المؤلفون: Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9

المؤلفون: Jeffrey W. Johannes (1414039), Amber Balazs (9436515), Derek Barratt (8921054), Michal Bista (160356), Matthew D. Chuba (11486389), Sabina Cosulich (466728), Susan E. Critchlow (1613527), Sébastien L. Degorce (1436623), Paolo Di Fruscia (3748813), Scott D. Edmondson (1416967), Kevin Embrey (1637887), Stephen Fawell (5867138), Avipsa Ghosh (1329021), Sonja J. Gill (11486392), Anders Gunnarsson (1454497), Sudhir M. Hande (2047519), Tom D. Heightman (236769), Paul Hemsley (4414534), Giuditta Illuzzi (11486395), Jordan Lane (11486398), Carrie Larner (11486401), Elisabetta Leo (16336), Lina Liu (227490), Andrew Madin (2369338), Scott Martin (8770), Lisa McWilliams (3115182), Mark J. O’Connor (512930), Jonathan P. Orme (2570623), Fiona Pachl (1643695), Martin J. Packer (1716334), Xiaohui Pei (8775905), Andrew Pike (689657), Marianne Schimpl (208250), Hongyao She (11486404), Anna D. Staniszewska (11486407), Verity Talbot (6084164), Elizabeth Underwood (9210380), Jeffrey G. Varnes (2499496), Lin Xue (826042), Tieguang Yao (9761206), Ke Zhang (115386), Andrew X. Zhang (1371321), Xiaolan Zheng (1638844)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, overlapping hematological toxicities, good secondary pharmacology, brca mutant hbcx, brca mutant background, achieved regulatory approval, 17 pdx model, parp family members, oxo ‑ 5, dihydro ‑ 1, selective parp1 inhibitor, 25 , n <, highly selective, vivo efficacy, usually due, reduced effects, recent literature, preclinical species, physicochemical properties, parps poly, parp1 inhibition, line chemotherapies

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_5_4-_7-Ethyl-6-oxo_5_6-dihydro_1_5-naphthyridin-3-yl_methyl_piperazin-1-yl_i_N_i_methyl_pyridine-2-carboxamide_AZD5305_A_PARP1_DNA_Trapper_with_High_Selectivity_for_PARP1_over_PARP2_and_Other_PARPs/16688962

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01012.s001

المؤلفون: Randolph A. Escobar (3093861), Jeffrey W. Johannes (1414039)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Sociology, Developmental Biology, Cancer, Mental Health, Virology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, halides, Alkyl Electrophiles Catalyzed, Reductive Radical Conjugate Addition, activation, alkyl bromides, alkyl radicals

Relation: https://figshare.com/articles/journal_contribution/Reductive_Radical_Conjugate_Addition_of_Alkyl_Electrophiles_Catalyzed_by_a_Cobalt_Iridium_Photoredox_System/14995498

الاتاحة: https://doi.org/10.1021/acs.orglett.1c02114.s001

المؤلفون: Cameron H. Chrisman, Max Kudisch, Katherine O. Puffer, Trevor K. Stewart, Yisrael M. L. Lamb, Chern-Hooi Lim, Randolph Escobar, Pall Thordarson, Jeffrey W. Johannes, Garret M. Miyake

المصدر: Journal of the American Chemical Society.

مصطلحات موضوعية: Colloid and Surface Chemistry, General Chemistry, Biochemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::42d21e94dc9d9352b3a05bf52806e128
https://doi.org/10.1021/jacs.3c02784

المؤلفون: David Hargreaves, Rodrigo J. Carbajo, Michael S. Bodnarchuk, Kevin Embrey, Philip B. Rawlins, Martin Packer, Sébastien L. Degorce, Alexander W. Hird, Jeffrey W. Johannes, Elisabetta Chiarparin, Markus Schade

المصدر: Proceedings of the National Academy of Sciences. 120

مصطلحات موضوعية: Multidisciplinary

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d2bffac636430c22137888d848f374ca
https://doi.org/10.1073/pnas.2221967120

