المؤلفون: Diemar, Michael G., Vinken, Mathieu, Teunis, Marc, Krul, Cyrille A. M., Busquet, Francois, Zajac, Julia Dominika, Kandarova, Helena, Corvi, Raffaella, Rosso, Matteo Z., Kharina, Anastasiia, Bryndum, Louise Stab, Santillo, Michael, Bloch, Denise, Kucheryavenko, Olena, Panagiotakos, Demosthenes, Rogiers, Vera, Beekhuijzen, Manon, Giusti, Arianna, Najjar, Abdulkarim, Courage, Carol, Koenig, Torben, Kolle, Susanne, Boonen, Harrie, Dhalluin, Stephane, Boberg, Julie, Müller, Boris P., Kukic, Predrag, Ritskes-Hoitinga, Merel, Grasselli, Elena, Zietek, Tamara, Stoddart, Gilly, Heusinkveld, Harm J., Castell, José V., Benfenati, Emilio, Yang, Huan, Perera-Del-Rosario, Simón, Paini, Alicia, Kramer, Nynke I., Hartung, Thomas, Janssen, Manoe, Fritsche, Ellen, Jennen, Danyel G. J., Piumatti, Matteo, Rathman, James, Marusczyk, Jörg, Milec, Lucia, Roggen, Erwin L.

المساهمون: European Commission

مصطلحات موضوعية: Artificial intelligence, Confidence, End-user acceptance, Hackathon, NAMs, New approach methodologies, Non-animal, Next generation risk assessment, Probabilistic risk assessment, Stakeholder network, Toxicology

وصف الملف: application/pdf

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/EC/H2020/963845; Publisher's version; https://doi.org/10.1177/02611929231225730; Sí; Alternatives to Laboratory Animals 52(2): 117-131 (2024); http://hdl.handle.net/10261/361010

الاتاحة: http://hdl.handle.net/10261/361010
https://doi.org/10.1177/02611929231225730

المؤلفون: Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, de Kok, Theo M

المصدر: Bischoff , N S , Proquin , H , Jetten , M J , Schrooders , Y , Jonkhout , M C M , Briedé , J J , van Breda , S G , Jennen , D G J , Medina-Reyes , E I , Delgado-Buenrostro , N L , Chirino , Y I , van Loveren , H & de Kok , T M 2023 , ' Correction: Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. ....

Relation: https://cris.maastrichtuniversity.nl/en/publications/f8bed257-80fd-40a0-a638-80e3b7f9ac24

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/f8bed257-80fd-40a0-a638-80e3b7f9ac24
https://doi.org/10.3390/nano13212888

المؤلفون: Gall, Louis, Jardi, Ferran, Lammens, Lieve, Piñero, Janet, Souza, Terezinha M, Rodrigues, Daniela, Jennen, Danyel G J, de Kok, Theo M, Coyle, Luke, Chung, Seung-Wook, Ferreira, Sofia, Jo, Heeseung, Beattie, Kylie A, Kelly, Colette, Duckworth, Carrie A, Pritchard, D Mark, Pin, Carmen

المصدر: Gall , L , Jardi , F , Lammens , L , Piñero , J , Souza , T M , Rodrigues , D , Jennen , D G J , de Kok , T M , Coyle , L , Chung , S-W , Ferreira , S , Jo , H , Beattie , K A , Kelly , C , Duckworth , C A , Pritchard , D M & Pin , C 2023 , ' A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity ' ....

Relation: https://cris.maastrichtuniversity.nl/en/publications/35413186-9c7a-49b9-b472-b3b65ebad373

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/35413186-9c7a-49b9-b472-b3b65ebad373
https://doi.org/10.1002/psp4.13029

المؤلفون: O’Donovan, Shauna D., Cavill, Rachel, Wimmenauer, Florian, Lukas, Alexander, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G. J., van Riel, Natal A. W., Driessens, Kurt, Peeters, Ralf L. M., de Kok, Theo M. C. M.

المساهمون: Kurtovic-Kozaric, Amina, Dutch Province of Limburg

المصدر: PLOS ONE ; volume 18, issue 11, page e0292030 ; ISSN 1932-6203

الاتاحة: http://dx.doi.org/10.1371/journal.pone.0292030
https://dx.plos.org/10.1371/journal.pone.0292030

