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1
المؤلفون: Su Chang Lin, Hao Wu, Miao Lu, Jee Y. Chung, Betty Lamothe, Amy Y. Lam, Yu Chih Lo, Kanagalaghatta R. Rajashankar, Bryant G. Darnay
المصدر: Journal of Molecular Biology. 376:526-540
مصطلحات موضوعية: Models, Molecular, Plasma protein binding, IκB kinase, Crystallography, X-Ray, Kidney, Protein Structure, Secondary, Substrate Specificity, Deubiquitinating enzyme, Ubiquitin, immune system diseases, Structural Biology, hemic and lymphatic diseases, Polyubiquitin, Conserved Sequence, Glutathione Transferase, Alanine, Intracellular Signaling Peptides and Proteins, NF-kappa B, Nuclear Proteins, Cell biology, Ubiquitin ligase, DNA-Binding Proteins, Biochemistry, Protein Binding, Deubiquitination, Ubiquitin-Protein Ligases, Molecular Sequence Data, Static Electricity, macromolecular substances, Biology, Article, Catalysis, Cell Line, Escherichia coli, Humans, Amino Acid Sequence, Molecular Biology, Tumor Necrosis Factor alpha-Induced Protein 3, TNF Receptor-Associated Factor 6, Binding Sites, Sequence Homology, Amino Acid, Ubiquitination, Hydrogen Bonding, Precipitin Tests, Protein Structure, Tertiary, Amino Acid Substitution, biology.protein, Gene Deletion
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2
المؤلفون: Hao Wu, Hong Ye, Young Chul Park, Jee Y. Chung
المصدر: Journal of Cell Science. 115:679-688
مصطلحات موضوعية: Models, Molecular, TRAF4, Protein Conformation, Upstream and downstream (transduction), Biology, TRAF-mediated signal transduction, Animals, Humans, Amino Acid Sequence, Phylogeny, TNF Receptor-Associated Factor 6, TNF Receptor-Associated Factor 5, TNF Receptor-Associated Factor 4, TNF Receptor-Associated Factor 3, Proteins, Cell Biology, TNF Receptor-Associated Factor 2, TNF Receptor-Associated Factor 1, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, Cell biology, Tumor Necrosis Factor Receptor-Associated Factors, MATH domain, Signal transduction, Functional divergence, Signal Transduction
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3
المؤلفون: Saranjit K. Chhabra, Jee Y. Chung, Mao Jung Lee, Guang Yu Yang, Chung S. Yang
المصدر: The Journal of Nutrition. 130:472S-478S
مصطلحات موضوعية: Polymers, Biological Availability, Medicine (miscellaneous), Apoptosis, Epigallocatechin gallate, medicine.disease_cause, Catechin, Structure-Activity Relationship, chemistry.chemical_compound, Species Specificity, Phenols, Caffeine, Neoplasms, Tumor Cells, Cultured, Animals, Humans, Medicine, Tissue Distribution, Camellia sinensis, Flavonoids, Nutrition and Dietetics, Cancer prevention, Tea, Traditional medicine, business.industry, Polyphenols, food and beverages, Cancer, Neoplasms, Experimental, medicine.disease, Disease Models, Animal, Intestinal Absorption, chemistry, Polyphenol, Animal studies, business, Carcinogenesis, Human cancer
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4
المؤلفون: Jae O. Park, Zigang Dong, Chung S. Yang, Hnin Phyu, Jee Y. Chung
المصدر: The FASEB Journal. 15:2022-2024
