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1
المؤلفون: Milton L. Hammond, Anne-Marie Cumiskey, Sheryl A. Hyland, Ray Rosa, Christopher F. Thompson, Amjad Ali, Ying Chen, Suoyu S. Xu, James V. Pivnichny, Xinchun Tong, Qiu Guo, Hong Li, Carl P. Sparrow, Peter J. Sinclair, Joann B. Napolitano, Melanie Latham, Zhijian Lu, Samuel D. Wright, Laurence B. Peterson, Matt S. Anderson, Suzanne S. Eveland, Cameron J. Smith, Gayle E. Taylor, Denise P. Milot
المصدر: Journal of Medicinal Chemistry. 54:4880-4895
مصطلحات موضوعية: Male, Stereochemistry, Mice, Transgenic, Ring (chemistry), Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Anacetrapib, Drug Discovery, Cholesterylester transfer protein, Animals, Humans, Oxazolidinones, Biphenyl, biology, Cholesterol, HDL, Stereoisomerism, Recombinant Proteins, Cholesterol Ester Transfer Proteins, Mice, Inbred C57BL, Macaca fascicularis, chemistry, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Methyl group
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2
المؤلفون: Dooseop Kim, Qiu Guo, Ying Chen, Milton L. Hammond, Xinchun Tong, Carl P. Sparrow, Amjad Ali, Denise P. Milot, Sheryl A. Hyland, Peter J. Sinclair, Samuel D. Wright, James V. Pivnichny, Julianne A. Hunt, Suoyu S. Xu, Cameron J. Smith, Florida Kallashi, Suzanne S. Eveland, You Jung Park, Matt S. Anderson, Melanie Latham, Ray Rosa, Jennifer E. Kowalchick, Anne-Marie Cumiskey, Laurence B. Peterson
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:558-561
مصطلحات موضوعية: Genetically modified mouse, Ratón, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Biochemistry, Mice, Structure-Activity Relationship, Blood serum, Pharmacokinetics, In vivo, Drug Discovery, Cholesterylester transfer protein, Animals, Moiety, Molecular Biology, chemistry.chemical_classification, Benzoxazoles, biology, Cholesterol, HDL, Organic Chemistry, Cholesterol Ester Transfer Proteins, chemistry, biology.protein, Molecular Medicine, Acetanilides, Glycoprotein
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3
المؤلفون: Matt S. Anderson, Denise P. Milot, Xinchun Tong, Ying Chen, Suzanne S. Eveland, Florida Kallashi, James V. Pivnichny, Silvia Gonzalez, Carl P. Sparrow, Julianne A. Hunt, Samuel D. Wright, Sheryl A. Hyland, Suoyu S. Xu, Qiu Guo, Milton L. Hammond, Peter J. Sinclair
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1019-1022
مصطلحات موضوعية: Benzoxazoles, biology, Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Reverse cholesterol transport, Pharmaceutical Science, Biological activity, Amides, Biochemistry, Chemical synthesis, In vitro, Cholesterol Ester Transfer Proteins, Bioavailability, Alcohols, Drug Discovery, Cholesterylester transfer protein, biology.protein, Molecular Medicine, Potency, Moiety, lipids (amino acids, peptides, and proteins), Molecular Biology
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4
المؤلفون: Gerard R. Kieczykowski, Carrie P. Jones, Ping Liu, Junying Wang, Conrad E. Raab, Qian Si, Xinchun Tong, Thomas J. Lanza, Anne Schuelke, Kelly M. Treonze, Richard A. Mumford, Salony Manior, Stella H. Vincent, James V. Pivnichny, Gloria C. Koo, James P. Jewell, William K. Hagmann, Regina W. Wang, Philip Davies, Linus S. Lin, Malcolm MacCoss
المصدر: Journal of Medicinal Chemistry. 52:3449-3452
مصطلحات موضوعية: chemistry.chemical_classification, Sulfonyl, Dipeptide, Stereochemistry, medicine.drug_class, Antagonist, Peptide, Phenylalanine, Carboxamide, Biological activity, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Molecular Medicine, Proline
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5
المؤلفون: Kwan Leung, James V. Pivnichny, Zhesheng Chen, Tom G. Holt
المصدر: Journal of Pharmacological and Toxicological Methods. 55:91-95
مصطلحات موضوعية: Male, Ibuprofen, Toxicology, Adduct, chemistry.chemical_compound, Hydrolysis, Glucuronides, Drug Stability, Zomepirac, medicine, Animals, Humans, Gemfibrozil, Tolmetin, Pharmacology, Chromatography, Uridine, Rats, Models, Chemical, chemistry, Covalent bond, Microsomes, Liver, Uridine Diphosphate Glucuronic Acid, Microsome, Half-Life, medicine.drug
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6
