المؤلفون: Jan C. Schuller, Ulf Henrik Göhle

المصدر: Leonardo. 56:95-97

مصطلحات موضوعية: Visual Arts and Performing Arts, Engineering (miscellaneous), Music, Computer Science Applications

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e3e9041c5e616334c225642384efbce2
https://doi.org/10.1162/leon_a_02292

المؤلفون: Ulf Henrik Göhle, Jan C. Schuller, Stefania Ferraro

المصدر: motorik. 45:135-141

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5b8ecdc79d280d8efe9d007951f7b2a2
https://doi.org/10.2378/mot2022.art24d

المؤلفون: Jan C. Schuller

المصدر: Journal of Applied Statistics. 39:215-221

مصطلحات موضوعية: Statistics and Probability, Mathematical optimization, Monty Hall problem, Conditional probability, Doors, Statistics, Probability and Uncertainty, Minimax, Mathematical economics, Popularity, Host (network), Mathematics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::95780af1dca7b93aa32606e1139d4c74
https://doi.org/10.1080/02664763.2011.580337

المؤلفون: Peter Brauchli, Nicolas Leupin, Jan C. Schuller, Doris Lanz, Shu-Fang Hsu Schmitz, M. Mayer

المصدر: Contemporary Clinical Trials. 30:201-204

مصطلحات موضوعية: medicine.medical_specialty, Lung Neoplasms, Operations research, Diagram (category theory), MEDLINE, Disease-Free Survival, Clinical Trials, Phase II as Topic, Chart, Software Design, Carcinoma, Non-Small-Cell Lung, Outcome Assessment, Health Care, medicine, Humans, Multimodal treatment, Pharmacology (medical), Medical physics, Prospective Studies, Neoplasm Staging, Randomized Controlled Trials as Topic, Complement (set theory), business.industry, technology, industry, and agriculture, General Medicine, Combined Modality Therapy, Leukemia, Lymphocytic, Chronic, B-Cell, humanities, Patient flow, Clinical trial, Flow chart, business, Software, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f90d7dbe7c8e11ef35d4dce6021b2a
https://doi.org/10.1016/j.cct.2009.01.010

المؤلفون: Michael Pfreundschuh, Susanne Albrecht, Gunter Schuch, Thomas Hany, Wolfgang Schmitt, Thorsten Fischer, Martin Pölcher, Qingyuan Zhang, Michael Zünd, Niels Murawski, George H. Sakorafas, Karl T.M. Schneider, Sabine Balmer-Majno, Wenjie Ma, Jingxuan Wang, Ina Thöm, Nikolaus de Gregorio, Spiros Christodoulou, Thomas Kubin, Christos Lappas, Rolf Kreienberg, Isabell Witzel, Shu Zhao, Egbert Nitzsche, Zhengyan Yu, Christine Wulff, Carsten Bokemeyer, Peter Brauchli, Antonia Dimitrakopoulou-Strauss, Clemens Caspar, Dieter Köberle, Gisela Walgenbach-Bruenagel, Michael Braun, Roger von Moos, Corinne Cescato-Wenger, Thorleif Etgen, Bernd Klaeser, Ruediger Hein, Nikolaos Antoniou, Eva Wardelmann, Christian Rudlowski, Shi Jin, Reinhard Büttner, Eckart Laack, Thomas Ruhstaller, Hanne Stensheim, Athanasios N. Chalazonitis, Manuel Debald, Nina Gottschalk, Ludwig G. Strauss, Flora Zagouri, Claudia Rogers, Meletios-Athanasios Dimopoulos, Aristotle Bamias, Jan C. Schuller, Maria Papaefthimiou, Birte Andritzky, Tobias Höller, Volker R. Jacobs, Bernhard C. Pestalozzi, Walther Kuhn, Stephanie Pildner von Steinburg, Georg Weidenhöfer, Axel Sauerwald, Lucas Widmer, Michael Safioleas, Matthias Wolfgarten, Yongzhi Zhuang, Dieter K. Hossfeld

المصدر: Onkologie. 32:IX-XIV

مصطلحات موضوعية: Cancer Research, Oncology, Hematology, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c5471e3bec0ecec42b9ae63837ef4f0c
https://doi.org/10.1159/000268090

