Diseases, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, significant waste reduction, low catalyst loading, disubstituted indenopyridine enables, catalyzed asymmetric hydrogenation, asymmetric pyridine reduction, scale enantioselective reduction, practical manufacturing process, overall process results, n ligand system, manufacturing scale, overall yield, boqphos ligand, asymmetric synthesis, physicochemical properties, key feature, enantioenriched indanopiperidine, effective meo, also described, 5 area, 1000 ppm, 1 inhibitor

Relation: https://figshare.com/articles/journal_contribution/Large-Scale_Enantioselective_Reduction_of_2_3-Disubstituted_Indenopyridine_Enables_a_Practical_Manufacturing_Process_for_an_11_-HSD_1_Inhibitor/16958521

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00290.s001

المؤلفون: Guisheng Li, Zhulin Tan, Yibo Xu, Kanwar P. S. Sidhu, Bo Qu, Melissa A. Herbage, Magnus C. Eriksson, Xingzhong Zeng, Carl A. Busacca, Jean-Nicolas Desrosiers, Thomas Hampel, Oliver Niemeier, Carsten Reichel, Mai Thi Quynh Dang, Marvin Schoerer, Dirk Kemmer, Melanie Eick, Holger Werle, Soojin Kim, Zhibin Li, Shankar Venkatraman, Lanqi Jia, David A. Claremon, Klaus Fuchs, Niklas Heine, Denis Byrne, Bikshandarkoil Narayanan, Max Sarvestani, Joe Johnson, Ajith Premasiri, Larry J. Nummy, Jon C. Lorenz, Nizar Haddad, Nina C. Gonnella, Scott Pennino, Mariusz Krawiec, Chris H. Senanayake, Frederic Buono, Heewon Lee, Azad Hossain, Jinhua J. Song, Jonathan T. Reeves

المصدر: Organic Process Research & Development. 26:3345-3372

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::13095e48d208ec1d6c944dd01aa3ad10
https://doi.org/10.1021/acs.oprd.2c00325

المؤلفون: Bo Qu, Jaehee Lee, Lifen Wu, Anjan K. Saha, Guisheng Li, Yibo Xu, Zhulin Tan, Jason Brazzillo, Nizar Haddad, Scott Pennino, Sonia Rodriguez, Jon C. Lorenz, Rogelio Frutos, Kanwar P. S. Sidhu, Xiao-Jun Wang, Yongda Zhang, Chris H. Senanayake, Jinhua J. Song

المصدر: Organic Process Research & Development. 26:2779-2787

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f1e5e57b2ea48c05cfb6fc0e573c6030
https://doi.org/10.1021/acs.oprd.2c00221

المؤلفون: Xiao-Jun Wang, Lifen Wu, Guisheng Li, Scott Pennino, Bo Qu, Heewon Lee, Xiaowen Hou, Anjan Saha, Jinhua J. Song, Xingzhong Zeng, Chris H. Senanayake, Nizar Haddad, Jon C. Lorenz

المصدر: Organic Process Research & Development. 25:583-590

مصطلحات موضوعية: Scale (ratio), 010405 organic chemistry, Chemistry, Organic Chemistry, Asymmetric hydrogenation, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Reductive amination, 0104 chemical sciences, Catalysis, Rhodium, Organic chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::650146305739e8743b8a842da574ba06
https://doi.org/10.1021/acs.oprd.0c00525

المؤلفون: Jinhua J. Song, Jonathan T. Reeves, Daniel R. Fandrick, Zhulin Tan, Nathan K. Yee, Chris H. Senanayake

المصدر: ARKIVOC, Vol 2010, Iss 1, Pp 390-449 (2010)

مصطلحات موضوعية: Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0011.110; https://doaj.org/toc/1551-7004; https://doaj.org/toc/1551-7012

URL الوصول: https://doaj.org/article/79030d9424644986af116dc3d2a086ba

المؤلفون: Linglin Wu, Lucille A. Wells, Bo Qu, Olga V. Zatolochnaya, Jinhua J. Song, Yongda Zhang, Marisa C. Kozlowski, Ling Wu, Chris H. Senanayake

المصدر: Organic Letters. 21:8952-8956

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Extramural, Stereochemistry, Ligand, Organic Chemistry, Enantioselective synthesis, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Catalysis, Adduct, chemistry.chemical_compound, Oxazepine, Computational analysis, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9c0c25363a1d7049e56cc3623cca5ee8
https://doi.org/10.1021/acs.orglett.9b03328

المؤلفون: Denis Byrne, Zhengxu S. Han, Philomen DeCroos, Bo Qu, Frank Roschangar, Larry Nummy, Yibo Xu, Jinhua J. Song, Jon C. Lorenz, Ling Wu, Chris H. Senanayake, Kanwar Sidhu, Heewon Lee

المصدر: Organic Process Research & Development. 23:263-268

مصطلحات موضوعية: Reaction conditions, Chemical substance, Lithium amide, 010405 organic chemistry, Scale (chemistry), Organic Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Transfer agent, Reagent, Scientific method, tert-Butanesulfinamide, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1afdd5f0b1773f3abbf934a4948f431c
https://doi.org/10.1021/acs.oprd.8b00399

