المؤلفون: Amy Li, Rebecca H. Herbst, David Canner, Jason M. Schenkel, Olivia C. Smith, Jonathan Y. Kim, Michelle Hillman, Arjun Bhutkar, Michael S. Cuoco, C. Garrett Rappazzo, Patricia Rogers, Celeste Dang, Livnat Jerby-Arnon, Orit Rozenblatt-Rosen, Le Cong, Michael Birnbaum, Aviv Regev, Tyler Jacks

المصدر: Cell Reports, Vol 29, Iss 10, Pp 2998-3008.e8 (2019)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719314536; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/23e127cdd30c49738de5fb370ca4ae6d

المؤلفون: Frederick J. Kohlhapp, Erica J. Huelsmann, Andrew T. Lacek, Jason M. Schenkel, Jevgenijs Lusciks, Joseph R. Broucek, Josef W. Goldufsky, Tasha Hughes, Janet P. Zayas, Hubert Dolubizno, Ryan T. Sowell, Regina Kühner, Sarah Burd, John C. Kubasiak, Arman Nabatiyan, Sh’Rae Marshall, Praveen K. Bommareddy, Shengguo Li, Jenna H. Newman, Claude E. Monken, Sasha H. Shafikhani, Amanda L. Marzo, Jose A. Guevara-Patino, Ahmed Lasfar, Paul G. Thomas, Edmund C. Lattime, Howard L. Kaufman, Andrew Zloza

المصدر: Cell Reports, Vol 17, Iss 4, Pp 957-965 (2016)

مصطلحات موضوعية: cancer, infection, concomitant, melanoma, breast cancer, influenza, mouse, PD-1, CD8+ T cells, viral, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716313249; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/21c3de3968b44525b8ba15963e57feea

المؤلفون: Sachin R. Jhawar, Aditya Thandoni, Praveen K. Bommareddy, Suemair Hassan, Frederick J. Kohlhapp, Sharad Goyal, Jason M. Schenkel, Ann W. Silk, Andrew Zloza

المصدر: Frontiers in Oncology, Vol 7 (2017)

مصطلحات موضوعية: oncolytic viruses, cancer immunotherapy, oncoimmunology, pathogens, viruses, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fonc.2017.00202/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/5607494a07a847aabe0433213e938815

المؤلفون: Pamela C. Rosato, Sahar Lotfi-Emran, Vineet Joag, Sathi Wijeyesinghe, Clare F. Quarnstrom, Hanna N. Degefu, Rebecca Nedellec, Jason M. Schenkel, Lalit K. Beura, Lars Hangartner, Dennis R. Burton, David Masopust

المصدر: Mucosal Immunology. 16:17-26

مصطلحات موضوعية: Immunology, Immunology and Allergy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2441ad98b2df16edd803962fe2dc62d0
https://doi.org/10.1016/j.mucimm.2022.11.004

المؤلفون: Alex M. Jaeger, JJ Patten, Olivia Smith, Haley Hauck, Ömer H. Yilmaz, Tyler Jacks, George Eng, Peter M. K. Westcott, Jason M. Schenkel, Coralie Backlund, Ryan Elbashir, Darrell J. Irvine, Zackery A. Ely, Daniel Zhang, Nathan J. Sacks, Mary Clare Beytagh

المصدر: Nature Cancer. 2:1071-1085

مصطلحات موضوعية: Cancer Research, Colorectal cancer, T-Lymphocytes, T cell, medicine.medical_treatment, Mice, Immune system, Antigens, Neoplasm, Animals, Humans, Medicine, integumentary system, business.industry, Cancer, Microsatellite instability, Immunotherapy, medicine.disease, Transplantation, medicine.anatomical_structure, Oncology, Immunoediting, Cancer research, Microsatellite Instability, Colorectal Neoplasms, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4273c6894f082d2418205f8f333ecec5
https://doi.org/10.1038/s43018-021-00247-z

