المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/journal_contribution/Reverse_transcriptase_qPCR_analysis_of_i_PINK1_i_in_LCLs_/16990626

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.s003

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/journal_contribution/Age_and_sex_of_PBMC_donors_/16990629

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.s004

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/journal_contribution/Characteristics_of_primary_antibodies_used_in_this_study_/16990632

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.s005

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/journal_contribution/Uncropped_unadjusted_images_of_western_blots_/16990638

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.s007

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/journal_contribution/Analysis_of_PINK1_expression_in_different_cell_types_/16990623

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.s002

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/journal_contribution/Time_course_analysis_of_MFN_ubiquitination_in_Jurkat_cells_/16990620

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.s001

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/dataset/S1_Data_-/16897731

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.s001

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/figure/Box_whisker_plots_of_mitochondrial_enzyme_activities_in_stage_1_/16897737

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.g002

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/figure/Diagram_of_the_organ_recovery_workstation_sup_sup_showing_the_installed_membrane_oxygenator_and_perfusate_flow_/16897734

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.g001

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/figure/Box_whisker_plots_of_mitochondrial_enzyme_activities_in_liver_segments_IV_and_VII_/16897743

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.g004

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/figure/Box_whisker_plots_of_mitochondrial_enzyme_activities_in_stage_2_/16897740

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.g003

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/figure/Oxygen_concentration_during_end-ischaemic_HMP_/16897746

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.g005

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/dataset/Comparison_of_donor_liver_characteristics_between_preservation_groups_/16897752

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.t002

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/dataset/Reasons_of_graft_decline_for_transplantation_and_characteristics_of_low-risk_livers_/16897755

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.t003

المؤلفون: Hamid Abudhaise (11619267), Jan-Willem Taanman (139411), Peter DeMuylder (11619270), Barry Fuller (499029), Brian R. Davidson (496581)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, static cold storage, ischaemia reperfusion injury, induce oxidative damage, hypothermic machine perfusion, oxygen delivery efficiency, 001 ), stabilised, p &# 8804, mitochondrial respiratory chain, mitochondrial function analysis, mitochondria likely respond, 28 minutes compared, lower complex ii, respiratory function, mitochondrial parameters, mitochondrial dysfunction, hour perfusion, consistently lower, oxygen supplemented, 36 minutes, 3 minutes

Relation: https://figshare.com/articles/dataset/Mitochondrial_enzyme_activity_in_low-_and_high-risk_livers_/16897758

الاتاحة: https://doi.org/10.1371/journal.pone.0257783.t004

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/figure/Analysis_of_CCCP-induced_MFN_ubiquitination_in_cultured_fibroblast_cells_/16990641

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.g001

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/dataset/Calculations_for_Figs_5A_and_5D_and_6A_6C_and_6D_/16990635

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.s006

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/figure/Analysis_of_CCCP-induced_MFN_ubiquitination_in_Jurkat_cells_/16990644

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.g002

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/figure/Analysis_of_CCCP-induced_MFN_ubiquitination_in_different_cell_types_/16990647

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.g003

المؤلفون: Aaron V. Bradshaw (11681739), Philip Campbell (9388052), Anthony H. V. Schapira (9292344), Huw R. Morris (11681742), Jan-Willem Taanman (139411)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Virology, screen idiopathic patients, sy5y neuroblastoma cells, cells could serve, potential mitophagy defects, pink1 &# 8212, div >< p, jurkat leukaemic cells, ubiquitinated mfn proteins, mitofusin proteins mfn1, protein expression levels, fibroblast cells, parkin proteins, comparable levels, western blotting, suitable biosample, remarkably low, readily detectable

Relation: https://figshare.com/articles/figure/CCCP_induces_mitochondrial_depolarisation_in_Jurkat_and_PBMC_samples_/16990653

الاتاحة: https://doi.org/10.1371/journal.pone.0259903.g004