المؤلفون: Huawei Chen, Corinne Reimer, Stephen E. Fawell, Keith Mikule, Michael Zinda, Edward W. Tate, Paul D. Lyne, Jonathan R. Dry, Deborah Lawson, Michelle L. Lamb, Jeffrey W. Johannes, David A. Scott, Dan Widzowski, Michele Mayo, Ryan T. Howard, Nancy Su, Jiaquan Wu, Farzin Gharahdaghi, Wenxian Wang, Xin Wang, Jingwen Zhang, Philip Petteruti, Tony Cheung, Shaun E. Grosskurth, Zebin Wang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c14ee784e9ce30d950b54ed3d29144
https://doi.org/10.1158/0008-5472.22418555

المؤلفون: Huawei Chen, Corinne Reimer, Stephen E. Fawell, Keith Mikule, Michael Zinda, Edward W. Tate, Paul D. Lyne, Jonathan R. Dry, Deborah Lawson, Michelle L. Lamb, Jeffrey W. Johannes, David A. Scott, Dan Widzowski, Michele Mayo, Ryan T. Howard, Nancy Su, Jiaquan Wu, Farzin Gharahdaghi, Wenxian Wang, Xin Wang, Jingwen Zhang, Philip Petteruti, Tony Cheung, Shaun E. Grosskurth, Zebin Wang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e72f443eea55562ffa6cc913b43229d
https://doi.org/10.1158/0008-5472.c.6510161.v1

المؤلفون: Huawei Chen, Corinne Reimer, Stephen E. Fawell, Keith Mikule, Michael Zinda, Edward W. Tate, Paul D. Lyne, Jonathan R. Dry, Deborah Lawson, Michelle L. Lamb, Jeffrey W. Johannes, David A. Scott, Dan Widzowski, Michele Mayo, Ryan T. Howard, Nancy Su, Jiaquan Wu, Farzin Gharahdaghi, Wenxian Wang, Xin Wang, Jingwen Zhang, Philip Petteruti, Tony Cheung, Shaun E. Grosskurth, Zebin Wang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c90f8ab65849ea462ef14da7c54638
https://doi.org/10.1158/0008-5472.22418558.v1

المؤلفون: Jeffrey W. Johannes, Fiona Pachl, Amber Balazs, Tieguang Yao, C. Larner, Lisa McWilliams, Marianne Schimpl, Scott W. Martin, Kevin J. Embrey, Tom D. Heightman, Paul Hemsley, Jonathan P. Orme, Derek Barratt, Giuditta Illuzzi, Andrew Madin, Paolo Di Fruscia, Avipsa Ghosh, Martin J. Packer, Scott D. Edmondson, Elisabetta Leo, Xiaolan Zheng, Matthew D. Chuba, Xiaohui Pei, Mark J. O'Connor, Verity Talbot, Ke Zhang, Stephen Fawell, Elizabeth Underwood, Anna Staniszewska, Lina Liu, Lin Xue, Sonja J. Gill, Anders Gunnarsson, Andrew Pike, Susan E. Critchlow, Jeffrey G. Varnes, Andrew X. Zhang, Sébastien L. Degorce, J. Lane, Sudhir M. Hande, Hongyao She, Sabina Cosulich, Michal Bista

المصدر: Journal of Medicinal Chemistry. 64:14498-14512

مصطلحات موضوعية: chemistry.chemical_compound, PARP1, Chemistry, In vivo, Poly ADP ribose polymerase, Drug Discovery, Mutant, Cancer research, Molecular Medicine, Progenitor cell, Homologous recombination, DNA, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5da59f02fe0bf1798c2492422c31c3
https://doi.org/10.1021/acs.jmedchem.1c01012