المؤلفون: European Commission, Diemar, Michael G., Vinken, Mathieu, Teunis, Marc, Krul, Cyrille A. M., Busquet, Francois, Zajac, Julia Dominika, Kandarova, Helena, Corvi, Raffaella, Rosso, Matteo Z., Kharina, Anastasiia, Bryndum, Louise Stab, Santillo, Michael, Bloch, Denise, Kucheryavenko, Olena, Panagiotakos, Demosthenes, Rogiers, Vera, Beekhuijzen, Manon, Giusti, Arianna, Najjar, Abdulkarim, Courage, Carol, Koenig, Torben, Kolle, Susanne, Boonen, Harrie, Dhalluin, Stephane, Boberg, Julie, Müller, Boris P., Kukic, Predrag, Ritskes-Hoitinga, Merel, Grasselli, Elena, Zietek, Tamara, Stoddart, Gilly, Heusinkveld, Harm J., Castell, José V., Benfenati, Emilio, Yang, Huan, Perera-Del-Rosario, Simón, Paini, Alicia, Kramer, Nynke I., Hartung, Thomas, Janssen, Manoe, Fritsche, Ellen, Jennen, Danyel G. J., Piumatti, Matteo, Rathman, James, Marusczyk, Jörg, Milec, Lucia, Roggen, Erwin L.

مصطلحات الفهرس: Artificial intelligence, Confidence, End-user acceptance, Hackathon, NAMs, New approach methodologies, Non-animal, Next generation risk assessment, Probabilistic risk assessment, Stakeholder network, Toxicology, artículo

URL: http://hdl.handle.net/10261/361010
https://doi.org/10.1177/02611929231225730
Publisher's version
https://doi.org/10.1177/02611929231225730
Sí
info:eu-repo/grantAgreement/EC/H2020/963845

المؤلفون: Rodrigues, Daniela, de Souza, Terezinha, Coyle, Luke, Di Piazza, Matteo, Herpers, Bram, Ferreira, Sofia, Zhang, Mian, Vappiani, Johanna, Sévin, Daniel C., Gabor, Attila, Lynch, Anthony, Chung, Seung-Wook, Saez-Rodriguez, Julio, Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M.

المساهمون: Innovative Medicines Initiative

المصدر: Archives of Toxicology ; ISSN 0340-5761 1432-0738

الاتاحة: http://dx.doi.org/10.1007/s00204-021-03092-2
https://link.springer.com/content/pdf/10.1007/s00204-021-03092-2.pdf
https://link.springer.com/article/10.1007/s00204-021-03092-2/fulltext.html

المؤلفون: Stierum, Rob H., Kroese, E. Dinant, Vogels, Jack W. T. E., Buist, Harrie, Jennen, Danyel G. J., Someren, Eugene P. van

المصدر: Handbook of Biomarkers and Precision Medicine ; page 64-73 ; ISBN 9780429202872

الاتاحة: http://dx.doi.org/10.1201/9780429202872-7

المؤلفون: O'Donovan, Shauna D, Driessens, Kurt, Lopatta, Daniel, Wimmenauer, Florian, Lukas, Alexander, Neeven, Jelmer, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G J, van Riel, Natal A W, Cavill, Rachel, Peeters, Ralf L M, de Kok, Theo M C M

المصدر: O'Donovan , S D , Driessens , K , Lopatta , D , Wimmenauer , F , Lukas , A , Neeven , J , Smirnov , E , Lenz , M , Ertaylan , G , Jennen , D G J , van Riel , N A W , Cavill , R , Peeters , R L M & de Kok , T M C M 2020 , ' Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes ' , PLOS ONE , vol. 15 , no. 8 , e0236392 ....

مصطلحات موضوعية: REPRESENTATIONS, TOXICOGENOMICS, TOXICOLOGY, TOXICITY

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/0aeb482b-c57a-49cf-a296-47bf5223a69c
https://doi.org/10.1371/journal.pone.0236392

المؤلفون: Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, de Kok, Theo M

URL الوصول: https://explore.openaire.eu/search/publication?articleId=narcis______::4d44ba4aaac7e2a2f75910902a3148de
http://hdl.handle.net/10029/626711

المؤلفون: Rodrigues, Daniela, Souza, Terezinha, Jennen, Danyel G. J., Lemmens, Lieve, Kleinjans, Jos C. S., de Kok, Theo M.

المصدر: Rodrigues , D , Souza , T , Jennen , D G J , Lemmens , L , Kleinjans , J C S & de Kok , T M 2019 , ' Drug-induced gene expression profile changes in relation to intestinal toxicity : State-of-the-art and new approaches ' , Cancer Treatment Reviews , vol. 77 , pp. 57-66 . https://doi.org/10.1016/j.ctrv.2019.06.004

مصطلحات موضوعية: Intestinal toxicity, 5-FU, TKIs, NSAIDs, Transcriptomics, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, TYROSINE KINASE INHIBITORS, GASTROINTESTINAL TOXICITY, COLORECTAL-CANCER, SMALL-BOWEL, MUCOSAL INJURY, TARGET GENES, IN-VITRO, 5-FLUOROURACIL, CELLS

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/20d466db-3b0c-4782-bff0-5bc17c8ebea6
https://doi.org/10.1016/j.ctrv.2019.06.004

المؤلفون: O'Donovan, Shauna D., Cavill, Rachel, Wimmenauer, Florian, Lukas, Alexander, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G. J., van Riel, Natal A. W., Driessens, Kurt, Peeters, Ralf L. M., de Kok, Theo M. C. M.

