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1
المؤلفون: Janet L. Wieber, James A. Nieman, Herbert M. Zerth, Brenda L. Schultz, Steven E. Heasley, Nancee L. Oien, Mary L. Knechtel, Ke Chen, Todd A. Hopkins, Michael W. Wathen, Kevin J. Stephanski, Richard A. Nugent, Sajiv Krishnan Nair
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3039-3042
مصطلحات موضوعية: Herpesvirus 3, Human, medicine.drug_class, viruses, Clinical Biochemistry, Cytomegalovirus, Pharmaceutical Science, Carboxamide, DNA-Directed DNA Polymerase, Herpesvirus 1, Human, medicine.disease_cause, Antiviral Agents, Biochemistry, Chemical synthesis, Virus, Structure-Activity Relationship, Alphaherpesvirinae, Drug Discovery, medicine, Humans, Pyrroles, Molecular Biology, Herpesviridae, Polymerase, Nucleic Acid Synthesis Inhibitors, biology, Chemistry, Organic Chemistry, Varicella zoster virus, virus diseases, biology.organism_classification, In vitro, Solubility, Quinolines, biology.protein, Molecular Medicine
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2
المؤلفون: Mary L. Knechtel, Michael W. Wathen, Fred L. Homa, Janet L. Wieber, Michele M. Cudahy, Thomas W. Pitts, Roger A. Poorman, Nancee L. Oien, Mark E. Schnute, Todd A. Hopkins, Roger J. Brideau
المصدر: Journal of Medicinal Chemistry. 48:5794-5804
مصطلحات موضوعية: Ganciclovir, Human cytomegalovirus, Herpesvirus 3, Human, Cell Survival, Pyridines, Pyridones, DNA polymerase, viruses, Cytomegalovirus, DNA-Directed DNA Polymerase, Herpesvirus 1, Human, Thiophenes, Viral Plaque Assay, medicine.disease_cause, Antiviral Agents, Herpesviridae, Virus, Cell Line, Structure-Activity Relationship, Viral Proteins, Chlorocebus aethiops, Drug Resistance, Viral, Drug Discovery, medicine, Animals, Humans, Point Mutation, Nucleic Acid Synthesis Inhibitors, biology, Chemistry, Varicella zoster virus, virus diseases, biochemical phenomena, metabolism, and nutrition, Nucleotidyltransferase, medicine.disease, Virology, Exodeoxyribonucleases, Herpes simplex virus, biology.protein, Molecular Medicine, medicine.drug
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3
المؤلفون: Nancee L. Oien, Janet L. Wieber, Vaillancourt Valerie A, Ellen E. Vera, Michael W. Wathen, Todd A. Hopkins, Mary L. Knechtel, Karen F. Wilkinson, Bob D. Rush, Roger J. Brideau, Francis J. Schwende, Audris Huang
المصدر: Antiviral Research. 54:19-28
مصطلحات موضوعية: Ganciclovir, Human cytomegalovirus, Muromegalovirus, viruses, Biology, medicine.disease_cause, Antiviral Agents, Simian varicella virus, Virus, Cell Line, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, Virology, Drug Resistance, Viral, medicine, Animals, Humans, Enzyme Inhibitors, Herpesviridae, Nucleic Acid Synthesis Inhibitors, Cytopathic effect, Pharmacology, Mice, Inbred BALB C, Varicella zoster virus, virus diseases, Herpesviridae Infections, medicine.disease, biology.organism_classification, Rats, Herpes simplex virus, chemistry, Quinolines, medicine.drug, Cidofovir
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4
المؤلفون: John A. Tucker, Roger A. Poorman, Nancee L. Oien, Roger J. Brideau, Todd A. Hopkins, John A. Shelly, Janet L. Wieber, Michael W. Wathen, Mary L. Knechtel, Audris Huang, Robert A. Anstadt, Peter A. Wells, Vallerie A. Vaillancourt, Terrance L. Clayton
المصدر: Antimicrobial Agents and Chemotherapy. 46:724-730
مصطلحات موضوعية: Human cytomegalovirus, Cell Survival, viruses, Viral Plaque Assay, medicine.disease_cause, Antiviral Agents, Binding, Competitive, Virus, Substrate Specificity, Structure-Activity Relationship, chemistry.chemical_compound, Viral life cycle, medicine, Humans, Pharmacology (medical), Enzyme Inhibitors, Cells, Cultured, Herpesviridae, Polymerase, Nucleic Acid Synthesis Inhibitors, Nucleoside binding, Pharmacology, biology, virus diseases, RNA virus, medicine.disease, biology.organism_classification, Amides, Virology, Kinetics, Infectious Diseases, Herpes simplex virus, chemistry, Hydroxyquinolines, biology.protein, DNA
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5
المؤلفون: Steven P. Tanis, Nancee L. Oien, Kevin J. Stephanski, Mary L. Knechtel, Janet L. Wieber, Timothy Parker, Perrault William R, Strohbach Joseph Walter, Malcom W. Moon, Todd A. Hopkins, Michael W. Wathen, Suvit Thaisrivongs
المصدر: Bioorganicmedicinal chemistry letters. 20(6)