المؤلفون: Emily C. Erickson, Inchul You, Grace Perry, Aurelien Dugourd, Katherine A. Donovan, Claire Crafter, Jeffrey W. Johannes, Stuart Williamson, Jennifer I. Moss, Susana Ros, Robert E. Ziegler, Simon T. Barry, Eric S. Fischer, Nathanael S. Gray, Ralitsa R. Madsen, Alex Toker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c9936b8bb18af7326b2f253aaaab2a45
https://doi.org/10.1101/2022.10.11.511726

المؤلفون: Randolph A. Escobar, Jeffrey W. Johannes

المصدر: Organic Letters. 23:6046-6051

مصطلحات موضوعية: chemistry.chemical_classification, Silanes, Chemistry, Aryl, Organic Chemistry, Halide, chemistry.chemical_element, Biochemistry, Medicinal chemistry, Catalysis, chemistry.chemical_compound, Electrophile, lipids (amino acids, peptides, and proteins), Iridium, Physical and Theoretical Chemistry, Cobalt, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e34bd0b9bf6f9eb7a2a1ce160b8aa2b
https://doi.org/10.1021/acs.orglett.1c02114

المؤلفون: Christopher S. Gravatt, Jeffrey W. Johannes, Eric R. King, Avipsa Ghosh

المصدر: The Journal of organic chemistry. 87(14)

مصطلحات موضوعية: Nickel, Organic Chemistry, Iodides, Iridium, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a885cbdc37d670deeddd4e40a9fc018
https://pubmed.ncbi.nlm.nih.gov/35786936

المؤلفون: Renee L. DesJarlais, Sebastian Salentin, Klavs F. Jensen, Tommi S. Jaakkola, Daniel J. Griffin, Daniel Rodriguez Greve, Li Xing, Richard I. Robinson, Justin S. Cisar, Xinjun Hou, Constantine Kreatsoulas, Jeffrey W. Johannes, Andrew Palmer, Christos A. Nicolaou, Juan C. Alvarez, Regina Barzilay, William H. Green, Thomas J. Struble, Connor W. Coley, Ola Engkvist, Brian R. Lahue, Milan Chytil, Scott P. Brown, Scott Alan Frank, Daniel J. Price, Georg Mogk, Miriam Mathea

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: 0303 health sciences, business.industry, Chemistry, Chemistry, Pharmaceutical, Pharmaceutical Research, Chemistry Techniques, Synthetic, 01 natural sciences, Medicinal chemistry, Field (computer science), 0104 chemical sciences, Machine Learning, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Workflow, Models, Chemical, Chemical Industry, Component (UML), Perspective, Drug Discovery, Molecular Medicine, Artificial intelligence, business, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43527bb6f8e5a5f497ea36b932a4df7
https://doi.org/10.1021/acs.jmedchem.9b02120

المؤلفون: Jeffrey W. Johannes, Randolph A. Escobar

المصدر: Chemistry – A European Journal. 26:5168-5173

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Aryl, Organic Chemistry, Heteroatom, chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, Reductive elimination, 0104 chemical sciences, Nickel, chemistry.chemical_compound, Excited state, Photosensitizer, Iridium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c55b95d55b0af8c56edf6a35f4d2e7
https://doi.org/10.1002/chem.202000052

المؤلفون: Jeffrey W. Johannes, Avipsa Ghosh, Nicholas R. Perl, Melissa M. Vasbinder

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::62f09cc9de2ef428970167d74cf5d277
https://doi.org/10.29200/acsmedchemrev-v56.ch10

المؤلفون: Avipsa Ghosh, Jeffrey W. Johannes, Christopher S. Gravatt

مصطلحات موضوعية: chemistry.chemical_compound, Nickel, Catalytic cycle, Chemistry, Aryl, Functional group, Photocatalysis, Halide, chemistry.chemical_element, Iridium, Combinatorial chemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc963fffdd89ad0b587684261d00b8e4
https://doi.org/10.26434/chemrxiv-2021-18xd5

