المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Gene_deletion_of_sepH_and_gene_reconstitution_of_the_sepL_disruption_sepL-1_/15137861

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.s002

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Deletion_and_complementation_of_A_fumigatus_genes_AFUB_067160_encoding_myosin_light_chain_mlcA_and_AFUB_055850_encoding_alpha-actinin_ainA_/15137864

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.s003

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Multiple_protein_kinases_contribute_to_cell_wall_integrity_in_i_A_i_i_fumigatus_i_/15137879

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g003

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Disruption_of_multiple_protein_kinase_genes_results_in_reduced_colony_growth_and_conidiation_of_A_fumigatus_/15137858

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.s001

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Construction_of_a_protein_kinase_disruption_library_in_i_A_i_i_fumigatus_i_by_CRISPR_Cas9-mediated_gene_editing_/15137873

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g001

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/The_Septation_Initiation_Network_SIN_kinases_are_each_required_for_hyphal_septation_and_protection_against_cell_wall_damage_in_i_A_i_i_fumigatus_i_/15137882

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g004

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Hyphae_of_SIN_kinase_mutants_exhibit_extensive_damage_in_the_presence_of_echinocandin_/15137888

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g006

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/dataset/S1_File_-/15137870

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.s005

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Colony_morphologies_of_selected_i_A_i_i_fumigatus_i_protein_kinase_disruption_mutants_/15137876

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g002

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Gene_disruption_of_A_fumigatus_cell_wall_integrity_kinases_mkk2_and_mpkA_and_the_protein_kinase_A_catalytic_subunit_pkaC1_generates_increased_susceptibility_to_echinocandins_/15137867

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.s004

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/SIN_kinase_activity_is_required_for_virulence_in_mouse_models_of_invasive_aspergillosis_/15137891

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g007

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Loss_of_virulence_among_the_SIN_kinase_mutants_is_associated_with_lack_of_tissue_invasion_/15137894

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g008

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Loss_of_hyphal_septation_improves_echinocandin_therapy_characterized_by_clearance_of_fungal_burden_from_lung_tissue_/15137903

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g010

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Loss_of_virulence_in_the_SIN_kinase_mutants_is_characterized_by_decreased_fungal_burden_and_host_response_to_infection_/15137900

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g009

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/The_i_A_i_i_fumigatus_i_genes_encoding_myosin_light_chain_i_mlcA_i_and_alpha-actinin_i_ainA_i_are_required_for_hyphal_septation_and_echinocandin_resistance_/15137906

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g011

المؤلفون: Ana Camila Oliveira Souza (8180958), Adela Martin-Vicente (5005538), Ashley V. Nywening (6738773), Wenbo Ge (5005541), David J. Lowes (2148166), Brian M. Peters (11250842), Jarrod R. Fortwendel (9984668)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, echinocandin stress, kinases blocks tissue invasion, echinocandin cidal activity, protein kinase disruption mutants, hyphal septation deficiency, cell wall stress, fumigatus protein kinases, echinocandin stress screening, phosphatase-mediated echinocandin a., SIN kinase gene, encode protein kinases, Septation Initiation Network, MEC, 118 disruption mutants, hyphal septation, echinocandin stress survival, protein kinase disruption, CRISPR, IA

Relation: https://figshare.com/articles/figure/Loss_of_septation_caused_by_deletion_of_i_mlcA_i_or_i_ainA_i_results_in_avirulence_associated_with_lack_of_tissue_invasion_/15137909

الاتاحة: https://doi.org/10.1371/journal.ppat.1009806.g012