المؤلفون: Nicholas Hasle, Anthony Cooke, Sanjay Srivatsan, Heather Huang, Jason J Stephany, Zachary Krieger, Dana Jackson, Weiliang Tang, Sriram Pendyala, Raymond J Monnat, Cole Trapnell, Emily M Hatch, Douglas M Fowler

المصدر: Molecular Systems Biology, Vol 16, Iss 6, Pp 1-18 (2020)

مصطلحات موضوعية: genetic screening, microscopy, pharmacology, subcellular localization, transcriptomics, Biology (General), QH301-705.5, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1744-4292

URL الوصول: https://doaj.org/article/f34f0d3435be4971918d05251757a448

المؤلفون: Melissa A Chiasson, Nathan J Rollins, Jason J Stephany, Katherine A Sitko, Kenneth A Matreyek, Marta Verby, Song Sun, Frederick P Roth, Daniel DeSloover, Debora S Marks, Allan E Rettie, Douglas M Fowler

المصدر: eLife, Vol 9 (2020)

مصطلحات موضوعية: membrane protein, pharmacogenetics, multiplex, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/58026; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/36b421f0fd264b0f97e516ab449e0b61

المؤلفون: John T Loffredo, Thomas C Friedrich, Enrique J León, Jason J Stephany, Denise S Rodrigues, Sean P Spencer, Alex T Bean, Dominic R Beal, Benjamin J Burwitz, Richard A Rudersdorf, Lyle T Wallace, Shari M Piaskowski, Gemma E May, John Sidney, Emma Gostick, Nancy A Wilson, David A Price, Esper G Kallas, Helen Piontkivska, Austin L Hughes, Alessandro Sette, David I Watkins

المصدر: PLoS ONE, Vol 2, Iss 11, p e1152 (2007)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC2062500?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/d08238c326d940c8b261ff79190160fc

المؤلفون: Kenneth A. Matreyek, Jason J. Stephany, Ethan Ahler, Douglas M. Fowler

المصدر: Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)

مصطلحات موضوعية: PTEN, Protein variants, Multiplex assays of variant effect, Cancer genomics, Dominant-negative, VAMP-seq, Medicine, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1756-994X

URL الوصول: https://doaj.org/article/43d8971ee72b4df69a4e5f58b510d88f

المؤلفون: John C. Rose, Nicholas A. Popp, Christopher D. Richardson, Jason J. Stephany, Julie Mathieu, Cindy T. Wei, Jacob E. Corn, Dustin J. Maly, Douglas M. Fowler

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/32953ad84ae148f1a96180fcc11e3524

المؤلفون: Kenneth A. Matreyek (11567118), Jason J. Stephany (11567121), Ethan Ahler (417528), Douglas M. Fowler (11567124)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Cancer, Mathematical Sciences not elsewhere classified, PTEN, Protein variants, Multiplex assays of variant effect, Cancer genomics, Dominant-negative, VAMP-seq

Relation: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Integrating_thousands_of_PTEN_variant_activity_and_abundance_measurements_reveals_variant_subgroups_and_new_dominant_negatives_in_cancers/16815900

الاتاحة: https://doi.org/10.6084/m9.figshare.16815900.v1

المؤلفون: Vanessa Nguyen, Ethan Ahler, Katherine A. Sitko, Jason J. Stephany, Dustin J. Maly, Douglas M. Fowler

المصدر: Protein Science.

مصطلحات موضوعية: Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c584276c01b87b9c7c9411e6925f9029
https://doi.org/10.1002/pro.4656

المؤلفون: Vanessa E. Gray, Katherine Sitko, Floriane Z. Ngako Kameni, Miriam Williamson, Jason J. Stephany, Nicholas Hasle, Douglas M. Fowler

المصدر: G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3683-3689 (2019)

مصطلحات موضوعية: amyloid, amyloid beta, deep mutational scanning, protein aggregation, Genetics, QH426-470

Relation: https://doaj.org/toc/2160-1836; https://doaj.org/article/3a130f00608a47b499fd78d1c5485daa

الاتاحة: https://doi.org/10.1534/g3.119.400535
https://doaj.org/article/3a130f00608a47b499fd78d1c5485daa

المؤلفون: Julie Mathieu, Dustin J. Maly, Jacob E. Corn, Cindy T. Wei, Christopher D. Richardson, Nicholas A. Popp, Douglas M. Fowler, John C. Rose, Jason J. Stephany

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, 11 (1)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, CRISPR-Cas9 genome editing, DNA Repair, Computer science, Science, General Physics and Astronomy, Computational biology, Cleavage (embryo), General Biochemistry, Genetics and Molecular Biology, Article, Genome engineering, Mice, 03 medical and health sciences, 0302 clinical medicine, Genome editing, Cell Line, Tumor, Animals, Humans, CRISPR, Guide RNA, lcsh:Science, Cells, Cultured, 030304 developmental biology, Subgenomic mRNA, Gene Editing, 0303 health sciences, Multidisciplinary, Binding Sites, Base Sequence, Models, Genetic, Cas9, RNA, food and beverages, General Chemistry, 030104 developmental biology, HEK293 Cells, Genetic engineering, Mutation, Biocatalysis, lcsh:Q, CRISPR-Cas Systems, 030217 neurology & neurosurgery, RNA, Guide, Kinetoplastida, Co administration

وصف الملف: application/application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be21945dce57cba53b0cd8e7294fb562
https://doaj.org/article/32953ad84ae148f1a96180fcc11e3524

المؤلفون: Sujata Chakraborty, Ethan Ahler, Jessica J. Simon, Linglan Fang, Zachary E. Potter, Katherine A. Sitko, Jason J. Stephany, Miklos Guttman, Douglas M. Fowler, Dustin J. Maly

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e7ae707de4e31560372338c6caa63e24
https://doi.org/10.1101/2021.12.05.471322

المؤلفون: Allan E. Rettie, Song Sun, Daniel DeSloover, Marta Verby, Frederick P. Roth, Katherine A. Sitko, Kenneth A. Matreyek, Nathan J Rollins, Jason J. Stephany, Melissa A Chiasson, Douglas M. Fowler, Debora S. Marks

المصدر: eLife
eLife, Vol 9 (2020)

مصطلحات موضوعية: Models, Molecular, QH301-705.5, WARFARIN SENSITIVITY, Science, Drug Resistance, Mutation, Missense, 030204 cardiovascular system & hematology, Vitamin k, Topology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Catalytic Domain, Vitamin K Epoxide Reductases, Humans, Missense mutation, membrane protein, Cysteine, Biology (General), pharmacogenetics, 030304 developmental biology, 0303 health sciences, General Immunology and Microbiology, Anticoagulant drug, biology, Chemistry, General Neuroscience, Genetic Variation, Active site, Genetics and Genomics, Sequence Analysis, DNA, General Medicine, multiplex, Transmembrane domain, Blood clotting factors, HEK293 Cells, Coagulation, Membrane protein, biology.protein, Medicine, Vitamin K epoxide reductase, Warfarin, Metabolism, Inborn Errors, 030217 neurology & neurosurgery, Function (biology), Research Article, Human

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1088afa0a0b15228fe6a7d65454e593c
https://doi.org/10.7554/elife.58026

المؤلفون: Song Sun, Kenneth A. Matreyek, Jason J. Stephany, Debora S. Marks, Marta Verby, Katherine A. Sitko, Nathan J Rollins, Melissa A Chiasson, Douglas M. Fowler, Frederick P. Roth, Allan E. Rettie, Daniel DeSloover

مصطلحات موضوعية: Physics, biology, Abundance (ecology), biology.protein, Active site, Computational biology, Multiplexing, Topology (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0983df6698d5f69329d155f48c9f1bb1
https://doi.org/10.7554/elife.58026.sa2

المؤلفون: Kenneth A. Matreyek (11567118), Jason J. Stephany (11567121), Ethan Ahler (417528), Douglas M. Fowler (11567124)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Cancer, Mathematical Sciences not elsewhere classified, PTEN, Protein variants, Multiplex assays of variant effect, Cancer genomics, Dominant-negative, VAMP-seq

Relation: https://figshare.com/articles/dataset/Additional_file_2_of_Integrating_thousands_of_PTEN_variant_activity_and_abundance_measurements_reveals_variant_subgroups_and_new_dominant_negatives_in_cancers/16815903

الاتاحة: https://doi.org/10.6084/m9.figshare.16815903.v1

المؤلفون: Esper G. Kallas, David I. Watkins, Gnankang Napoé, Thomas C. Friedrich, Nancy A, Kim L. Weisgrau, Denise S. Rodrigues, Sarah R. Martin, Jason Reed, Shari M. Piaskowski, P. Spencer, Jason J. Stephany, Juan Pablo, Giraldo Vela, John T. Loffredo, Benjamin J. Burwitz, Eva G. Rakasz, T+immunodeficiency Virus-specific Cd

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jvi.asm.org/content/81/6/2624.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.553.742; http://jvi.asm.org/content/81/6/2624.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.553.742
http://jvi.asm.org/content/81/6/2624.full.pdf

المؤلفون: Nicholas Hasle, Cole Trapnell, Weiliang Tang, Sanjay Srivatsan, Jason J. Stephany, Emily M. Hatch, Sriram Pendyala, Heather Z Huang, Anthony Cooke, Dana Jackson, Raymond J. Monnat, Douglas M. Fowler, Zachary Krieger