مصطلحات موضوعية: biology, Kinase, Mitogen-Activated Protein Kinase 3, food and beverages, complex mixtures, Biochemistry, Molecular biology, In vitro, Polyphenol, Cell culture, Mitogen-activated protein kinase, Genetics, biology.protein, Phosphorylation, Molecular Biology, Transcription factor, Biotechnology
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5
المؤلفون: Rebecca L. Rich, David G. Myszka, Upendra Maddineni, Jee Y. Chung, Yu Chih Lo, Hao Wu
مصطلحات موضوعية: chemistry.chemical_classification, congenital, hereditary, and neonatal diseases and abnormalities, Sequence Homology, Amino Acid, Molecular Sequence Data, Isothermal titration calorimetry, Peptide, IκB kinase, Biology, Surface Plasmon Resonance, Biochemistry, Article, I-kappa B Kinase, Kinetics, chemistry, Biophysics, Humans, Thermodynamics, Electrophoresis, Polyacrylamide Gel, Amino Acid Sequence, Surface plasmon resonance, CHUK, skin and connective tissue diseases, Protein Binding
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6
المؤلفون: Miao Lu, Qian Yin, Hao Wu, Jee Y. Chung
المصدر: Advances in Experimental Medicine and Biology ISBN: 9780387706290
مصطلحات موضوعية: TRAF2, Immunoglobulin superfamily, Cellular homeostasis, Tumor necrosis factor alpha, Biology, Receptor, Acquired immune system, Intracellular, Transmembrane protein, Cell biology
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7
المؤلفون: Su Chang Lin, Miao Lu, Qian Yin, Jee Y. Chung, Hao Wu
المصدر: Advances in Experimental Medicine and Biology ISBN: 9780387706290
مصطلحات موضوعية: Interleukin-21 receptor, Enzyme-linked receptor, 5-HT5A receptor, Signal transduction, Biology, Vascular endothelial growth inhibitor, Lymphotoxin beta receptor, Coagulation factor II receptor, Protease-activated receptor 2, Cell biology
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8
المؤلفون: Jee Y, Chung, Miao, Lu, Qian, Yin, Hao, Wu
المصدر: Advances in experimental medicine and biology. 597
مصطلحات موضوعية: Animals, Humans, TNF Receptor-Associated Factor 2, Receptors, Tumor Necrosis Factor, Signal Transduction
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9
المؤلفون: Jee Y, Chung, Miao, Lu, Qian, Yin, Su-Chang, Lin, Hao, Wu
المصدر: Advances in experimental medicine and biology. 597
مصطلحات موضوعية: TNF Receptor-Associated Factor 6, Animals, Humans
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10
المؤلفون: Jee Y. Chung, Hong Ye, W U Hao, Young Chul Park
المصدر: Handbook of Cell Signaling
مصطلحات موضوعية: Kinase, C-terminus, Signal transducing adaptor protein, Signal transduction, Biology, Receptor, TRADD, Function (biology), Intracellular, Cell biology
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11
المؤلفون: John M. Abrams, John P. Adelman, Joseph L. Alcorn, Dario R. Alessi, Emil Alexov, Simon Alford, Kari Alitalo, James P. Allison, Steven C. Almo, Christelle Alory, Aymen Al-Shamkhani, Sally A. Amundson, Carl W. Anderson, Jannik N. Andersen, Peter Angel, Ettore Appella, William J. Arendshorst, Steve Arkinstall, Anjon Audhya, Joseph Avruch, Gary D. Bader, Cinzia Bagala, William E. Balch, Jesus Balsinde, Utpal Banerjee, David Barford, Dafna Bar-Sagi, Perry F. Bartlett, Philippe I.H. Bastiaens, Chiara Battelli, Linnea M. Baudhuin, Andrew J. Beavil, Rebecca L. Beavil, Joseph A. Beavo, Elsa Bello-Reuss, Stephen