المؤلفون: Antonia Dimitrakopoulou-Strauss, Eckart Laack, Christine Wulff, Karl Schneider, Bernhard C. Pestalozzi, Eva Wardelmann, Hanne Stensheim, Maria Papaefthimiou, Birte Andritzky, Shu Zhao, Nikolaus de Gregorio, Michael Braun, Roger von Moos, Clemens B. Caspar, Athanasios N. Chalazonitis, Tobias Höller, Volker R. Jacobs, Niels Murawski, Spiros Christodoulou, Peter Brauchli, Yongzhi Zhuang, Susanne Albrecht, Nikolaos Antoniou, Jingxuan Wang, Wolfgang Schmitt, Zhengyan Yu, George H. Sakorafas, Nina Gottschalk, Flora Zagouri, Claudia Rogers, Michael Zünd, Axel Sauerwald, Carsten Bokemeyer, Aristotle Bamias, Thomas Kubin, Jan C. Schuller, Ruediger Hein, Corinne Cescato-Wenger, Dieter Köberle, Georg Weidenhöfer, Wenjie Ma, Gisela Walgenbach-Bruenagel, Dieter K. Hossfeld, Meletios-Athanasios Dimopoulos, Bernd Klaeser, Ludwig G. Strauss, Martin Pölcher, Isabell Witzel, Manuel Debald, Rolf Kreienberg, Ina Thöm, Sabine Balmer-Majno, Thorsten Fischer, Egbert Nitzsche, Christos Lappas, Shi Jin, Reinhard Büttner, Thorleif Etgen, Matthias Wolfgarten, Thomas F. Hany, Lucas Widmer, Michael Safioleas, Qingyuan Zhang, Stephanie Pildner von Steinburg, Gunter Schuch, Michael Pfreundschuh, Christian Rudlowski, Thomas Ruhstaller, Walther Kuhn

المصدر: Onkologie. 32:III-VIII

مصطلحات موضوعية: Cancer Research, Oncology, Hematology, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3cfd3f36161ec58c8844146a4a7cd025
https://doi.org/10.1159/000268102

المؤلفون: Rolf A. Stahel, Karin Ribi, Roger Stupp, Stephan Bodis, Walter Weder, Markus Jörger, Hans-Beat Ris, Daniel Betticher, Jürg Bernhard, Ralph A. Schmid, Jan C. Schuller

المساهمون: University of Zurich, Ribi, K

المصدر: Lung Cancer. 61:398-404

مصطلحات موضوعية: Adult, Male, Mesothelioma, Pulmonary and Respiratory Medicine, Cancer Research, medicine.medical_specialty, 10255 Clinic for Thoracic Surgery, Pleural Neoplasms, medicine.medical_treatment, 610 Medicine & health, Disease-Free Survival, Quality of life, Humans, Medicine, Preoperative chemotherapy, 1306 Cancer Research, In patient, Stage (cooking), Aged, Neoplasm Staging, Rotterdam Symptom Checklist, business.industry, Middle Aged, medicine.disease, Combined Modality Therapy, humanities, Radiation therapy, Clinical trial, Oncology, 2740 Pulmonary and Respiratory Medicine, 10032 Clinic for Oncology and Hematology, Disease Progression, Quality of Life, Physical therapy, Feasibility Studies, Female, 2730 Oncology, business

وصف الملف: Ribi_et_al_LC_2008V.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1429e4fbce537b37d21020e0d8688b5a
https://doi.org/10.1016/j.lungcan.2008.01.013

المؤلفون: Susanne Albrecht, Michael Zünd, Nikolaus de Gregorio, Yongzhi Zhuang, Bernd Klaeser, Ludwig G. Strauss, Thomas Hany, Eckart Laack, Nina Gottschalk, Peter Brauchli, Egbert Nitzsche, Spiros Christodoulou, Axel Sauerwald, Rolf Kreienberg, Dieter Köberle, Matthias Wolfgarten, Gisela Walgenbach-Bruenagel, Zhengyan Yu, Gunter Schuch, Christine Wulff, Flora Zagouri, Claudia Rogers, Niels Murawski, Thorleif Etgen, Corinne Cescato-Wenger, Lucas Widmer, Karl T.M. Schneider, Jingxuan Wang, Eva Wardelmann, Michael Pfreundschuh, Michael Safioleas, Sabine Balmer-Majno, Wolfgang Schmitt, Hanne Stensheim, George H. Sakorafas, Thomas Kubin, Aristotle Bamias, Antonia Dimitrakopoulou-Strauss, Roger von Moos, Martin Pölcher, Christian Rudlowski, Ina Thöm, Georg Weidenhöfer, Dieter K. Hossfeld, Tobias Höller, Volker R. Jacobs, Clemens Caspar, Thomas Ruhstaller, Christos Lappas, Birte Andritzky, Stephanie Pildner von Steinburg, Walther Kuhn, Ruediger Hein, Bernhard C. Pestalozzi, Wenjie Ma, Maria Papaefthimiou, Isabell Witzel, Thorsten Fischer, Qingyuan Zhang, Shu Zhao, Michael Braun, Meletios-Athanasios Dimopoulos, Jan C. Schuller, Shi Jin, Reinhard Büttner, Athanasios N. Chalazonitis, Nikolaos Antoniou, Manuel Debald, Carsten Bokemeyer

