المؤلفون: Jean-Baptiste Brault, Catherine Thouvenot, Magda Cannata Serio, Sylvain Paisant, Julien Fernandes, David Gény, Lydia Danglot, Adeline Mallet, Nadia Naffakh

المصدر: PLoS ONE, Vol 19, Iss 1 (2024)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10810476/?tool=EBI; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/562a089a16f740808459a04032b7b585

المؤلفون: Jacopo A. Carpentieri, Amandine Di Cicco, Marusa Lampic, David Andreau, Laurence Del Maestro, Fatima El Marjou, Laure Coquand, Nadia Bahi-Buisson, Jean-Baptiste Brault, Alexandre D. Baffet

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/e0959b6370cd4f02bf58ce3d591308e6

المؤلفون: Jean-Baptiste Brault, Cécile Khou, Justine Basset, Laure Coquand, Vincent Fraisier, Marie-Pascale Frenkiel, Bruno Goud, Jean-Claude Manuguerra, Nathalie Pardigon, Alexandre D. Baffet

المصدر: EBioMedicine, Vol 10, Iss C, Pp 71-76 (2016)

مصطلحات موضوعية: Medicine, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396416303231; https://doaj.org/toc/2352-3964

URL الوصول: https://doaj.org/article/634f49cf24f5409fa1ce48b628ef1585

المؤلفون: Jean-Baptiste Brault, Catherine Thouvenot, Magda Cannata Serio, Sylvain Paisant, Julien Fernandes, David Gény, Lydia Danglot, Adeline Mallet, Nadia Naffakh

مصطلحات موضوعية: Microbiology, Cell Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequently perform immunostaining, 3 microcarrier beads, notably intracellular trafficking, allows imaging along, grow polarized monolayers, subcellular resolution imaging, subcellular resolution, subcellular imaging, intracellular organization, confocal imaging, polarized cells, polarized iav, %22">xlink ">, viral genome, two dimensions, tc7 cells, static cytodex, polarizing conditions, multiple interactions, mechanistic study, life cycle

Relation: https://figshare.com/articles/journal_contribution/S1_Protocols_-/25065083

الاتاحة: https://doi.org/10.1371/journal.pone.0292977.s003
https://figshare.com/articles/journal_contribution/S1_Protocols_-/25065083

المؤلفون: Jean-Baptiste, Brault, Catherine, Thouvenot, Magda, Cannata Serio, Sylvain, Paisant, Julien, Fernandes, David, Gény, Lydia, Danglot, Adeline, Mallet, Nadia, Naffakh

المساهمون: Biologie des ARN et virus influenza - RNA Biology of Influenza Virus (CNRS-UMR3569), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Plate-forme de bioimagerie ultrastructurale - Ultrastructural BioImaging Core Facility, Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), BioImagerie Photonique – Photonic BioImaging (UTechS PBI), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), This work was funded by a Human Frontiers Science Program (HFSP) grant held by NN (HFSP-RGP0040/2019), and a grant from the French National Research Agency (ANR) held jointly by NN and LD (FluNanotrack, ANR-21-CE11-0010-03). JBB was funded by the HFSP-RGP0040/2019 and the ANR-21-CE11-0010-03 grants. MCS was funded by the HFSP-RGP0040/2019 grant.The UtechS Photonic BioImaging (Imagopole), C2RT, Institut Pasteur is supported by the FrenchNational Research Agency (France BioImaging, ANR-10-INSB-04-01, ANR-10–INBS-04 and ANR-10-LABX-62-IBEID).The NeurImag Imaging core facility at the Institute of Psychiatry and Neuroscience of Paris is a memberof the national infrastructure France-BioImaging supported by the ANR (ANR-10-INBS-04). We thankthe staff of NeurImag imaging core facility for their scientific expertise in data acquisitions and theLeducq foundation or funding the Leica SP8 Confocal/STED 3DX system., ANR-21-CE11-0010,FluNanoTrack,Dynamique et Topologie à l'échelle nanométrique du complexe Rab11-vRNP associé aux membranes dans des cellules infectées par le virus influenza(2021), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010)

