المؤلفون: Noah Tu, Kennan C. Marsh, Karl W. Mollison, Rolf Wagner, Gin C. Hsieh, Cynthia L. Henry, Merrill Nuss, Jay R. Luly, Denise Wilcox, Nwe Y. Bamaung, Benjamin C. Lane, Richard P. Carlson, Yung-Wu Chen, Thomas A. Fey, Luping Liu, Paul E. Wiedeman, Yat-Sun Or, James M. Trevillyan, George W. Carter, Peer B. Jacobson, Teresa A. Rosenberg, Stevan W. Djuric

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:5340-5343

مصطلحات موضوعية: Male, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Chemical synthesis, Arthritis, Rheumatoid, Rats, Sprague-Dawley, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Molecular Biology, Sirolimus, Chemistry, Organic Chemistry, Biological activity, Rats, Radiography, Safety profile, Rats, Inbred Lew, Antirheumatic Agents, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036756a7d35bbf41755d205775e590ad
https://doi.org/10.1016/j.bmcl.2005.06.106

المؤلفون: Jay R. Luly, Kenneth G. Carson, David J Heilig, Wen Song Yue, Shixin Qin, Jie Jack Li, David T. Connor, Joseph Edwin Low, Roberta A Glynn, Bharat K. Trivedi, Qing Ye, Stephen W. Hunt, Steven R. Miller, Bruce D. Roth, Weixing Yang

المصدر: Bioorganic & Medicinal Chemistry. 11:3777-3790

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Antineoplastic Agents, Diamines, Biochemistry, Chemical synthesis, Receptors, Interleukin-8A, Structure-Activity Relationship, Quinoxalines, Drug Discovery, Humans, Structure–activity relationship, Interleukin 8, Receptor, Molecular Biology, Bicyclic molecule, Chemistry, Chemotaxis, Organic Chemistry, Interleukin-8 receptor, Small molecule, In vitro, Molecular Medicine, Calcium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e74b9b8847daee0af115d942196a4b
https://doi.org/10.1016/s0968-0896(03)00399-7

المؤلفون: Marc Elgort, Jeffrey N. Miner, Jay R. Luly, Philip R. Kym, Steven W. Elmore, George W. Carter, Curtis M. Tyree, Ben Lane, Chun Wei Lin, Michael J. Coghlan, Junlian Hu, Jon Rosen, Peer B. Jacobson, Russell T. Turner, Masaki Nakane

المصدر: Molecular Endocrinology. 17:860-869

مصطلحات موضوعية: Male, Prednisolone, Drug Evaluation, Preclinical, Pharmacology, Biology, Bone and Bones, Proinflammatory cytokine, Rats, Sprague-Dawley, Nuclear Receptor Coactivator 2, Endocrinology, In vivo, medicine, Animals, Edema, Humans, Benzopyrans, Receptor, Glucocorticoids, Molecular Biology, Cells, Cultured, Inflammation, Regulation of gene expression, Tibia, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, Peroxisome, Arthritis, Experimental, In vitro, Rats, Gene Expression Regulation, Quinolines, Nuclear receptor coactivator 2, Glucocorticoid, Transcription Factors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7becbddb98014712fb5159bc83265f3
https://doi.org/10.1210/me.2002-0355

المؤلفون: Paul E. Wiedeman, Jay R. Luly, Julie Wilkins, Yung-Wu Chen, Gerard D. Gagne, Michael P. Sheets, Morey L. Smith, Usha Warrior, James M. Trevillyan, Stephen J. Ballaron, Jane A. Fagerland, X. Grace Chiou, Karl W. Mollison, George W. Carter, Earl J. Gubbins, Stevan W. Djuric

المصدر: Journal of Biological Chemistry. 276:48118-48126

مصطلحات موضوعية: Transcription, Genetic, T-Lymphocytes, T cell, Molecular Sequence Data, Electrophoretic Mobility Shift Assay, Enzyme-Linked Immunosorbent Assay, Biology, Biochemistry, Jurkat cells, Jurkat Cells, Cyclosporin a, Phosphoprotein Phosphatases, medicine, Animals, Humans, Electrophoretic mobility shift assay, Amino Acid Sequence, Phosphorylation, Nuclear protein, Molecular Biology, Transcription factor, DNA Primers, Cell Nucleus, Aniline Compounds, Base Sequence, NFATC Transcription Factors, Nuclear Proteins, NFAT, Cell Biology, DNA-Binding Proteins, Molecular Weight, medicine.anatomical_structure, COS Cells, Cancer research, Interleukin-2, Pyrazoles, Calcium, Lymphocyte Culture Test, Mixed, Cell Division, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351374c705555e71a354368792ddee7c
https://doi.org/10.1074/jbc.m107919200

