المؤلفون: Farrukh Vohidov (2072296), Jannik N. Andersen (199563), Kyriakos D. Economides (10332160), Michail V. Shipitsin (10332163), Olga Burenkova (10332166), James C. Ackley (10332169), Bhavatarini Vangamudi (1313319), Hung V.-T. Nguyen (2885066), Nolan M. Gallagher (1795861), Peyton Shieh (1586818), Matthew R. Golder (1678135), Jenny Liu (647696), William K. Dahlberg (2188987), Deborah J. C. Ehrlich (10332172), Julie Kim (10332175), Samantha L. Kristufek (10332178), Sung Jin Huh (2401033), Allison M. Neenan (10332181), Joelle Baddour (10332184), Sattanathan Paramasivan (10332187), Elisa de Stanchina (153061), Gaurab KC (10332190), David J. Turnquist (10332193), Jennifer K. Saucier-Sawyer (10332196), Paul W. Kopesky (10332199), Samantha W. Brady (5211746), Michael J. Jessel (10332202), Lawrence A. Reiter (335508), Donald E. Chickering (4847407), Jeremiah A. Johnson (1316577), Peter Blume-Jensen (199585)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, drug development, novel BETi prodrugs, protein inhibitors, prodrug design, prodrug activation kinetics, vivo tumor pharmacokinetics, Such approaches, traceless linkers, tissues offer, Superior Efficacy, BET Inhibitor Bottlebrush Prodrugs, dose-limiting toxicities, antitumor efficacies, syngeneic triple-negative breast ca., trial-and-error design, TI, Systemic Toxicities Prodrugs, prodrug platform

Relation: https://figshare.com/articles/journal_contribution/Design_of_BET_Inhibitor_Bottlebrush_Prodrugs_with_Superior_Efficacy_and_Devoid_of_Systemic_Toxicities/14251084

الاتاحة: https://doi.org/10.1021/jacs.1c00312.s001

المؤلفون: Jeremiah A. Johnson, DeborahJ. C. Ehrlich, MatthewR. Golder, Allison M. Neenan, Peter Blume-Jensen, James C. Ackley, William K. Dahlberg, Kyriakos D. Economides, Jennifer K. Saucier-Sawyer, Lawrence A. Reiter, Paul W. Kopesky, Elisa de Stanchina, Olga Burenkova, David J. Turnquist, Jannik N. Andersen, Sattanathan Paramasivan, Jenny Liu, Bhavatarini Vangamudi, Sung Jin Huh, Nolan M. Gallagher, Samantha W. Brady, Michael J. Jessel, Donald E. Chickering, Peyton Shieh, Farrukh Vohidov, Joelle Baddour, Julie Kim, Michail Shipitsin, Hung V.-T. Nguyen, Gaurab Kc

مصطلحات موضوعية: BET inhibitor, Therapeutic index, Drug development, Tolerability, In vivo, business.industry, medicine.medical_treatment, medicine, Prodrug, Pharmacology, business, Targeted therapy, Bromodomain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4231b129eb3966639444cef3e553ca
https://doi.org/10.26434/chemrxiv.13241966.v1

المؤلفون: Sattanathan Paramasivan, Kyriakos D. Economides, Deborah C. Ehrlich, Eric J. Held, Joelle Baddour, Peter Blume-Jensen, Matthew R. Golder, Allison M. Neenan, Jeremiah A. Johnson, Samantha W. Brady, James C. Ackley, Jennifer K. Saucier-Sawyer, Bhavatarini Vangamudi, Farrukh Vohidov, Paul W. Kopesky, Sung Jin Huh, Hung V.-T. Nguyen, Donald E. Chickering, Michail Shipitsin, Jannik N. Andersen, Jenny Liu, Lawrence A. Reiter

المصدر: Nature biomedical engineering

مصطلحات موضوعية: 0301 basic medicine, Liver Cirrhosis, Male, medicine.medical_specialty, medicine.drug_class, Polymers, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, Pharmacology, 010402 general chemistry, 01 natural sciences, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Medicine, Animals, Prodrugs, Telmisartan, Antihypertensive drug, Carbon Tetrachloride, chemistry.chemical_classification, Mice, Inbred BALB C, business.industry, Prodrug, Molecular medicine, 3. Good health, 0104 chemical sciences, Computer Science Applications, Rats, Disease Models, Animal, 030104 developmental biology, Enzyme, chemistry, Gene Expression Regulation, Liver, Drug Design, Drug delivery, Histopathology, Female, Hepatic fibrosis, business, Angiotensin II Type 1 Receptor Blockers, Biotechnology, medicine.drug, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98eadcb9d6da5cc80f3eab8653dfa20
https://pubmed.ncbi.nlm.nih.gov/31015683

