المؤلفون: Jeffrey W. Schubert, Olivia Zhang

المصدر: The Journal of Organic Chemistry. 85:6225-6232

مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Organic Chemistry, Structural diversity, Tripeptide, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Amino acid, chemistry.chemical_compound, Dehydroalanine, Amines, Amino Acids, Peptides, Derivatization, Oxidation-Reduction, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbebae948e761e2c1332b082fd66d71
https://doi.org/10.1021/acs.joc.0c00635

المؤلفون: John A. Morrow, Robert Mazzola, Cristian Salinas, Eric D. Hostetler, Stefania Risso, Fiona Thomson, Tjerk Bueters, Nicholas B. Hastings, Jenny Wai, Sony Agrawal, Liza Gantert, Brian C. Magliaro, Paul McQuade, Zhizhen Zeng, Marie A. Holahan, David Hesk, Melissa Egbertson, Jeffrey W. Schubert, Ling Tong, Robert Gomez, Jongrock Kong, Aniket Joshi, Frederick J. Monsma, David M. Tellers, Kristen L.G. Jones, Jason M. Uslaner, Jing Liao, Patricia Miller, Michelle Smith, Oleg Selyutin, Kerry Riffel, Xiaolei Gao, Scott T. Harrison, Zhaoyang Meng, James Mulhearn, Michael Man-Chu Lo, Wenping Li, Michael T. Rudd, Barbara Hanney, Mona Purcell, Jianming Bao, Hyking Haley

المصدر: Journal of Medicinal Chemistry. 63:2411-2425

مصطلحات موضوعية: Agonist, 0303 health sciences, Carbachol, medicine.diagnostic_test, Chemistry, medicine.drug_class, Allosteric regulation, Pharmacology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, In vivo, Positron emission tomography, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Molecular Medicine, Receptor, Preclinical imaging, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::949c4dbede58ed2de44d27f608635d36
https://doi.org/10.1021/acs.jmedchem.9b01406

المؤلفون: Jeffrey W. Schubert, Abdelatif ElMarrouni, James J. Perkins, Eric Streckfuss, Jaume Balsells

المصدر: European Journal of Organic Chemistry. 2020:1515-1522

مصطلحات موضوعية: chemistry.chemical_classification, Silylation, Chemistry, Organic Chemistry, Photoredox catalysis, Physical and Theoretical Chemistry, Alkylation, Medicinal chemistry, Alkyl, Minisci reaction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7275921a372fbcc6b0a9a3a65b89444f
https://doi.org/10.1002/ejoc.201900611

المؤلفون: Sarah L Huszar Agrapides, Susan E. Browne, Jeffrey W. Schubert, Jaime Lynn Bunda, Robert Gomez, Tynebor Robert M, John M. Sanders, Melissa Egbertson, Kristen L.G. Jones, Jason M. Uslaner, Natasa Pajkovic, James Mulhearn, Anthony L. Gotter, Christopher D. Cox, Brian C. Magliaro, Barbara Hanney, Jenny Wai, Julie A. O'Brien, Scott T. Harrison, Stefania Risso, Anne Marie Taylor, John A. Mccauley, Sean M. Smith

المصدر: ChemMedChem. 14:943-951

مصطلحات موضوعية: Pharmacology, Agonist, 010405 organic chemistry, medicine.drug_class, Organic Chemistry, Allosteric regulation, Pyrazole, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Safety profile, chemistry, Drug Discovery, Muscarinic acetylcholine receptor, Knockout mouse, Pyridine, medicine, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Xanomeline

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::77782222be3d0457fcb67bd3fe6f175d
https://doi.org/10.1002/cmdc.201900088

المؤلفون: Ling, Tong, Wenping, Li, Michael Man-Chu, Lo, Xiaolei, Gao, Jenny Miu-Chen, Wai, Michael, Rudd, David, Tellers, Aniket, Joshi, Zhizhen, Zeng, Patricia, Miller, Cristian, Salinas, Kerry, Riffel, Hyking, Haley, Mona, Purcell, Marie, Holahan, Liza, Gantert, Jeffrey W, Schubert, Kristen, Jones, James, Mulhearn, Melissa, Egbertson, Zhaoyang, Meng, Barbara, Hanney, Robert, Gomez, Scott T, Harrison, Paul, McQuade, Tjerk, Bueters, Jason, Uslaner, John, Morrow, Fiona, Thomson, Jongrock, Kong, Jing, Liao, Oleg, Selyutin, Jianming, Bao, Nicholas B, Hastings, Sony, Agrawal, Brian C, Magliaro, Frederick J, Monsma, Michelle D, Smith, Stefania, Risso, David, Hesk, Eric, Hostetler, Robert, Mazzola

المصدر: Journal of medicinal chemistry. 63(5)

مصطلحات موضوعية: Cricetulus, Allosteric Regulation, Receptor, Muscarinic M4, Pyridines, Positron-Emission Tomography, Animals, Humans, Neurodegenerative Diseases, CHO Cells, Carbon Radioisotopes, Muscarinic Agonists, Macaca mulatta

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cd3ef3c047c980065bd64efde0a0b7e9
https://pubmed.ncbi.nlm.nih.gov/32101422

المؤلفون: Jeffrey W, Schubert, Scott T, Harrison, James, Mulhearn, Robert, Gomez, Robert, Tynebor, Kristen, Jones, Jaime, Bunda, Barbara, Hanney, Jenny Miu-Chen, Wai, Chris, Cox, John A, McCauley, John M, Sanders, Brian, Magliaro, Julie, O'Brien, Natasa, Pajkovic, Sarah L, Huszar Agrapides, Anne, Taylor, Anthony, Gotter, Sean M, Smith, Jason, Uslaner, Susan, Browne, Stefania, Risso, Melissa, Egbertson

