المؤلفون: Keith F. McDaniel, Andrew Bogdan, Lisa A. Hasvold, Ana L. Aguirre, Denise Wilcox, Xiaoyu Lin, Le Wang, Mai H. Bui, Leiming Li, Warren M. Kati, Terrance J. Magoc, James H. Holms, Dachun Liu, Steven D. Fidanze, Justin D. Dietrich, Charles W. Hutchins, Ganesh Rajaraman, Yu Shen, George S. Sheppard, Rongqi Wang, Daniel H. Albert, Chang H. Park, Jasmina Marjanovic, Robert A. Mantei, Xiaoli Huang, Peter Kovar, Yujia Dai, John K. Pratt

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1804-1810

مصطلحات موضوعية: 0301 basic medicine, Pyridones, Transplantation, Heterologous, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Cell Cycle Proteins, Computational biology, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, Protein structure, In vivo, Cell Line, Tumor, Microsomes, Drug Discovery, Animals, Humans, Structure–activity relationship, Binding site, Molecular Biology, Tumor xenograft, Cell Proliferation, Binding Sites, Chemistry, Organic Chemistry, Nuclear Proteins, Protein Structure, Tertiary, Bromodomain, Transplantation, 030104 developmental biology, Molecular Medicine, Multiple Myeloma, Half-Life, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec20af598ffa68abcb2f81c612b36b03
https://doi.org/10.1016/j.bmcl.2018.04.020

المؤلفون: Keith F. McDaniel, Carol K. Wada, Terrance J. Magoc, Warren M. Kati, Dachun Liu, Chaohong Sun, Lisa A. Hasvold, Le Wang, Robert A. Mantei, John K. Pratt, Yu Shen, Michael D. Wendt, T. Matthew Hansen, Charles W. Hutchins, Andrew M. Petros, Robin R. Frey, Denise Wilcox, Xiaoyu Lin, Chang H. Park, Rongqi Wang, Xiaoli Huang, Robert D. Hubbard, Peter Kovar, William J. McClellan, James H. Holms, George S. Sheppard, Leiming Li, Ganesh Rajaraman, Daniel H. Albert, Sanjay C. Panchal, Scott E. Warder, Steven D. Fidanze, Todd N. Soltwedel, Steven W. Elmore

المصدر: Journal of medicinal chemistry. 60(9)

مصطلحات موضوعية: 0301 basic medicine, BRD4, Macrocyclic Compounds, Stereochemistry, Pyridones, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Potency, Structure–activity relationship, Animals, Molecular Structure, 010405 organic chemistry, Chemistry, Drug discovery, Fragment (computer graphics), Cell based assays, 0104 chemical sciences, Bromodomain, Rats, 030104 developmental biology, Biochemistry, Molecular Medicine, Tumor growth inhibition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e1929bf0879c380bd4f0cda1201778
https://pubmed.ncbi.nlm.nih.gov/28368119

المؤلفون: Douglas W. Morgan, Jennifer J. Bouska, H. Robin Heyman, Patrick A. Marcotte, Yujia Dai, Steven K. Davidsen, Carole L. Goodfellow, Carol K. Wada, Daniel H. Albert, Jamie R. Stacey, Robert B. Garland, Douglas H. Steinman, Paul Tapang, Alan S. Florjancic, Michael L. Curtin, James H. Holms, Yan Guo, Michael R. Michaelides, Ildiko Elmore

المصدر: Journal of Medicinal Chemistry. 45:219-232

مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Stereochemistry, Administration, Oral, Biological Availability, Antineoplastic Agents, Ether, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Hydroxylamines, Chemical synthesis, Cell Line, Sulfone, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Protease Inhibitors, Hydroxamic acid, Formamides, biology, Tumor Necrosis Factor-alpha, Metalloendopeptidases, Xenograft Model Antitumor Assays, Macaca fascicularis, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d27c6f11163737a28ed10fca7c5bbc9
https://doi.org/10.1021/jm0103920

