المؤلفون: Jiesheng Kang, Roy J. Vaz, Yongyi Luo, David Rampe

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:446-451

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, ERG1 Potassium Channel, Loperamide, Metabolite, Clinical Biochemistry, hERG, Pharmaceutical Science, Torsades de pointes, 030204 cardiovascular system & hematology, Nav1.5, Pharmacology, Biochemistry, QT interval, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Potassium Channel Blockers, medicine, Humans, KvLQT1, Molecular Biology, Cardiotoxicity, Dose-Response Relationship, Drug, Molecular Structure, biology, Organic Chemistry, medicine.disease, 030104 developmental biology, chemistry, biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc46fd2ce619143a94f4c900ecad85e
https://doi.org/10.1016/j.bmcl.2017.12.020

المؤلفون: Jiesheng Kang, Lin Wang, Xiao-Liang Chen, David J Triggle, David Rampe

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://molpharm.aspetjournals.org/content/molpharm/59/1/122.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1060.8123; http://molpharm.aspetjournals.org/content/molpharm/59/1/122.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1060.8123
http://molpharm.aspetjournals.org/content/molpharm/59/1/122.full.pdf

المؤلفون: Michelle Searles, David Rampe, Jiesheng Kang, Yongyi Luo

المصدر: Journal of Applied Toxicology. 37:445-453

مصطلحات موضوعية: 0301 basic medicine, Drug, congenital, hereditary, and neonatal diseases and abnormalities, biology, business.industry, media_common.quotation_subject, hERG, Plasma protein binding, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, QT interval, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Pharmacodynamics, biology.protein, Medicine, Terfenadine, cardiovascular diseases, Patch clamp, business, IC50, medicine.drug, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8f31da1b3cd5caba6cf6e361605a365d
https://doi.org/10.1002/jat.3377

المؤلفون: Junzhi Ji, David Rampe, Jiesheng Kang

المصدر: ASSAY and Drug Development Technologies. 12:352-360

مصطلحات موضوعية: Membrane potential, Calcium Channels, L-Type, Dose-Response Relationship, Drug, Voltage-dependent calcium channel, Chemistry, Guinea Pigs, Original Articles, 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester, Embryonic stem cell, Cell Line, Membrane Potentials, Dephosphorylation, Calcium Channel Agonists, Electrophysiology, Biochemistry, Cell culture, Drug Discovery, Biophysics, Animals, Humans, Molecular Medicine, Myocyte, Myocytes, Cardiac, Stem cell, Embryonic Stem Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763b2bc4d2cd4e37c311bb85956a95d7
https://doi.org/10.1089/adt.2014.596

المؤلفون: Jiesheng Kang, Roy J. Vaz, David R. Compton, David Rampe

المصدر: Naunyn-Schmiedeberg's archives of pharmacology. 389(10)

مصطلحات موضوعية: Loperamide, medicine.medical_specialty, ERG1 Potassium Channel, Patch-Clamp Techniques, Time Factors, Long QT syndrome, hERG, Action Potentials, Torsades de pointes, 030204 cardiovascular system & hematology, Nav1.5, Pharmacology, Transfection, QT interval, NAV1.5 Voltage-Gated Sodium Channel, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Torsades de Pointes, Internal medicine, medicine, Humans, Myocytes, Cardiac, Antidiarrheals, Voltage-Gated Sodium Channel Blockers, biology, Dose-Response Relationship, Drug, business.industry, General Medicine, medicine.disease, Opioid-Related Disorders, Cardiotoxicity, Diarrhea, Long QT Syndrome, Endocrinology, HEK293 Cells, Opioid, KCNQ1 Potassium Channel, biology.protein, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602ad69a0141232658e8af5c9450c92c
https://pubmed.ncbi.nlm.nih.gov/27530870

المؤلفون: Jiesheng, Kang, Yongyi, Luo, Michelle, Searles, David, Rampe

المصدر: Journal of applied toxicology : JAT. 37(4)

