-
1
المؤلفون: D. Gary Gilliland, Jannik N. Andersen, Peter Strack, Kumiko Nagashima, Pamela M. Carroll, Erica M. Cook, Thi D.T. Nguyen, Marc Ferrer, Erick J. Morris, Bryan Severyn, Andrey Loboda, Jeff Hermes, Michelle A. Cleary, Sriram Sathyanarayanan, Bill Arthur, Yair Benita, Lixia Li, G. Naumov, Michael D. Altman, James Watters, Matthew Tudor
المصدر: SLAS Discovery. 21:989-997
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cell signaling, MAP Kinase Signaling System, Apoptosis, Biology, medicine.disease_cause, Biochemistry, Analytical Chemistry, Chemical library, Proto-Oncogene Proteins p21(ras), Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Neoplasms, medicine, Humans, Cell Proliferation, Regulation of gene expression, Dose-Response Relationship, Drug, Gene Expression Profiling, Gene signature, Molecular biology, High-Throughput Screening Assays, Gene expression profiling, 030104 developmental biology, Gene Expression Regulation, chemistry, Mutation, Cancer research, Molecular Medicine, KRAS, Biotechnology
-
2
المؤلفون: Timothy A. Blizzard, Nichelle Hairston, Jason E. Imbriglio, Young-Whan Park, Douglas Wisniewski, Paula M.D. Fitzgerald, Sookhee Ha, Nandini Sharma, Katherine Young, Jane Y. Wu, Giovanna Scapin, Aimie Ogawa, Susan L. Raghoobar, Jeff Hermes, Seongkon Kim, Ronald E. Painter, Rena Bodner, Jun Lu, Candido Gude, Helen Chen, Milton L. Hammond
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:780-785
مصطلحات موضوعية: Imipenem, Klebsiella, medicine.drug_class, Clinical Biochemistry, Antibiotics, Cilastatin, Imipenem Drug Combination, Pharmaceutical Science, Microbial Sensitivity Tests, Crystallography, X-Ray, Models, Biological, Biochemistry, Microbiology, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Pseudomonas, Drug Resistance, Bacterial, Drug Discovery, medicine, Enzyme Inhibitors, Molecular Biology, Vaborbactam, Bicyclic molecule, biology, Chemistry, Organic Chemistry, biology.organism_classification, In vitro, Drug Combinations, Cilastatin, Molecular Medicine, Piperidine, beta-Lactamase Inhibitors, Azabicyclo Compounds, medicine.drug
-
3
المؤلفون: Jane Y. Wu, Andrew S. Misura, Seongkon Kim, Ronald E. Painter, Nandini Sharma, Sookhee Ha, Amy Ogawa, Katherine Young, Jeff Hermes, Susan L. Raghoobar, Jun Lu, Sang Ho Lee, Young-Whan Park, T. Felcetto, Nichelle Hairston, Paula M.D. Fitzgerald, Timothy A. Blizzard, Helen Chen, Milton L. Hammond, Emily Hickey
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:918-921
مصطلحات موضوعية: Carbapenem, Imipenem, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, beta-Lactam Resistance, beta-Lactamases, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Monobactam, Pseudomonas Infections, Molecular Biology, Beta-Lactamase Inhibitors, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Bridged Bicyclo Compounds, Heterocyclic, In vitro, Drug Combinations, Carbapenems, Enzyme inhibitor, Pseudomonas aeruginosa, biology.protein, Molecular Medicine, beta-Lactamase Inhibitors, medicine.drug
-
4
المؤلفون: Douglas Wisniewski, Nichelle Hairston, Seongkon Kim, Timothy A. Blizzard, Aimie M. Ogawa, Jane Y. Wu, Young-Whan Park, Milton L. Hammond, Ronald E. Painter, Katherine Young, Jeff Hermes, Susan L. Raghoobar, Giovanna Scapin, Nandini Sharma, Helen Chen, Paula M.D. Fitzgerald, Jun Lu
المصدر: Bioorganicmedicinal chemistry letters. 21(14)
مصطلحات موضوعية: Imipenem, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Biochemistry, beta-Lactamases, Structure-Activity Relationship, Drug Discovery, polycyclic compounds, medicine, Side chain, Monobactam, Computer Simulation, Enzyme Inhibitors, Molecular Biology, Antibacterial agent, chemistry.chemical_classification, Binding Sites, Bicyclic molecule, biology, Organic Chemistry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Anti-Bacterial Agents, Protein Structure, Tertiary, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, beta-Lactamase Inhibitors, medicine.drug, Monobactams