المؤلفون: Michael R. Michaelides, James H. Holms, Douglas W. Morgan, Katherine Mast, Steven K. Davidsen, Ildiko Elmore, Lori J. Pease, Keith B. Glaser, Junling Li, Patrick A. Marcotte

المصدر: Bioorganic & Medicinal Chemistry Letters. 11:2907-2910

مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Matrix metalloproteinase, Hydroxamic Acids, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Hydroxamic acid, biology, Tumor Necrosis Factor-alpha, Organic Chemistry, Metalloendopeptidases, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Tumor necrosis factor alpha

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807e22a4ed221029459cedc3cffedc50
https://doi.org/10.1016/s0960-894x(01)00603-5

المؤلفون: Douglas W. Morgan, H. Robin Heyman, Michael R. Michaelides, Jamie R. Stacey, Patrick A. Marcotte, Yan Guo, Steven K. Davidsen, Michael L. Curtin, Carole L. Goodfellow, Joseph F. Dellaria, Daniel H. Albert, Jane Gong, James H. Holms, Terrance J. Magoc, Jennifer J. Bouska, Ildiko B. Elmore, Carol K. Wada

المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1553-1556

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Antineoplastic Agents, Ether, Matrix Metalloproteinase Inhibitors, Hydroxamic Acids, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, chemistry.chemical_compound, Pharmacokinetics, Oral administration, Drug Discovery, Animals, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Hydroxamic acid, biology, Organic Chemistry, Bioavailability, Macaca fascicularis, Enzyme, chemistry, Enzyme inhibitor, Injections, Intravenous, biology.protein, Molecular Medicine, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788fb32bf8edf4d1c3ceda6d5a875b22
https://doi.org/10.1016/s0960-894x(01)00031-2

المؤلفون: Steven K. Davidsen, Patrick A. Marcotte, Terrance J. Magoc, James H. Holms, Zhiwen Guan, Robert B. Garland, Douglas H. Steinman, Douglas W. Morgan, Daniel H. Albert, Carol K. Wada, Yan Guo, H. Robin Heyman, Michael L. Curtin, George S. Sheppard, Ildiko Elmore

المصدر: Journal of Enzyme Inhibition. 14:425-435

مصطلحات موضوعية: Carboxypeptidases A, Swine, Matrix metalloproteinase inhibitor, Thermolysin, Angiotensin-Converting Enzyme Inhibitors, Carboxypeptidases, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Hydroxamic Acids, Biochemistry, Aminopeptidase, Inhibitory Concentration 50, Leucyl Aminopeptidase, Bacterial Proteins, Animals, Protease Inhibitors, Neprilysin, chemistry.chemical_classification, biology, Metalloendopeptidases, Angiotensin-converting enzyme, Carboxypeptidase, Rats, Amino acid, Zinc, chemistry, biology.protein, Molecular Medicine, Cattle, Rabbits

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34821c159675e7f12526b12b79130320
https://doi.org/10.3109/14756369909030333

المؤلفون: Terrance J. Magoc, Richard G. Conway, Douglas H. Steinman, Daisy Pireh, Michael L. Curtin, James H. Holms, James B. Summers, H. Robin Heyman, Steven K. Davidsen, Paul Tapang, Daniel H. Albert, George M. Carrera, George S. Sheppard, Rhein Da

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:2913-2918

مصطلحات موضوعية: Indole test, Improved solubility, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Prodrug, Biochemistry, Combinatorial chemistry, Water soluble, Orally active, Drug Discovery, Aqueous solubility, Molecular Medicine, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::56f13f4772af4862d22906eb73903181
https://doi.org/10.1016/0960-894x(95)00511-q

