نتائج البحث - "Janine Ondrus"

1

Supplementary Data 4 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b412d4d52e0d535f1c8c6d13401b4a02
https://doi.org/10.1158/1535-7163.22522974.v1

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2

Supplementary Data 8 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34804cb0125a81473c7d210b57a8ac51
https://doi.org/10.1158/1535-7163.22522962.v1

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3

Data from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb756fdc24c04d7164e04381faf2716
https://doi.org/10.1158/1535-7163.c.6543534

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4

Supplementary Data 2 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f427283d55abb76e964cda4ea0a4f9
https://doi.org/10.1158/1535-7163.22522980

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5

Supplementary Data 6 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa35053fc761b250e3b1e58cb6ddca8
https://doi.org/10.1158/1535-7163.22522968.v1

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6

Supplementary Data 5 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c60f9d4ec5dd81e09281d56be0371c
https://doi.org/10.1158/1535-7163.22522971

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7

Supplementary Data 1 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a67e34f3b97f6a1cb6d6d88a89a877f
https://doi.org/10.1158/1535-7163.22522983

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8

Supplementary Data 3 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9357ac4b74d0a19b1138db2c193e9a97
https://doi.org/10.1158/1535-7163.22522977.v1

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9

Supplementary Data 7 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217aba4d9eeb9f12924f124c1bf8b96f
https://doi.org/10.1158/1535-7163.22522965.v1

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10

Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer

المؤلفون: Zhuming Zhang, Heng-Keang Lim, Jonathan Branch, Vineet Pande, Janine Ondrus, James R. Bischoff, Peter J. Connolly, Bush Tammy, Lieven Meerpoel, Ian Hickson, Christian Rocaboy, Luis B. Trabalón Escolar, Gilles Bignan

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Chemistry, Antiandrogens, Point mutation, Organic Chemistry, Apalutamide, Mutant, Wild type, urologic and male genital diseases, medicine.disease, Biochemistry, Androgen receptor, Prostate cancer, chemistry.chemical_compound, Drug Discovery, medicine, Cancer research, Enzalutamide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a2583de003d65667131bf1b1caba4e
https://doi.org/10.1021/acsmedchemlett.1c00032

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11

Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)

المؤلفون: Zhuming Zhang, Yolanda T. Chong, James R. Bischoff, Jonathan Branch, Christopher J. Parrett, Janine Ondrus, Gilles Bignan, Lieven Meerpoel, Kathryn Packman, Leopoldo Luistro, Marco Gottardis, Bush Tammy, Salam H. Ibrahim, Christopher A. Teleha, Vineet Pande, Peter J. Connolly, Heng-Keang Lim, Ian Hickson

المصدر: Journal of Medicinal Chemistry. 64:909-924

مصطلحات موضوعية: Male, Models, Molecular, Pyridines, medicine.disease_cause, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Prostate cancer, chemistry.chemical_compound, Dogs, Piperidines, Cell Line, Tumor, Nitriles, Drug Discovery, Androgen Receptor Antagonists, medicine, Animals, Humans, Enzalutamide, Spiro Compounds, Biotransformation, 030304 developmental biology, 0303 health sciences, Mutation, Point mutation, Apalutamide, Antagonist, Wild type, Prostatic Neoplasms, medicine.disease, Rats, 0104 chemical sciences, Androgen receptor, Prostatic Neoplasms, Castration-Resistant, 010404 medicinal & biomolecular chemistry, chemistry, Drug Resistance, Neoplasm, Picolines, Hepatocytes, Cancer research, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a913df6dcf096e8ad0ea7030d6423e6f
https://doi.org/10.1021/acs.jmedchem.0c01563

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12

Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)

المؤلفون: Zhuming Zhang (1846087), Peter J. Connolly (2456890), Heng Keang Lim (6057113), Vineet Pande (2538973), Lieven Meerpoel (1457320), Christopher Teleha (10009764), Jonathan R. Branch (10009767), Janine Ondrus (10009770), Ian Hickson (1981597), Tammy Bush (10009773), Leopoldo Luistro (10009776), Kathryn Packman (93334), James R. Bischoff (124533), Salam Ibrahim (10009779), Christopher Parrett (10009782), Yolanda Chong (3863953), Marco M. Gottardis (107229), Gilles Bignan (1889356)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Pharmacology, Cancer, Hematology, Infectious Diseases, Plant Biology, Computational Biology, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, F 877L Metabolite identification st., prostate cancer, CRPC, bioactivation pathway, AR mutations, second-generation AR pathway inhibitors, Wild-Type Castration-Resistant Pros., F 877L Mutant, point mutations, activation drives, pan-AR antagonist, next-generation AR antagonist, resistance mechanism, Clinical Stage Androgen Receptor An., castration-resistant prostate cancer, Persistent androgen receptor

Relation: https://figshare.com/articles/dataset/Discovery_of_JNJ-63576253_A_Clinical_Stage_Androgen_Receptor_Antagonist_for_F877L_Mutant_and_Wild-Type_Castration-Resistant_Prostate_Cancer_mCRPC_/13614723

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01563.s001

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13

Abstract 2179: Antitumor activity of JNJ-63576253 (TRC253), a small molecule antagonist of F877L mutant and wild-type androgen receptor

المؤلفون: Tammy L. Bush, Georges Habineza Ndikuyeze, Gilles Bignan, Jonathan Branch, Janine Ondrus, Yifan Shi, Leopoldo Luistro, James Hastings, Joseph Erhardt, Ian Hickson, Shefali Patel, Peter Connolly, Zhuming Zhang, James Bischoff, Brent Rupnow, Marco Gottardis, Kathryn Packman

المصدر: Cancer Research. 79:2179-2179

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c62bf3336d6c971209dd4171d567109
https://doi.org/10.1158/1538-7445.am2019-2179

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14

Abstract 1319: Establishment and characterization of fresh primary human colorectal tumor implants

المؤلفون: Thomas R. Hundley, Rajneesh Uzgare, Dhanrajan Tiruchinapalli, Damon Hostin, Malathi Sathyamoorthy, Christina Griffin, Shaobin Zhong, Nicole Todaro, Rao Mulpuri, Jeffery Otto, Alexei Miagkov, Lisa Leary, Janine Ondrus, Hao Chen

المصدر: Cancer Research. 72:1319-1319

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Pathology, Colorectal cancer, business.industry, Cancer, Translational research, medicine.disease, Primary tumor, In vivo, Internal medicine, medicine, Biomarker (medicine), business, Colorectal tumor, Tumor Graft

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::247efbd905ca9aa9167b2370684bced3
https://doi.org/10.1158/1538-7445.am2012-1319

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