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1
المؤلفون: Richard M. Shepard, Christopher A. Gabel, Allen J. Duplantier, Mark A. Dombroski, Kwansik Yoon, Michael A. Fisher, Jeff M. Labasi, Carrie Whitney-Pickett, Shang-Poa Chang, Chakrapani Subramanyam, David G. Perregaux
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5475-5479
مصطلحات موضوعية: Volume of distribution, Multi parametric, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Metabolic stability, Pyrazole, Pharmacology, Biochemistry, Bioavailability, chemistry.chemical_compound, Drug Discovery, Molecular Medicine, Potency, Molecular Biology, P2x7 receptor
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2
المؤلفون: Ethan J. Stam, David G. Perregaux, Christopher A. Gabel, Jeff M. Labasi, Mike Solle, Ron Laliberte, Bev Koller, R. J. Griffiths
المصدر: Drug Development Research. 53:83-90
مصطلحات موضوعية: Programmed cell death, Lipopolysaccharide, Nigericin, Monocyte, medicine.medical_treatment, Interleukin, Biology, chemistry.chemical_compound, medicine.anatomical_structure, Cytokine, chemistry, Biochemistry, Drug Discovery, medicine, Secretion, Intracellular
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3
المؤلفون: Ethan J. Stam, E. R. Pettipher, John B. Cheng, E. D. Salter, Jeff M. Labasi, R. J. Griffiths
المصدر: British Journal of Pharmacology. 117:1530-1534
مصطلحات موضوعية: Lipopolysaccharides, Male, medicine.medical_specialty, Phosphodiesterase Inhibitors, medicine.drug_class, medicine.medical_treatment, Stimulation, Mice, chemistry.chemical_compound, Peritoneal cavity, Corticosterone, Internal medicine, Escherichia coli, medicine, Animals, Rolipram, Pharmacology, Mice, Inbred BALB C, Tumor Necrosis Factor-alpha, Adrenalectomy, Anti-Inflammatory Agents, Non-Steroidal, Propranolol, Pyrrolidinones, Mifepristone, Endocrinology, medicine.anatomical_structure, chemistry, Corticosteroid, Tumor necrosis factor alpha, Glucocorticoid, Research Article, medicine.drug
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4
المؤلفون: Chakrapani, Subramanyam, Allen J, Duplantier, Mark A, Dombroski, Shang-Poa, Chang, Christopher A, Gabel, Carrie, Whitney-Pickett, David G, Perregaux, Jeff M, Labasi, Kwansik, Yoon, Richard M, Shepard, Michael, Fisher
المصدر: Bioorganicmedicinal chemistry letters. 21(18)
مصطلحات موضوعية: Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Purinergic P2X Receptor Antagonists, Benzamides, Drug Discovery, Animals, Humans, Stereoisomerism, Chemistry Techniques, Synthetic, Receptors, Purinergic P2X7
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5
المؤلفون: Christopher A. Gabel, Timothy J. Taylor, Amit S. Kalgutkar, Kwansik Yoon, Chakrapani Subramanyam, David G. Perregaux, Shang Poa Chang, Allen J. Duplantier, Kenneth G. Kraus, Mark A. Dombroski, Aimee M. Beaulieu, Christopher Mussari, Carrie Whitney-Pickett, Crystal K. Jordan, Kristen A. Trevena, Rick Shepard, Jeff M. Labasi
المصدر: Bioorganicmedicinal chemistry letters. 21(12)
مصطلحات موضوعية: medicine.drug_class, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Purinergic P2 Receptor Antagonists, Structure–activity relationship, Potency, Animals, Humans, Receptor, Uracil, Molecular Biology, Molecular Structure, Drug discovery, Chemistry, Organic Chemistry, Receptor antagonist, Rats, Antirheumatic Agents, Lipophilicity, Benzamides, Molecular Medicine, Receptors, Purinergic P2X7, Lead compound, Protein Binding
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6
المؤلفون: Thomas J. Carty, Nancy C. Elliott, Hang T. Nguyen, Franco Lombardo, Kendra Louise Nelson, Christopher A. Gabel, Kathleen M. Donahue, Jun Zhou, Jennifer M. McCoy, Mark A. Dombroski, Laurent P. Audoly, John F. Braganza, Brian M. Naiman, Ronald E. Laliberte, Amit S. Kalgutkar, Jeff M. Labasi, Walter A. Volberg, Kevin M. Peese, Kim F. McClure, Timothy J. Taylor, John T. Barberia, Ellen R. Laird, Colleen P. Gibbons, Catherine E. Trebino, Crystal K. Jordan, Francis J. Sweeney, Alexander V. Kuperman, Yuriy A. Abramov, Santo R. Cortina, Demetrius Carter, Michael A. Letavic, Justin Bach
المصدر: Bioorganicmedicinal chemistry letters. 16(16)
مصطلحات موضوعية: Pyridines, Chemistry, Pharmaceutical, Clinical Biochemistry, Triazole, Pharmaceutical Science, Biochemistry, Chemical synthesis, p38 Mitogen-Activated Protein Kinases, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Humans, Enzyme Inhibitors, Molecular Biology, Oxazoles, Oxazole, biology, Organic Chemistry, Triazoles, Kinetics, chemistry, Models, Chemical, Solubility, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Triazolopyridine, Identification (biology)
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7
المؤلفون: Michael A. Letavic, Linne Svensson, Kevin M. Peese, Alan J. Dipesa, Crystal K. Jordan, Santo R. Cortina, Ingrid A. Stock, Kim F. McClure, Nancy C. Elliott, Christopher A. Gabel, Jeff M. Labasi, Chul Yu, William H. Martin, Mark A. Dombroski, John T. Barberia, Thomas J. Carty, Csilla Csiki, Francis J. Sweeney
المصدر: Bioorganicmedicinal chemistry letters. 14(4)
مصطلحات موضوعية: Stereochemistry, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Alpha (ethology), Biochemistry, Chemical synthesis, Mitogen-Activated Protein Kinase 14, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Pyridine, Structure–activity relationship, Enzyme Inhibitors, Protein kinase A, Molecular Biology, chemistry.chemical_classification, biology, Molecular Structure, Chemistry, Organic Chemistry, Imidazoles, In vitro, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Mitogen-Activated Protein Kinases