المؤلفون: John E. Stelmach, Jianming Bao, Julianne A. Hunt, Ruixiu Wang, James B. Doherty, Cornelis E. C. A. Hop, Stephen J. O'Keefe, Chris M. Thompson, Sanjeev Kumar, Wen Xiao Zhang, Kathleen M. Rupprecht, Rowena D. Ruzek, Wesley L. Shoop, James E. Thompson, Dennis M. Zaller, James V. Pivnichny, Shouwu Miao, Luping Liu, Rose M. Cubbon, Edward A. O'Neill, Peter J. Sinclair
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:64-68
مصطلحات موضوعية: Lipopolysaccharides, Time Factors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Quinolones, p38 Mitogen-Activated Protein Kinases, Biochemistry, Chemical synthesis, Dexamethasone, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Dogs, Piperidines, In vivo, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Naphthyridines, Protein kinase A, Molecular Biology, chemistry.chemical_classification, biology, Tumor Necrosis Factor-alpha, Kinase, Organic Chemistry, Biological activity, Haplorhini, Arthritis, Experimental, Rats, Enzyme, Models, Chemical, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Collagen, Piperidine
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7
المؤلفون: Kevin T. Chapman, Jerry Di Salvo, Gloria Y. Kwei, Salvatore J. Siciliano, Dong-Ming Shen, Min Shu, Janet Lineberger, Kathy Lyons, Gwen Carver, Karen Holmes, Renee Danzeisen, Jennifer L. Loebach, Joseph Kessler, Martin S. Springer, James V. Pivnichny, Lorraine Malkowitz, Kerry A Parker, William A. Schleif, Emilio A. Emini, Daria J. Hazuda, Sander G. Mills, Sandra L. Gould, Anthony Carella, Julie A. DeMartino, Michael D. Miller
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:947-952
مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Substituent, Biological Availability, Pharmaceutical Science, CCR5 receptor antagonist, Biochemistry, Chemical synthesis, Monocytes, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Drug Discovery, Animals, Humans, Structure–activity relationship, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Rats, CCR5 Receptor Antagonists, Alkoxy group, Benzyl group, Pyrazoles, Molecular Medicine, Piperidine, Selectivity, HeLa Cells
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8
المؤلفون: James V. Pivnichny, Gene Porter, Sherrie X McCormick, Zhen Wang, Stephen J. O'Keefe, Sanjeev Kumar, James E. Thompson, James B. Doherty, Andrea Woods, Rowena D. Ruzek, Cornelis E. C. A. Hop, Dennis M. Zaller, Julianne A. Hunt, Ida Ita, Edward A. O'Neill, Florida Kallashi, Peter J. Sinclair
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:467-470
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Quinolones, p38 Mitogen-Activated Protein Kinases, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Anti-Infective Agents, Piperidines, Drug Discovery, Animals, Structure–activity relationship, Enzyme Inhibitors, Naphthyridines, Molecular Biology, chemistry.chemical_classification, biology, Bicyclic molecule, Tumor Necrosis Factor-alpha, Organic Chemistry, Macaca mulatta, Rats, Bioavailability, Enzyme, chemistry, Enzyme inhibitor, Area Under Curve, Quinazolines, biology.protein, Lactam, Molecular Medicine, Piperidine, Mitogen-Activated Protein Kinases, Half-Life
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9
المؤلفون: James V. Pivnichny, Luping Liu, Elizabeth A. Nichols, Dennis M. Zaller, Zhen Wang, Chris M. Thompson, Dennis M. Schmatz, Stephen J. O'Keefe, Suresh B. Singh, Cheryl D. Schwartz, Cornelis E. C. A. Hop, John R. Strauss, Sangita B. Patel, John E. Stelmach, Edward A. O'Neill, Patricia M. Cameron, James B. Doherty, Giovanna Scapin
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:277-280
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Biological Availability, Pharmaceutical Science, In Vitro Techniques, p38 Mitogen-Activated Protein Kinases, Biochemistry, Chemical synthesis, Monocytes, Structure-Activity Relationship, Oral administration, In vivo, Drug Discovery, Animals, Enzyme Inhibitors, Protein kinase A, Molecular Biology, IC50, Whole blood, chemistry.chemical_classification, biology, Tumor Necrosis Factor-alpha, Organic Chemistry, Rats, Enzyme, chemistry, Enzyme inhibitor, Area Under Curve, Drug Design, Microsomes, Liver, Quinazolines, biology.protein, Molecular Medicine, Mitogen-Activated Protein Kinases
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10
المؤلفون: Junying Wang, Song Zheng, Judy Fenyk-Melody, James V. Pivnichny, Chris Nunes, Xiaolan Shen, M. Donnelly, Ken Vakerich, Xinchun S Tong, Patrick R. Griffin
المصدر: Analytical Chemistry. 74:6305-6313
مصطلحات موضوعية: Male, Drug Evaluation, Preclinical, Administration, Oral, Excipient, Mass spectrometry, Sensitivity and Specificity, Mass Spectrometry, Polyethylene Glycols, Analytical Chemistry, Excipients, Rats, Sprague-Dawley, Pharmacokinetics, Liquid chromatography–mass spectrometry, Oral administration, medicine, Animals, Dosing, Chromatography, Chemistry, Rats, Pharmaceutical Preparations, Injections, Intravenous, Selectivity, Quantitative analysis (chemistry), Chromatography, Liquid, medicine.drug
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11
المؤلفون: Thomas L. Shih, Pei Ran Wang, Lawrence F. Colwell, Constantin Tamvakopoulos, James V. Pivnichny
المصدر: Journal of Chromatography B. 772:89-98
مصطلحات موضوعية: Clinical Biochemistry, Tetrazoles, Mass spectrometry, Tandem mass spectrometry, Sensitivity and Specificity, Biochemistry, Mass Spectrometry, Analytical Chemistry, chemistry.chemical_compound, Pharmacokinetics, Humans, Acetonitrile, Chromatography, High Pressure Liquid, Sulfonamides, Chromatography, Atmospheric pressure, Elution, Drug discovery, Reproducibility of Results, Cell Biology, General Medicine, Atmospheric Pressure, Pharmaceutical Preparations, chemistry, Ammonium acetate
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12
المؤلفون: Peter T. Meinke, Lynn M. Warmke, Steven L. Colletti, Michael H. Fisher, Michelle Zakson-Aiken, James V. Pivnichny, Karen Owens, Dennis M. Schmatz, Wesley L. Shoop, Matthew J. Wyvratt, Pierre deMontigny, Richard A. Berger
المصدر: Organic Letters. 3:3715-3718
مصطلحات موضوعية: Insecticides, Indoles, Natural product, Organic Chemistry, Nanotechnology, Biochemistry, Combinatorial chemistry, Thiazoles, chemistry.chemical_compound, Ticks, chemistry, Nodulisporic acid A, Side chain, Animals, Siphonaptera, Physical and Theoretical Chemistry, Oxazoles
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13
المؤلفون: Xinchun Tong, Junying Wang, James V. Pivnichny, Ida Ita
المصدر: Journal of Pharmaceutical and Biomedical Analysis. 20:773-784
مصطلحات موضوعية: Male, Detection limit, Analyte, Chromatography, Chemistry, Calibration curve, Clinical Biochemistry, Drug Evaluation, Preclinical, Analytical chemistry, Pharmaceutical Science, Ion suppression in liquid chromatography–mass spectrometry, Mass spectrometry, Tandem mass spectrometry, Mass Spectrometry, Rats, Analytical Chemistry, Rats, Sprague-Dawley, Column chromatography, Drug Discovery, Animals, Drug Interactions, Pharmacokinetics, Quantitative analysis (chemistry), Chromatography, High Pressure Liquid, Spectroscopy
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14
المؤلفون: James V. Pivnichny, Helmut Mrozik, John D. Stong, F. S. Waksmunski
المصدر: Journal of Pharmaceutical Sciences. 81:1000-1003
مصطلحات موضوعية: Ivermectin, Free Radicals, Autoxidation, Chemistry, Chemistry, Pharmaceutical, Pharmaceutical Science, Oxidation reduction, Metabolism, Peroxides, Drug Stability, tert-Butylhydroperoxide, Molecule, Organic chemistry, Identification (biology), Oxidation-Reduction, Tert-Butylhydroperoxide, Benzofurans
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15
المؤلفون: Z. Yao, Song Zheng, Xinchun Tong, James V. Pivnichny, S. Xu, X. Shen
المصدر: Journal of pharmaceutical and biomedical analysis. 44(2)
مصطلحات موضوعية: Sample purification, Brain Chemistry, Chromatography, Autoanalysis, Chemistry, Clinical Biochemistry, Pharmaceutical Science, Tissue sample, Reproducibility of Results, Brain tissue, Robotics, Tandem mass spectrometry, Homogenization (chemistry), Analytical Chemistry, Highly sensitive, Rats, Mice, Tandem Mass Spectrometry, Drug Discovery, Animals, Sample preparation, Spectrophotometry, Ultraviolet, Spectroscopy, Chromatography, High Pressure Liquid
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16
المؤلفون: Claude Dufresne, Song Zheng, Xinchun S Tong, Suoyu Xu, James V. Pivnichny, Jesús Martín