المؤلفون: William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Jason W. Reeves, Rahul Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi, Denis Schapiro, Prajan Divakar, Eric Miller, Daniel R. Zollinger, George Eng, Jason M. Schenkel, Jennifer Su, Carina Shiau, Patrick Yu, William A. Freed-Pastor, Domenic Abbondanza, Arnav Mehta, Joshua Gould, Conner Lambden, Caroline B. M. Porter, Alexander Tsankov, Danielle Dionne, Julia Waldman, Michael S. Cuoco, Lan Nguyen, Toni Delorey, Devan Phillips, Jaimie L. Barth, Marina Kem, Clifton Rodrigues, Debora Ciprani, Jorge Roldan, Piotr Zelga, Vjola Jorgji, Jonathan H. Chen, Zackery Ely, Daniel Zhao, Kit Fuhrman, Robin Fropf, Joseph M. Beechem, Jay S. Loeffler, David P. Ryan, Colin D. Weekes, Cristina R. Ferrone, Motaz Qadan, Martin J. Aryee, Rakesh K. Jain, Donna S. Neuberg, Jennifer Y. Wo, Theodore S. Hong, Ramnik Xavier, Andrew J. Aguirre, Orit Rozenblatt-Rosen, Mari Mino-Kenudson, Carlos Fernandez-del Castillo, Andrew S. Liss, David T. Ting, Tyler Jacks, Aviv Regev

المصدر: Nat Genet

مصطلحات موضوعية: Pancreatic Neoplasms, Gene Expression Profiling, Genetics, Biomarkers, Tumor, Humans, Prognosis, Transcriptome, Article, Neoadjuvant Therapy, Carcinoma, Pancreatic Ductal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52fea7e3e72f452826d1f68df747811
https://europepmc.org/articles/PMC10290535/

المؤلفون: Alex M. Jaeger, Lauren E. Stopfer, Ryuhjin Ahn, Emma A. Sanders, Demi A. Sandel, William A. Freed-Pastor, William M. Rideout, Santiago Naranjo, Tim Fessenden, Kim B. Nguyen, Peter S. Winter, Ryan E. Kohn, Peter M. K. Westcott, Jason M. Schenkel, Sean-Luc Shanahan, Alex K. Shalek, Stefani Spranger, Forest M. White, Tyler Jacks

المصدر: Nature

مصطلحات موضوعية: Proteomics, Antigen Presentation, Multidisciplinary, Lung Neoplasms, Histocompatibility Antigens Class I, CD8-Positive T-Lymphocytes, Article, Pancreatic Neoplasms, Mice, Antigens, Neoplasm, Alveolar Epithelial Cells, Animals, RNA, Messenger, Peptides, Carcinoma, Pancreatic Ductal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c592d9e991788f10c2d2d6252e7d29e
https://europepmc.org/articles/PMC9945857/

المؤلفون: Santiago Naranjo, Christina M. Cabana, Lindsay M. LaFave, Rodrigo Romero, Sean-Luc Shanahan, Arjun Bhutkar, Peter M.K. Westcott, Jason M. Schenkel, Arkopravo Ghosh, Laura Z. Liao, Isabella Del Priore, Dian Yang, Tyler Jacks

المصدر: Genesdevelopment. 36(15-16)

مصطلحات موضوعية: Organoids, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), Mice, Lung Neoplasms, Genetics, Animals, Humans, Receptor Protein-Tyrosine Kinases, Adenocarcinoma of Lung, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a4c2a4e367aa7bbfd6d6098e733c19
https://pubmed.ncbi.nlm.nih.gov/36175034

المؤلفون: Diana D Shi, Jimmy A Guo, Hannah I Hoffman, Jennifer Su, Mari Mino-Kenudson, Jaimie L Barth, Jason M Schenkel, Jay S Loeffler, Helen A Shih, Theodore S Hong, Jennifer Y Wo, Andrew J Aguirre, Tyler Jacks, Lei Zheng, Patrick Y Wen, Timothy C Wang, William L Hwang

المصدر: Lancet Oncol

مصطلحات موضوعية: Clinical Trials as Topic, Oncology, Drug Resistance, Neoplasm, Neoplasms, Neurosciences, Tumor Microenvironment, Humans, Nervous System Physiological Phenomena, Cancer Pain, Immune Checkpoint Inhibitors, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f994935a5a186b670240b1520becb7c
https://europepmc.org/articles/PMC9516432/

المؤلفون: Santiago Naranjo, Christina M. Cabana, Lindsay M. LaFave, Peter M.K. Westcott, Rodrigo Romero, Arkopravo Ghosh, Laura Z. Liao, Jason M. Schenkel, Isabella Del Priore, Arjun Bhutkar, Dian Yang, Tyler Jacks

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bba5cb79ef9b6a168b81ecf9aafb767e
https://doi.org/10.1101/2021.12.07.471632