المصدر: https://pasteur.hal.science/pasteur-04269651 ; 2023.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

Relation: pasteur-04269651; https://pasteur.hal.science/pasteur-04269651; https://pasteur.hal.science/pasteur-04269651/document; https://pasteur.hal.science/pasteur-04269651/file/2023.10.03.560780v1.full.pdf; BIORXIV: 2023.10.03.560780

الاتاحة: https://pasteur.hal.science/pasteur-04269651
https://pasteur.hal.science/pasteur-04269651/document
https://pasteur.hal.science/pasteur-04269651/file/2023.10.03.560780v1.full.pdf
https://doi.org/10.1101/2023.10.03.560780

المؤلفون: Jean-Baptiste Brault, Catherine Thouvenot, Magda Cannata Serio, Sylvain Paisant, Julien Fernandes, David Gény, Lydia Danglot, Adeline Mallet, Nadia Naffakh

مصطلحات موضوعية: Microbiology, Cell Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequently perform immunostaining, 3 microcarrier beads, notably intracellular trafficking, allows imaging along, grow polarized monolayers, subcellular resolution imaging, subcellular resolution, subcellular imaging, intracellular organization, confocal imaging, polarized cells, polarized iav, %22">xlink ">, viral genome, two dimensions, tc7 cells, static cytodex, polarizing conditions, multiple interactions, mechanistic study, life cycle

Relation: https://figshare.com/articles/figure/Accumulation_of_influenza_vRNPs_at_the_apical_membrane_of_polarized_Caco-2_TC7_cells_/25065077

الاتاحة: https://doi.org/10.1371/journal.pone.0292977.s001
https://figshare.com/articles/figure/Accumulation_of_influenza_vRNPs_at_the_apical_membrane_of_polarized_Caco-2_TC7_cells_/25065077

المؤلفون: Jean-Baptiste Brault, Catherine Thouvenot, Magda Cannata Serio, Sylvain Paisant, Julien Fernandes, David Gény, Lydia Danglot, Adeline Mallet, Nadia Naffakh

مصطلحات موضوعية: Microbiology, Cell Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequently perform immunostaining, 3 microcarrier beads, notably intracellular trafficking, allows imaging along, grow polarized monolayers, subcellular resolution imaging, subcellular resolution, subcellular imaging, intracellular organization, confocal imaging, polarized cells, polarized iav, %22">xlink ">, viral genome, two dimensions, tc7 cells, static cytodex, polarizing conditions, multiple interactions, mechanistic study, life cycle

Relation: https://figshare.com/articles/figure/Fig_4_-/25065095

الاتاحة: https://doi.org/10.1371/journal.pone.0292977.g004
https://figshare.com/articles/figure/Fig_4_-/25065095

المؤلفون: Jean-Baptiste Brault, Catherine Thouvenot, Magda Cannata Serio, Sylvain Paisant, Julien Fernandes, David Gény, Lydia Danglot, Adeline Mallet, Nadia Naffakh

مصطلحات موضوعية: Microbiology, Cell Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequently perform immunostaining, 3 microcarrier beads, notably intracellular trafficking, allows imaging along, grow polarized monolayers, subcellular resolution imaging, subcellular resolution, subcellular imaging, intracellular organization, confocal imaging, polarized cells, polarized iav, %22">xlink ">, viral genome, two dimensions, tc7 cells, static cytodex, polarizing conditions, multiple interactions, mechanistic study, life cycle

Relation: https://figshare.com/articles/figure/Fig_1_-/25065086

الاتاحة: https://doi.org/10.1371/journal.pone.0292977.g001
https://figshare.com/articles/figure/Fig_1_-/25065086

المؤلفون: Jean-Baptiste Brault, Catherine Thouvenot, Magda Cannata Serio, Sylvain Paisant, Julien Fernandes, David Gény, Lydia Danglot, Adeline Mallet, Nadia Naffakh

مصطلحات موضوعية: Microbiology, Cell Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequently perform immunostaining, 3 microcarrier beads, notably intracellular trafficking, allows imaging along, grow polarized monolayers, subcellular resolution imaging, subcellular resolution, subcellular imaging, intracellular organization, confocal imaging, polarized cells, polarized iav, %22">xlink ">, viral genome, two dimensions, tc7 cells, static cytodex, polarizing conditions, multiple interactions, mechanistic study, life cycle