مصطلحات موضوعية: Microscope, Cell, Computational biology, Biology, Cell sorting, Phenotype, law.invention, Transcriptome, medicine.anatomical_structure, law, Gene expression, medicine, Throughput (business), Nuclear localization sequence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b135481a550cae94e26ba9baa2c7dae

المؤلفون: Kenneth A. Matreyek, Douglas M. Fowler, Nicholas Hasle, Melissa A Chiasson, Jason J. Stephany

المصدر: Nucleic Acids Research

مصطلحات موضوعية: Transgene, Genetic Vectors, Green Fluorescent Proteins, Computational biology, Biology, Viral vector, Recombinases, Mice, 03 medical and health sciences, Negative selection, 0302 clinical medicine, Genetics, Recombinase, Animals, Humans, Genomic library, Multiplex, Transgenes, Gene Library, 030304 developmental biology, Recombination, Genetic, 0303 health sciences, Cell growth, Tumor Suppressor Proteins, Lentivirus, HEK 293 cells, Oncogenes, Recombinant Proteins, Luminescent Proteins, HEK293 Cells, NIH 3T3 Cells, Methods Online, Biological Assay, HT29 Cells, 030217 neurology & neurosurgery, Plasmids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278bfcf663874293feffe57620961d3c
https://doi.org/10.1093/nar/gkz910

المؤلفون: Nicholas Hasle, Miriam Williamson, Floriane Z. Ngako Kameni, Katherine A. Sitko, Jason J. Stephany, Douglas M. Fowler, Vanessa E. Gray

المصدر: G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3683-3689 (2019)
G3: Genes|Genomes|Genetics

مصطلحات موضوعية: Amyloid, Amyloid beta, Context (language use), Investigations, QH426-470, Protein aggregation, Biology, 010402 general chemistry, Fibril, Protein Aggregation, Pathological, 01 natural sciences, protein aggregation, 03 medical and health sciences, 0302 clinical medicine, deep mutational scanning, Genetics, Humans, Proline, Molecular Biology, Genetics (clinical), Gene Library, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Amyloid beta-Peptides, Mutagenesis, amyloid, Alanine scanning, Peptide Fragments, In vitro, Yeast, 0104 chemical sciences, Amino acid, amyloid beta, Amino Acid Substitution, chemistry, Mutation, biology.protein, Biophysics, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa50404cc29df5080dedd698a35a95ce

المؤلفون: Jennifer N. Dines, Martin Kircher, William E. Evans, Douglas M. Fowler, Wenjian Yang, Smita Bhatia, Ronald J. Hause, Jay Shendure, Beth Martin, Kenneth A. Matreyek, Mary V. Relling, Vanessa E. Gray, Jason J. Stephany, Arineh Khechaduri, Melissa A Chiasson, Lea M. Starita

المصدر: Nature genetics

مصطلحات موضوعية: 0301 basic medicine, Low protein, Sequence analysis, Mutation, Missense, Computational biology, medicine.disease_cause, Article, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Abundance (ecology), Genetics, medicine, Humans, PTEN, Missense mutation, Multiplex, Amino Acids, Gene, 030304 developmental biology, Mutation, 0303 health sciences, Massive parallel sequencing, biology, Mechanism (biology), PTEN Phosphohydrolase, High-Throughput Nucleotide Sequencing, Sequence Analysis, DNA, 3. Good health, HEK293 Cells, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994b60fa749c7a52249d03e6dada223e
https://doi.org/10.1101/211011

المؤلفون: Douglas M. Fowler, Dustin J. Maly, John C. Rose, Jason J. Stephany, Cindy T. Wei

المصدر: ACS Chemical Biology

مصطلحات موضوعية: 0301 basic medicine, Streptococcus pyogenes, CRISPR-Associated Proteins, bcl-X Protein, Biology, Biochemistry, Polymerase Chain Reaction, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Genome editing, INDEL Mutation, law, CRISPR-Associated Protein 9, Humans, DNA Breaks, Double-Stranded, Benzothiazoles, Letters, Polymerase chain reaction, Double strand, Gene Editing, Cas9, Activator (genetics), HEK 293 cells, General Medicine, DNA, Isoquinolines, Molecular biology, Small molecule, Cell biology, 030104 developmental biology, HEK293 Cells, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, CRISPR-Cas Systems

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2058120de5bf8f3f826b509121e6de
https://pubmed.ncbi.nlm.nih.gov/28895730

المؤلفون: Jason stephany, John C. Rose, Jason J. Stephany, William J. Valente, Bridget M. Trevillian, Ha V. Dang, Jason H. Bielas, Dustin J. Maly, Douglas M. Fowler

المصدر: Protocol Exchange.

مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, Cas9, Cancer research, General Earth and Planetary Sciences, Biology, Protocol (object-oriented programming), General Environmental Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d4a22e73e2e97b51349f0ec2c021dd6a
https://doi.org/10.1038/protex.2017.066