المصدر: Onkologie. 32:785-787

مصطلحات موضوعية: Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), Hematology, General Medicine, Mathematics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::13816c6a904844eae640dad59fe4e9b1
https://doi.org/10.1159/000268100

المؤلفون: Karin Ribi, Stefanie Pederiva, Christian von Briel, Thomas Ruhstaller, Roger von Moos, Andreas Lohri, Dieter Koeberle, Norbert Lombriser, R. A. Popescu, Arnoud J. Templeton, Sandra Thierstein, Markus Borner, Jan C. Schuller

المصدر: Onkologie. 33(5)

مصطلحات موضوعية: Male, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, Locally advanced, Adenocarcinoma, Disease-Free Survival, Drug Administration Schedule, Antineoplastic Combined Chemotherapy Protocols, medicine, Carcinoma, Humans, In patient, Prospective Studies, Aged, Neoplasm Staging, business.industry, Standard treatment, General surgery, Radiotherapy Dosage, Hematology, General Medicine, Esophageal cancer, Middle Aged, medicine.disease, Combined Modality Therapy, Surgery, Systemic metastasis, Oncology, Lymphatic Metastasis, Carcinoma, Squamous Cell, Feasibility Studies, Female, Radiotherapy, Conformal, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23211d2a09062796a1e598d5071cb946
https://pubmed.ncbi.nlm.nih.gov/20502055

المؤلفون: Kurt Beretta, Mario Bargetzi, Alicia Rovó, Andreas Himmelmann, Max Solenthaler, Dominik Heim, Peter Brauchli, Reinhard Zenhäusern, Silvia Hanselmann, Jan C. Schuller, Michael Gregor, Nicolas Leupin

المصدر: Leukemialymphoma. 51(4)

مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Transplantation Conditioning, Cyclophosphamide, Chronic lymphocytic leukemia, Nodular Partial Remission, Neutropenia, Gastroenterology, Drug Administration Schedule, Antibodies, Monoclonal, Murine-Derived, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Granulocyte Colony-Stimulating Factor, medicine, Humans, Cladribine, Aged, Dose-Response Relationship, Drug, business.industry, Remission Induction, Hematopoietic Stem Cell Transplantation, Antibodies, Monoclonal, Hematology, Middle Aged, medicine.disease, Combined Modality Therapy, Leukemia, Lymphocytic, Chronic, B-Cell, Hematopoietic Stem Cell Mobilization, Surgery, Leukemia, Treatment Outcome, Oncology, Feasibility Studies, Rituximab, Female, Lymphocytopenia, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85224ded77fd956404564e3a6b82fe53
https://pubmed.ncbi.nlm.nih.gov/20141447

المؤلفون: Peter Bauerfeind, Jean-Louis Frossard, Janek Binek, Thomas Ruhstaller, Christa Meyenberger, Baseli Werth, Peter Brauchli, Juerg Knuchel, U. Metzger, Christian Jost, Philipp Bertschinger, Jan C. Schuller

المصدر: Gastrointestinal Endoscopy, Vol. 71, No 7 (2010) pp. 1114-1121

مصطلحات موضوعية: Male, Radiation-Sensitizing Agents, Esophageal Neoplasms/drug therapy/mortality/radiotherapy/*ultrasonography, Esophageal Neoplasms, medicine.medical_treatment, Docetaxel, Endosonography, Prospective Studies, Stage (cooking), Carcinoma, Squamous Cell/drug therapy/mortality/radiotherapy/ultrasonography, Fisher's exact test, Esophagus/pathology/*ultrasonography, Tumor Regression Grade, ddc:616, Survival Rate/trends, Cisplatin/*therapeutic use, Gastroenterology, Adenocarcinoma/drug therapy/mortality/radiotherapy/ultrasonography, Esophageal cancer, Middle Aged, Neoadjuvant Therapy, Survival Rate, Treatment Outcome, Esophagectomy, symbols, Carcinoma, Squamous Cell, Disease Progression, Adenocarcinoma, Drug Therapy, Combination, Female, Taxoids, Adult, Antineoplastic Agents, symbols.namesake, Esophagus, Predictive Value of Tests, medicine, Humans, Radiology, Nuclear Medicine and imaging, Endosonography/*methods, Aged, Neoplasm Staging, business.industry, Radiation-Sensitizing Agents/therapeutic use, Antineoplastic Agents/therapeutic use, Odds ratio, medicine.disease, Clinical trial, Neoplasm Staging/methods, Cisplatin, business, Nuclear medicine, Taxoids/*therapeutic use, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d7b525e64751ca6fbd02a26ff67835
https://pubmed.ncbi.nlm.nih.gov/20304399