المؤلفون: Terrance J. Magoc, Daisy Pireh, George S. Sheppard, H. Robin Heyman, Richard G. Conway, Douglas H. Steinman, James H. Holms, Steven K. Davidsen, Rhein Da, Gongjin Luo, George M. Carrera, Nichael L. Curtin, James B. Summers, Paul Tapang, Daniel H. Albert

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:2903-2908

مصطلحات موضوعية: Indole test, Platelet-activating factor, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Thiazolidine, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Molecular Medicine, Pharmacophore, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::588d2ed92275742c29377dbac13be3ca
https://doi.org/10.1016/0960-894x(95)00509-r

المؤلفون: H. R. Heyman, George W. Carter, Steven K. Davidsen, Conway Rg, T. J. Magoc, James B. Summers, James H. Holms, Rhein Da, Daniel H. Albert

المصدر: Journal of Medicinal Chemistry. 37:4423-4429

مصطلحات موضوعية: Male, Platelet-activating factor, Pyridinium Compounds, Chemistry, Antagonist, Prodrug, Pharmacology, Chemical synthesis, Rats, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Solubility, Biochemistry, In vivo, Drug Discovery, Animals, Molecular Medicine, Prodrugs, Pyridinium, Platelet Activating Factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0b5adaa68fa57c4cda5a93233ea11e
https://doi.org/10.1021/jm00052a001

المؤلفون: Jimmie L. Moore, James H. Holms, George W. Carter, Dee W. Brooks, Francis A. J. Kerdesky, Randy L. Bell, Richard D. Dyer

المصدر: ChemInform. 22

مصطلحات موضوعية: chemistry.chemical_classification, Enzyme, chemistry, biology, Stereochemistry, Arachidonate 5-lipoxygenase, biology.protein, General Medicine, Cyclooxygenase, IC50, In vitro, Whole blood

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2316c4bf00420243bc2e1239508803ae
https://doi.org/10.1002/chin.199152183

المؤلفون: Daisy Pireh, James H. Holms, Daniel H. Albert, T. J. Magoc, G. M. Jun. Carrera, G. S. Sheppard, D. H. Steinman, Rhein Da, H. R. Heyman, Paul Tapang, S. K. Davidsen, Richard G. Conway, James B. Summers, Michael L. Curtin

المصدر: ChemInform. 27

مصطلحات موضوعية: Indole test, Water soluble, Chemistry, Organic chemistry, General Medicine, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::28b1a02626b4f7b7ba3e0064000ceb8c
https://doi.org/10.1002/chin.199614129

المؤلفون: Shari L. DeNinno, James D. Ratajczyk, Clint D. W. Brooks, Richard A. Craig, Hormoz Mazdiyasni, Karen E. Rodriques, Francis A. J. Kerdesky, George W. Carter, Randy L. Bell, Andrew O. Stewart, James H. Holms, Patrick R. Young, Jimmie L. Moore, Jonathan G. Martin, Robert G. Maki, James B. Summers, Teodozyj Kolasa, Michael B. Martin, Jennifer B. Bouska, C. Lanni, Pramila Bhatia

المصدر: ChemInform. 28

مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Oral administration, Arachidonate 5-lipoxygenase, Glucuronidation, biology.protein, Potency, Stereoselectivity, General Medicine, N-Hydroxyurea, Metabolism, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5ec88b137b0828a6a2c0b790aaeb73a6
https://doi.org/10.1002/chin.199740106

المؤلفون: James H. Holms, Katherine Mast, Douglas W. Morgan, Lori J. Pease, Steven K. Davidsen, Patrick A. Marcotte, Keith B. Glaser, Junling Li, Michael R. Michaelides, Ildiko Elmore

المصدر: ChemInform. 33

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Enzyme, Hydroxamic acid, chemistry, Biochemistry, Cellular Assay, Substituent, Tumor necrosis factor alpha, General Medicine, Matrix metalloproteinase, Selectivity, Tumor necrosis factor α

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ec9ef5b449c789791c2d3c904f37e961
https://doi.org/10.1002/chin.200209162

