المؤلفون: Kevin Dykstra, Alexei Buevich, Qi Gao, Yu-Hong Lam, Jeffrey T. Kuethe

المصدر: Molecules, Vol 27, Iss 2, p 417 (2022)

مصطلحات موضوعية: photoredox, dihydropyridones, vinylogous amides and esters, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/2/417; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/b3ad529952574e3eb96dba68476e8e4c

المؤلفون: Jeffrey T. Kuethe

المصدر: CHIMIA, Vol 60, Iss 9 (2006)

مصطلحات موضوعية: Dihydrobenzofuran, Indole, Nitrostyrene, Reductive cyclization, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://chimia.ch/chimia/article/view/4205; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424

URL الوصول: https://doaj.org/article/1e673a28f69a4a58bf2eba1d53bcf793

المؤلفون: Christopher K. Prier, Karla Camacho Soto, Jacob H. Forstater, Nadine Kuhl, Jeffrey T. Kuethe, Wai Ling Cheung-Lee, Michael J. Di Maso, Claire M. Eberle, Shane T. Grosser, Hsing-I Ho, Erik Hoyt, Anne Maguire, Kevin M. Maloney, Amanda Makarewicz, Jonathan P. McMullen, Jeffrey C. Moore, Grant S. Murphy, Karthik Narsimhan, Weilan Pan, Nelo R. Rivera, Anumita Saha-Shah, David A. Thaisrivongs, Deeptak Verma, Adeya Wyatt, Daniel Zewge

المصدر: ACS Catalysis. :7707-7714

مصطلحات موضوعية: General Chemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90db8b74a305bd69c240df125bc8b9b
https://doi.org/10.1021/acscatal.3c00941

المؤلفون: Nadine Kuhl, Ben W. H. Turnbull, Yining Ji, Reed T. Larson, Michael Shevlin, Christopher K. Prier, Cheol K. Chung, Richard Desmond, Erik Guetschow, Cyndi Qixin He, Tetsuji Itoh, Jeffrey T. Kuethe, Justin A. Newman, Mikhail Reibarkh, Nelo R. Rivera, Gao Shang, Zhixun Wang, Daniel Zewge, David A. Thaisrivongs

المصدر: Green Chemistry. 25:606-613

مصطلحات موضوعية: Environmental Chemistry, Pollution

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::76254159f72e72785c230763f61657ab
https://doi.org/10.1039/d2gc04117k

المؤلفون: Stephan M. Rummelt (10700904), Ji Qi (10699746), Yonggang Chen (10700895), James F. Dropinski (10716713), Gregory Hughes (10700923), Jeffrey T. Kuethe (10700926), Donghong Li (10700927), Kevin M. Maloney (6176340), Eric Margelefsky (10700932), Rose Mathew (10700936), Daniel J. Muzzio (10700938), Christopher C. Nawrat (10700939), Justin A. Newman (3982850), Honggui Ouyang (10700962), Niki R. Patel (10700965), Zhen Qiao (10716723), Gao Shang (10700967), Eric Sirota (10700971), Zhiguo Jake Song (10716725), Lushi Tan (10700976), Richard J. Varsolona (10716728), Baoqiang Wan (10716731), Brian M. Wyvratt (10716734), Feng Xu (10716737), Yingju Xu (10716740), Jingjun Yin (10716741), Shaoguang Zhang (10716744), Ralph Zhao (10716745)

مصطلحات موضوعية: Process Chemistry, 2-Ethynylglycerol, green chemistry, manufacturing synthesis, 1,3-dihydroxyacetone

Relation: https://figshare.com/articles/preprint/Development_of_an_Efficient_Route_to_2-Ethynylglycerol_for_the_Synthesis_of_Islatravir/14502744

الاتاحة: https://doi.org/10.26434/chemrxiv.14502744.v1

المؤلفون: Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G. Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M. Garbaccio, Erik D. Guetschow, Yan Guo, Sookhee N. Ha, Jennifer M. Johnston, Hubert Josien, Eunkyung A. Kauh, Kenneth A. Koeplinger, Jeffrey T. Kuethe, Eseng Lai, Christine L. Lanning, Anita Y.H. Lee, Li Li, Anilkumar G. Nair, Edward A. O’Neill, S. Aubrey Stoch, David A. Thaisrivongs, Thomas J. Tucker, Petr Vachal, Kristien van Dyck, Frederic P. Vanhoutte, Bram Volckaert, Dennis G. Wolford, Andy Xu, Tian Zhao, Dan Zhou, Susan Zhou, Xiaohong Zhu, Hratch J. Zokian, Abbas Walji, Harold B. Wood

المصدر: Circulation.