المؤلفون: Jason M. Schenkel, Sara Z. Tavana, Michelle Hillman, Peter M. K. Westcott, Megan L. Burger, Sarah E. Blatt, Tyler Jacks, David Canner, Marta M. Holovatska, Michael Manos, Giorgio Gaglia, Izumi de los Rios Kobara, Aviv Regev, Alex M. Jaeger, Arjun Bhutkar, Sandro Santagata, William L. Hwang, F. Stephen Hodi, Cecily C. Ritch, Amanda M. Cruz, Tamina Kienka, Andrea Garmilla, Alexia L. Barandiaran, Amy Li, Grace E. Crossland

المصدر: Cell

مصطلحات موضوعية: Receptors, CCR6, Subdominant, Lung Neoplasms, Programmed Cell Death 1 Receptor, Receptors, Antigen, T-Cell, Adenocarcinoma of Lung, Immunodominance, Biology, CD8-Positive T-Lymphocytes, Major histocompatibility complex, General Biochemistry, Genetics and Molecular Biology, Article, Epitopes, Mice, Antigen, Antigens, Neoplasm, Cytotoxic T cell, Animals, Humans, CTLA-4 Antigen, Amino Acid Sequence, Hepatocyte Nuclear Factor 1-alpha, RNA-Seq, Immune Checkpoint Inhibitors, Progenitor, Stem Cells, Vaccination, Immune checkpoint, Phenotype, biology.protein, Cancer research, Female, Single-Cell Analysis, Peptides, CD8

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881da5a74e035825ca947128bb7a8b0b
https://europepmc.org/articles/PMC8522630/

المؤلفون: William L. Hwang, Megan L. Burger, Orit Rozenblatt-Rosen, Le Cong, Michael S. Cuoco, Tyler Jacks, Jonathan Y. Kim, David Canner, George Eng, Amy Li, Sean-Luc Shanahan, Peter M. K. Westcott, Olivia Smith, Patricia Rogers, Rebecca H. Herbst, Kristen E. Pauken, Grace Gibbons, Aviv Regev, Jason M. Schenkel, Jin K. Park, Michelle Hillman, William A. Freed-Pastor

المصدر: Immunity

مصطلحات موضوعية: Lung Neoplasms, Immunology, Adenocarcinoma of Lung, Dendritic cell, Dendritic Cells, Biology, CD8-Positive T-Lymphocytes, medicine.disease, Tumor antigen, Immune checkpoint, Article, Mice, Infectious Diseases, Tumor progression, T-Lymphocyte Subsets, medicine, Cancer research, T Cell Transcription Factor 1, Immunology and Allergy, Adenocarcinoma, Cytotoxic T cell, Animals, Lymph, Lymph Nodes, CD8

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4e9ed93c4fcd85dd5b84259ce61603
https://europepmc.org/articles/PMC8604155/

المؤلفون: Joseph R. Broucek, Eileena F. Giurini, Nora L. Herzog, Lisa K. Denzin, Gabriel Guevara-Aleman, C. Brent Chesson, Ricardo Estupinian, Marco Rossi, Mary J. Fidler, Raquel E. Redondo, Jai S. Rudra, Joyce Paras, Jochen Reiser, Amanda L. Marzo, Jyoti Malhotra, Shang Jui Wang, Emily S. Ruiz, Stuti Buddhadev, Howard L. Kaufman, Saeed Tarabichi, Sachin R. Jhawar, Frederick J. Kohlhapp, Daniel J. Medina, Mones M. Aboelatta, David Rotter, Shengguo Li, Leonard Y. Lee, Vineet Gupta, John Langenfeld, Ann W. Silk, Russell J. Pepe, Kajal Gupta, Timothy M. Kuzel, Jason M. Schenkel, Derek B. Sant'Angelo, Abdulkareem Abed, Jenna H. Newman, Michael J. Lee, Praveen K. Bommareddy, Salvatore M. Aspromonte, Ahmed Lasfar, Eric A. Singer, Michael P. Kane, Christina Nowicki, Arnold B. Rabson, Andrew Zloza, Paul G. Thomas, Josef W. Goldufsky