Relation: https://figshare.com/articles/figure/Imaging_the_baso-lateral_axis_of_Caco-2_TC7_cells_grown_on_beads_versus_in_a_2D_system_/25065080

الاتاحة: https://doi.org/10.1371/journal.pone.0292977.s002
https://figshare.com/articles/figure/Imaging_the_baso-lateral_axis_of_Caco-2_TC7_cells_grown_on_beads_versus_in_a_2D_system_/25065080

المؤلفون: Jean-Baptiste Brault, Catherine Thouvenot, Magda Cannata Serio, Sylvain Paisant, Julien Fernandes, David Gény, Lydia Danglot, Adeline Mallet, Nadia Naffakh

مصطلحات موضوعية: Microbiology, Cell Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequently perform immunostaining, 3 microcarrier beads, notably intracellular trafficking, allows imaging along, grow polarized monolayers, subcellular resolution imaging, subcellular resolution, subcellular imaging, intracellular organization, confocal imaging, polarized cells, polarized iav, %22">xlink ">, viral genome, two dimensions, tc7 cells, static cytodex, polarizing conditions, multiple interactions, mechanistic study, life cycle

Relation: https://figshare.com/articles/figure/Fig_2_-/25065089

الاتاحة: https://doi.org/10.1371/journal.pone.0292977.g002
https://figshare.com/articles/figure/Fig_2_-/25065089

المؤلفون: Jean-Baptiste Brault, Catherine Thouvenot, Magda Cannata Serio, Sylvain Paisant, Julien Fernandes, David Gény, Lydia Danglot, Adeline Mallet, Nadia Naffakh

مصطلحات موضوعية: Microbiology, Cell Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequently perform immunostaining, 3 microcarrier beads, notably intracellular trafficking, allows imaging along, grow polarized monolayers, subcellular resolution imaging, subcellular resolution, subcellular imaging, intracellular organization, confocal imaging, polarized cells, polarized iav, %22">xlink ">, viral genome, two dimensions, tc7 cells, static cytodex, polarizing conditions, multiple interactions, mechanistic study, life cycle

Relation: https://figshare.com/articles/figure/Fig_3_-/25065092

الاتاحة: https://doi.org/10.1371/journal.pone.0292977.g003
https://figshare.com/articles/figure/Fig_3_-/25065092

المؤلفون: Jean-Baptiste Brault, Bruno Goud, Alexandre Baffet

المصدر: médecine/sciences. 39:9-12

مصطلحات موضوعية: General Medicine, General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::102549fe2e8e4436071becb6bc89633a
https://doi.org/10.1051/medsci/2022185

المؤلفون: Maud Dupont, Tim Krischuns, Quentin Giai-Gianetto, Sylvain Paisant, Stefano Bonazza, Jean-Baptiste Brault, Thibaut Douché, Joel I Perez-Perri, Matthias W Hentze, Stephen Cusack, Mariette Matondo, Catherine Isel, David G Courtney, Nadia Naffakh

المساهمون: Biologie des ARN et virus influenza - RNA Biology of Influenza Virus (CNRS-UMR3569), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Plateforme de Protéomique / Proteomics platform, Université Paris Cité (UPCité)-Spectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology (UTechS MSBio), Institut Pasteur [Paris] (IP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Wellcome-Wolfson Institute for Experimental Medicine, Queen's University [Belfast] (QUB), European Molecular Biology Laboratory [Heidelberg] (EMBL), European Molecular Biology Laboratory [Grenoble] (EMBL), This work was funded by the Agence Nationale de la Recherche [ANR-18-CE18-0028 to SC and NN, ANR-10-LABX-62IBEID to MM and NN, ANR-21-CE35-0007 to MM], the Marie-Skłodowska Curie Global Fellowship [MSCA-IF-GF:747810 to DGC], and the European Research Council Fellowship [PTFLU 949506 to DGC and SB]. Funding for open access charges [Agence Nationale de la Recherche/ANR-10-LABX-62IBEID], We would like to thank Dr. Feng Zhang (Broad Institute, Cambridge, USA), Dr. Mikhael Matrosovich (Philipps Universität, Marburg, Germany), Dr. Pierre-Olivier Vidalain (CIRI, Lyon), Dr. Daniel Marc (INRAE, Nouzilly, France), Dr. Caroline Demeret, Dr. Sandie Munier and the National Reference Center for Respiratory Viruses (all at Institut Pasteur, Paris, France) and for sharing reagents used in this work. We would like to thank Yves Jacob, Anastasia Komarova and Valérie Najburg (Institut Pasteur, Paris, France) for helpful discussions. Some figures were created with BioRender.com, ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-21-CE35-0007,PureMagRupture,Un flux de travail de la gMEP (Genetic magnetic-extraction-proteomics) pour comprendre le lien entre la rupture vacuolaire de Shigella et l'autophagie(2021)