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6f19bd0c61c330917293f0ae4cf3d908
https://doi.org/10.1161/circulationaha.122.063372

المؤلفون: Thomas J. Tucker, Nianyu Li, Scott P. Salowe, Harold B. Wood, Danila Branca, Alan S. Bass, Rupesh P. Amin, BethAnn Murphy, Aurash Shahripour, Angela Kerekes, Abbas Walji, Nicole Buist, Jeffrey T. Kuethe, Huaibing He, Rodger Tracy, Kenneth A. Koeplinger, Weixun Wang, Bhavana Bhatt, Candice Alleyne, Sookhee Ha, Douglas G. Johns, Elisabetta Bianchi, Chengwei Wu, Peter Orth, Tjerk Bueters, Yusheng Xiong, Hratch J. Zokian, Michael J. Hafey, Mark W. Embrey, John Higgins

المصدر: Journal of Medicinal Chemistry. 64:16770-16800

مصطلحات موضوعية: chemistry.chemical_classification, Molecular Structure, biology, PCSK9, PCSK9 Inhibitors, Administration, Oral, Biological Availability, Peptide, Pharmacology, Crystallography, X-Ray, Proprotein convertase, Peptides, Cyclic, Rats, Bioavailability, Macaca fascicularis, Structure-Activity Relationship, chemistry, Drug Discovery, biology.protein, Animals, Molecular Medicine, Kexin, Dosing, Antibody, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01cd83054fdae5294b50a6dbca9f594
https://doi.org/10.1021/acs.jmedchem.1c01599

المؤلفون: Dong-Ming Shen, Michael Wolff, Shirly Pinto, Deodial Guiadeen, Bindhu V. Karanam, James M. Balkovec, Arto D. Krikorian, Shuwen He, Maria Madeira, Donald M. Sperbeck, Andreas Verras, Judyann Wiltsie, Jian Liu, Jackie Shang, Tim Cernak, Beth Ann Murphy, Qingmei Hong, Christine C. Chung, Ravi P. Nargund, Kevin D. Dykstra, Judith N. Gorski, Robert J. DeVita, Sharon Tong, Tianying Jian, Lisa M. Sonatore, Jeffrey T. Kuethe, Jianying Xiao, Jinqi Liu, Zhong Lai, Zhicai Wu, Mikhail Reibarkh, Ginger X. Yang, Yang Yu

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1182-1186

مصطلحات موضوعية: Benzimidazole, Cyclohexane, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, 01 natural sciences, Biochemistry, Mass Spectrometry, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Isomerism, In vivo, Drug Discovery, Animals, Humans, Moiety, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Molecular Biology, Chromatography, High Pressure Liquid, Active metabolite, chemistry.chemical_classification, Cyclohexanones, 010405 organic chemistry, Chemistry, Organic Chemistry, In vitro, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Hepatocytes, Molecular Medicine, Benzimidazoles, Isomerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d804bc7e0890d2b1abe6ee34b194779
https://doi.org/10.1016/j.bmcl.2019.03.025

المؤلفون: Robert K. Orr, Eric R. Ashley, Lushi Tan, Jeffrey T. Kuethe, Marc Poirier, Kallol Basu

المصدر: Bioorganic & Medicinal Chemistry. 26:938-944

مصطلحات موضوعية: Chromatography, Gas, 010405 organic chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Stereoisomerism, Ether, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Drug Design, Scientific method, Drug Discovery, Molecular Medicine, Organic chemistry, Stereoselectivity, Molecular Biology, Cyclobutanes, Ethers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7274b0cedc16be5f8927aaf280144b
https://doi.org/10.1016/j.bmc.2017.07.018

المؤلفون: Hong Liu, Shawn P. Walsh, Yan Qi, Jiaqiang Cai, Jack D. Scott, Xin-Jie Chu, Cuizhi Mu, Brandon M. Taoka, Yaxian Cai, Jinsong Hao, Quang Truong, Zhong Lai, Xing Dai, Wen-Lian Wu, Jeffrey T. Kuethe, Eric J. Gilbert, Andrew Brunskill, Jared N. Cumming

المصدر: Tetrahedron. 72:6011-6020

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, 010402 general chemistry, Ring (chemistry), Oxetane, 01 natural sciences, Biochemistry, Pyrrolidine, 0104 chemical sciences, Stereocenter, chemistry.chemical_compound, Cascade reaction, Intramolecular force, Drug Discovery, Proline

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4f6ea7d457ba02cc5aae8322fdf057d3
https://doi.org/10.1016/j.tet.2016.08.017

المؤلفون: Hong D. Chu, Huaibing He, Ying-Duo Gao, Xiaohua Li, Aleksandr Petrov, Tesfaye Biftu, Joseph M. Metzger, Jeffrey T. Kuethe, Kathryn A. Lyons, Jason M. Cox, Ranabir SinhaRoy, George J. Eiermann, Ann E. Weber, Shiyao Xu, Giovanna Scapin, Joseph K. Wu

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:2622-2626

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Pyrrolidines, Dipeptidyl Peptidase 4, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Omarigliptin, 01 natural sciences, Biochemistry, Pyrrolidine, Dipeptidyl peptidase, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, Dipeptidyl peptidase-4, chemistry.chemical_classification, Dipeptidyl-Peptidase IV Inhibitors, Protease, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Organic Chemistry, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, Molecular Medicine, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a833eafac9cd4e3200a1ac5a452339c
https://doi.org/10.1016/j.bmcl.2016.04.020

المؤلفون: Michel Journet, Zhihui Peng, Dalian Zhao, Arlene E. Mckeown, Guy R. Humphrey, Jeffrey T. Kuethe

المصدر: Organic Process Research & Development. 20:227-232

مصطلحات موضوعية: 010405 organic chemistry, Magnesium, Organic Chemistry, Antagonist, Regioselectivity, chemistry.chemical_element, Ate complex, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, Piperazine, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Yield (chemistry), Organic chemistry, Physical and Theoretical Chemistry, 030217 neurology & neurosurgery, Amination

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9ff56dfdcc1dda616fbcb2bfe14089a9
https://doi.org/10.1021/acs.oprd.5b00388

المؤلفون: James M. Balkovec, Kevin D. Dykstra, Beth Ann Murphy, Edward C. Sherer, Donald M. Sperbeck, Claire Lee, Tim Cernak, James Cuff, Jeffrey T. Kuethe, Ravi P. Nargund, Andreas Verras, Zhi-Cai Shi, Spencer D. Dreher, Shuwen He, Maud Reiter, Petr Vachal, Stephen D. Goble, Dong-Ming Shen, Zhicai Wu, Yang Yu, Robert J. DeVita, Nicholas Perrotto, Steven Williams, Lisa M. Sonatore, Shirly Pinto, Nathan J. Gesmundo, Maria Madeira

المصدر: Journal of medicinal chemistry. 60(9)

مصطلحات موضوعية: Benzimidazole, 010405 organic chemistry, Drug discovery, Proton Magnetic Resonance Spectroscopy, Nanotechnology, 010402 general chemistry, 01 natural sciences, Mass Spectrometry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Drug Discovery, Molecular Medicine, Diacylglycerol Acyltransferase, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Microscale chemistry, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572283ae6d3dcf65fa072d0c3033562b
https://pubmed.ncbi.nlm.nih.gov/28252959

المؤلفون: Shirly Pinto, Deodial Guiadeen, David X. Yang, Tianying Jian, Ravi P. Nargund, Donald M. Sperbeck, Tim Cernak, Qingmei Hong, James M. Balkovec, Christine C. Chung, Dong-Ming Shen, Jeffrey T. Kuethe, Sharon Tong, Pauline C. Ting, Judyann Wiltsie, Jack Gibson, Lisa M. Sonatore, Zhicai Wu, Ginger X. Yang, Michael Wolff, Judith N. Gorski, Robert J. DeVita, Yang Yu, Jian Liu, JeanMarie Lisnock, Zhong Lai, Shuwen He, Jianying Xiao, Jinqi Liu, Bindhu V. Karanam, Arto D. Krikorian, Kevin D. Dykstra, Maria Madeira

المصدر: ACS Medicinal Chemistry Letters. 5:1082-1087

مصطلحات موضوعية: Benzimidazole, Stereochemistry, Metabolite, Organic Chemistry, Pharmacology, Cyclohexanecarboxylic acid, Biology, Biochemistry, Ames test, chemistry.chemical_compound, chemistry, Free fraction, Drug Discovery, Moiety, Epimer, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5736a4f35707b793d0b53f6a00a346de
https://doi.org/10.1021/ml5003426

المؤلفون: Shuwen He, Kelvin H. Yong, Tao Li, Jacob M. Janey, Juan D. Arredondo, Matthew D. Truppo, Jeffrey T. Kuethe

المصدر: Tetrahedron. 70:4563-4570

مصطلحات موضوعية: Chemistry, Organic Chemistry, Diphenylpyraline, Diastereomer, Biochemistry, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, Biocatalysis, Drug Discovery, medicine, Triethylsilane, Protecting group, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6b1d36f81098d946b608d1a123c66bdf
https://doi.org/10.1016/j.tet.2014.04.064

المؤلفون: Jeffrey T. Kuethe

المصدر: Tetrahedron. 75:130446

مصطلحات موضوعية: Molecular complexity, 010405 organic chemistry, Chemistry, Organic Chemistry, Drug Discovery, 010402 general chemistry, Base (exponentiation), 01 natural sciences, Biochemistry, Combinatorial chemistry, Transformation (music), 0104 chemical sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea66da0136b32ceb392cb5e9d1f4a453
https://doi.org/10.1016/j.tet.2019.07.004

المؤلفون: Yong Zhang, Jeffrey J. Hale, Andreas Verras, Shirly Pinto, Huaibing He, Zhu Shen, Urmi R. Bhatt, Elaine C. Tung, John S. Debenham, Matthew J. Clements, Dunlu Chen, Dong-Ming Shen, Wayne M. Geissler, Thomas H. Graham, JeanMarie Lisnock, Qing Chen, Suoyu Xu, Xiaohua Li, Margarita Garcia-Calvo, Wensheng Liu, Xinchun Tong, Judyann Wiltsie, Christina B. Madsen-Duggan, Jeffrey T. Kuethe

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:6228-6233

مصطلحات موضوعية: Male, Oral dose, Cyclohexane, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Carboxypeptidases, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Cyclohexanes, Drug Discovery, Animals, Obesity, Enzyme Inhibitors, Molecular Biology, Binding affinities, Serine protease, Molecular Structure, biology, Organic Chemistry, Mice, Inbred C57BL, Orally active, chemistry, biology.protein, Molecular Medicine, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a2d166f3f282c60327beda62c09726
https://doi.org/10.1016/j.bmcl.2013.09.094

المؤلفون: Yong-Li Zhong, Spencer D. Dreher, Nobuyoshi Yasuda, Mary Kim, Guy R. Humphrey, Katherine Linn, Benjamin Marcune, Tao Pei, Gregory L. Beutner, Jeffrey T. Kuethe

المصدر: Organic Letters. 15:4174-4177

مصطلحات موضوعية: Cyclopropanes, Sulfonamides, Macrocyclic Compounds, Molecular Structure, Chemistry, Hepatitis C virus, Organic Chemistry, Enantioselective synthesis, Hepacivirus, medicine.disease_cause, Amides, Antiviral Agents, Biochemistry, Virology, NS2-3 protease, Quinoxalines, medicine, Protease Inhibitors, Protease inhibitor (pharmacology), Carbamates, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a56b4faa33bc67323789a3badf5175
https://doi.org/10.1021/ol401864t

المؤلفون: Jeffrey T. Kuethe, Pernilla Royster, Catherine A. Quinn, Eric D. Soli

المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 56:600-608

مصطلحات موضوعية: Active ingredient, biology, Cholesterol, Stable isotope ratio, Organic Chemistry, Pharmacology, medicine.disease, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Hypocholesterolemia, chemistry, Anacetrapib, Drug Discovery, Cholesterylester transfer protein, biology.protein, medicine, Radiology, Nuclear Medicine and imaging, Spectroscopy, Drug metabolism, Absolute bioavailability

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f63fd38d9f5aa20a6c8ed9960e86304
https://doi.org/10.1002/jlcr.3073

المؤلفون: David Won-Shik Kim, Ravi P. Nargund, Zhicai Wu, Maria Madeira, Jian Liu, JeanMarie Lisnock, Tianying Jian, Jeffrey T. Kuethe, Bindhu V. Karanam, Qingmei Hong, Dong-Ming Shen, Michael Wolff, Sharon Tong, Jack Gibson, Zhong Lai, Shirly Pinto, Deodial Guiadeen, Yang Yu, Donald M. Sperbeck, Beth Ann Murphy, James M. Balkovec, Christine C. Chung, Dunlu Chen, Judyann Wiltsie, Jinqi Liu, Xiaoli Chen, Shuwen He, Arto D. Krikorian, Lisa M. Sonatore, Pauline C. Ting, Judith N. Gorski, Robert J. DeVita, Ginger X. Yang

المصدر: ACS Medicinal Chemistry Letters. 4:773-778

مصطلحات موضوعية: Benzimidazole, Stereochemistry, Metabolite, Organic Chemistry, Cyclohexanecarboxylic acid, Biology, Biochemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Moiety, Epimer, Selectivity, Active metabolite

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cc6718ba0c1555d5839bf034018f4f
https://doi.org/10.1021/ml400168h