المؤلفون: Jennifer C. Louth, Imane Ghafir El Idrissi, James D Grayson, Valerie J. Gillet, Sasha Stimpson, Emma Mead, Antonio de la Vega de León, Margarita Segovia Roldan, Gary Sharman, Claire J. Garwood, Jim A. Thomas, Matthew P. Baumgartner, Amélia P. Rauter, Beining Chen, Samuel J Dawes, Joanna Wolak, Charlotte Dunbar, Ke Ning, Anastasia Zhuravleva, Cleide dos Santos Souza, Benjamin M. Partridge, Nicola Antonio Colabufo, David A. Evans

المصدر: Chemical Science. 12:3768-3785

مصطلحات موضوعية: 0303 health sciences, Amyloid, Amyloid β, Drug discovery, Chemistry, HEK 293 cells, General Chemistry, Cortical neurons, Disease, Inhibitory postsynaptic potential, Cell biology, 03 medical and health sciences, 0302 clinical medicine, Receptor, 030217 neurology & neurosurgery, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::04daccd30e1189b255839170ec5be975
https://doi.org/10.1039/d0sc04769d

المؤلفون: Joel R. Gever, Steven Ferrara, Henry Roehl, Edward J. Cochrane, Jennifer C. Louth, Matthew P. Jackson, B. Michael Silber, Sarah Baxendale, Beining Chen, Fiona J. Sorrell, Mark J. Thompson

المصدر: European Journal of Medicinal Chemistry. 46:4125-4132

مصطلحات موضوعية: Pharmacology, Indole test, Indoles, Low toxicity, Prions, Stereochemistry, Chemistry, Drug discovery, Organic Chemistry, Biological activity, General Medicine, Metabolic stability, Cell Line, Structure-Activity Relationship, Biochemistry, Cell culture, Microsomes, Drug Discovery, Microsome, Animals, Structure–activity relationship, Zebrafish

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdca545244382b2e5d887e2155bdf2f
https://doi.org/10.1016/j.ejmech.2011.06.013

المؤلفون: Susan M. Little, Mark J. Thompson, Iain Coldham, Beining Chen, Jennifer C. Louth

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3644-3647

مصطلحات موضوعية: Prions, Stereochemistry, Plasmodium falciparum, Clinical Biochemistry, Pharmaceutical Science, Context (language use), Biochemistry, Antimalarials, Structure-Activity Relationship, Chloroquine, Drug Discovery, medicine, Antimalarial Agent, Prion protein, Molecular Biology, Structural class, Molecular Structure, biology, Mefloquine, Chemistry, Organic Chemistry, Biological activity, biology.organism_classification, Thiazoles, Quinacrine, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ff8ad616ea3877df68fb0151a44b08
https://doi.org/10.1016/j.bmcl.2011.04.090

المؤلفون: Edward J. Cochrane, Benjamin J. Irving, Jennifer C. Louth, Steven J. Ferrara, Fiona J. Sorrell, Mark J. Thompson, Beining Chen, Anthony J. H. M. Meijer

المصدر: ChemMedChem. 6:115-130

مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Indoles, Prions, Protein Conformation, Stereochemistry, Quantitative Structure-Activity Relationship, Ligands, Biochemistry, Cell Line, Prion Diseases, Small Molecule Libraries, Mice, Protein structure, In vivo, Drug Discovery, Animals, Moiety, Structure–activity relationship, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Indole test, Drug discovery, Chemistry, Organic Chemistry, In vitro, High-Throughput Screening Assays, Kinetics, Sulfonylurea Compounds, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2f2dab0cffad47ac474134d89988c4
https://doi.org/10.1002/cmdc.201000383

المؤلفون: Mark J. Thompson, Jennifer C. Louth, Kai Guo, Beining Chen

المصدر: Current topics in medicinal chemistry. 13(19)

مصطلحات موضوعية: Drug discovery, Prions, animal diseases, Chemical biology, General Medicine, Computational biology, Biology, Virology, nervous system diseases, Prion Diseases, Small Molecule Libraries, Drug Discovery, Animals, Humans, Clinical efficacy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea7ed953553e6ae41e7d0153012ccaf
https://pubmed.ncbi.nlm.nih.gov/24059337

المؤلفون: Nathan B. P. Adams, Jennifer C. Louth, Fiona J. Sorrell, Gemma K. Greenwood, Mark J. Thompson, Beining Chen, Sandra G. Knight

المصدر: ChemMedChem. 5(9)

مصطلحات موضوعية: Stereochemistry, Prions, Biochemistry, Cell Line, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Amide, Drug Discovery, Sense (molecular biology), Structure–activity relationship, Potency, Peptide bond, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Thiazole, Pharmacology, Drug discovery, Organic Chemistry, Combinatorial chemistry, Affinities, Amides, Thiazoles, chemistry, Microsomes, Liver, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5d62b6afc55c6a86b6dd6d002185be
https://pubmed.ncbi.nlm.nih.gov/20635376

المؤلفون: Jennifer C. Louth, Beining Chen, Vinciane Borsenberger, Mark J. Thompson, Katie E Judd

المصدر: Journal of medicinal chemistry. 52(23)

مصطلحات موضوعية: Indole test, Indoles, Chemistry, animal diseases, Scrapie, Disease, Amides, In vitro, Cell Line, Prion Diseases, Small Molecule Libraries, Mice, Structure-Activity Relationship, Design synthesis, Biochemistry, Cell culture, Drug Design, Drug Discovery, Molecular Medicine, Structure–activity relationship, Animals, Prion protein, Amines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391c3297cd020d9d62b42da93773e909
https://pubmed.ncbi.nlm.nih.gov/19842664

المؤلفون: Beining Chen, Nathan B. P. Adams, Gemma K. Greenwood, Mark J. Thompson, Sandra G. Knight, Fiona J. Sorrell, Jennifer C. Louth

المصدر: ChemMedChem. 5:1406-1406

مصطلحات موضوعية: Pharmacology, Stereochemistry, Chemistry, Organic Chemistry, Sense (electronics), Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, Amide, Drug Discovery, Molecular Medicine, Potency, Cover (algebra), General Pharmacology, Toxicology and Pharmaceutics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ab987145f64c8a2bc8f627a6856435c9
https://doi.org/10.1002/cmdc.201090037

المؤلفون: Mark J. Thompson, Vinciane Borsenberger, Jennifer C. Louth, Katie E. Judd, Beining Chen

المصدر: Journal of Medicinal Chemistry; Dec2009, Vol. 52 Issue 23, p7503-7511, 9p