المؤلفون: Sergei Tcyrulnikov, Joshua D. Sieber, Nitinchandra D. Patel, Kendricks S. Lao, Marisa C. Kozlowski, Soumik Biswas, Chris H. Senanayake, Nelu Grinberg, Krishnaja Duvvuri, Neil K. Garg, B. Frank Gupton, Daniel Rivalti, Jinhua J. Song, Scott Pennino, Bo Qu, Heewon Lee, Donghong A. Gao, Yongda Zhang, Hari P. R. Mangunuru, Nizar Haddad, Bryan J. Simmons, Keith R. Fandrick

المصدر: ACS Catalysis. 8:10190-10209

مصطلحات موضوعية: biology, 010405 organic chemistry, Negishi coupling, chemistry.chemical_element, General Chemistry, 010402 general chemistry, biology.organism_classification, 01 natural sciences, Combinatorial chemistry, Catalysis, Reductive elimination, Coupling reaction, 0104 chemical sciences, Transmetalation, chemistry, Catalytic cycle, Tetra, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::32b26b125cfed63d417f88d7a249b313
https://doi.org/10.1021/acscatal.8b02509

المؤلفون: Christian A. Malapit, Heewon Lee, Sonia Rodriguez, Hari P. R. Mangunuru, Carl A. Busacca, Chris H. Senanayake, Nathan K. Yee, Bo Qu, Nizar Haddad, Jinhua J. Song, Jonathan T. Reeves

المصدر: Synthesis. 50:4435-4443

مصطلحات موضوعية: 010405 organic chemistry, Ligand, Aryl, Organic Chemistry, Enantioselective synthesis, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Stereocenter, chemistry.chemical_compound, chemistry, Enantiomer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c953a91aeb1ed5997d43c36dd5ea629d
https://doi.org/10.1055/s-0036-1591590

المؤلفون: Amy R. Howell, Yibo Xu, Heewon Lee, Nizar Haddad, Yongda Zhang, Zhengxu S. Han, Jean-Nicolas Desrosiers, Jinhua J. Song, Nathan K. Yee, Linglin Wu, Xiao-Jun Wang, Kendricks S. Lao, Chris H. Senanayake, Joshua D. Sieber

المصدر: Synthesis. 50:4429-4434

مصطلحات موضوعية: Coupling, 010405 organic chemistry, Chemistry, Ligand, Organic Chemistry, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Phosphine, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c3ea0b80e236b6de4ea5024dd0433094
https://doi.org/10.1055/s-0037-1610158

المؤلفون: Yanchao Xin, Frank Roschangar, Zeena Williams, Denis Byrne, Dmitry Kurouski, Jason A. Mulder, Jinhua J. Song, Alice T. Granger, Laurence J. Nummy, Jon C. Lorenz, Scott Pennino, Frederic G. Buono, Chris H. Senanayake, Yaping Hong, Ajith Premasiri, Nathan K. Yee, Joe Gao, Sonia Rodriguez, Xinzhu Zhang, Bo Qu, Jack D. Brown, Rogelio P. Frutos, Bikshandarkoil A. Narayanan, Zhantong Mao, Azad Hossain, Ning Li, Mariusz Krawiec, Heewon Lee, Yongda Zhang, Zhengxu S. Han, Nizar Haddad, Zhibin Li, Yibo Xu, Nelu Grinberg, Joshua D. Sieber, Carl A. Busacca

المصدر: The Journal of Organic Chemistry. 83:1448-1461

مصطلحات موضوعية: Chiral auxiliary, Trifluoromethyl, Chromatography, 010405 organic chemistry, Ligand, Organic Chemistry, Asymmetric hydrogenation, Enantioselective synthesis, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Yield (chemistry), Vinyl acetate, Enantiomeric excess

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbfec6caeeb7cc523f73c8b888a370ad
https://doi.org/10.1021/acs.joc.7b03022

المؤلفون: Joshua D. Sieber, Heewon Lee, Yongda Zhang, Sergei Tcyrulnikov, Jean-Nicolas Desrosiers, Joyce C. Leung, Nathan K. Yee, Olga V. Zatolochnaya, Kendricks S. Lao, Sonia Rodriguez, Soumik Biswas, Hari P. R. Mangunuru, Bo Qu, Nelu Grinberg, Daniel Rivalti, Chris H. Senanayake, Xiao-Jun Wang, Guisheng Li, Marisa C. Kozlowski, Nizar Haddad, Jinhua J. Song

المصدر: Chemical Science. 9:4505-4510

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Asymmetric hydrogenation, General Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Stereocenter, Kinetic resolution, chemistry.chemical_compound, Crystallography, Copper catalyzed, Copper hydride, Single crystal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3f300707b574c078ea4fb4e1b3d7e04b
https://doi.org/10.1039/c8sc00434j