مصطلحات موضوعية: Serum, Patch-Clamp Techniques, Myocardium, Temperature, Heart, CHO Cells, Ether-A-Go-Go Potassium Channels, Culture Media, Translational Research, Biomedical, Cricetulus, Torsades de Pointes, Cricetinae, Potassium, Potassium Channel Blockers, Animals

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e8cd041e34b569ee4bd4c78a17c943c0
https://pubmed.ncbi.nlm.nih.gov/27553911

المؤلفون: Haoyu Zeng, Jiesheng Kang

المصدر: ADME-Enabling Technologies in Drug Design and Development

مصطلحات موضوعية: business.industry, Toxicity, Medicine, Pharmacology, business, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eedbcfab779463eb8ebbfe4b972b5e70
https://doi.org/10.1002/9781118180778.ch32

المؤلفون: Xiao-Liang Chen, Qiubo Lei, Jiesheng Kang, Junzhi Ji, David Rampe

المصدر: Journal of Pharmacology and Experimental Therapeutics. 341:510-517

مصطلحات موضوعية: Pharmacology, Voltage-dependent calcium channel, Biology, Bay K8644, Embryonic stem cell, chemistry.chemical_compound, chemistry, Bepridil, medicine, Molecular Medicine, Myocyte, Stem cell, Induced pluripotent stem cell, Ion channel, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6cde526b606c59d6c0a676821c9dceea
https://doi.org/10.1124/jpet.112.192609

المؤلفون: Xin Chen, Poli Gregory B, Joseph T. Tsay, Jiesheng Kang, Ying Zhang, Anne Minnich, Keith Sides, Qingping Wang, Yong Mi Choi-Sledeski, Patrick Wai-Kwok Shum, Guyan Liang, Vasant Kumar

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1606-1610

مصطلحات موضوعية: Models, Molecular, Benzylamines, ERG1 Potassium Channel, Scaffold, Molecular model, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Thiophenes, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Benzylamine, Drug Stability, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, Serine protease, biology, Chemistry, Organic Chemistry, Cytochrome P450, Ether-A-Go-Go Potassium Channels, In vitro, Potassium channel, biology.protein, Molecular Medicine, Tryptases, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11005196f65f43ed0cb5d4f3f5282312
https://doi.org/10.1016/j.bmcl.2011.12.127

المؤلفون: Xiaoyou Ying, Harry Meng, Junzhi Ji, James Cao, Jiesheng Kang, William F. Reynolds, David Rampe

المصدر: Toxicology Letters. 208:62-68

مصطلحات موضوعية: Male, Cardiac output, medicine.drug_class, Guinea Pigs, Hemodynamics, Blood Pressure, Pharmacology, Toxicology, Designer Drugs, Methamphetamine, Rats, Sprague-Dawley, Mephedrone, Heart Rate, Tachycardia, Heart rate, Toxicity Tests, Acute, medicine, Animals, Myocytes, Cardiac, Cells, Cultured, Ejection fraction, Dose-Response Relationship, Drug, Illicit Drugs, business.industry, Heart, General Medicine, Stroke volume, Rats, Designer drug, Blood pressure, Echocardiography, Hypertension, Electrophysiologic Techniques, Cardiac, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb573877cd9817015305927833156c1e
https://doi.org/10.1016/j.toxlet.2011.10.010

المؤلفون: Junzhi Ji, Josephine Incardona, Hsien Cheng, Jiesheng Kang, David Rampe

المصدر: Journal of Pharmacology and Experimental Therapeutics. 334:619-626

مصطلحات موضوعية: Patch-Clamp Techniques, Potassium Channels, Calcium Channels, L-Type, Guinea Pigs, CHO Cells, In Vitro Techniques, Pharmacology, Epigallocatechin gallate, complex mixtures, QT interval, Catechin, Ion Channels, Sodium Channels, Electrocardiography, QRS complex, chemistry.chemical_compound, Cricetulus, Cricetinae, Animals, Humans, heterocyclic compounds, Patch clamp, KvLQT1, Tea, Voltage-dependent calcium channel, biology, Chemistry, food and beverages, Heart, Stereoisomerism, Electrophysiology, Biochemistry, biology.protein, Molecular Medicine, sense organs, Ion Channel Gating