المصدر: PLoS ONE; 11/30/2023, Vol. 18 Issue 11, p1-17, 17p

مصطلحات موضوعية: GENE expression, HUMAN genes, POISONS, RATS, DRUG side effects, DEEP learning

المؤلفون: Bischoff, Nicolaj S., Proquin, Héloïse, Jetten, Marlon J., Schrooders, Yannick, Jonkhout, Marloes C. M., Briedé, Jacco J., van Breda, Simone G., Jennen, Danyel G. J., Medina-Reyes, Estefany I., Delgado-Buenrostro, Norma L., Chirino, Yolanda I., van Loveren, Henk, de Kok, Theo M.

المصدر: Nanomaterials (2079-4991); Nov2023, Vol. 13 Issue 21, p2888, 4p

مصطلحات موضوعية: TRANSGENIC mice, TITANIUM dioxide, LABORATORY mice, COLORECTAL cancer, GENE expression, FOOD additives, IRINOTECAN

المؤلفون: Buesen, Roland, Chorley, Brian N, da Silva Lima, Beatriz, Daston, George P., Deferme, Lize, Ebbels, Timothy, Gant, Timothy W, Goetz, Amber, Greally, John, Gribaldo, Laura, Hackermüller, Jörg, Hubesch, Bruno, Jennen, Danyel G J, Johnson, Kamin, Kanno, Jun, Kauffmann, Hans-Martin, Laffont, Madeleine, McMullen, Patrick, Meehan, Richard, Pemberton, Mark, Perdichizzi, Stefania, Piersma, Aldert H, Sauer, Ursula G, Schmidt, Kerstin, Seitz, Hervé, Sumida, Kayo, Tollefsen, Knut Erik, Tong, Weida, Tralau, Tewes, van Ravenzwaay, Ben, Weber, Ralf J M, Worth, Andrew, Yauk, Carole, Poole, Alan

المساهمون: LS IRAS Tox RTX (Reprod.en ontw.toxic.), dIRAS RA-1

مصطلحات موضوعية: Regulatory toxicology, Transcriptomics, Metabolomics, Good laboratory practice (GLP), Weight-of-evidence (WoE), Adverse outcome pathway (AOP), Mode-of-action (MoA), Gene expression, Differentially expressed genes

وصف الملف: image/pdf

Relation: https://dspace.library.uu.nl/handle/1874/361049

الاتاحة: https://dspace.library.uu.nl/handle/1874/361049

المؤلفون: Boei, Jan J. W. A., Vermeulen, Sylvia, Klein, Binie, Hiemstra, Pieter S., Verhoosel, Renate M., Jennen, Danyel G. J., Lahoz, Agustin, Gmuender, Hans, Vrieling, Harry

المصدر: Boei , J J W A , Vermeulen , S , Klein , B , Hiemstra , P S , Verhoosel , R M , Jennen , D G J , Lahoz , A , Gmuender , H & Vrieling , H 2017 , ' Xenobiotic metabolism in differentiated human bronchial epithelial cells ' , Archives of Toxicology , vol. 91 , no. 5 , pp. 2093-2105 . https://doi.org/10.1007/s00204-016-1868-7

مصطلحات موضوعية: Lung, Metabolic activity, Gene expression profiling, Bronchial epithelial cells, Cytochrome P450, CIGARETTE-SMOKE EXPOSURE, AIR-LIQUID INTERFACE, MOUSE LUNG-TUMORS, CYTOCHROME-P450 ENZYMES, IN-VITRO, TISSUE-CULTURES, STYRENE OXIDE, CYP2F1 GENE, EXPRESSION, IDENTIFICATION

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/fc836acf-c56e-47ff-a9f7-e5f8223e673d
https://doi.org/10.1007/s00204-016-1868-7

المؤلفون: Smit, Evelyn, Souza, Terezinha, Jennen, Danyel G. J., Kleinjans, Jos C. S., van den Beucken, Twan

المصدر: Smit , E , Souza , T , Jennen , D G J , Kleinjans , J C S & van den Beucken , T 2017 , ' Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics ' , Toxicology , vol. 390 , pp. 74-82 . https://doi.org/10.1016/j.tox.2017.09.002

