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1
المؤلفون: Srinivasan Chandrasekhar, Bradley Condon, Matthew Allen Schiffler, Kuklish Steven Lee, Kim Euibong Jemes, Bryan H. Norman, John R. Rizzo, Jeremy Schulenburg York, Kristina M. Campanale, Stefan Jon Thibodeaux, Richard E. Rathmell, Michael J. Hickey, Christopher Groshong, Shobha N. Bhattachar, Norman Earle Hughes, Anita K. Harvey, John G. Luz, Stephen Antonysamy, Scott Alan Jones, Timothy Andrew Woods, Prashant V. Desai, Matthew J. Fisher, Xiao-Peng Yu, Thomas W. Seng
المصدر: Journal of Medicinal Chemistry. 59:194-205
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, medicine.medical_treatment, Biological Availability, Pharmacology, Structure-Activity Relationship, 03 medical and health sciences, Dogs, Microsomes, Drug Discovery, Cytochrome P-450 CYP3A, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Structure–activity relationship, Potency, Cyclooxygenase Inhibitors, IC50, Prostaglandin-E Synthases, ADME, Analgesics, CYP3A4, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Imidazoles, Rats, Intramolecular Oxidoreductases, 030104 developmental biology, Biochemistry, Celecoxib, Molecular Medicine, Prostaglandin E
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2
المؤلفون: Srinivasan Chandrasekhar, Warshawsky Alan M, Xiao-Peng Yu, Xushan Wang, Kuklish Steven Lee, Anita K. Harvey, Jeremy Schulenburg York, Matthew J. Fisher, Matthew Allen Schiffler
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:3176-3178
مصطلحات موضوعية: Lipopolysaccharides, Prostaglandin E2 receptor, Clinical Biochemistry, EP4 Receptor, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, Dogs, Pharmacokinetics, Drug Discovery, Animals, Humans, Molecular Biology, Whole blood, Analgesics, Blood Cells, Tumor Necrosis Factor-alpha, Chemistry, Organic Chemistry, Antagonist, Bioavailability, Molecular Medicine, lipids (amino acids, peptides, and proteins), Tumor necrosis factor alpha, Receptors, Prostaglandin E, EP4 Subtype, Half-Life, Protein Binding
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3
المؤلفون: Karen Gooding, Peter R. Manninen, James McGee, Matthew J. Fisher, Antonio Navarro, Warshawsky Alan M, Srinivasan Chandrasekhar, Daniel R. Mudra, Stephen Antonysamy, Adrian J. Fretland, Xiao-Peng Yu, Jeremy Schulenburg York, Jennifer M. Weller, Kuklish Steven Lee, Ashley V. Sloan, Shobha N. Bhattachar, Anita K. Harvey, Katherine M. Partridge, Steven James Quimby, Norman Earle Hughes, John G. Luz, Bryan H. Norman, Matthew Allen Schiffler
المصدر: Bioorganicmedicinal chemistry letters. 27(6)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Benzoates, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Microsomes, Drug Discovery, Anthranilic acid, Potency, Animals, Molecular Biology, CYP2C9, Benzoic acid, Whole blood, Prostaglandin-E Synthases, chemistry.chemical_classification, Organic Chemistry, Rational design, In vitro, Rats, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine
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4
المؤلفون: Shobha N. Bhattachar, Stephen Antonysamy, Warshawsky Alan M, Norman Earle Hughes, Matthew Allen Schiffler, Anita K. Harvey, Jeremy Schulenburg York, Antonio Navarro, John G. Luz, Bryan H. Norman, Katherine M. Partridge, Steven James Quimby, Xiao-Peng Yu, Karen Gooding, James McGee, Matthew J. Fisher, Kuklish Steven Lee, Srinivasan Chandrasekhar, Ashley V. Sloan, Peter R. Manninen, Adrian J. Fretland
المصدر: Bioorganicmedicinal chemistry letters. 26(19)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Piperidines, Species Specificity, Drug Discovery, medicine, Animals, Humans, Molecular Biology, IC50, Whole blood, Prostaglandin-E Synthases, Volume of distribution, Chemistry, Organic Chemistry, Bioavailability, Rats, 030104 developmental biology, A549 Cells, 030220 oncology & carcinogenesis, Microsome, Molecular Medicine, lipids (amino acids, peptides, and proteins), Piperidine, Ex vivo, Prostaglandin E
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5
المؤلفون: Yanping Xu, Nathan Bryan Mantlo, Fatima Iradier, Leonard L. Winneroski, Gary J. Etgen, Chahrzad Montrose-Rafizadeh, Carol L. Broderick, Jason Eric Lamar, Nathan Yumibe, Richard W. Zink, Brian A. Oldham, Jeremy Schulenburg York, Isabel C. Gonzalez
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1052-1055
مصطلحات موضوعية: Agonist, chemistry.chemical_classification, medicine.medical_specialty, medicine.drug_class, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, medicine.disease, Biochemistry, Chemical synthesis, Endocrinology, Nuclear receptor, chemistry, In vivo, Internal medicine, Diabetes mellitus, Drug Discovery, medicine, Molecular Medicine, Rosiglitazone, Molecular Biology, medicine.drug
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6