المؤلفون: Jianxing Shao, Jay R. Luly, Geraldine C Harriman

المصدر: Tetrahedron Letters. 41:8853-8856

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Piperidine, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::015570e306ac45b9660014b5b9d1e03e
https://doi.org/10.1016/s0040-4039(00)01610-5

المؤلفون: David G. Nettesheim, Jay R. Luly, Andrew M. Petros, Karl W. Mollison, Yat Sun Or, Benjamin C. Lane, Paul E. Wiedeman, Stephen W. Fesik

المصدر: Journal of Medicinal Chemistry. 42:4456-4461

مصطلحات موضوعية: Male, Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, Recombinant Fusion Proteins, Molecular Sequence Data, Chemical synthesis, Tacrolimus, Rats, Sprague-Dawley, Tacrolimus Binding Proteins, Drug Discovery, medicine, Animals, Humans, Amino Acid Sequence, Ascomycin, Immunophilins, Peptidylprolyl isomerase, chemistry.chemical_classification, Hyperplasia, Hydrogen bond, Biological activity, Peptidylprolyl Isomerase, Nucleotidyltransferases, Rats, FKBP, chemistry, Rats, Inbred Lew, Cis-trans-Isomerases, Molecular Medicine, Lymph Nodes, Lymphocyte Culture Test, Mixed, Immunosuppressive Agents, Lactone, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6233d7da414002f74d2161a781b9de80
https://doi.org/10.1021/jm980252z

المؤلفون: Michael P. Sheets, Karl W. Mollison, Cannon John Burns, Robin M Kolano, Morey L. Smith, Jay R. Luly, Yung-Wu Chen, Melissa S. Pong, Thomas A. Fey, Donna M. Gauvin, George W. Carter, Nikolaos M. Nikolaidis, Yat-Sun Or, Benjamin C. Lane, Kennan C. Marsh, Gin C. Hsieh, James M. Trevillyan

المصدر: Journal of Investigative Dermatology. 112:729-738

مصطلحات موضوعية: Allergy, atopic dermatitis, business.industry, medicine.medical_treatment, T cell, contact dermatitis, psoriasis, Cell Biology, Dermatology, Atopic dermatitis, medicine.disease, Biochemistry, corticosteroids, Cytokine, medicine.anatomical_structure, Psoriasis, Immunology, medicine, Ascomycin, business, Molecular Biology, Contact dermatitis, Allergic contact dermatitis, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83611ed3e1ea2610853c4ca908de9c9
https://doi.org/10.1046/j.1523-1747.1999.00567.x

المؤلفون: Melissa S. Pong, Michael P. Sheets, Thomas A. Fey, James M. Trevillyan, Morey L. Smith, Karl W. Mollison, Jay R. Luly, Joy Bauch, Stevan W. Djuric, Stephen J. Ballaron, Yung-Wu Chen, Kennan C. Marsh, Gin C. Hsieh, Robin M Kolano, Donna M. Gauvin, George W. Carter

المصدر: Clinical Immunology. 90:133-140

مصطلحات موضوعية: Swine, medicine.medical_treatment, Immunology, Pharmacology, Biology, Lymphocyte Activation, Peripheral blood mononuclear cell, Tacrolimus, chemistry.chemical_compound, medicine, Animals, Immunology and Allergy, Potency, Lymphocytes, Dosing, Whole blood, Ionomycin, Immunosuppression, Blood proteins, chemistry, Leukocytes, Mononuclear, Interleukin-2, Tetradecanoylphorbol Acetate, Immunosuppressive Agents, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286540ed19f03f23692a4bed78d93c52
https://doi.org/10.1006/clim.1998.4625

المؤلفون: Jay R. Luly, Michael J. Coghlan, Michael P. Sheets, Qinghua Xie, Karl W. Mollison, Alan X. Wang, Kennan C. Marsh, Gin C. Hsieh, Benjamin C. Lane