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27588ea7439c895daeb07877156ed5b9
https://hal-pasteur.archives-ouvertes.fr/pasteur-04093384

المؤلفون: Jean-Baptiste Brault, Zengzhen Liu, Sabine Bardin, Delphine Ladarre, Vincent Fraisier, Anna Tchenio, Zsolt Lenkei, Jean Salamero, Cedric Delevoye, Bruno Goud, Stephanie Miserey

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b13f2f33fd30d363a5b66bc21959da52
https://doi.org/10.1101/2023.04.05.535676

المؤلفون: Jean‐Baptiste Brault, Sabine Bardin, Marusa Lampic, Jacopo A Carpentieri, Laure Coquand, Maxime Penisson, Hugo Lachuer, Guiliana Soraya Victoria, Sarah Baloul, Fatima El Marjou, Gaelle Boncompain, Stephanie Miserey‐Lenkei, Richard Belvindrah, Vincent Fraisier, Fiona Francis, Franck Perez, Bruno Goud, Alexandre D Baffet

المساهمون: Biologie Cellulaire et Cancer, Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Fer à Moulin (IFM - Inserm U1270 - SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Francis, Fiona, Institut Curie [Paris], BioImaging Cell and Tissue Core Facility (PICT-IBiSA), Goud, Bruno

المصدر: EMBO Reports
EMBO Reports, 2022, 23, ⟨10.15252/embr.202254605⟩
EMBO Reports, 2022, 23 (10), ⟨10.15252/embr.202254605⟩

مصطلحات موضوعية: Neurons, dynein, polarized trafficking, [SDV]Life Sciences [q-bio], Dyneins, Golgi Apparatus, Biochemistry, Microtubules, neocortex development, [SDV] Life Sciences [q-bio], cell polarity, RAB6, rab GTP-Binding Proteins, Genetics, Humans, Molecular Biology, Microtubule-Associated Proteins

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8d041adf01f5c876dc45e103ca020b
https://pubmed.ncbi.nlm.nih.gov/35979738

المؤلفون: Sabine Bardin, Laure Coquand, Maxime Penisson, Fiona Francis, Bruno Goud, Sarah Baloul, Franck Perez, Hugo Lachuer, Stéphanie Miserey-Lenkei, Jacopo Carpentieri, Vincent Fraisier, Guiliana Soraya Victoria, Jean-Baptiste Brault, Marusa Lampic, Alexandre D Baffet, Gaelle Boncompain

مصطلحات موضوعية: Neuroepithelial cell, symbols.namesake, RAB6A, Microtubule, Live cell imaging, Chemistry, Dynein, symbols, Golgi apparatus, Secretory pathway, Neural stem cell, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::99fcdda9a72a87b8a4354e029843851f
https://doi.org/10.1101/2021.07.23.453475

المؤلفون: Laure Coquand, Alice Tata, Alexandre D Baffet, Vincent Fraisier, Guiliana Soraya Victoria, Jean-Baptiste Brault, Jacopo Amerigo Carpentieri, Fabien Guimiot