Bellum, Juan Carlos Izpisúa Belmonte, Craig B. Bennett, Jeffrey L. Benovic, Michael J. Berridge, Penny J. Beuning, Rashna Bhandari, Ananya Bhattacharya, Martin Biel, Vincent A. Bielinski, Hana Bilak, Lutz Birnbaumer, Geoff Birrell, Gail A. Bishop, Trillium Blackmer, Perry J. Blackshear, Christine Blattner, Mordecai P. Blaustein, Gary M. Bokoch, Lynda F. Bonewald, Marco Bonomi, Michelle A. Booden, Charles Boone, Martin D. Bootman, Johannes L. Bos, Jane M. Bradbury, Ralph A. Bradshaw, Anne R. Bresnick, Lena Brevnova, Ross I. Brinkworth, Michael S. Brown, Steven A. Brown, Anne Brunet, Robert Bucki, Robert D. Burgoyne, Janice E. Buss, Ronald A. Butow, Javier Capdevila, Ernesto Carafoli, Cathrine R. Carlson, Graham Carpenter, Juan J. Carrillo, Patrick J. Casey, William A. Catterall, Richard A. Cerione, Gianni Cesareni, Andrew C. Chan, Geoffrey Chang, Moses V. Chao, Harry Charbonneau, Philip Chen, Alan Cheng, Chris Chiu, Dar-chone Chow, Ted D. Chrisman, Anne Elisabeth Christensen, Jee Y. Chung, Grant C. Churchill, Aaron Ciechanover, Gino Cingolani, Sylvie Claeysen, Jean Closset, Shamshad Cockcroft, Patricia T.W. Cohen, Philip Cohen, Roger J. Colbran, Clay E.S. Comstock, Marco Conti, Jackie D. Corbin, Daniela Corda, Sabine Costagliola, Rick H. Cote, Shaun R. Coughlin, L. Ashley Cowart, Adrienne D. Cox, Mark S. Cragg, José L. Crespo, Claudia Crosio, Christopher Daly, Sami Damak, Mary Dasso, Michael David, Anthony J. Davis, Roger J. Davis, Richard N. Day, Eva Degerman, Warren L. DeLano, Mark L. Dell'Acqua, Emmanuèle Délot, Bruce Demple, Edward A. Dennis, John M. Denu, Anna A. DePaoli-Roach, Channing J. Der, Johan de Rooij, Frederic de Sauvage, Peter N. Devreotes, Valérie Dewaste, Robert B. Dickson, Becky A. Diebold, Pier Paolo Di Fiori, Maria Di Girolamo, Julie Diplexcito, Jack E. Dixon, Robert W. Doms, Daniel J. Donoghue, Russell F. Doolittle, Stein Ove Døskeland, Wolfgang R.G. Dostmann, Matthias K. Dreyer, Guo Guang Du, Keyong Du, Michael R. Duchen, William G. Dunphy, Joanne Durgan, Michael L. Dustin, Peter A. Edwards, Jackson G. Egen, Lee E. Eiden, Elaine A. Elion, Scott Emr, Othmar G. Engelhardt, Christophe Erneux, Peter J. Espenshade, Edward D. Esplin, B. Mark Evers, Joanne L. Eyles, Sheelagh Fame, Marilyn Farquhar, Robert Feil, Gui-Jie Feng, Stanley Fields, James J. Fiordalisi, Richard A. Firtel, Garret A. Fitzgerald, Andrew Flint, Marco Foiani, Barry Marc Forman, Albert J. Fornace, Sharron H. Francis, Günter Fritz, David A. Fruman, Antony Galione, Chris S. Gandhi, David L. Garbers, K. Christopher Garcia, Benjamin Geiger, Larry Gerace, Andrea Gerstner, Amato J. Giaccia, Michele Giannattasio, Vincent Giguère, Christopher K. Glass, Martin J. Glennie, Jennifer L. Glick, Joseph L. Goldstein, Venkatesh Gopal, Myriam Gorospe, Cedric Govaerts, Paul R. Graves, Patrick W. Gray, Irene Graziani, Douglas R. Green, Michael E. Greenberg, Iva Greenwald, Haihua Gu, Nuri Gueven, J. Silvio Gutkind, Jesper Z. Haeggström, Alan Hall, Michael N. Hall, Otto Haller, Heidi E. Hamm, Yusef A. Hannun, Carl A. Hansen, T. Kendall Harden, D. Grahame Hardie, Kiminori Hasegawa, Phillip T. Hawkins, Timothy A.J. Haystead, Xiao-lin He, Claus W. Heizmann, Carl-Henrik