مصطلحات موضوعية: Human cytomegalovirus, DNA polymerase, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Quinoxaline, Quinoxalines, Drug Discovery, medicine, Potency, Protease Inhibitors, Molecular Biology, Polymerase, biology, Aryl, Organic Chemistry, Serine Endopeptidases, medicine.disease, In vitro, chemistry, Drug Design, biology.protein, Molecular Medicine, Ethylamine
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6
المؤلفون: Mari L. Stephan, Michele M. Cudahy, Janet L. Wieber, Allen Scott, Sarah A. Collier, Robert S. Sackett, Mark E. Schnute, Roger J. Brideau, Todd A. Hopkins, Michael W. Wathen, Nancee L. Oien, Mary L. Knechtel
المصدر: Bioorganicmedicinal chemistry letters. 18(14)
مصطلحات موضوعية: Human cytomegalovirus, Herpesvirus 3, Human, Herpesvirus 4, Human, Nucleic Acid Synthesis Inhibitor, medicine.drug_class, Pyridones, viruses, Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Cytomegalovirus, Carboxamide, medicine.disease_cause, Biochemistry, Chemical synthesis, Antiviral Agents, Inhibitory Concentration 50, Drug Discovery, medicine, Gammaherpesvirinae, Simplexvirus, Enzyme Inhibitors, Furans, Molecular Biology, Polymerase, Herpesviridae, Nucleic Acid Synthesis Inhibitors, biology, Chemistry, RNA-Directed DNA Polymerase, Organic Chemistry, virus diseases, Esters, medicine.disease, biology.organism_classification, Models, Chemical, Drug Design, biology.protein, Molecular Medicine
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7
المؤلفون: Michael J. Hageman, Janet L. Wieber, Roger J. Brideau, Scott D. Larsen, Stefanski Kevin J, Francis J. Schwende, Mary L. Knechtel, Bob D. Rush, Michael W. Wathen, Peter R. Manninen, Kathyrn M. Zamora, Zhijun Zhang, Todd A. Hopkins, Douglas C. Rohrer, Brian A. DiPaolo, Nancee L. Oien, Karen F. Wilkinson
المصدر: Bioorganicmedicinal chemistry letters. 17(14)
مصطلحات موضوعية: Nucleic Acid Synthesis Inhibitor, DNA polymerase, Stereochemistry, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Cytomegalovirus, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Polymerase, Nucleic Acid Synthesis Inhibitors, chemistry.chemical_classification, biology, Organic Chemistry, Biological activity, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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8
المؤلفون: Roger J. Brideau, David J. Anderson, Steven P. Tanis, Michael J. Genin, Euibong J. Kim, Nancee L. Oien, James A. Nieman, Mark E. Schnute, Valerie A. Vaillancourt, Allen Scott, Thomas M. Judge, Fred L. Ciske, Mary L. Knechtel, Sajiv Krishnan Nair, Marijean Eggen, Michele M. Cudahy, Sarah A. Collier, Janet L. Wieber, Michael W. Wathen, Todd A. Hopkins
المصدر: Bioorganicmedicinal chemistry letters. 17(12)
مصطلحات موضوعية: Human cytomegalovirus, Herpesvirus 4, Human, medicine.drug_class, Stereochemistry, Pyridines, viruses, Clinical Biochemistry, Pharmaceutical Science, Cytomegalovirus, Carboxamide, DNA-Directed DNA Polymerase, Herpesvirus 1, Human, medicine.disease_cause, Biochemistry, Antiviral Agents, Binding, Competitive, Herpes Zoster, Structure-Activity Relationship, Viral Proteins, Alphaherpesvirinae, Drug Discovery, medicine, Ethylamines, Humans, Enzyme Inhibitors, Molecular Biology, Polymerase, Herpesviridae, Nucleic Acid Synthesis Inhibitors, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Varicella zoster virus, virus diseases, medicine.disease, Nucleotidyltransferase, biology.organism_classification, Enzyme, Exodeoxyribonucleases, Models, Chemical, biology.protein, Molecular Medicine
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9
المؤلفون: Mary L. Knechtel, Michael W. Wathen, Yoshihiko Yagi, Sandra Staley, Vaillancourt Valerie A, Michele M. Cudahy, Steven J. Conrad, Roger J. Brideau, Janet L. Wieber, Nancee L. Oien
المصدر: Bioorganicmedicinal chemistry letters. 10(18)
مصطلحات موضوعية: Human cytomegalovirus, DNA polymerase, medicine.drug_class, viruses, Clinical Biochemistry, Pharmaceutical Science, Cytomegalovirus, Carboxamide, DNA-Directed DNA Polymerase, Naphthols, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, Viral Proteins, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Molecular Biology, Polymerase, Nucleic Acid Synthesis Inhibitors, chemistry.chemical_classification, biology, Organic Chemistry, medicine.disease, Nucleotidyltransferase, DNA Polymerase I, Amides, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine