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1
المؤلفون: Methvin Isaac, Rima Al-awar, Deeba Ensan, Dimitrios Panagopoulos, Jeff A O'Meara, Eleanor Williams, Roslin Adamson, Carlos Zepeda-Velázquez, David Smil, Alex N. Bullock, Ahmed Aman, Taira Kiyota, Jong Fu Wong, Owen G Roberts, Aled M. Edwards
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Male, Cell Membrane Permeability, Pyridines, hERG, Mice, SCID, Pharmacology, 01 natural sciences, Article, Piperazines, Serine, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Humans, Benzamide, Receptor, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, biology, Molecular Structure, Kinase, Diffuse Intrinsic Pontine Glioma, Pediatric cancer, Potassium channel, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, HEK293 Cells, chemistry, Benzamides, Mutation, biology.protein, Microsomes, Liver, Molecular Medicine, Female, Caco-2 Cells, Activin Receptors, Type I
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2
المؤلفون: Kurumi Y. Horiuchi, Roslin Adamson, Ahmed Aman, Ahmed Mamai, Soyoung Kim, Haiching Ma, Sue Cramp, Taira Kiyota, Alex N. Bullock, David Uehling, Jeff A O'Meara, Eleanor Williams, Methvin Isaac, J Nicole Hamblin, Ekaterina Kuznetsova, Julie Owen, David McLeod, Jong Fu Wong, Gennady Poda, David Smil, Owen G Roberts, Aled M. Edwards, Alison Howarth, Brian J. Wilson, Rima Al-awar
مصطلحات موضوعية: Male, Open science, medicine.medical_treatment, Antineoplastic Agents, Mice, SCID, 01 natural sciences, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Molecular Structure, Drug discovery, Chemistry, Diffuse Intrinsic Pontine Glioma, Activin receptor, Pediatric cancer, 0104 chemical sciences, Radiation therapy, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Tolerability, Cancer research, Molecular Medicine, Female, Activin Receptors, Type I
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3
المؤلفون: Eleanor Williams, Roslin J Adamson, Jong Fu Wong, Alison Howarth, Tobias Krojer, David Smil, David A McLeod, Ahmed Mamai, Soyoung Kim, Brian J Wilson, Taira Kiyota, Ahmed Aman, Julie Owen, Gennady Poda, Kurumi Y Horiuchi, Ekaterina Kuznetsova, Haiching Ma, J Nicole Hamblin, Sue Cramp, Owen G Roberts, Aled M Edwards, Lisa Rooney, David Uehling, Rima Al-Awar, Jeff A O'Meara, Methvin B Isaac, Frank von Delft, Alex N Bullock
مصطلحات موضوعية: Structure, Protein, Target Enabling Package, Structural Genomics, Probe, Disease, Drug Discovery, Orphan disease, Drug Target, Chemical Biology, Structure Discovery, Inflammation, Cancer, ACVR1, Activin A
Relation: https://www.thesgc.org/tep; https://zenodo.org/communities/sgcteps; https://doi.org/10.5281/zenodo.4436324; https://doi.org/10.5281/zenodo.4436325; oai:zenodo.org:4436325
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4
المؤلفون: Florian Grebien, Abootaleb Sedighi, Roman Wolfgang Fleck, Siawash Ahmar, Kay Noel, Mulu Geletu, Ji Sung Park, Elizabeth Heyes, Mohammad S. Eram, Elvin D. de Araujo, Angel Sampedro, Patrick T. Gunning, Helena Sorger, Gary Tin, Dziyana Kraskouskaya, Ruth Villalonga, Marco Herling, Jeff A O'Meara, John R. Proudfoot, Anna Orlova, Richard Moriggl, Satu Mustjoki
المصدر: Cancer Research. 80:LB-108
مصطلحات موضوعية: Cancer Research, medicine.diagnostic_test, biology, Chemistry, Kinase, Molecular biology, 3. Good health, Oncology, Western blot, Cell culture, Apoptosis, hemic and lymphatic diseases, STAT protein, medicine, biology.protein, STAT1, STAT3, STAT5
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5
المؤلفون: Murray D. Bailey, Peter W. White, Josée Bordeleau, Michel Garneau, Jeff A. O'Meara, Mélissa Leblanc, Montse Llinas-Brunet, Christopher T. Lemke
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4447-4452