المؤلفون: W. Mingrone, L. Terraciano, Thomas Ruhstaller, Markus Borner, Dieter Köberle, R. von Moos, Jan C. Schuller, Viviane Hess, Arnaud Roth, Sabine Balmer-Majno, Lucas Widmer, Stephan Bodis, R. A. Popescu, Armin Schnider, B. Pestalozzi

المصدر: Ruhstaller, T; Widmer, L; Schuller, J C; Roth, A; Hess, V; Mingrone, W; von Moos, R; Borner, M; Pestalozzi, B C; Balmermajno, S; Köberle, D; Terraciano, L; Schnider, A; Bodis, S; Popescu, R (2009). Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02). Annals of oncology, 20(9), pp. 1522-8. Oxford: Oxford University Press 10.1093/annonc/mdp045 <http://dx.doi.org/10.1093/annonc/mdp045>
Annals of Oncology, Vol. 20, No 9 (2009) pp. 1522-1528

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Docetaxel, Kaplan-Meier Estimate, Carcinoma/mortality/*therapy, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, medicine, Mucositis, Humans, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use, Neoadjuvant Therapy, Neoadjuvant therapy, Digestive System Surgical Procedures, Aged, Neoplasm Staging, ddc:616, Taxoids/administration & dosage/adverse effects, Radiotherapy, business.industry, Esophageal disease, Esophageal Neoplasms/mortality/*therapy, Induction chemotherapy, Hematology, Esophageal cancer, Cisplatin/administration & dosage/adverse effects, Middle Aged, medicine.disease, Chemotherapy regimen, Combined Modality Therapy, Surgery, ddc:616.8, Treatment Outcome, Oncology, Taxoids, Female, Cisplatin, business, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd2ffb79791a1caf26f8554802d9674

المؤلفون: Bernhard C. Pestalozzi, Peter Brauchli, Clemens B. Caspar, Susanne Albrecht, Egbert Nitzsche, Michael Zünd, Bernd Klaeser, Roger von Moos, Dieter Köberle, Jan C. Schuller, Corinne Cescato-Wenger, Thomas Ruhstaller, Sabine Balmer-Majno, Thomas F. Hany, Lucas Widmer

مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Preoperative care, Sensitivity and Specificity, Fluorodeoxyglucose F18, Germany, Preoperative Care, Carcinoma, medicine, Humans, Prospective Studies, Aged, Tumor Regression Grade, Chemotherapy, Predictive marker, business.industry, Induction chemotherapy, Reproducibility of Results, Hematology, General Medicine, Esophageal cancer, Middle Aged, medicine.disease, Prognosis, Treatment Outcome, Oncology, Positron-Emission Tomography, Female, Radiology, Radiopharmaceuticals, business, Chemoradiotherapy, Switzerland

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a569a312f1aeccab7170dd5b1e25f857
https://edoc.unibas.ch/26215/

المؤلفون: Bernhard C. Pestalozzi, Roger von Moos, Norbert Lombriser, Viviane Hess, Dieter Koeberle, Peter Moosmann, Thomas Ruhstaller, Karin Ribi, Hanspeter Honegger, Markus Borner, Jan C. Schuller, Arnaud Roth

المصدر: Ribi, Karin; Koeberle, Dieter; Schuller, Jan C; Honegger, Hanspeter; Roth, Arnaud; Hess, Viviane; Moosmann, Peter; von Moos, Roger; Borner, Markus; Lombriser, Norbert; Pestalozzi, Bernhard; Ruhstaller, Thomas (2009). Is a change in patient-reported dysphagia after induction chemotherapy in locally advanced esophageal cancer a predictive factor for pathological response to neoadjuvant chemoradiation? Supportive care in cancer, 17(8), pp. 1109-1116. Berlin: Springer 10.1007/s00520-008-0570-6 <http://dx.doi.org/10.1007/s00520-008-0570-6>
Supportive Care in Cancer, Vol. 17, No 8 (2009) pp. 1109-1116