المؤلفون: Jennifer K. Saucier-Sawyer, Eric Song, Elias Quijano, W. Mark Saltzman, Yang Deng, Andrew J. Sawyer, Alice Gaudin, Young-Eun Seo, Anita Huttner

المصدر: Journal of Controlled Release. 232:103-112

مصطلحات موضوعية: Male, medicine.medical_specialty, Green Fluorescent Proteins, Brain tumor, Pharmaceutical Science, Nanoparticle, Convection, Article, Rats, Sprague-Dawley, Rats, Nude, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, 0302 clinical medicine, Polylactic Acid-Polyglycolic Acid Copolymer, Cell Line, Tumor, medicine, Animals, Humans, Lactic Acid, U87, Volume of distribution, Brain Neoplasms, Chemistry, Brain, medicine.disease, Rats, Inbred F344, Tumor Burden, Surgery, PLGA, 030220 oncology & carcinogenesis, Cancer research, Nanoparticles, Glioblastoma, Convection-Enhanced Delivery, Infiltration (medical), Polyglycolic Acid, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611337c07f6e5625439e7573baf4ea86
https://doi.org/10.1016/j.jconrel.2016.04.006

المؤلفون: W. Mark Saltzman, Jennifer K. Saucier-Sawyer, Junwei Zhang, Young-Eun Seo, Yang Deng, Elias Quijano, Christopher J. Cheng

المصدر: Journal of Drug Targeting. 23:736-749

مصطلحات موضوعية: Polymers, Central nervous system, Pharmaceutical Science, Pharmacology, Blood–brain barrier, Article, Mice, Drug Delivery Systems, Cell Line, Tumor, Glioma, Polymer chemistry, medicine, Animals, Humans, Tissue Distribution, Drug Carriers, Mice, Inbred BALB C, Brain Neoplasms, Chemistry, Brain, Biological Transport, Neoplasms, Experimental, medicine.disease, Antineoplastic Agents, Phytogenic, Controlled release, Adenosine, medicine.anatomical_structure, Blood-Brain Barrier, Delayed-Action Preparations, Nanoparticles for drug delivery to the brain, Injections, Intravenous, Nanoparticles, Camptothecin, Drug carrier, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fe66d06588d1fb29a524eb25fe9339
https://doi.org/10.3109/1061186x.2015.1065833

المؤلفون: Christopher J. Cheng, Jennifer K. Saucier-Sawyer, W. Mark Saltzman, Gregory T. Tietjen

المصدر: Nature Reviews Drug Discovery. 14:239-247

مصطلحات موضوعية: Pharmacology, Polymers, Computer science, Extramural, Nanotechnology, General Medicine, Polymeric nanoparticles, Article, Clinical Practice, Drug Delivery Systems, Nanomedicine, Targeted nanoparticles, Targeted drug delivery, Drug Discovery, Animals, Humans, Nanoparticles

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936a7690fd62ad7316b909874fbe3058
https://doi.org/10.1038/nrd4503

المؤلفون: Alice Gaudin, Jennifer K. Saucier-Sawyer, Amanda King, Eric Song, Didier Desmaële, W. Mark Saltzman, Patrick Couvreur, Ranjit S. Bindra

المصدر: Biomaterials. 105

مصطلحات موضوعية: Squalene, Radiosensitizer, Antimetabolites, Antineoplastic, Materials science, Cell Survival, Biophysics, Nanoparticle, Bioengineering, 02 engineering and technology, Pharmacology, Deoxycytidine, Nanocapsules, Article, Polyethylene Glycols, Biomaterials, Diffusion, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, PEG ratio, medicine, Distribution (pharmacology), Animals, Humans, Dose-Response Relationship, Drug, Brain Neoplasms, technology, industry, and agriculture, 021001 nanoscience & nanotechnology, Gemcitabine, Molecular Imaging, Rats, Treatment Outcome, chemistry, Absorption, Physicochemical, Mechanics of Materials, 030220 oncology & carcinogenesis, Ceramics and Composites, 0210 nano-technology, Glioblastoma, Nucleoside, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985545784e06f5080b877c15a7e26a08
https://pubmed.ncbi.nlm.nih.gov/27521616

المؤلفون: Jennifer K. Saucier-Sawyer, Richard L. Edelson, Douglas Hanlon, W. Mark Saltzman, Clarence T. Sasaki, Shashi Prasad, Virginia Cody, Martin A. Birchall

المصدر: Nanomedicine: Nanotechnology, Biology and Medicine. 7:1-10

مصطلحات موضوعية: Materials science, Polymers, medicine.medical_treatment, Antigen presentation, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, In Vitro Techniques, Article, Antigen, Cell Line, Tumor, Neoplasms, medicine, Humans, General Materials Science, Cells, Cultured, Monocyte, Dendritic Cells, Dendritic cell, Immunotherapy, Squamous carcinoma, medicine.anatomical_structure, Immunology, Cancer cell, Microscopy, Electron, Scanning, Cancer research, Nanoparticles, Molecular Medicine, CD8