Heldin, Michelle L. Hermiston, Peter Herrlich, Elizabeth A. Hewat, Bertil Hille, Douglas J. Hilton, K.A. Hinchliffe, Steffan N. Ho, Su-Chin Ho, Mark Hochstrasser, Franz Hofmann, Christopher W. Hogue, Wim G.J. Hol, Jocelyn Holash, Robert A. Holmgren, Barry Honig, Bruce S. Hostager, Stevan R. Hubbard, Michael Huber, Tony Hunter, Anna Huttenlocher, Sarah G. Hymowitz, James N. Ihle, Jean-Luc Imler, R.F. Irvine, Ehud Y. Isacoff, Xavier Iturrioz, Lars F. Iversen, Ravi Iyengar, Stephen P. Jackson, Lily Yeh Jan, Fabiola Janiak-Spens, Paul A. Janmey, Peter Gildsig Jansen, Sophie Jarriault, Jonathan A. Javitch, Elwood V. Jensen, Kristen Jepsen, E. Yvonne Jones, Katherine A. Jones, J. Dedrick Jordan, Jomon Joseph, Louis B. Justement, Yariv Kafri, Richard A. Kahn, Shin W. Kang, Arthur Karlin, Heidi R. Kast-Woelbern, Randal J. Kaufman, Andrius Kazlauskas, James H. Keen, Rolf Kemler, Bruce E. Kemp, Mary B. Kennedy, Matthew A. Kennedy, Ushio Kikkawa, Albert H. Kim, Soo-A Kim, Sung-Hou Kim, Youngjoo Kim, Kirst King-Jones, Chris Kintner, Saul Kivimäe, Claude B. Klee, Rüdiger Klein, Thomas Kleppisch, Steven A. Kliewer, Richard A. Klinghoffer, Juergen A. Knoblich, Bostjan Kobe, George Kochs, Monica Kong-Beltran, Rolf König, Albert C. Koong, Murray Korc, Daniel Kornitzer, Anthony A. Kossiakoff, Jun Kotera, M.V. Kovalenko, Tohru Kozasa, Sergei Kozlov, Keith G. Kozminski, Sonja Krugmann, John Kuriyan, Riki Kurokawa, Peter D. Kwong, Wi S. Lai, Elise Lamar, Millard H. Lambert, David G. Lambright, Doron Lancet, Reiko Landry, Wallace Y. Langdon, Lorene K. Langeberg, Paul Lasko, Vaughn Latham, Martin F. Lavin, Kevin A. Lease, Hakon Leffler, Mark A. Lemmon, Ann E. Leonard, Alexander Levitzki, Hong-Jun Liao, Lucy Liaw, Giordano Liberi, Heiko Lickert, Robert C. Liddington, Thomas M. Lincoln, Jürgen U. Linder, Maurine E. Linder, Hui Liu, Zhengchang Liu, Marja K. Lohela, Sarah H. Louie, Deirdre K. Luttrell, Louis M. Luttrell, Karen M. Lyons, S. Lance Macaulay, Michael Maceyka, Thomas Maciag, Fernando Macian, Carol MacKintosh, David H. MacLennan, Nadir A. Mahmood, Craig C. Malbon, Sohail Malik, Orna Man, Carol L. Manahan, Anna Mandinova, Vincent C. Manganiello, James L. Manley, Matthias Mann, Gerald Manning, Ed Manser, Marta Margeta-Mitrovic, Robert F. Margolskee, Julia Marinissen, Roy A. Mariuzza, Mina D. Marmor, G. Steven Martin, Karen H. Martin, Sergio E. Martinez, Michael B. Mathews, Bruce J. Mayer, Mark L. Mayer, Maria R. Mazzoni, Frank McCormick, Clare H. McGowan, Melissa M. McKay, Wallace L. McKeehan, Alison J. McLean, Anthony R. Means, Ruedi Meili, Jingwei Meng, Mark Merchant, Frank Mercurio, Graeme Milligan, Guo-Li Ming, Daniel L. Minor, Nadeem Moghal, Neils Peter H. Møller, Marco Mongillo, Marc Montminy, Randall T. Moon, Richard I. Morimoto, Stephen E. Moss, Helen R. Mott, Carla Mouta, Marco Muda, Marc C. Mumby, Gretchen A. Murphy, Marco Muzi-Falconi, Raghavendra Nagaraj, Stefan R. Nahorski, Angus C. Nairn, Piers Nash, Benjamin G. Neel, Alexandra C. Newton, Yasutomi Nishizuka, Joseph P. Noel, Ellen A.A. Nollen, Irene M.A. Nooren, Rodney O'Connor, Stefan Offermanns, Tsviya Olender, Shao-En Ong, Darerca Owen, Lisa J. Pagliari, Lily Pao, John