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1Academic JournalThe Structure-Based Design of SARS-CoV‑2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors
المؤلفون: Tomáš Otava (11002064), Michal Šála (1398271), Fengling Li (176389), Jindřich Fanfrlík (1265010), Kanchan Devkota (1822468), Sumera Perveen (9974693), Irene Chau (2276365), Paknoosh Pakarian (171283), Pavel Hobza (1279320), Masoud Vedadi (210076), Evzen Boura (302259), Radim Nencka (808341)
مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Pharmacology, Infectious Diseases, Plant Biology, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, methyl group, homology model, SARS-CoV nsp 14, crystal structure, SARS-CoV -2 nsp 14, SARS-CoV -2 methyltransferases, SAM, guanosine triphosphate moiety, docking studies, Structure-Based Design, adenine nucleobase, MTase catalyzes, position 7, novel SAH derivatives, 7- deaza analogues, inhibitor, RNA
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2Academic Journal
المؤلفون: Mario Bakardjiev (1684117), Josef Holub (1455901), Dmytro Bavol (9409390), Jan Vrána (6310928), Maksim A. Samsonov (10941551), Aleš Růžička (1378164), Zdeňka Růžičková (1588816), Jindřich Fanfrlík (1265010), Drahomír Hnyk (1455898)
مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Evolutionary Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, methylation pathways, B-functionalized thiaboranes, CH, closo -1- SB 11, closo -1- SB 11 H 11, icosahedral thiaboranes, 1- SB 11 H 11, electrophilic substitution, methyl iodide, parent thiaborane, Terminal Hydrogens, Such polyfunctionalizations, icosahedral closo, thiaborane icosahedral barrier, B 11, polysubstituted polyhedral boron cl., SB 11, 9 -1- closo