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60effcc8aed313a6ff79b4d485a18f5
https://doi.org/10.1124/jpet.110.169391

المؤلفون: Jiesheng Kang, Sathapana Kongsamut, Junzhi Ji, Craig P. Smith, Hongge Wang, David Rampe

المصدر: Clinical and Experimental Pharmacology and Physiology. 36:1104-1109

مصطلحات موضوعية: Indoles, Pyridines, Physiology, CHO Cells, Pharmacology, Membrane Potentials, chemistry.chemical_compound, Cricetulus, Cricetinae, Physiology (medical), Kv1.2 Potassium Channel, Animals, Drosophila Proteins, Humans, Medicine, Channel blocker, 4-Aminopyridine, biology, business.industry, Multiple sclerosis, Chinese hamster ovary cell, biology.organism_classification, medicine.disease, In vitro, Electrophysiology, chemistry, Shaker Superfamily of Potassium Channels, Female, Kv1.1 Potassium Channel, business, Derivative (chemistry), Sodium Channel Blockers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f92c1eb11526dd61d666311cba86cc
https://doi.org/10.1111/j.1440-1681.2009.05200.x

المؤلفون: William P. Reynolds, Jiesheng Kang, David Rampe, Xiao-Liang Chen

المصدر: Clinical and Experimental Pharmacology and Physiology. 34:1313-1316

مصطلحات موضوعية: Male, Methyl Ethers, medicine.medical_specialty, Cardiotonic Agents, Physiology, Guinea Pigs, Population, Action Potentials, Torsades de pointes, Pharmacology, QT interval, Piperazines, Sevoflurane, Physiology (medical), Internal medicine, medicine, Animals, Myocytes, Cardiac, education, education.field_of_study, Chemistry, Sodium channel, Heart, Cardiac action potential, medicine.disease, Potassium channel, Long QT Syndrome, Electrophysiology, Anesthetics, Inhalation, Cardiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bb4ffceb9efd989c09e22d717a7de7
https://doi.org/10.1111/j.1440-1681.2007.04805.x

المؤلفون: Robert W. Singleton, David Rampe, Giovanni Cianchetta, Meng Zhang, Yi Li, Jiesheng Kang, Roy J. Vaz, Marianne Wildgoose

المصدر: Molecular Interaction Fields: Applications in Drug Discovery and ADME Prediction, Volume 27

مصطلحات موضوعية: Chemistry, Molecular interaction fields, Nanotechnology, Medicinal chemistry, ADME

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::338e52ff97e2273ea99d289b6d13eb66
https://doi.org/10.1002/3527607676.ch9

المؤلفون: Gabriele Cruciani, Giovanni Cianchetta, David Rampe, Roy J. Vaz, Arnaldo Fravolini, Jiesheng Kang, Yi Li

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3637-3642

مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, General method, Clinical Biochemistry, hERG, Quantitative Structure-Activity Relationship, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Isomerism, Grind, Drug Discovery, Potassium Channel Blockers, medicine, Humans, Inhibitory concentration 50, Molecular Biology, Binding Sites, biology, Chemistry, Organic Chemistry, Potassium channel blocker, Potassium channel, Potassium Channels, Voltage-Gated, Correlation analysis, biology.protein, Molecular Medicine, Biological system, Anti-Arrhythmia Agents, Software, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2ebb920bf96b8c039374bd227dd9ab
https://doi.org/10.1016/j.bmcl.2005.03.062

المؤلفون: Zhongli Gao, Raisa Nagorny, Jiesheng Kang, William F. Reynolds, Ryan Hartung, Pascal George, Hall Daniel A, Hurst William J, James A. Hendrix

المصدر: Bioorganicmedicinal chemistry. 23(3)