المصدر: Bioorganic & Medicinal Chemistry Letters. 8:2787-2792

مصطلحات موضوعية: Stereochemistry, medicine.drug_class, T-Lymphocytes, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Carboxamide, Pyrazole, Lymphocyte Activation, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Mode of action, Molecular Biology, IC50, Organic Chemistry, Biological activity, Isoxazoles, Mixed lymphocyte reaction, Rats, Mechanism of action, chemistry, Pyrazoles, Molecular Medicine, Lymphocyte Culture Test, Mixed, medicine.symptom, Immunosuppressive Agents, Leflunomide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879bc9a28dc28c5d8fcbb7b1e20d4177
https://doi.org/10.1016/s0960-894x(98)00501-0

المؤلفون: Karl W. Mollison, Thomas A. Fey, Donna M. Gauvin, Michael P. Sheets, Morey L. Smith, Melissa Pong, Ruth Krause, Loan Miller, Yat Sun Or, Megumi Kawai, Rolf Wagner, Paul E. Wiedeman, Richard F. Clark, Indrani W. K. Gunawardana, Teresa A. Rhoades, Cynthia L. Henry, Noah P. Tu, Nwe Y. BaMaung, Hana Kopecka, Luping Liu, Qinghua Xie, Benjamin C. Lane, James M. Trevillyan, Kennan Marsh, George W. Carter, Yung-Wu Chen, Gin C. Hsieh, Jay R. Luly

المصدر: Current Pharmaceutical Design. 4:367-379

مصطلحات موضوعية: Pharmacology, Drug Discovery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::04ee09e4e142ab4edb1bf712d6a1bd71
https://doi.org/10.2174/138161280405221010155826

المؤلفون: Janet M Andrews, Patrick K Cusick, Gin C. Hsieh, Karl W. Mollison, Thomas A. Fey, Pat T. Bretheim, Jay R. Luly, R. A. Krause

المصدر: Toxicology. 125:169-181

مصطلحات موضوعية: Male, medicine.medical_specialty, Normal diet, Metabolic Clearance Rate, Drug Evaluation, Preclinical, Biological Availability, Mice, Inbred Strains, Pharmacology, Toxicology, Models, Biological, Nephrectomy, Tacrolimus, Nephrotoxicity, Mice, Therapeutic index, Pharmacokinetics, Oral administration, Internal medicine, Animals, Medicine, Ascomycin, Dose-Response Relationship, Drug, business.industry, Drug Administration Routes, Rats, Inbred Strains, Diet, Sodium-Restricted, Rats, Calcineurin, Endocrinology, Toxicity, Kidney Diseases, business, Immunosuppressive Agents, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae36daaa818fead3753a95e24e01b850
https://doi.org/10.1016/s0300-483x(97)00167-4

المؤلفون: Teresa A. Rhoades, Yat Sun Or, Jay R. Luly, Rolf Wagner, Benjamin C. Lane

المصدر: Tetrahedron. 52:9643-9654

مصطلحات موضوعية: Chemistry, Stereochemistry, Antifungal antibiotic, Organic Chemistry, Biochemistry, Semisynthesis, chemistry.chemical_compound, FKBP, Amide, Drug Discovery, medicine, Lactam, Ascomycin, Conformational isomerism, Cis–trans isomerism, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bc80daaeedc6a973f601c310294fa2c6
https://doi.org/10.1016/0040-4020(96)00527-3

المؤلفون: Jay R. Luly, Gary T. Wang, Ben Lane, Andrew M. Petros, Stephen W. Fesik, Grant A. Krafft

المصدر: Bioorganic & Medicinal Chemistry Letters. 4:1161-1166

مصطلحات موضوعية: chemistry.chemical_classification, biology, Stereochemistry, Binding protein, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Active site, Peptide, Biochemistry, Chemical synthesis, Small molecule, chemistry.chemical_compound, FKBP, chemistry, Drug Discovery, biology.protein, Molecular Medicine, Methylene, Molecular Biology, Methyl group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::27bfdd9caa8ff532cc14c7db7aeef7b9
https://doi.org/10.1016/s0960-894x(01)80248-1

