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1
المؤلفون: Cornel Catana, Lisa A. Perrin, Jeff Ohren, Jeremy J. Edmunds, John Quin, Derek James Sheehan, Sangita M. Baxi, Jennifer K. Hoffman, Jeffrey T. Kohrt, Amy M. Delaney, Fred L. Ciske, Michael Kaufman, Noel A. Powell, Patrick I. McConnell
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1046-1050
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, education, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Substrate Specificity, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, Kinase, Organic Chemistry, Receptor Protein-Tyrosine Kinases, Hit to lead, Highly selective, Amides, humanities, Pyrimidines, Diaminopyrimidine, chemistry, Molecular Medicine, Substrate specificity, Selectivity
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2
المؤلفون: Yuli Wang, Derek James Sheehan, Cornel Catana, Doh-Yeel Lee, Amy M. Delaney, Lisa A. Perrin, Fang Sun, Jeff Ohren, Frank Schwende, Kevin J. Filipski, Patrick I. McConnell, Jeffrey T. Kohrt, Noel A. Powell, Michael Kaufman, Francis Bourbonais, Huifen Chen, Jeremy E. Edmunds
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:190-193
مصطلحات موضوعية: Platelet Aggregation, Platelet aggregation, Chemistry, Pharmaceutical, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Absorption, Inhibitory Concentration 50, Adenosine Triphosphate, Drug Discovery, Animals, Humans, Kinome, Molecular Biology, Binding Sites, Chemistry, Kinase, Organic Chemistry, Receptor Protein-Tyrosine Kinases, Rats, Intestines, Models, Chemical, Drug Design, Molecular Medicine
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3
المؤلفون: Don Emerson, Doh-Yeel Lee, Venkataraman Thanabal, Michael Melnick, J. Richard Miller, Ronald W. Sarver, Jeff Ohren, Manjinder S. Lall, Charles Francis Donovan
المصدر: Chemical Biology & Drug Design. 75:444-454
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, High-throughput screening, Organic Chemistry, Isothermal titration calorimetry, Biology, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, medicine, Molecular Medicine, Phosphopantetheine adenylyltransferase, Enzyme kinetics, Target protein, Phosphopantetheine, Escherichia coli
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4
المؤلفون: Mark C. Sulavik, Debra Hanna, Bill Dunkle, Li Ann Wang, V. Hayden Thomas, Laura A. Skerlos, Tong Zhu, Chris Limberakis, Zhigang Wang, Amy Whitton, Michael Kuhn, C. Kendall Stover, Jeff Ohren, John A. Shelly, J.V.N. Vara Prasad, Steve Dunham, H. James Harwood, Michael D. Huband, J. Richard Miller, Shawn Mehrens, Alla Karnovsky, Susan Buist, W. Thomas Mueller, Jia Y. Liu, Steve Vanderroest, Craig Banotai, Adam Ogden, Lakshmi Narasimhan, Matthew Bowman, Igor Mochalkin
المصدر: Proceedings of the National Academy of Sciences. 106:1737-1742
مصطلحات موضوعية: Biotin carboxylase, Multidisciplinary, Gram-negative bacteria, biology, Drug discovery, Kinase, High-throughput screening, Small Molecule Libraries, biology.organism_classification, Biochemistry, Mechanism of action, medicine, Pharmacophore, medicine.symptom
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5
المؤلفون: Kevin M. Walton, Jeff Ohren, John D. Knafels, Amy Rosado, Travis T. Wager, Butler Todd W, Andy N. Mead, Blossom Sneed, Katherine Fisher, David Horton, Shenping Liu, George J DeMarco, Scot Richard Mente, Helen Berke, Angela C. Doran, Cheng Chang, Jenifer Bradley, Michael Marconi, Ramalakshmi Yegna Chandrasekaran, David M. Rubitski
المصدر: ACS chemical neuroscience. 5(12)
مصطلحات موضوعية: Time Factors, Physiology, Cognitive Neuroscience, Drug-Seeking Behavior, Self Administration, Biology, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Mice, In vivo, Casein Kinase I, medicine, Potency, Animals, Humans, Kinome, Enzyme Inhibitors, IC50, Analysis of Variance, Cross-Over Studies, Dose-Response Relationship, Drug, Kinase, Cell Biology, General Medicine, Isoxazoles, Circadian Rhythm, Rats, Analgesics, Opioid, Fentanyl, Mice, Inbred C57BL, Macaca fascicularis, Protein Transport, Pyrimidines, Opioid, Conditioning, Operant, Casein kinase 1, Reinforcement, Psychology, medicine.drug
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6
المؤلفون: John M. Humphrey, Shenping Liu, Jeff Ohren, Katherine Fisher, Ramalakshmi Yegna Chandrasekaran, Kevin M. Walton, Kevin Cherry, Butler Todd W, W. Scott McDonald, Eric P. Arnold, Jianke Li, Ken Dirico, Angela C. Doran, Blossom Sneed, Travis T. Wager, Subramanyam Chakrapani, Michael Eric Green, Scot Richard Mente, John D. Knafels, Matthew Merrill Hayward, Paul Galatsis, Vanessa Paradis, Michael Marconi
المصدر: Journal of medicinal chemistry. 56(17)
مصطلحات موضوعية: Gene isoform, chemistry.chemical_classification, Models, Molecular, Magnetic Resonance Spectroscopy, p38 mitogen-activated protein kinases, Circadian clock, Proteins, Ligands, Mass Spectrometry, Enzyme, Biochemistry, chemistry, In vivo, Casein Kinase Idelta, Drug Discovery, Molecular Medicine, Casein kinase 1, Circadian rhythm, Protein Kinase Inhibitors
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7
المؤلفون: Jeffrey T. Kohrt, Noel A. Powell, Lisa A. Perrin, Zhong Min, Jeff Ohren, Fred L. Ciske, Jennifer K. Hoffman, Yun-Wen Peng, Cornel Catana, Jeremy J. Edmunds, Sangita M. Baxi
المصدر: Bioorganicmedicinal chemistry letters. 23(4)
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, ADME, Chemistry, Kinase, Organic Chemistry, Receptor Protein-Tyrosine Kinases, Hit to lead, Highly selective, Combinatorial chemistry, Amides, Diaminopyrimidine, Pyrimidines, Molecular Medicine
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8
المؤلفون: J Richard, Miller, Venkataraman, Thanabal, Michael M, Melnick, Manjinder, Lall, Charles, Donovan, Ronald W, Sarver, Doh-Yeel, Lee, Jeff, Ohren, Don, Emerson
المصدر: Chemical biologydrug design. 75(5)
مصطلحات موضوعية: Kinetics, Structure-Activity Relationship, Magnetic Resonance Spectroscopy, Catalytic Domain, Escherichia coli, Quinazolines, Fluorine, Calorimetry, Binding, Competitive, Nucleotidyltransferases, Biophysical Phenomena, Anti-Bacterial Agents, High-Throughput Screening Assays