مصطلحات موضوعية: Gene expression, Aflatoxin B1, Benzo(a)pyrene, shRNA screen, Transcription factor, NUCLEOTIDE EXCISION-REPAIR, GENE-EXPRESSION PROFILE, HEPG2 CELLS, H2AX PHOSPHORYLATION, EPITHELIAL-CELLS, HISTONE H2AX, HUMAN LIVER, P53 FAMILY, IN-VIVO, GENOTOXICITY

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/5074123a-d0b2-4c9a-bf8f-377f5f4f2957
https://doi.org/10.1016/j.tox.2017.09.002

المؤلفون: Souza, Terezinha M., Kleinjans, Jos C. S., Jennen, Danyel G. J.

المصدر: Souza , T M , Kleinjans , J C S & Jennen , D G J 2017 , ' Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure : Novel Insights from Gene Regulatory Networks ' , Frontiers in Genetics , vol. 8 , 142 . https://doi.org/10.3389/fgene.2017.00142

مصطلحات موضوعية: gene regulatory networks, network inference, toxicity pathways, hepatotoxicity, transcription networks, MICE LACKING, TOXICITY, DAMAGE

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/979180ad-299b-4640-b2bf-155b092e2bf4
https://doi.org/10.3389/fgene.2017.00142

المؤلفون: Hendrickx, Diana M., Souza, Terezinha, Jennen, Danyel G. J., Kleinjans, Jos C. S.

المصدر: Hendrickx , D M , Souza , T , Jennen , D G J & Kleinjans , J C S 2017 , ' DTNI : a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds ' , Archives of Toxicology , vol. 91 , no. 6 , pp. 2343-2352 . https://doi.org/10.1007/s00204-016-1922-5

مصطلحات موضوعية: Time series, Dose-response, Gene regulatory network inference, Mode of action, Molecular initiating event, Key event, INDUCED LIVER-INJURY, GENE-EXPRESSION PROFILES, FACTOR-KAPPA-B, ACETAMINOPHEN HEPATOTOXICITY, DIFFERENTIAL EXPRESSION, OUTCOME PATHWAYS, RISK-ASSESSMENT, IN-VITRO, CANCER, KNOWLEDGE

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/e8f5b647-e1dc-4800-b202-c8c30b71314e
https://doi.org/10.1007/s00204-016-1922-5

المؤلفون: Georgiadis, Panagiotis, Hebels, Dennie G, Valavanis, Ioannis, Liampa, Irene, Bergdahl, Ingvar A, Johansson, Anders, 1955, Palli, Domenico, Chadeau-Hyam, Marc, Chatziioannou, Aristotelis, Jennen, Danyel G J, Krauskopf, Julian, Jetten, Marlon J, Kleinjans, Jos C S, Vineis, Paolo, Kyrtopoulos, Soterios A

المصدر: Scientific Reports. 6

مصطلحات موضوعية: Epidemiology, epidemiologi

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117920
https://doi.org/10.1038/srep20544
https://umu.diva-portal.org/smash/get/diva2:909380/FULLTEXT01.pdf

المؤلفون: Jennen, Danyel G J, van Herwijnen, Marcel, Jetten, Marlon, Vandebriel, Rob J, Keizers, Peter, Geertsma, Robert E, de Jong, Wim H, Kleinjans, Jos C S

المصدر: International journal of molecular sciences ; 23 ; 21 ; Switzerland

مصطلحات موضوعية: 3D skin model, dermal fillers, hyaluronic acid, inflammation, transcriptomics

Relation: http://hdl.handle.net/10029/626225; International journal of molecular sciences 2022;23(21):13046

الاتاحة: http://hdl.handle.net/10029/626225
https://doi.org/10.3390/ijms232113046

المؤلفون: Pennings, Jeroen L. A., Jennen, Danyel G. J., Nygaard, Unni C., Namork, Ellen, Haug, Line S., van Loveren, Henk, Granum, Berit

المصدر: Pennings , J L A , Jennen , D G J , Nygaard , U C , Namork , E , Haug , L S , van Loveren , H & Granum , B 2016 , ' Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood ' , Journal of Immunotoxicology , vol. 13 , no. 2 , pp. 173-180 . https://doi.org/10.3109/1547691X.2015.1029147

مصطلحات موضوعية: Immunotoxicity, perfluoroalkyl carboxylic acids, perfluoroalkyl substances, perfluoroalkyl sulfonic acids, prenatal exposure, toxicogenomics

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/f9c03664-a10b-4063-a30c-d2f7265e0a8a
https://doi.org/10.3109/1547691X.2015.1029147