المؤلفون: Elisabetta Chiarparin, Amber Balazs, Martin J. Packer, Jeffrey W. Johannes, Nichola L. Davies, William McCoull, Graeme R. Robb, Piotr Raubo, Yu Dong, Alexander Hird, Rodrigo J. Carbajo, Michelle Lamb

المصدر: Journal of Medicinal Chemistry. 62:9418-9437

مصطلحات موضوعية: Models, Molecular, 0303 health sciences, Macrocyclic Compounds, Magnetic Resonance Spectroscopy, Protein Conformation, Chemistry, Ligand, Nuclear magnetic resonance spectroscopy, Ligands, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Kinetics, Structure-Activity Relationship, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Protein structure, Drug Design, Drug Discovery, Myeloid Cell Leukemia Sequence 1 Protein, Molecular Medicine, Structure–activity relationship, Structure based, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9d114d84c70c6c182fea2acc56e784
https://doi.org/10.1021/acs.jmedchem.9b00716

المؤلفون: Emma L. Cooke, Xiaoyun Wu, Timothy Pontz, Les A. Dakin, Michael Howard Block, Michelle Lamb, Allan Wu, Jeffrey W. Johannes, Lakshmaiah Gingipalli, Hai-Jun Zhang, Paul Lyne, Xiaolan Zheng, Larry Bao, Nicholas A. Larsen, Andrew D. Ferguson, Christopher R. Denz, James E. Dowling, Tao Wang

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1336-1341

مصطلحات موضوعية: 0301 basic medicine, Pyrazine, Carboxylic acid, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, Humans, Kinase activity, Casein Kinase II, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Kinase, Organic Chemistry, Combinatorial chemistry, 030104 developmental biology, Enzyme, chemistry, Pim kinases, Drug Design, Pyrazines, 030220 oncology & carcinogenesis, Molecular Medicine, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3184309f06f9fb9145a001cf4a00b8d
https://doi.org/10.1016/j.bmcl.2018.03.018

المؤلفون: Eric Gangl, Xiaolan Zheng, Shenghua Wen, Chungang Gu, Jeffrey W. Johannes, Peter Doig, Yanjun Wang

المصدر: Drug Metabolism and Disposition. 45:1345-1353

مصطلحات موضوعية: inorganic chemicals, Erythrocytes, Metabolite, Administration, Oral, Pharmaceutical Science, Mice, SCID, Biology, 030226 pharmacology & pharmacy, Metal Chelator, Piperazines, Phosphates, Xenobiotics, Mice, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, medicine, Animals, Humans, Phosphorylation, Edetic Acid, Whole blood, Pharmacology, chemistry.chemical_classification, Tankyrases, Heparin, Phosphotransferases, Molecular biology, In vitro, Rats, enzymes and coenzymes (carbohydrates), Enzyme, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Hepatocytes, Quinazolines, bacteria, Female, Xenobiotic, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbf1e8d271eaf225513d3ffd121f63b
https://doi.org/10.1124/dmd.117.076869

المؤلفون: Charlie N Saunders, Ryan T. Howard, Paul Hemsley, Javier A Molina Bermejo, James S. Scott, Edward W. Tate, Jeffrey W. Johannes, Philip Petteruti

المصدر: ACS Chemical Biology

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Ultraviolet Rays, Poly ADP ribose polymerase, Cell, Aziridines, Poly (ADP-Ribose) Polymerase-1, Photoaffinity Labels, Poly(ADP-ribose) Polymerase Inhibitors, 01 natural sciences, Biochemistry, Piperazines, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, PARP1, Cell Line, Tumor, medicine, Humans, Letters, Polymerase, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, General Medicine, 06 Biological Sciences, 0104 chemical sciences, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Cell culture, PARP inhibitor, biology.protein, Molecular Medicine, Phthalazines, Poly(ADP-ribose) Polymerases, 03 Chemical Sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ef1b13545b46aaf99d8dbe059fea1c
http://hdl.handle.net/10044/1/77571