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1Academic Journal
المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
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المصدر: Drug discovery today. 27(11)
مصطلحات موضوعية: Pharmacology, Drug Discovery
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المؤلفون: Berni Sweeney, Marta Westwood, Kerry Louise Tyson, David McMillan, Geofrey Odede, Gillian Burgess, Terry Baker, Daniel John Lightwood, Patrick Downey, Georges Mairet-Coello, Rebecca Munro, Martin Citron, Robert G. Griffin, Dale Starkie, Marie-Laetitia Mushikiwabo, Nathalie Pacico, Ruodan Nan, Sophie Jung, Rachel Angers, Jean-Philippe Courade, Andrew George Popplewell
المصدر: Acta Neuropathologica
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Cell, Tau protein, tau Proteins, Transfection, Antibodies, Epitope, Pathology and Forensic Medicine, Progressive supranuclear palsy, Epitopes, Protein Aggregates, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Alzheimer Disease, mental disorders, medicine, Humans, Original Paper, biology, Neurodegeneration, food and beverages, Surface Plasmon Resonance, medicine.disease, Tau antibody, Tauopathy, HEK293 Cells, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Cancer research, Neurology (clinical), Tau, Antibody, Alzheimer’s disease, Epitope Mapping, 030217 neurology & neurosurgery, Intracellular
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المؤلفون: Jean-Philippe Courade, Joël Mercier, Michel Gillard, Jonas Hannestad, Delphine Viot, Georges Mairet-Coello, Martin Citron, Philippe Motte, Celine Vermeiren
المصدر: Movement Disorders. 33:273-281
مصطلحات موضوعية: 0301 basic medicine, Monoamine oxidase, Contrast Media, tau Proteins, Tritium, Progressive supranuclear palsy, law.invention, Rats, Sprague-Dawley, Radioligand Assay, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, law, medicine, Animals, Humans, Monoamine Oxidase, chemistry.chemical_classification, Dose-Response Relationship, Drug, biology, Brain, medicine.disease, Molecular biology, Rats, 030104 developmental biology, Enzyme, Monoamine neurotransmitter, Neurology, chemistry, Positron-Emission Tomography, biology.protein, Recombinant DNA, Biomarker (medicine), Supranuclear Palsy, Progressive, Neurology (clinical), Monoamine oxidase A, 030217 neurology & neurosurgery, Carbolines, Protein Binding
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المؤلفون: Raphaëlle Caillierez, Mathieu Schmitt, Clément Danis, Martin Citron, Sébastien Carrier, Marie Albert, Luc Buée, Anne Michel, Isabelle Landrieu, Patrick Downey, Georges Mairet-Coello, Sarah Lieger, Emilie Skrobala, Morvane Colin, Jean-Philippe Courade
المساهمون: BUEE, Luc, Appel à projets générique - Transfert différentiel intercellulaire des assemblages de Tau - - SPREADTAU2014 - ANR-14-CE13-0031 - Appel à projets générique - VALID, APPEL À PROJETS GÉNÉRIQUE 2018 - Caractérisation moléculaire et cellulaire de nanobodies dirigés contre Tau - - ToNIC2018 - ANR-18-CE44-0016 - AAPG2018 - VALID, Alzheimer & Tauopathies [JPArc], Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, UCB BioPharma [Braine l’Alleud, Belgium], Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Mémoire de Ressources et de Recherche -CMRR [Lille-Bailleul], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Hôpital Roger Salengro, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), This work was supported by grants from UCB Biopharma SPRL, the program Investissement d’avenir LabEx (laboratory excellence) DISTALZ (Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer’s disease), SPREADTAU ANR-14-CE13–0031, TONIC ANR-18-CE44–0016 and SUSTAIN TUNABLE (I-SITE ULNE). Our laboratories are also supported by LiCEND (Lille Centre of Excellence in Neurodegenerative Disorders), CNRS, Inserm, Me´tropole Europe´enne de Lille, Univ. Lille and DN2M., ANR-14-CE13-0031,SPREADTAU,Transfert différentiel intercellulaire des assemblages de Tau(2014), ANR-18-CE44-0016,ToNIC,Caractérisation moléculaire et cellulaire de nanobodies dirigés contre Tau(2018), CHU Lille, CNRS, Inserm, Université de Lille, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], Lille Neurosciences & Cognition (LilNCog) - U 1172
المصدر: Brain-A Journal of Neurology
Brain-A Journal of Neurology, 2019, 142 (6), pp.1736-1750. ⟨10.1093/brain/awz100⟩
Brainمصطلحات موضوعية: Male, 0301 basic medicine, Genetically modified mouse, medicine.medical_treatment, Tau protein, Cell, Mice, Transgenic, tau Proteins, Antibodies, Epitope, Epitopes, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, In vivo, mental disorders, propagation, medicine, Animals, Immunologic Factors, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], biology, Propagation, Seeding, Alzheimer\u2019s disease, Immunotherapy, Brain, Neurofibrillary Tangles, Original Articles, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, In vitro, 3. Good health, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Tauopathies, Disease Progression, biology.protein, Cancer research, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), immunotherapy, Antibody, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, Alzheimer’s disease, 030217 neurology & neurosurgery, seeding
وصف الملف: application/pdf; application/octet-stream
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المؤلفون: Jean-Philippe Courade, Martin Citron, Clément Danis, Sarah Lieger, Georges Mairet-Coello, Marie Albert, Luc Buée, Séverine Bégard, Raphaëlle Caillierez, Morvane Colin
المصدر: Alzheimer's & Dementia. 14
مصطلحات موضوعية: Genetically modified mouse, Lysis, Epidemiology, Health Policy, Passive Immunotherapy, Disease, Biology, Fibril, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cancer research, Seeding, Neurology (clinical), Geriatrics and Gerontology
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المؤلفون: Caroline H. Johnson, Gary Siuzdak, Leah P. Shriver, Marianne Manchester, Linh Hoang, Gary J. Patti, Jean-Philippe Courade
المصدر: Journal of Neuroimmune Pharmacology. 10:396-401
مصطلحات موضوعية: Male, medicine.drug_class, Metabolite, Immunology, Central nervous system, Pregabalin, Neuroscience (miscellaneous), Oleic Acids, Endogeny, Pharmacology, Antimetabolite, Article, Rats, Sprague-Dawley, chemistry.chemical_compound, Sphingosine, medicine, Animals, Metabolomics, Immunology and Allergy, Cannabinoid Receptor Agonists, Analgesics, business.industry, Lipid metabolism, Spinal cord, Rats, Disease Models, Animal, medicine.anatomical_structure, Spinal Cord, chemistry, Ethanolamines, Neuropathic pain, Neuralgia, business, Endocannabinoids, medicine.drug
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المؤلفون: Jean-Philippe Courade, Judith van Asperen, Olivier Lorthioir, Kyoko Koshibu, Helga Gerets, Javier Garcia-Ladona
المصدر: Pharmacology. 96:240-247
مصطلحات موضوعية: Male, Neurite, Cell Survival, Metabolic Clearance Rate, Cell, Protein Serine-Threonine Kinases, Pharmacology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Blood–brain barrier, Substrate Specificity, Rats, Sprague-Dawley, Drug Stability, In vivo, Drug Discovery, medicine, Animals, Humans, Tissue Distribution, Protein kinase A, Protein Kinase Inhibitors, Benzodiazepinones, Chemistry, Parkinson Disease, Hep G2 Cells, General Medicine, LRRK2, In vitro, nervous system diseases, Pyrimidines, medicine.anatomical_structure, Blood-Brain Barrier, Toxicity, Hepatocytes, Microsomes, Liver, Caco-2 Cells
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المؤلفون: Veronika Szombati, Misato Tsuge, Yun-Yun Zhan, Tsutomu Kawabe, Yun-Xuan Li, Jie Zu, Lucrezia Sarti, Young Lee, Qianqian He, Mariangela Manfredi, Toshinori Shiga, Oun-Cheol Back, Cheng-Cheng Yang, Komei Ito, Yan Lan, Tomohiro Nabekura, Martyn Harvey, Basim A.S. Messiha, Simona Barni, Judith van Asperen, Rong Hua, Xiang Fang, Frederik B. Pruijn, Jie Cai, Neri Pucci, Rita Benko, Elio Novembre, Wen-Zhe Jin, Zhen-He Wang, Hui Zhao, Lei Bao, Swarma Gamage, Eun-Seok Park, Kensuke Orito, Dae-Eun Kim, Olivier Lorthioir, Ji-Sook Lee, Helga Gerets, In Sik Kim, Tamas F. Molnar, Jin-Di Shi, Lisa Pecorari, Chun-Ping Chu, Istvan Benko, Kanae Mori, Yuka Kodera, Inas El Sayed Darwish, James Sleigh, Francesca Mori, Xinchun Ye, Da-Peng Dai, Yasmin Moustafa Ahmed, Guiyun Cui, Hong-Xia Pei, Su Zhou, William Denny, Nanako Ogasawara, Kyoko Koshibu, Iman Samy Dessouky, Yuta Tokai, Cha-Xiang Guan, Javier Garcia-Ladona, Ali Ahmed Abo-Saif, Loránd Barthó, Marika Shiga, Guo-Xin Hu, Miyoko Matsushima, Masahiro Yasui, Tatsuya Kawasaki, Hiroeki Sahara, Druckerei Stückle, Logan Voss, Yuichi Uwai, Hyung-Seok Jang, Jian-Ping Cai, Aya Omura, De-Lai Qiu, Jiney Jose, Jean-Philippe Courade, Heng Liu, Seiji Kojima