مصطلحات موضوعية: Models, Molecular, Peptidomimetic, medicine.medical_treatment, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, Literature based, Hepacivirus, Viral Nonstructural Proteins, Cleavage (embryo), medicine.disease_cause, Biochemistry, Structure-Activity Relationship, Dogs, Drug Discovery, medicine, Animals, Humans, Protease Inhibitors, Molecular Biology, Serine protease, NS3, Protease, biology, Chemistry, Organic Chemistry, Succinates, Haplorhini, Amides, Combinatorial chemistry, Rats, Peptide backbone, Microsomes, Liver, biology.protein, Molecular Medicine, Half-Life
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6
المؤلفون: Rebekah J. Carson, Sylvain Bordeleau, Michael J. Little, Pierre L. Beaulieu, Steven R. LaPlante, Jeff A. O'Meara, James Gillard, Pierre R. Bonneau, Norman Aubry, René Coulombe
المصدر: Journal of Medicinal Chemistry. 56:5142-5150
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Aqueous medium, Chemistry, Drug discovery, Detergents, food and beverages, Nuclear magnetic resonance spectroscopy, Combinatorial chemistry, Pharmaceutical Preparations, Solubility, Drug Discovery, Proton NMR, Molecular Medicine, Molecule, Sample preparation
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7
المؤلفون: Vida Gorys, Peter W. White, Josée Bordeleau, Cédrickx Godbout, Jeff A. O'Meara, Michel Garneau, Benoît Moreau, Elisia Villemure, Mélissa Leblanc, Montse Llinas-Brunet
المصدر: Journal of Medicinal Chemistry. 57:1770-1776
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, NS3, Magnetic Resonance Spectroscopy, Protease, Chemistry, medicine.medical_treatment, Hepatitis C virus, Viral Nonstructural Proteins, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Virology, Liver, Drug Discovery, Hcv protease, medicine, Hepatitis C Virus NS3/4A Protease Inhibitors, Humans, Molecular Medicine, Distribution (pharmacology), Potency, Protease Inhibitors, ADME
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8
المؤلفون: Lisette Lagacé, George Kukolj, Benoît Moreau, Peter W. White, Cédrickx Godbout, Montse Llinas-Brunet, Diane Thibeault, Christopher T. Lemke, Jeff A. O'Meara
المصدر: Journal of Biological Chemistry. 288:5673-5681
مصطلحات موضوعية: Models, Molecular, Proteases, Genotype, Hepatitis C virus, medicine.medical_treatment, Molecular Conformation, Drug resistance, Viral Nonstructural Proteins, Biology, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Cell Line, Drug Resistance, Viral, medicine, Humans, Potency, Protease Inhibitors, Protease inhibitor (pharmacology), Cloning, Molecular, Molecular Biology, Serine protease, Sulfonamides, NS3, Protease, X-Rays, Intracellular Signaling Peptides and Proteins, Molecular Bases of Disease, Cell Biology, Hepatitis C, Virology, Models, Chemical, biology.protein, Carrier Proteins
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9
المؤلفون: Bruno Simoneau, Serge Landry, Li Zhang, Heewon Lee, Chris H. Senanayake, Jeff A. O'Meara, Xiufeng Sun, Nathan K. Yee, Christiane Yoakim, Xiao-Jun Wang, Dhileepkumar Krishnamurthy
المصدر: Organic Process Research & Development. 16:561-566
مصطلحات موضوعية: Chemistry, Organic Chemistry, Human immunodeficiency virus (HIV), Convergent synthesis, Ether, Grignard reagent, medicine.disease_cause, Chloride, Combinatorial chemistry, chemistry.chemical_compound, medicine, Benzophenone, Organic chemistry, Reactivity (chemistry), Physical and Theoretical Chemistry, medicine.drug
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10
المؤلفون: Jeff A. O'Meara, Alexandre Gagnon, Sébastien Morin, Serge Landry, Michael Bös, Patrick Deroy, Christopher T. Lemke, Pierre R. Bonneau, Steve Titolo, Yves Bousquet, Stephen W. Mason, Bruno Simoneau, Eric Malenfant, Oliver Hucke, René Coulombe, Ingrid Guse, Richard Bethell, Chantal Grand-Maître, Anne-Marie Faucher, Jean-Eric Lacoste, Christiane Yoakim, Michael G. Cordingley, Stephen H. Kawai, Nathalie Goudreau, Lee Fader
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:398-404
مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pyrazole, Biochemistry, Chemical synthesis, Enamine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Molecular Biology, Benzodiazepinones, Bicyclic molecule, Reverse-transcriptase inhibitor, Organic Chemistry, Imidazoles, HIV Reverse Transcriptase, Diazepine, chemistry, Capsid, HIV-1, Pyrazoles, Reverse Transcriptase Inhibitors, Molecular Medicine, Capsid Proteins, Lead compound, medicine.drug
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11
المؤلفون: Anne-Marie Faucher, René Coulombe, Jeff A. O'Meara, Pierre R. Bonneau, Bruno Simoneau, Araz Jakalian, Jennifer Racine, Steven R. LaPlante, Serge Landry, Ingrid Guse, Christiane Yoakim, Bounkham Thavonekham
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3362-3366
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Molecular model, Anti-HIV Agents, Stereochemistry, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Virus Replication, Biochemistry, Nucleoside Reverse Transcriptase Inhibitor, Inhibitory Concentration 50, Structure-Activity Relationship, Thiocarbamates, Drug Resistance, Viral, Drug Discovery, medicine, Humans, Molecular Biology, Reverse-transcriptase inhibitor, biology, Chemistry, Organic Chemistry, Rational design, virus diseases, Nucleotidyltransferase, Amides, HIV Reverse Transcriptase, Thiocarbamate, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Reverse Transcriptase Inhibitors, Molecular Medicine, Carbamates, medicine.drug
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12
المؤلفون: Jeff A. O'Meara, Peter W. White, Christiane Yoakim, Nathalie Goudreau, Graham A. McGibbon, William W. Ogilvie
المصدر: Helvetica Chimica Acta. 86:3427-3444
مصطلحات موضوعية: Stereochemistry, Ligand binding assay, Organic Chemistry, Ring (chemistry), Mass spectrometry, Biochemistry, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, E2 protein, Physical and Theoretical Chemistry, Human papillomavirus, Tetrahydrofuran
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13
المؤلفون: Ingrid Guse, Christiane Yoakim, Bounkham Thavonekham, Jeff A. O'Meara
المصدر: Synlett. :0473-0476
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Reagent, Organic Chemistry, Organic chemistry, Mitsunobu reaction, General Medicine, Triphenylphosphine, Combinatorial chemistry, Phosphine
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14
المؤلفون: Jeff A. O'Meara, Bruno Haché, Catherine Chabot, Ingrid Guse, Chantal Grand-Maître, D R Cameron, Stephen H. Kawai, Julie Naud, Robert Deziel, Christiane Yoakim, William W. Ogilvie, Raymond Plante
المصدر: Scopus-Elsevier
مصطلحات موضوعية: 0301 basic medicine, Human cytomegalovirus, Serine Proteinase Inhibitors, medicine.medical_treatment, 030106 microbiology, Cytomegalovirus, Tetrazoles, Biology, beta-Lactams, Antiviral Agents, 01 natural sciences, Virus, Viral Proteins, 03 medical and health sciences, chemistry.chemical_compound, medicine, Humans, Urea, Monobactam, Protease inhibitor (pharmacology), chemistry.chemical_classification, Protease, Molecular Structure, General Medicine, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Biochemistry, chemistry, Cell culture, Drug Design, Lactam, medicine.drug
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15
المؤلفون: Lisette Lagacé, Steven R. LaPlante, Chantal Grand-Maître, Daniel J. Greenwood, Stephen H. Kawai, William W. Ogilvie, Pierre R. Bonneau, Jeff A. O'Meara, Marie-Josée Massariol
المصدر: Biochemistry. 36:12644-12652
مصطلحات موضوعية: chemistry.chemical_classification, Conformational change, Magnetic Resonance Spectroscopy, Protease, Ketone, Protein Conformation, Stereochemistry, medicine.medical_treatment, Serine Endopeptidases, Cytomegalovirus, Substrate (chemistry), Ketones, Biochemistry, Adduct, Protein structure, Enzyme, chemistry, Covalent bond, Endopeptidases, medicine, Humans, Protease Inhibitors