مصطلحات موضوعية: Oncology, Adult, Male, medicine.medical_specialty, Time Factors, Esophageal Neoplasms, medicine.medical_treatment, Adenocarcinoma, Eating, Quality of life, Internal medicine, medicine, Humans, Longitudinal Studies, Neoplasms, Squamous Cell, Prospective Studies, Neoadjuvant therapy, Aged, ddc:616, business.industry, Induction chemotherapy, Induction Chemotherapy, Esophageal cancer, Middle Aged, medicine.disease, Dysphagia, Combined Modality Therapy, humanities, Neoadjuvant Therapy, Radiation therapy, Esophagectomy, Treatment Outcome, Quality of Life, medicine.symptom, business, Deglutition Disorders, Follow-Up Studies

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0b1b82022525abd5cf9719ad6317d2
https://boris.unibe.ch/31372/1/s00520-008-0570-6.pdf

المؤلفون: Antony J. Lomax, Alessandra Bolsi, C. Ares, Eros Pedroni, Jan C. Schuller, Beate Timmermann, Hans Peter Rutz, Eugen B. Hug, Gudrun Goitein

المصدر: International journal of radiation oncology, biology, physics. 75(4)

مصطلحات موضوعية: musculoskeletal diseases, Adult, Male, Cancer Research, Neoplasm, Residual, Adolescent, Maximum Tolerated Dose, medicine.medical_treatment, Chondrosarcoma, Skull Base Neoplasms, Young Adult, medicine, Relative biological effectiveness, Chordoma, Proton Therapy, Humans, Radiology, Nuclear Medicine and imaging, Child, Proton therapy, Survival rate, Survival analysis, Aged, Analysis of Variance, Radiation, business.industry, Radiotherapy Dosage, Middle Aged, medicine.disease, Tumor Burden, Radiation therapy, Survival Rate, Oncology, Toxicity, Female, Protons, business, Nuclear medicine, Relative Biological Effectiveness, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85decb4382e571eb2756885b4ba4c71
https://pubmed.ncbi.nlm.nih.gov/19386442

المؤلفون: Theo Gasser, Ursula Schreiter Gasser, Jan C. Schuller

المساهمون: University of Zurich, Gasser, T

مصطلحات موضوعية: Computer science, 610 Medicine & health, Electromyography, Electroencephalography, Quantitative eeg, symbols.namesake, 2809 Sensory Systems, 2737 Physiology (medical), Alzheimer Disease, Physiology (medical), medicine, Humans, Beta Rhythm, Muscle, Skeletal, Aged, medicine.diagnostic_test, Fourier Analysis, business.industry, Spectral density, Reproducibility of Results, Pattern recognition, Anatomy, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Sensory Systems, Power (physics), body regions, Alpha Rhythm, Cerebral activity, 2728 Neurology (clinical), Neurology, Fourier analysis, 2808 Neurology, Data Interpretation, Statistical, symbols, Regression Analysis, Neurology (clinical), Artificial intelligence, business, Artifacts

وصف الملف: Correction_of_muscle.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b89efffbaff64f8f7d192f1d9a41f52

المؤلفون: Max Solenthaler, Reinhard Zenhäusern, Alois Gratwohl, Nicolas Leupin, Andreas Himmelmann, Kurt Beretta, Mario Bargetzi, Jan C. Schuller, Susanne Hanselmann, André Tichelli

المصدر: Blood. 110:2057-2057

مصطلحات موضوعية: medicine.medical_specialty, Cyclophosphamide, Performance status, business.industry, Chronic lymphocytic leukemia, Immunology, Cell Biology, Hematology, Neutropenia, CHOP, Nodular Partial Remission, medicine.disease, Biochemistry, Gastroenterology, Regimen, Internal medicine, medicine, Rituximab, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7c8aaaf1adbfd2b041f717c18100679a
https://doi.org/10.1182/blood.v110.11.2057.2057

المؤلفون: Viviane Hess, Jan C. Schuller, A. Roth, Thomas Ruhstaller, Karin Ribi, M. Zuend, Norbert Lombriser, E. Nitzsche, B. Klaeser, Thomas F. Hany

المصدر: Journal of Clinical Oncology. 25:4587-4587

مصطلحات موضوعية: Tumor Regression Grade, Cancer Research, medicine.medical_specialty, business.industry, Esophageal cancer, medicine.disease, Dysphagia, medicine.anatomical_structure, Oncology, Docetaxel, Concomitant, medicine, Adenocarcinoma, Radiology, medicine.symptom, Esophagus, business, Chemoradiotherapy, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a9a9ae87526e331dbda3933ecd25de3c
https://doi.org/10.1200/jco.2007.25.18_suppl.4587