Papaconstantinou, Leonardo Pardo, Hay-Oak Park, Young Chul Park, Peter J. Parker, J. Thomas Parsons, J.M. Passner, Tony Pawson, Achille Pelliccioli, J. Regino Perez-Polo, Norbert Perrimon, Fabrice G. Petite, Emmanuel Petroulakis, Samuel L. Pfaff, Jacob Piehler, Linda J. Pike, Michael J. Pinkoski, Fiona J. Pixley, Paolo Plevani, Mu-ming Poo, Tullioi Pozzan, Stephen M. Prescott, Igor Prudovsky, James W. Putney, Thomas Radimerski, Elzbieta Radzio-Andzelm, Prahlad T. Ram, Lucia Rameh, Danica Ramljak, Barbara Ranscht, Anjana Rao, Carol J. Raport, Jacqueline D. Reeves, Holger Rehman, Trevor W. Reichman, Eric Reiter, Michael A. Resnick, Michael Reth, Sue Goo Rhee, Joel D. Richter, Rodney L. Rietze, James M. Rini, Jürgen A. Ripperger, Josep Rizo, Janet D. Robishaw, H. Llewelyn Roderick, Robert G. Roeder, Larry R. Rohrschneider, David Ron, Michael G. Rosenfeld, Hans Rosenfeldt, Kent L. Rossman, Christopher B. Roth, Markus G. Rudolph, Anja Ruppelt, Lino Saez, Thomas P. Sakmar, Guy S. Salvesen, Paolo Sassone-Corsi, Charles L. Saxe, Beat W. Schäfer, Ueli Schibler, Christian W. Schindler, Tobias Schmelzle, Sandra L. Schmid, Anja Schmidt, Eric F. Schmidt, Gideon Schreiber, Joachim E. Schultz, Beat Schwaller, Klaus Schwamborn, Thue Schwartz, William F. Schwindinger, Giorgio Scita, John D. Scott, Shaun Scott, Thomas Seebeck, Charles N. Serhan, John B. Shabb, Andrey S. Shaw, Stephen B. Shears, Shirish Shenolikar, Lei Shi, Chanseok Shin, Kazuhiro Shiozaki, Kevan M. Shokat, Trevor J. Shuttleworth, David P. Siderovski, Steven A. Siegelbaum, Adam M. Silverstein, Robert H. Singer, Michael K. Skinner, Jill K. Slack-Davis, Stephen J. Smerdon, Graeme C.M. Smith, Guillaume Smits, Sarah M. Smolik, Jessica E. Smotrys, Emer M. Smyth, Jason T. Snyder, Naoko Sogame, Raffaella Soldi, John Sondek, Nahum Sonenberg, Erica Dutil Sonneberg, Lindsay G. Sparrow, Sarah Spiegel, Stephen R. Sprang, Deepak Srivastava, Robyn L. Stanfield, E. Richard Stanley, Deborah J. Stauber, Christopher Stefan, Lena Stenson-Holst, Len Stephens, Paul W. Sternberg, Paul C. Sternweis, Ruth Steward, John T. Stickney, Andrew W. Stoker, Stephen M. Strittmatter, Beth E. Stronach, Roland K. Strong, Robert M. Stroud, Thomas C. Südhof, Roger K. Sunahara, Brian J. Sutton, Sipeki Szabolcs, Xiao-Bo Tang, Kjetil Taskén, Hisashi Tatebe, Servane Tauszig-Delamasure, Colin W. Taylor, Garry L. Taylor, Laura J. Taylor, Susan S. Taylor, George Thomas, Robert P. Thomas, E. Brad Thompson, Michael J. Thompson, Janet M. Thornton, Carl S. Thummel, Hideaki Togashi, Amy Hin Yan Tong, Nicholas K. Tonks, Peter Tontonoz, M.K. Topham, Knut Martin Torgersen, Hien Tran, Michel L. Tremblay, Ming-Jer Tsai, Sophia Y. Tsai, Susan Tsunoda, Stewart Turley, Darren Tyson, Robert L. Van Etten, Gilbert Vassart, Peter J. Verveer, Virginie Vlaeminck, Abraham M. de Vos, Ty C. Voss, Robert Walczak, Graham C. Walker, John C. Walker, Gernot Walter, Mark R. Walter, Fen Wang, Jean Y.J. Wang, Weiru Wang, Richard J. Ward, Philip Wedegaertner, Christian Wehrle, Arthur Weiss, Jamie L. Weiss, Alan Wells, Claudia Werner, Ann H. West, Marie C. Weston, John K. Westwick, Anders Wetterholm, Morris F. White, Malcolm Whitman, Matt R. Whorton, Christian