المصدر: ChemMedChem. 14(9)

مصطلحات موضوعية: Structure-Activity Relationship, Allosteric Regulation, Receptor, Muscarinic M4, Pyridines, Drug Discovery, Animals, Humans, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::475ab82d66001ed942e40ff31fcd1945
https://pubmed.ncbi.nlm.nih.gov/30920765

المؤلفون: Zhijian Zhao, Nathan R. Kett, Sujata Sharma, James C. Barrow, Robert F. Smith, Jeffrey W. Schubert, Nancy A. Sachs, Scott E. Wolkenberg, Ronald G. Robinson, Jeffrey Y. Melamed, Michael S. Poslusney, James Mulhearn, Pete H. Hutson, Scott T. Harrison, Dawn L. Hall, John M. Sanders, Timothy J. Allison, Sangita B. Patel

المصدر: ACS Medicinal Chemistry Letters. 6:318-323

مصطلحات موضوعية: chemistry.chemical_classification, Catechol, Catechol-O-methyl transferase, biology, Tolcapone, Chemistry, Stereochemistry, Organic Chemistry, Biochemistry, Cocrystal, Cofactor, chemistry.chemical_compound, Enzyme, Drug Discovery, biology.protein, medicine, Entacapone, Toxicity profile, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0ee80fe9b95ccf26d22c6a22811b6f
https://doi.org/10.1021/ml500502d

المؤلفون: Ronald G. Robinson, Kausik K. Nanda, B. Wesley Trotter, Pete H. Hutson, Monika Kandebo, James Mulhearn, Debra McLoughlin, Sean M. Smith, Stacey L. Polsky-Fisher, Tiffany L. Walker, Jennifer L. Kershner, Peter J. Manley, Neetesh Bhandari, Nancy A. Sachs, James C. Barrow, Dawn L. Hall, Zhijian Zhao, Scott T. Harrison, Lihang Yao, Robert F. Smith, John M. Sanders, Christopher R. Gibson, Sujata Sharma, Jeffrey W. Schubert, Scott E. Wolkenberg

المصدر: ACS Chemical Neuroscience. 3:129-140

مصطلحات موضوعية: Male, Physiology, Dopamine, Cognitive Neuroscience, Metabolite, Blotting, Western, Pharmacology, Catechol O-Methyltransferase, behavioral disciplines and activities, Biochemistry, Substrate Specificity, Nitrophenols, Rats, Sprague-Dawley, Benzophenones, chemistry.chemical_compound, mental disorders, medicine, Animals, Humans, Entacapone, Enzyme Inhibitors, Rats, Wistar, Prefrontal cortex, Membrane Potential, Mitochondrial, Catechol-O-methyl transferase, Tolcapone, Chemistry, Cell Membrane, fungi, Homovanillic acid, Catechol O-Methyltransferase Inhibitors, Cell Biology, General Medicine, Human brain, Matrix Metalloproteinases, Recombinant Proteins, Rats, Isoenzymes, medicine.anatomical_structure, nervous system, Schizophrenia, Biomarkers, Antipsychotic Agents, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9770c94c8f1b9c6ee1243d503fbc1a52
https://doi.org/10.1021/cn200109w

المؤلفون: Christopher R. Gibson, Stacey L. Polsky-Fisher, Lihang Yao, Nanyan Rena Zhang, Ronald G. Robinson, Jeffrey W. Schubert, John M. Sanders, Scott E. Wolkenberg, Pete H. Hutson, Nancy A. Sachs, Scott T. Harrison, Debra McLoughlin, Zhijian Zhao, James C. Barrow, Sean M. Smith, Monika Kandebo

المصدر: Bioorganicmedicinal chemistry letters. 26(12)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Methyltransferase, Stereochemistry, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Catechol O-Methyltransferase, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Dopamine, In vivo, Heterocyclic Compounds, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Catechol, Catechol-O-methyl transferase, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Homovanillic acid, Catechol O-Methyltransferase Inhibitors, Ligand (biochemistry), Rats, 030104 developmental biology, chemistry, Lipophilic efficiency, Molecular Medicine, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bbebc8732cb49d22f101f002ebfabc
https://pubmed.ncbi.nlm.nih.gov/27133481

المؤلفون: Brian K. Ohta, Ruth E. Hough, Jeffrey W. Schubert

المصدر: Organic Letters. 9:2317-2320

مصطلحات موضوعية: Isotope, Physics::Plasma Physics, Chemical physics, Chemistry, Organic Chemistry, Degenerate energy levels, Analytical chemistry, Perturbation (astronomy), Halonium ion, Physical and Theoretical Chemistry, Carbon-13 NMR, Biochemistry, Ion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8780bad41130dec7543fa2542213a60
https://doi.org/10.1021/ol070673n

المؤلفون: Brian K. Ohta, Jeffrey W. Schubert, Timothy J. Dudley

المصدر: The Journal of organic chemistry. 72(7)

مصطلحات موضوعية: Crystallography, Molecular geometry, Computational chemistry, Hydride, Chemistry, Organic Chemistry, Electronic structure, Physics::Chemical Physics, Oxonium ion, Isomerization, Lone pair, Transition state, Ion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d22e50f47212c112c77af789e4efec
https://pubmed.ncbi.nlm.nih.gov/17335233

المؤلفون: Brian K. Ohta, Ruth E. Hough, Jeffrey W. Schubert

المصدر: Organic Letters; Jun2007, Vol. 9 Issue 12, p2317-2320, 4p