المصدر: The Journal of Cell Biology

مصطلحات موضوعية: Time Factors, Neurogenesis, Ependymoglial Cells, Population, Gestational Age, Neocortex, Dendrite, Biology, Microtubules, Time-Lapse Imaging, Mice, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, Neural Stem Cells, Cell Movement, Live cell imaging, Microtubule, Report, medicine, Animals, Humans, Cell Lineage, education, Cytoskeleton, 030304 developmental biology, 0303 health sciences, education.field_of_study, Stem Cells, Cell Biology, Cell biology, medicine.anatomical_structure, Microscopy, Fluorescence, Neuroglia, Stem cell, Microtubule-Associated Proteins, 030217 neurology & neurosurgery, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80f9648c18c5c405369bcad7cee64f9
https://doi.org/10.1083/jcb.202003151

المؤلفون: Amandine Di Cicco, Laurence Del Maestro, Nadia Bahi-Buisson, Jacopo Amerigo Carpentieri, Jean-Baptiste Brault, David Andreau, Laure Coquand, Fatima El Marjou, Alexandre D Baffet

المصدر: Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

مصطلحات موضوعية: Programmed cell death, Microcephaly, MAP Kinase Signaling System, Science, Green Fluorescent Proteins, General Physics and Astronomy, Developmental neurogenesis, Nerve Tissue Proteins, Endosomes, Biology, Nervous System Malformations, General Biochemistry, Genetics and Molecular Biology, Article, Mice, Neural Stem Cells, Cyclin D2, medicine, Animals, Humans, Megalencephaly, Progenitor cell, Transport Vesicles, Cells, Cultured, Loss function, Cell Proliferation, Progenitor, Multidisciplinary, Cell growth, Growth factor signalling, Brain, General Chemistry, medicine.disease, Neural progenitors, Cell biology, Protein Transport, Neuroglia

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff11a9f038fc01ec2e420a9939f4361
https://doi.org/10.1101/2020.08.17.254037

المؤلفون: Jean-Baptiste Brault, Fabien Guimiot, Laure Coquand, Guiliana Soraya Victoria, Alice Tata, Vincent Fraisier, Alexandre D Baffet

مصطلحات موضوعية: education.field_of_study, Neocortex, Chemistry, Population, Dendrite, Cell biology, Cortex (botany), Basal (phylogenetics), medicine.anatomical_structure, Microtubule, Live cell imaging, medicine, Progenitor cell, education

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714d1a072fc125962a5c2b54106c2186
https://doi.org/10.1101/2020.03.16.993295

المؤلفون: Nathalie Da Silva, Alexandre D Baffet, Carole Pennetier, Jean-Baptiste Brault, Tristan Piolot, Véronique Marthiens, Ludovic Leconte, Renata Basto, Diana Vargas-Hurtado

المساهمون: CHU Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Compartimentation et dynamique cellulaires (CDC), Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Muséfrem, Centre d'Histoire 'Espaces et Cultures' (CHEC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), Virology Laboratory, Hôpital Rothchild, Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC)

المصدر: Current Biology-CB
Current Biology-CB, 2019, 29 (18), pp.2993-3005.e9. ⟨10.1016/j.cub.2019.07.061⟩
Current Biology-CB, Elsevier, 2019, 29 (18), pp.2993-3005.e9. ⟨10.1016/j.cub.2019.07.061⟩
Current Biology

مصطلحات موضوعية: 0301 basic medicine, Male, Cell type, [SDV]Life Sciences [q-bio], Neurogenesis, Mitosis, Cell Cycle Proteins, Spindle Apparatus, Biology, Microtubules, General Biochemistry, Genetics and Molecular Biology, Chromosome segregation, 03 medical and health sciences, Mice, 0302 clinical medicine, Neural Stem Cells, Microtubule, Pregnancy, Chromosome Segregation, Animals, Kinetochores, ComputingMilieux_MISCELLANEOUS, Mammals, Embryogenesis, Brain, Embryonic stem cell, Neural stem cell, Cell biology, Spindle apparatus, Mice, Inbred C57BL, 030104 developmental biology, Female, General Agricultural and Biological Sciences, Microtubule-Associated Proteins, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0851a5159c5d5827221819257864e6
https://pubmed.ncbi.nlm.nih.gov/31495584