المؤلفون: Stephen W. Fesik, Heng Liang, Jay R. Luly, Andrew M. Petros

المصدر: Journal of the American Chemical Society. 115:9920-9924

مصطلحات موضوعية: Peptidylprolyl isomerase, Aqueous solution, Stereochemistry, Chemistry, General Chemistry, Nuclear magnetic resonance spectroscopy, Isomerase, Biochemistry, Catalysis, Colloid and Surface Chemistry, FKBP, Cis-trans-Isomerases, medicine, Ascomycin, Cis–trans isomerism, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c430073dbd4a44384bf9dde650b554ec
https://doi.org/10.1021/ja00075a007

المؤلفون: Ben Lane, Jay R. Luly, Takayoshi Kuno, Chang-Duk Chang, Chikako Tanaka, Hideyuki Mukai

المصدر: The Journal of Biochemistry. 113:292-298

مصطلحات موضوعية: Calmodulin, Binding protein, Phosphatase, General Medicine, Biology, Biochemistry, Calcineurin, Enzyme activator, Tacrolimus Binding Protein 1A, FKBP, polycyclic compounds, biology.protein, Phosphorylation, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b376012b3ed70c4f493cb3f6ee4a2cea
https://doi.org/10.1093/oxfordjournals.jbchem.a124041

المؤلفون: Megumi Kawai, Benjamin C. Lane, Gin C. Hsieh, Jay R. Luly, George W. Carter, Karl W. Mollison

المصدر: FEBS Letters. 316:107-113

مصطلحات موضوعية: Phosphatase, Biophysics, Pharmacology, Biochemistry, Tacrolimus, Tacrolimus Binding Proteins, Structure-Activity Relationship, Ascomycin, Structural Biology, In vivo, Genetics, medicine, Humans, Structure–activity relationship, Lymphocytes, Molecular Biology, Cells, Cultured, Immunosuppressant, Hyperplasia, Chemistry, Calcineurin, Antagonist, Cell Biology, medicine.disease, Transplant rejection, Mechanism of action, Interleukin-2, Lymph Nodes, C-18 hydroxyl analogue, medicine.symptom, FK-506, Carrier Proteins, Cell Division, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b61ed4365c8b57ce8af8040cbc940e4
https://doi.org/10.1016/0014-5793(93)81196-7

المؤلفون: Rodger F. Henry, James B. McAlpine, Richard F. Clark, Qinghua Xie, David N. Whittern, Yat Sun Or, Jay R. Luly

المصدر: Tetrahedron. 49:8771-8786

مصطلحات موضوعية: Conformational change, Chemical research, Chemistry, Stereochemistry, Organic Chemistry, Biological activity, Pyrazole, Biochemistry, chemistry.chemical_compound, Drug Discovery, medicine, Side chain, Molecule, Ascomycin, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::603c850c5add5e2fbd33d88910c4c7ca
https://doi.org/10.1016/s0040-4020(01)81899-8

المؤلفون: H. Liang, Andrew M. Petros, Jay R. Luly, Stephen W. Fesik

المصدر: ChemInform. 25

مصطلحات موضوعية: FKBP, Aqueous solution, Stereochemistry, Chemistry, General Medicine, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::acc5d1fab48ae095a13e67380ddbb0f5
https://doi.org/10.1002/chin.199406220

المؤلفون: David N. Whittern, Rodger F. Henry, Qinghua Xie, James B. McAlpine, Richard F. Clark, Jay R. Luly, Yat Sun Or

المصدر: ChemInform. 25

مصطلحات موضوعية: chemistry.chemical_compound, Conformational change, Chemical research, chemistry, Stereochemistry, Side chain, medicine, Biological activity, General Medicine, Ascomycin, Pyrazole, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::615fb7ce5201e6e97fa983057b6a278b
https://doi.org/10.1002/chin.199402282

المؤلفون: Jay R. Luly, Gunawardana Indrani W, Benjamin C. Lane, Gin C. Hsieh, Karl W. Mollison, Megumi Kawai

المصدر: ChemInform. 29

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Stereochemistry, In vivo, Aqueous solubility, medicine, General Medicine, Ascomycin, Lymphocyte proliferation, Popliteal Lymph Node, In vitro, Derivative (chemistry), medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f2fdff8ea19324da24c298973be127f1
https://doi.org/10.1002/chin.199833294