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91964770297abaaf4b67cf19fa257fbb
https://doi.org/10.1016/j.nano.2010.07.002

المؤلفون: Carmen J. Booth, Jennifer K. Saucier-Sawyer, Joseph M. Piepmeier, W. Mark Saltzman, Andrew J. Sawyer, Jie Liu, Toral R. Patel

المصدر: Drug Delivery and Translational Research. 1:34-42

مصطلحات موضوعية: Drug, Chemotherapy, medicine.medical_specialty, business.industry, media_common.quotation_subject, medicine.medical_treatment, Pharmaceutical Science, Pharmacology, medicine.disease, Controlled release, Article, Surgery, PLGA, chemistry.chemical_compound, chemistry, Glioma, Drug delivery, medicine, business, IC50, Camptothecin, media_common, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff842f6322eab0f8f921b4b0aa6c2019
https://doi.org/10.1007/s13346-010-0001-3

المؤلفون: Sattanathan Paramasivan, Eric J. Held, Hung V.-T. Nguyen, Jennifer K. Saucier-Sawyer, James C. Ackley, Donald E. Chickering, Jeremiah A. Johnson, Matthew R. Golder, Deborah C. Ehrlich, Paul W. Kopesky, Peter Blume-Jensen, Joelle Baddour, Jannik N. Andersen, Sung Jin Huh, Michail Shipitsin, Allison M. Neenan, Jenny Liu, Lawrence A. Reiter, Samantha W. Brady, Farrukh Vohidov, Bhavatarini Vangamudi, Kyriakos D. Economides

المصدر: Nature Biomedical Engineering. 2:707-707

مصطلحات موضوعية: Statement (logic), Published Erratum, Liver fibrosis, Philosophy, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Linguistics, 0104 chemical sciences, Computer Science Applications, 0210 nano-technology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dc5a5b00c05939bab05d3ac76668806d
https://doi.org/10.1038/s41551-018-0299-6

المؤلفون: Virginia Cody, C M Solbrig, W M Saltzman, Jennifer K. Saucier-Sawyer, Douglas Hanlon

المصدر: Molecular Pharmaceutics. 4:47-57

مصطلحات موضوعية: Antigenicity, Lysis, Ovalbumin, Polymers, Pharmaceutical Science, CD8-Positive T-Lymphocytes, Mice, chemistry.chemical_compound, Polylactic Acid-Polyglycolic Acid Copolymer, Antigen, Western blot, Antigens, Neoplasm, In vivo, Neoplasms, Drug Discovery, medicine, Animals, Lactic Acid, Gel electrophoresis, Membrane Glycoproteins, biology, medicine.diagnostic_test, Chemistry, Dendritic Cells, Molecular biology, Mice, Inbred C57BL, Molecular Weight, PLGA, Biophysics, biology.protein, Nanoparticles, Molecular Medicine, Female, Immunotherapy, Polyglycolic Acid, gp100 Melanoma Antigen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afabb22b1ee71aaa5e9f9b4c0a66d2f7
https://doi.org/10.1021/mp060107e

المؤلفون: Themis R. Kyriakides, W. Mark Saltzman, Jennifer K. Saucier-Sawyer, Andrew J. Sawyer, Laura Beth Moore

المصدر: Biomaterials. 89

مصطلحات موضوعية: 0301 basic medicine, Giant Cells, Foreign-Body, Foreign-body giant cell, Materials science, Biophysics, Bioengineering, Article, Biomaterials, Cell Fusion, 03 medical and health sciences, Mice, mir-223, Polylactic Acid-Polyglycolic Acid Copolymer, microRNA, Macrophage fusion, Animals, Lactic Acid, Cells, Cultured, Regulation of gene expression, Mice, Knockout, Cell fusion, Macrophages, Interleukin, Transfection, Cell biology, MicroRNAs, 030104 developmental biology, Gene Expression Regulation, Mechanics of Materials, Immunology, Ceramics and Composites, Nanoparticles, Polyglycolic Acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd40e924d3d9f1b010834662ebbf322
https://pubmed.ncbi.nlm.nih.gov/26967647

المؤلفون: Junwei Zhang, Young-Eun Seo, Jillian W. Andrejecsk, Christopher J. Hoimes, Yang Deng, Jennifer K. Saucier-Sawyer, W. Mark Saltzman