Wiesmann, Roger L. Williams, William D. Willis, Timothy M. Willson, Ian A. Wilson, Ofer Wiser, Matthew J. Wishart, Alfred Wittinghofer, James R. Woodgett, David K. Worthylake, Jeffrey L. Wrana, Hao Wu, Yijin Xiao, H. Eric Xu, Yan Xu, Zheng Xu, Michael B. Yaffe, Kenneth M. Yamada, Seun-Ah Yang, Wannian Yang, Yosef Yarden, Hong Ye, Weilan Ye, Todd O. Yeates, Helen L. Yin, John D. York, Edgar C. Young, Kenneth W. Young, Matthew A. Young, Michael W. Young, Minmin Yu, Nathan R. Zaccai, Manuela Zaccolo, Eli Zamir, Mark von Zastrow, Chao Zhang, Xuewu Zhang, Zhong-Yin Zhang, Wenhong Zhou, Roya Zoraghi
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12
المؤلفون: Chung S. Yang, Jee Y. Chung, Chun Li, Guang Yu Yang, Mao-Jung Lee
المصدر: Nutrition and Cancer Prevention ISBN: 9781461354772
مصطلحات موضوعية: Cancer prevention, business.industry, Polyphenol, Medicine, Tumor cells, Tissue distribution, Pharmacology, business, Intestinal absorption, Biological availability
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13
المؤلفون: Bozena Winnik, Mao-Jung Lee, Chuan Li, Baoming Huang, Saileta Prabhu, Shuqun Sheng, Xiaofeng Meng, Chi-Tang Ho, Jee Y. Chung, Chung S. Yang, Shunqi Yan
المصدر: Chemical research in toxicology. 13(3)
مصطلحات موضوعية: Adult, Male, Chromatography, Magnetic Resonance Spectroscopy, Molecular Structure, Tea, Chemistry, Urinary system, Kinetics, Catechin, General Medicine, Urine, Toxicology, Green tea, Mass Spectrometry, chemistry.chemical_compound, Lactones, Renal physiology, Ingestion, Humans, Food science, Feces, Chromatography, High Pressure Liquid, Chromatography, Liquid
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14
المؤلفون: Mao Jung Lee, Jie Liao, Guang Yu Yang, Chi-Tang Ho, Jee Y. Chung, Sungbin Kim, Chung S. Yang
المصدر: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 220(4)
مصطلحات موضوعية: Lung Neoplasms, Polymers, Active components, Biological Availability, Pharmacology, Biology, medicine.disease_cause, complex mixtures, General Biochemistry, Genetics and Molecular Biology, law.invention, Phenols, law, medicine, Animals, Anticarcinogenic Agents, Humans, Tea consumption, Flavonoids, Tea, food and beverages, Cancer, Polyphenols, Neoplasms, Experimental, medicine.disease, Bioavailability, Disease Models, Animal, Polyphenol, Drug Screening Assays, Antitumor, Phytotherapy, Carcinogenesis, Human cancer
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15Academic Journal
المؤلفون: Jee Y. Chung, Chuanshu Huang, Xiaofeng Meng, Contact The Aacr Publications, Zigang Dong, Chung S. Yang
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.2609; http://cancerres.aacrjournals.org/content/59/18/4610.full.pdf
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16Academic Journal
المؤلفون: Su-chang Lin, Jee Y. Chung
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.496.6459; http://www-users.med.cornell.edu/~haowu/lin_jmb_a20.pdf
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17Academic Journal
المؤلفون: Qian Yin, Hyun Ho Park, Jee Y. Chung, Xuejun Jiang, Hao Wu
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.496.232; http://www-users.med.cornell.edu/~haowu/yin_molcell_2006.pdf