المصدر: Pharmacology. 96:I-IV
مصطلحات موضوعية: Pharmacology, General Medicine
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المؤلفون: J. van Asperen, C Van Der Perren, V Declercq, S Cornelis, Michel Famelart, P De Ron, B Mullier, Eric Jnoff, Jean-Philippe Courade, P Ghisdal, Patrick Downey, A Mingorance-Le Meur
المصدر: British Journal of Pharmacology. 170:1053-1063
مصطلحات موضوعية: Pharmacology, Glycine transporter, Tolerability, Drug development, In vivo, Toxicity, Chronic pain, medicine, Glycine Agents, Biology, medicine.disease, Acute toxicity
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المؤلفون: Elizabeth S. Fernandes, Jean-Philippe Courade, Susan D. Brain, Julie Keeble, F. A. Russell
المصدر: Pain. 142:264-274
مصطلحات موضوعية: Male, Hot Temperature, medicine.medical_treatment, Interleukin-1beta, TRPV1, TRPV Cation Channels, Arthritis, Inflammation, Pharmacology, Mice, medicine, Animals, Protein Kinase C, biology, Tumor Necrosis Factor-alpha, business.industry, medicine.disease, Mice, Inbred C57BL, Anesthesiology and Pain Medicine, Cytokine, Nociception, Neurology, Eicosanoid, Cyclooxygenase 2, Hyperalgesia, Immunology, biology.protein, Female, Neurology (clinical), Cyclooxygenase, medicine.symptom, business, Signal Transduction
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المؤلفون: Georges Mairet-Coello, Jean-Philippe Courade, Celine Vermeiren, Delphine Viot, Martin Citron, Jonas Hannestad, Michel Gillard, Joël Mercier
المصدر: Alzheimer's & Dementia. 11
مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, biology, Biochemistry, Epidemiology, Chemistry, Health Policy, TRACER, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Monoamine oxidase A
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المؤلفون: Alyson Fox, Marcus Peacock, Alice Chen, Alex Groarke, Christopher Thomas Brain, Yvonne Loong, Jean-Philippe Courade, Alex Dyson, Mohammed Yaqoob
المصدر: Pain. 116:129-137
مصطلحات موضوعية: Male, Time Factors, Cannabinoid receptor, medicine.medical_treatment, Freund's Adjuvant, Hypothermia, Pharmacology, Radioligand Assay, Cricetinae, Drug Interactions, Dronabinol, Pain Measurement, Analgesics, Chromatography, Chronic pain, Neurology, Anesthesia, Neuropathic pain, Hyperalgesia, medicine.symptom, medicine.drug, Pain Threshold, Agonist, medicine.drug_class, Morpholines, Analgesic, Pain, Motor Activity, Naphthalenes, Tritium, Cell Line, Cricetulus, Sulfur Isotopes, medicine, Animals, Humans, Rats, Wistar, Ligation, Inflammation, Catalepsy, Dose-Response Relationship, Drug, Cannabinoids, business.industry, Cyclohexanols, medicine.disease, Benzoxazines, Rats, Disease Models, Animal, Anesthesiology and Pain Medicine, Ajulemic acid, Guanosine 5'-O-(3-Thiotriphosphate), Rotarod Performance Test, Neurology (clinical), Cannabinoid, Sciatic Neuropathy, business
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المصدر: Drugs. 63:1-4
مصطلحات موضوعية: Nonsteroidal, Mechanism (biology), organic chemicals, digestive, oral, and skin physiology, Pharmacology, digestive system, digestive system diseases, Acetaminophen, chemistry.chemical_compound, Nociception, Mechanism of action, chemistry, health services administration, medicine, Morphine, Pharmacology (medical), medicine.symptom, medicine.drug
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16Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex
المؤلفون: Edward Beaumont, Mark A. Brooks, Eric Jnoff, Vincent Anthony Corden, Christophe Genicot, Stephanie Duclos, John J. Barker, Zara A. Sands, Graham Dawson, Oliver Barker, Steven Bromidge, Rosemary Maghames, Claudia Albrecht, Jason Kwong, Jean-Philippe Courade, Tara Fryatt, Richard Pike, Tom Ceska, Frederick Arthur Brookfield, Emilie Jigorel, Innocent Mushi, Christian Bubert, Christopher C. Stimson, Myron A. Smith