المؤلفون: and Lea M. Johnson, Bryan D. Anderson, Paul Lee, Miriam del Prado, C. Richard NevillJr., Sehila Pleite, Yong Wang, † Jaime Blanco-Urgoiti, Luisa M. Martín Cabrejas, Jeremy Schulenburg York, Robert M. Campbell, Deborah D. Giera, Michal Vieth, Jeffrey A. Wolos, Denis J. McCann, Chuan Shih, Li C. Li, Beatriz López de Uralde, Nicholas A. Magnus, Concepción Sánchez, Rosanne Bonjouklian, Richard M. Schultz, María José Lorite, Alfonso De Dios
المصدر: Journal of Medicinal Chemistry. 48:2270-2273
مصطلحات موضوعية: Lipopolysaccharides, Models, Molecular, Anti-Inflammatory Agents, Administration, Oral, Biological Availability, Crystallography, X-Ray, Mitogen-Activated Protein Kinase 14, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Protein kinase A, chemistry.chemical_classification, Mice, Inbred BALB C, Binding Sites, biology, CYP3A4, Tumor Necrosis Factor-alpha, Arthritis, Experimental, In vitro, Rats, Enzyme binding, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, Macrophages, Peritoneal, biology.protein, Molecular Medicine, Benzimidazoles, Collagen, Lead compound
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7
المؤلفون: Anita K. Harvey, Srinivasan Chandrasekhar, C. Lin, Tatiana Natali Vetman, Xushan Wang, Matthew Allen Schiffler, Warshawsky Alan M, J.L. Oskins, Jeremy Schulenburg York, Mark Chambers, Alison M. Bendele, Matthew J. Fisher, Maria-Jesus Blanco, Xiao-Peng Yu, Kuklish Steven Lee
المصدر: Pharmacology Research & Perspectives
مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, EP4 Receptor, Arthritis, Prostaglandin, Inflammation, Pharmacology, Anti-inflammatory, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Medicine, pain, Selective receptor modulator, General Pharmacology, Toxicology and Pharmaceutics, Prostaglandin E2, business.industry, Original Articles, medicine.disease, 030104 developmental biology, arthritis, Neurology, chemistry, Discovery and development of TRPV1 antagonists, EP4 antagonist, inflammation, Original Article, lipids (amino acids, peptides, and proteins), Anti‐inflammatory drugs, prostaglandin, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
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8
المؤلفون: Jeremy Schulenburg York, Samuel J. Dominianni, Richard C. Hoying, Matt R. Reinhard, Margaret M. Faul, Leonard L. Winneroski, William Harlan Gritton
المصدر: ChemInform. 32
مصطلحات موضوعية: Type ii diabetes, chemistry.chemical_classification, Biochemistry, Stereochemistry, Chemistry, Insulin sensitivity, General Medicine, Enhancer, Amino acid
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9
المؤلفون: Qing Shi, Garret J. Etgen, Richard W. Zink, Nathan Bryan Mantlo, Nathan Yumibe, Chaoyu Xie, Yanping Xu, Cathleen K. Clutinger, Jeremy Schulenburg York, Michael E. Laurila, Warshawsky Alan M, Lynnie A. Irwin, Carol L. Broderick, Minmin Wang, Leonard L. Winneroski, Emily Jane Canada, Brian A. Oldham, Chahrzad Montrose-Rafizadeh
المصدر: Bioorganicmedicinal chemistry letters. 17(24)
مصطلحات موضوعية: Agonist, Indoles, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Amide, Drug Discovery, medicine, Animals, Combinatorial Chemistry Techniques, PPAR delta, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Rational design, Amides, In vitro, Rats, PPAR gamma, Disease Models, Animal, chemistry, Nuclear receptor, Diabetes Mellitus, Type 2, Drug Design, Molecular Medicine, Rosiglitazone, medicine.drug
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10
المؤلفون: Nathan Bryan Mantlo, John J. Osborne, Chaoyu Xie, Jeremy Schulenburg York, Qing Shi, Brian A. Oldham, Carol L. Broderick, Chahrzad Montrose-Rafizadeh, Garret J. Etgen, Emily Jane Canada, Leonard L. Winneroski, Nathan Yumibe, Yanping Xu, Jason Eric Lamar, Richard W. Zink, Isabel C. Gonzalez
المصدر: Journal of medicinal chemistry. 49(19)
مصطلحات موضوعية: Agonist, Blood Glucose, Male, Transcriptional Activation, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Peroxisome proliferator-activated receptor, Weight Gain, Chemical synthesis, Cell Line, Mice, Radioligand Assay, Internal medicine, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, PPAR alpha, PPAR delta, Receptor, Dyslipidemias, chemistry.chemical_classification, Phenylpropionates, Insulin, Phenyl Ethers, Stereoisomerism, Peroxisome, PPAR gamma, Endocrinology, chemistry, Nuclear receptor, Diabetes Mellitus, Type 2, Drug Design, Molecular Medicine, Female, Rosiglitazone, medicine.drug
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11
المؤلفون: Matt R. Reinhard, Leonard L. Winneroski, Margaret M. Faul, Richard C. Hoying, William Harlan Gritton, Jeremy Schulenburg York, Samuel J. Dominianni
المصدر: HETEROCYCLES. 55:689
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, medicine.drug_class, Chemistry, Tetrahydroisoquinoline, Organic Chemistry, Non insulin dependent diabetes mellitus, Insulin sensitivity, Analytical Chemistry, Amino acid, Type ii diabetes, chemistry.chemical_compound, β elimination, medicine, Thiazolidinedione, Enhancer