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Lung Neoplasms, Skin Neoplasms, medicine.medical_treatment, CD8-Positive T-Lymphocytes, Injections, Intralesional, Mice, Influenza A Virus, H1N1 Subtype, Immunology and Inflammation, 0302 clinical medicine, Cancer immunotherapy, Neoplasms, vaccine, Tumor Microenvironment, Medicine, Lung, Skin, B-Lymphocytes, Immunity, Cellular, 0303 health sciences, Multidisciplinary, Vaccination, Biological Sciences, Interleukin-10, 3. Good health, Basic-Leucine Zipper Transcription Factors, PNAS Plus, Influenza Vaccines, Immunotherapy, Seasons, influenza, flu shot, Adjuvant, Squalene, Virus, 03 medical and health sciences, Adjuvants, Immunologic, Influenza, Human, Animals, Humans, cancer, 030304 developmental biology, Tumor microenvironment, business.industry, Cancer, medicine.disease, Blockade, Mice, Inbred C57BL, Repressor Proteins, intratumoral, Cancer research, business, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab3df47d5bd7978884f383d0b95e201
https://doi.org/10.1073/pnas.1904022116

المؤلفون: Kim L. Mercer, Jason M. Schenkel, Roderick T. Bronson, Elliot H. Akama-Garren, Tyler Jacks, Arjun Bhutkar, Sheng Rong Ng, William M. Rideout

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Candidate gene, Lung Neoplasms, Apoptosis, Retinoblastoma-Like Protein p107, Disease, law.invention, Mice, 0302 clinical medicine, Loss of Function Mutation, law, CRISPR, Genes, Tumor Suppressor, Lung, Gene Editing, 0303 health sciences, Multidisciplinary, Biological Sciences, humanities, Tumor Burden, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Disease Progression, Mice, Transgenic, Biology, Cell Line, 03 medical and health sciences, p107, Genetics, medicine, Animals, Humans, Lung cancer, neoplasms, Gene, Cell Proliferation, Neoplasm Staging, 030304 developmental biology, Retinoblastoma-Like Protein p130, medicine.disease, Small Cell Lung Carcinoma, respiratory tract diseases, Disease Models, Animal, GEMM, Tumor progression, Cancer research, Feasibility Studies, Suppressor, small cell lung cancer, CRISPR-Cas Systems, Tumor Suppressor Protein p53

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b45760e5451ba332143960777de434b
https://doi.org/10.1073/pnas.1821893117

المؤلفون: Jonathan Y. Kim, Michael E. Birnbaum, Patricia Rogers, Olivia Smith, Tyler Jacks, Celeste Dang, Arjun Bhutkar, Aviv Regev, Jason M. Schenkel, Michelle Hillman, Amy Li, David Canner, Livnat Jerby-Arnon, Le Cong, Orit Rozenblatt-Rosen, Rebecca H. Herbst, C. Garrett Rappazzo, Michael S. Cuoco

المصدر: Cell Reports, Vol 29, Iss 10, Pp 2998-3008.e8 (2019)

مصطلحات موضوعية: 0301 basic medicine, Male, Regulatory T cell, IL1RL1, chemical and pharmacologic phenomena, Biology, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, immune system diseases, Neoplasms, medicine, Immune Tolerance, Tumor Microenvironment, Animals, lcsh:QH301-705.5, Immunosuppression Therapy, Effector, hemic and immune systems, medicine.disease, Interleukin-33, Phenotype, Interleukin 33, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), Cancer research, Adenocarcinoma, Female, 030217 neurology & neurosurgery, CD8, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8549f266915d6223298250da3f750a9
http://www.sciencedirect.com/science/article/pii/S2211124719314536

المؤلفون: David M. Dorfman, Graham Dudley, Mai Drew, Jason M. Schenkel, Christopher B. Hergott, Karry Charest

المصدر: American Journal of Clinical Pathology. 151:584-592

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Population, Chronic myelomonocytic leukemia, CD13 Antigens, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Immunophenotyping, hemic and lymphatic diseases, Internal medicine, medicine, Humans, education, Aged, Dominance (genetics), Aged, 80 and over, education.field_of_study, Receiver operating characteristic, business.industry, Area under the curve, HLA-DR Antigens, General Medicine, Middle Aged, Flow Cytometry, medicine.disease, medicine.anatomical_structure, Normal bone, Myelodysplastic Syndromes, 030220 oncology & carcinogenesis, Female, Bone marrow, business, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c80c55355ad1f6d014ead3114615a7
https://doi.org/10.1093/ajcp/aqz004