مصطلحات موضوعية: Male, Patch-Clamp Techniques, Stereochemistry, Clinical Biochemistry, hERG, Guinea Pigs, Pharmaceutical Science, CHO Cells, Pharmacology, Scaffold hopping, Biochemistry, Structure-Activity Relationship, Cricetulus, Dogs, Pharmacokinetics, Transcriptional Regulator ERG, Drug Discovery, Animals, Humans, Molecular Biology, Ion channel, biology, Chemistry, Organic Chemistry, Antagonist, Stereoisomerism, In vitro, Drug Design, biology.protein, Trans-Activators, Molecular Medicine, Female, Histamine H3 receptor, Selectivity, Histamine H3 Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bf3ad789a944a8bb6479b9bc75631a
https://pubmed.ncbi.nlm.nih.gov/25577710

المؤلفون: Nguyen D. Nguyen, Ralph B. Puchalski, Christine C. Chang, Jiesheng Kang, John H. Teeter, Stephen P. Brazier

المصدر: Journal of Neurochemistry. 76:1465-1474

مصطلحات موضوعية: animal structures, biology, Voltage-gated ion channel, fungi, Protein primary structure, Anatomy, Molecular cloning, biology.organism_classification, Biochemistry, Potassium channel, Cell biology, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Ictalurus, Taste bud, medicine, Peptide sequence, Catfish

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::852344708189cfedea9b8207b4cb7ad7
https://doi.org/10.1046/j.1471-4159.2001.00137.x

المؤلفون: Xiaying Wu, Zhuyin Li, Lin Wang, David Rampe, Weimin Tang, Tina Garyantes, Damien Dunnington, Hong Shen, Jiesheng Kang

المصدر: SLAS Discovery. 6:325-331

مصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, Potassium Channels, hERG, Color, Dofetilide, CHO Cells, Pharmacology, Sensitivity and Specificity, 01 natural sciences, Biochemistry, Membrane Potentials, Analytical Chemistry, 03 medical and health sciences, Sertindole, Cricetinae, Methods, Potassium Channel Blockers, medicine, Animals, Cation Transport Proteins, Chromatography, biology, Voltage-gated ion channel, Chemistry, Potassium channel blocker, Rubidium, Ether-A-Go-Go Potassium Channels, Potassium channel, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Astemizole, Potassium Channels, Voltage-Gated, biology.protein, Molecular Medicine, Efflux, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c062face926a413f61d3e4cea4c8e02
https://doi.org/10.1177/108705710100600506

المؤلفون: Naomi J. Logsdon, Edward P. Christian, James A. Togo, Jayashree Aiyar, Jiesheng Kang

المصدر: Journal of Biological Chemistry. 272:32723-32726

مصطلحات موضوعية: Potassium Channels, Charybdotoxin, Databases, Factual, T-Lymphocytes, Molecular Sequence Data, Kaliotoxin, Biology, Transfection, Apamin, Biochemistry, Potassium Channels, Calcium-Activated, KCNN4, chemistry.chemical_compound, Scyllatoxin, Humans, Amino Acid Sequence, Cloning, Molecular, Molecular Biology, Base Sequence, Margatoxin, Cell Biology, Iberiotoxin, Intermediate-Conductance Calcium-Activated Potassium Channels, Molecular biology, Calcium-activated potassium channel, Potassium channel, chemistry, Calcium, Lymph Nodes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ebcfc7588c80193489be1fafba7f75
https://doi.org/10.1074/jbc.272.52.32723

المؤلفون: Kathryn F. Medler, Jiesheng Kang, Michael L. Moore, Richard C. Bruch

المصدر: Journal of Neurobiology. 33:387-394

مصطلحات موضوعية: G protein-coupled receptor kinase, Olfactory receptor, General Neuroscience, Tropomyosin receptor kinase B, Biology, Molecular biology, Tropomyosin receptor kinase C, Cellular and Molecular Neuroscience, medicine.anatomical_structure, medicine, Enzyme-linked receptor, 5-HT5A receptor, Receptor, Protein kinase C

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::75421e09070786501987698e07af1af1
https://doi.org/10.1002/(sici)1097-4695(199710)33:4<387::aid-neu4>3.0.co;2-6