مصطلحات موضوعية: endocrine system, Materials science, Polymers, Biophysics, Nanoparticle, Bioengineering, macromolecular substances, Article, Polyethylene Glycols, Biomaterials, chemistry.chemical_compound, Carcinoma, Lewis Lung, Mice, Drug Delivery Systems, Polylactic acid, stomatognathic system, Coated Materials, Biocompatible, PEG ratio, medicine, Organic chemistry, Animals, Particle Size, Cell Proliferation, Cell Death, technology, industry, and agriculture, respiratory system, Immunohistochemistry, Endocytosis, Surface coating, Chemical engineering, chemistry, Mechanics of Materials, Emulsion, Drug delivery, Ceramics and Composites, Nanoparticles, Camptothecin, Ethylene glycol, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d315ee008c58c5671f7561335ed3ba54
https://europepmc.org/articles/PMC4062180/

المؤلفون: Tarek R. Fadel, Virginia Cody, Martin A. Birchall, Douglas Hanlon, Richard L. Edelson, Shashi Prasad, Jennifer K. Saucier-Sawyer

المصدر: Pharmaceutical research. 29(9)

مصطلحات موضوعية: medicine.medical_treatment, Kinetics, Pharmaceutical Science, Nanoparticle, Article, chemistry.chemical_compound, Mice, Lymphocytes, Tumor-Infiltrating, Antigen, Polylactic Acid-Polyglycolic Acid Copolymer, Antigens, Neoplasm, Cell Line, Tumor, medicine, Animals, Pharmacology (medical), Lactic Acid, Pharmacology, Chemistry, Immunogenicity, Organic Chemistry, technology, industry, and agriculture, Immunotherapy, Dendritic cell, Tumor antigen, Coculture Techniques, Mice, Inbred C57BL, PLGA, Immunology, Biophysics, Microscopy, Electron, Scanning, Molecular Medicine, Nanoparticles, Female, Polyglycolic Acid, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d2a2b0490089bf0d6fc408b1cf073e
https://pubmed.ncbi.nlm.nih.gov/22798259

المؤلفون: Yang Deng, Young-Eun Seo, Jennifer K. Saucier-Sawyer, Christopher J. Cheng, Junwei Zhang, Elias Quijano, W. Mark Saltzman

مصطلحات الفهرس: Collection

المؤلفون: Monica J. Wood, W. Mark Saltzman, Camille Solbrig, Jennifer K. Saucier-Sawyer, Kim A. Woodrow

المصدر: Tissue engineering. Part A. 15(5)

مصطلحات موضوعية: Cell type, Cell Survival, Polymers, Polyesters, Biomedical Engineering, Protein Array Analysis, Bioengineering, Biocompatible Materials, Matrix (biology), Biochemistry, Article, Cell Line, Biomaterials, Extracellular matrix, Tissue engineering, Materials Testing, Cell Adhesion, Animals, Humans, Lactic Acid, Cell adhesion, Cells, Cultured, Extracellular Matrix Proteins, biology, Tissue Engineering, Tissue Scaffolds, Chemistry, Coculture Techniques, Cell biology, Fibronectin, Cell culture, Hepatic stellate cell, biology.protein, Hepatocytes, Microscopy, Electron, Scanning, Cattle

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a089ba639df76ff60d2e9fc34e020be
https://pubmed.ncbi.nlm.nih.gov/19072719

المؤلفون: Monica J. Wood, Yen Cu, Jennifer K. Saucier-Sawyer, Kim A. Woodrow, W. Mark Saltzman, Carmen J. Booth

المصدر: Nature materials

مصطلحات موضوعية: Small interfering RNA, Biocompatible Materials, 02 engineering and technology, Article, Fluorescence, Cell Line, 03 medical and health sciences, Mice, Polylactic Acid-Polyglycolic Acid Copolymer, Gene expression, Gene Knockdown Techniques, Gene silencing, Animals, Humans, General Materials Science, Gene Silencing, Lactic Acid, RNA, Small Interfering, 030304 developmental biology, 0303 health sciences, Gene knockdown, Mice, Inbred ICR, Mucous Membrane, Chemistry, Mechanical Engineering, RNA, General Chemistry, Transfection, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Molecular biology, Biodegradable polymer, 3. Good health, Cell biology, Mechanics of Materials, Vagina, Nanoparticles, Female, 0210 nano-technology, Polyglycolic Acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb2eb6e6c98b6c1479c4bf54b28276a
https://pubmed.ncbi.nlm.nih.gov/19458640

المؤلفون: Gregory T. Tietjen, W. Mark Saltzman, Christopher J. Cheng, Jennifer K. Saucier-Sawyer

المصدر: Nature Reviews Drug Discovery. 14:365-365

مصطلحات موضوعية: Pharmacology, Docetaxel, Drug discovery, Chemistry, Drug Discovery, medicine, Nanotechnology, Doxorubicin, General Medicine, Polymeric nanoparticles, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::79c4ff7dd7953508fe4092b9e63c51d6
https://doi.org/10.1038/nrd4633