المؤلفون: Nancy J. Fares-Frederickson, Kathryn A. Fraser, Lalit K. Beura, Milcah C. Scott, Jason M. Schenkel, Vaiva Vezys, Elizabeth M. Steinert, Emily A. Thompson, David Masopust

المصدر: The Journal of Experimental Medicine

مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Male, Chemokine, Immunology, CD8-Positive T-Lymphocytes, Granzymes, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Movement, medicine, Immunology and Allergy, Animals, Arenaviridae Infections, Lymphocytic choriomeningitis virus, RNA-Seq, Immunologic Surveillance, Research Articles, biology, Chimera, Mucous membrane, Phenotype, Small intestine, Cell biology, Immunosurveillance, Granzyme B, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Lymphatic system, biology.protein, Female, Transcriptome, Immunologic Memory, CD8, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beba05d34fc23bee0ff5ac7c90b03668
http://europepmc.org/articles/PMC6504216

المؤلفون: Jason M. Schenkel, Prajan Divakar, Alex M. Jaeger, Ana P. Garcia, Peter M. K. Westcott, Tyler Hether, Zackery A. Ely, Roderick T. Bronson, Laurens J. Lambert, Jason Reeves, William A. Freed-Pastor, Devan Phillips, Vikram Deshpande, Arjun Bhutkar, Kim L. Mercer, Ömer H. Yilmaz, Tyler Jacks, George Eng, Lin Lin, William L. Hwang, Nimisha B. Pattada, Aviv Regev, Toni Delorey, William M. Rideout

المصدر: Cancer Cell

مصطلحات موضوعية: Cancer Research, endocrine system diseases, medicine.medical_treatment, Article, Mice, Immune system, Lymphocytes, Tumor-Infiltrating, TIGIT, Pancreatic cancer, MHC class I, medicine, Animals, Humans, CD155, Immune Evasion, biology, business.industry, Cancer, Immunotherapy, medicine.disease, digestive system diseases, Pancreatic Neoplasms, Oncology, Cancer research, biology.protein, Receptors, Virus, business, CD8

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b53f9987c16263228fdea161ccfed14
https://europepmc.org/articles/PMC8511341/

المؤلفون: Alex K. Shalek, Kohn R, Forest M. White, Santiago Naranjo, William M. Rideout, Alex M. Jaeger, Demi Sandel, Tim B. Fessenden, Shanahan S, Tyler Jacks, Sanders E, Jason M. Schenkel, William A. Freed-Pastor, Winter Ps, Lauren E. Stopfer, Stefani Spranger

مصطلحات موضوعية: Immunosurveillance, biology, Antigen, In vivo, Tumor progression, Genetically Engineered Mouse, Antigen presentation, biology.protein, Cancer research, Proteomics, Major histocompatibility complex

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fe4dd68f5179f45d41273fa6d4792588
https://doi.org/10.1101/2021.06.30.450516

المؤلفون: Conor Delaney, Kaitlyn A. Lagattuta, Jacob M. Luber, Osmaan Shahid, Kelly P. Burke, Jaclyn M. Long, Kelly M. Mahuron, Margaret M. Lowe, Arlene H. Sharpe, Katy K. Tsai, Melissa Chow, Adil Daud, Megan E. Fung, Jason M. Schenkel, Juhi R. Kuchroo, Samantha Guinn, Kristen E. Pauken, Linglin Huang, Meromit Singer, Kathleen Newcomer, Michael Rosenblum

المصدر: The Journal of experimental medicine, vol 218, iss 4
The Journal of Experimental Medicine

مصطلحات موضوعية: 0301 basic medicine, Skin Neoplasms, Cell, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, Inbred C57BL, Medical and Health Sciences, Transcriptome, Mice, 0302 clinical medicine, Receptors, Immunology and Allergy, Cytotoxic T cell, 2.1 Biological and endogenous factors, Melanoma, Cancer, Tumor, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Antigen, Colonic Neoplasms, Female, Single-Cell Analysis, Tumor Immunology, T cell, Immunology, Receptors, Antigen, T-Cell, Biology, Adenocarcinoma, Article, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Biomarkers, Tumor, medicine, Genetics, Animals, Humans, Cluster of differentiation, T-cell receptor, NKG2D, medicine.disease, T-Cell, Molecular biology, Mice, Inbred C57BL, 030104 developmental biology, CD8, Biomarkers

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e16c9d37a6d6d8e3291b55e838f3777
https://escholarship.org/uc/item/1wg2169b