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16
المصدر: Phytochemistry. 46:495-498
مصطلحات موضوعية: biology, Stereochemistry, Plant Science, General Medicine, Rudbeckia hirta, Rudbeckia, Horticulture, Phototoxin, Asteraceae, biology.organism_classification, Biochemistry, chemistry.chemical_compound, chemistry, Manduca sexta, Darkness, Thiophene, Bioassay, Molecular Biology
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17
المؤلفون: Pieter Leyssen, Tim Guo, Edith Bellavance, Jeff A. O'Meara, Frédéric H. Vaillancourt, Johan Neyts, Sophie Desmeules, Catherine Spickler, Annick Gauthier, Anne Decor, Marie-Kristine Laberge, Michael Franti, Michel Garneau, Oliver Hucke, Julie Lippens
المصدر: Antimicrobial Agents and Chemotherapy
مصطلحات موضوعية: Small interfering RNA, Rhinovirus, Common Cold, Biology, Pharmacology, medicine.disease_cause, Virus Replication, Antiviral Agents, Polymorphism, Single Nucleotide, chemistry.chemical_compound, Mice, Aminothiazole, Cell Line, Tumor, Oximes, medicine, Potency, Animals, Humans, Pharmacology (medical), Phosphatidylinositol, RNA, Small Interfering, 1-Phosphatidylinositol 4-Kinase, Sulfonamides, Kinase, Virology, Cephalosporins, Thiazoles, Infectious Diseases, chemistry, Viral replication, Benzimidazoles, Female, RNA Interference, PI4KB, HeLa Cells
وصف الملف: Print-Electronic
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18
المؤلفون: Léa Constantineau Forget, Cyrille Kuhn, Vida Gorys, Colette Boucher, Chantal Grand-Maître, Sylvain Bordeleau, Michael J. Little, Christian Brochu, Tim Guo, Marc Pesant, Michel Garneau, Megan Bertrand-Laperle, Catherine Spickler, Gulrez Fazal, Pascal Turcotte, Annick Gauthier, Eric Malenfant, Josée Bordeleau, Anne Decor, Jeff A. O'Meara, Ghiro Elise, Oliver Hucke
المصدر: Bioorganicmedicinal chemistry letters. 23(13)
مصطلحات موضوعية: Rhinovirus, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Pharmacology, medicine.disease_cause, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Humans, Phosphatidylinositol, Molecular Biology, ADME, Biological evaluation, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Kinase, Organic Chemistry, Virology, Thiazoles, Mechanism of action, Tolerability, Drug Design, Molecular Medicine, medicine.symptom
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19
المؤلفون: Norman Aubry, François Bilodeau, Jeff A. O'Meara, James Gillard, René Coulombe, Steven R. LaPlante
المصدر: Bioorganicmedicinal chemistry letters. 23(16)
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Alkylation, Molecular Structure, Stereochemistry, Drug discovery, Chemistry, Nitrogen, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Combinatorial chemistry, HIV Reverse Transcriptase, Oxygen, Inhibitory Concentration 50, Drug Discovery, Molecular Medicine, Humans, Enzyme Inhibitors, Molecular Biology, Heteronuclear single quantum coherence spectroscopy
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20
المؤلفون: Ghiro Elise, Murray D. Bailey, Vida Gorys, Montse Llinas-Brunet, Mélissa Leblanc, Christopher T. Lemke, Julie Naud, Jeff A. O'Meara, François Bilodeau, Josée Bordeleau, Eric Jolicoeur, Punit Bhardwaj, Peter W. White, Michel Garneau, Ted Halmos, Pat Forgione
المصدر: Bioorganicmedicinal chemistry letters. 23(14)
مصطلحات موضوعية: Proline, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Computational biology, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, Biochemistry, Antiviral Agents, Structure-Activity Relationship, Drug Discovery, medicine, Moiety, Animals, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, NS3, Protease, Binding Sites, Organic Chemistry, Cell based assays, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, Enzyme, chemistry, Drug Design, Hcv ns3 protease, Molecular Medicine, Half-Life