المصدر: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 833(2)
مصطلحات موضوعية: Sample purification, High-throughput screening, Clinical Biochemistry, Analytical chemistry, Biochemistry, Mass Spectrometry, Analytical Chemistry, Animals, Humans, Process engineering, Throughput (business), Chromatography, business.industry, Chemistry, Drug discovery, Reproducibility of Results, Cell Biology, General Medicine, Metabolic stability, Automation, Handling system, Drug Design, Microsomes, Liver, Report generation, business, Chromatography, Liquid
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17
المؤلفون: Kevin T. Chapman, Barry R. Cunningham, Malcolm MacCoss, B. F. Michael, Richard T. Cummings, Dennis M. Schmatz, Jeffrey D. Hermes, Bartizal Kenneth F, Wesley L. Shoop, James V. Pivnichny, Arthur M. Friedlander, Edward M. Scolnick, J. Guo, Giovanna Scapin, Y. Xiong, T. Felcetto, Alka Bansal, Judyann Wiltsie, Douglas Wisniewski, Cameron M. Douglas, Scott P. Salowe, Dennis M. Zaller, Andrea Woods, Sangita B. Patel
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 102(22)
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, medicine.medical_treatment, Antibiotics, Bacterial Toxins, medicine.disease_cause, Hydroxamic Acids, Virulence factor, law.invention, Microbiology, Anthrax, Mice, law, Ciprofloxacin, medicine, Animals, DNA Primers, Metalloproteinase, Antigens, Bacterial, Mice, Inbred BALB C, Multidisciplinary, Protease, Crystallography, biology, Toxin, Macrophages, Biological Sciences, biology.organism_classification, Cytotoxicity Tests, Immunologic, Virology, Bacillus anthracis, Recombinant DNA, Drug Therapy, Combination, Rabbits, medicine.drug
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18
المؤلفون: Salvatore J. Siciliano, Karen Holmes, Jeffrey J. Hale, Dong-Ming Shen, Shrenik K. Shah, Christopher A. Willoughby, Michael D. Miller, Anthony Carella, Lorraine Malkowitz, Julie A. DeMartino, Kathy Lyons, Min Shu, James V. Pivnichny, Emilio A. Emini, William A. Schleif, Gloria Y. Kwei, Martin S. Springer, Gwen Carver, Renee Danzeisen, Sandra L. Gould, Joseph Kessler, Daria J. Hazuda, Sander G. Mills, Christopher L. Lynch, Janet Lineberger, Kevin T. Chapman
المصدر: Bioorganicmedicinal chemistry letters. 14(4)
مصطلحات موضوعية: Anti-HIV Agents, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Pyrazole, Acetates, Biochemistry, Chemical synthesis, Pyrrolidine, Monocytes, chemistry.chemical_compound, Acetic acid, Structure-Activity Relationship, Dogs, Piperidines, Pyrazole Compound, Drug Discovery, Organic chemistry, Animals, Humans, Molecular Biology, Molecular Structure, Organic Chemistry, Combinatorial chemistry, Macaca mulatta, Rats, chemistry, CCR5 Receptor Antagonists, Molecular Medicine, Pyrazoles, Piperidine, Trifluoromethanesulfonate, Isopropyl, HeLa Cells
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19
المؤلفون: Junying Wang, Xinchun S Tong, Song Zheng, James V. Pivnichny
المصدر: Journal of pharmaceutical and biomedical analysis. 35(4)
مصطلحات موضوعية: Detection limit, Male, Chromatography, Serial dilution, Chemistry, Clinical Biochemistry, Extraction (chemistry), Pipette, Pharmaceutical Science, Standard solution, Integrin alpha4beta1, Tandem mass spectrometry, Mass Spectrometry, Analytical Chemistry, Rats, Rats, Sprague-Dawley, Drug Discovery, Animals, Sample preparation, Solid phase extraction, Spectroscopy, Chromatography, High Pressure Liquid, Chromatography, Liquid
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20
المؤلفون: Dennis M. Schmatz, Peter T. Meinke, Wesley L. Shoop, Matthew J. Wyvratt, B. Pikounis, L.M. Gregory, James V. Pivnichny, Michelle Zakson-Aiken, B.F. Michael, M. H. Fisher
المصدر: The Journal of parasitology. 87(5)
مصطلحات موضوعية: Male, Veterinary medicine, Flea, Insecticides, Indoles, Administration, Oral, Random Allocation, Dogs, Pharmacokinetics, Oral administration, medicine, Potency, Animals, Anthelmintic, Dog Diseases, Ecology, Evolution, Behavior and Systematics, Ctenocephalides, biology, biology.organism_classification, Amides, Pulicidae, Siphonaptera, Parasitology, Ancylostoma caninum, medicine.drug, Half-Life