المصدر: ChemMedChem. 9(4)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, NF-E2-Related Factor 2, Phthalimides, Crystal structure, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, Nrf2 pathway, Drug Discovery, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Adaptor Proteins, Signal Transducing, Pharmacology, Kelch-Like ECH-Associated Protein 1, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Transcription inhibitor, Isoquinolines, Symptomatic relief, KEAP1, Keap1 nrf2, Crystallography, Cytoskeletal Proteins, Docking (molecular), Molecular Medicine
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المؤلفون: P. Foerch, M. De Ryck, D. Dardou, Serge N. Schiffmann, S. Monlezun, Jean-Philippe Courade, Laetitia Cuvelier
المصدر: Brain research, 1507
مصطلحات موضوعية: Male, medicine.medical_specialty, SV2 proteins, Tyrosine 3-Monooxygenase, Dopamine, Nerve Tissue Proteins, Striatum, Nucleus accumbens, Biology, Basal Ganglia, chemistry.chemical_compound, Mice, Reward, Cocaine, Internal medicine, Basal ganglia, medicine, Animals, Maze Learning, Oxidopamine, Molecular Biology, Mice, Knockout, Membrane Glycoproteins, Tyrosine hydroxylase, General Neuroscience, Dopaminergic Neurons, Dopaminergic, MPTP Poisoning, Enkephalins, Sciences bio-médicales et agricoles, Acetylcholine, Corpus Striatum, Mice, Inbred C57BL, medicine.anatomical_structure, Endocrinology, chemistry, nervous system, Gene Knockdown Techniques, Neurology (clinical), Neuron, Locomotion, Developmental Biology, medicine.drug
وصف الملف: 2 full-text file(s): application/pdf; application/pdf
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المؤلفون: Christophe Mallet, Jean-Philippe Courade, Jérôme Bonnefont, Monique Etienne, Eric Clottes, Laurence Daulhac, Lemlih Ouchchane, Alain Eschalier, Eric Chapuy, Marc Ferrara, Christiane Deval
المساهمون: Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Auvergne - Clermont-Ferrand I (UdA), CHU Clermont-Ferrand, Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 71 (2), pp.407-415. ⟨10.1124/mol.106.025775⟩
Molecular Pharmacology, 2007, 71 (2), pp.407-415. ⟨10.1124/mol.106.025775⟩مصطلحات موضوعية: medicine.medical_specialty, Pain, Growth hormone receptor, Pharmacology, Serotonergic, Receptor, IGF Type 1, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Animals, Cyclooxygenase Inhibitors, Receptor, Acetaminophen, 030304 developmental biology, G alpha subunit, Mitogen-Activated Protein Kinase 1, 0303 health sciences, Mitogen-Activated Protein Kinase 3, biology, Chemistry, business.industry, Receptors, Somatotropin, SYSTEME SEROTOGENIQUE, Analgesics, Non-Narcotic, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Spine, Rats, Endocrinology, Anesthesiology and Pain Medicine, Nociception, Somatostatin, Mechanism of action, Receptor, Serotonin, 5-HT1A, Emergency Medicine, biology.protein, Molecular Medicine, Analgesia, Signal transduction, medicine.symptom, business, 030217 neurology & neurosurgery, Signal Transduction, Neurotrophin
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المؤلفون: John V. Roughan, Siân L. Wright-Williams, Claire Richardson, Jean-Philippe Courade, Paul A. Flecknell
المصدر: Pain. 130(1-2)
مصطلحات موضوعية: Male, medicine.medical_specialty, Ratón, medicine.medical_treatment, Thiazines, Male mice, Meloxicam, chemistry.chemical_compound, Feces, Mice, Species Specificity, Corticosterone, Stress, Physiological, Internal medicine, Vasectomy, medicine, Animals, Saline, Pain Measurement, Mice, Inbred C3H, Pain, Postoperative, Behavior, Animal, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Body Weight, Laboratory mouse, Surgery, Mice, Inbred C57BL, Thiazoles, Anesthesiology and Pain Medicine, Endocrinology, Neurology, chemistry, Neurology (clinical), business, medicine.drug
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المصدر: Drugs.
مصطلحات موضوعية: Isoenzymes, Cyclooxygenase 2 Inhibitors, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, Receptors, Serotonin, Humans, Membrane Proteins, Pain, Cyclooxygenase Inhibitors, Analgesics, Non-Narcotic, Acetaminophen