المؤلفون: Dee W. Brooks, Daniel H. Albert, James H. Holms, Francis A. J. Kerdesky, Jimmie L. Moore, Richard D. Dyer, James D. Ratajcyk, George W. Carter, Anwer Basha, Pramila Bhatia, Patrick R. Young, Jonathan G. Martin, Steven P. Schmidt

المصدر: Bioorganic & Medicinal Chemistry Letters. 2:1357-1360

مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Marked effect, Inhibitory postsynaptic potential, Biochemistry, chemistry.chemical_compound, Drug Discovery, Arachidonate 5-lipoxygenase, Toxicity, biology.protein, Molecular Medicine, Molecular Biology, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c53ea50883be2624e53281bd44661130
https://doi.org/10.1016/s0960-894x(00)80512-0

المؤلفون: Patrick A. Marcotte, Shannon S. Murphy, Jennifer J. Bouska, James H. Holms, Zhiqin Ji, Paul L. Richardson, Lori J. Pease, Steven K. Davidsen, Terrance J. Magoc, Michael L. Curtin, Keith B. Glaser, Paul Tapang, Jun Guo, Daniel H. Albert, Michael R. Michaelides, Carol K. Wada, Robin R. Frey, Robert B. Garland, Junling Li

المصدر: Bioorganicmedicinal chemistry letters. 13(19)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Histone Deacetylases, chemistry.chemical_compound, Mice, In vivo, Amide, Cell Line, Tumor, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Histone deacetylase 5, biology, Chemistry, Organic Chemistry, Histone acetyltransferase, Amides, Xenograft Model Antitumor Assays, In vitro, Histone Deacetylase Inhibitors, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1340a4c74e3a5e9a610abb78e0e4f82
https://pubmed.ncbi.nlm.nih.gov/12951120

المؤلفون: Steven K. Davidsen, Robin R. Frey, Richard A. G. Smith, Rohinton Edalji, Junling Li, Michael J. Staver, Keith B. Glaser, Michael R. Michaelides, James H. Holms, Michael L. Curtin

المصدر: Life sciences. 74(22)

مصطلحات موضوعية: Recombinant Fusion Proteins, Blotting, Western, Histone Deacetylase 1, Transfection, General Biochemistry, Genetics and Molecular Biology, Chromatin remodeling, Gene Expression Regulation, Enzymologic, Histone Deacetylases, law.invention, Substrate Specificity, Affinity chromatography, law, Multienzyme Complexes, Transcriptional regulation, Humans, General Pharmacology, Toxicology and Pharmaceutics, Cloning, Molecular, Enzyme Inhibitors, Regulation of gene expression, biology, Dose-Response Relationship, Drug, General Medicine, HDAC1, Histone, Biochemistry, biology.protein, Recombinant DNA, Cell Division, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fa4ccf08f8cf98ac33e9084c5aa5be
https://pubmed.ncbi.nlm.nih.gov/15043985

المؤلفون: Terrance J. Magoc, Douglas W. Morgan, Robert B. Garland, Michael L. Curtin, Douglas H. Steinman, Yan Guo, Paul Tapang, H. Robin Heyman, Carol K. Wada, James H. Holms, Ildiko B. Elmore, Steven K. Davidsen, Joy Bauch, Alan S. Florjancic, Patrick A. Marcotte, Daniel H. Albert, Joseph F. Dellaria, Carole L. Goodfellow, Jane Gong, Jennifer J. Bouska, Michael R. Michaelides, Kennan C. Marsh

المصدر: Bioorganicmedicinal chemistry letters. 11(12)

مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Stereochemistry, Metabolic Clearance Rate, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Antineoplastic Agents, Matrix Metalloproteinase Inhibitors, Hydroxamic Acids, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, In vivo, Oral administration, Drug Discovery, Tumor Cells, Cultured, Structure–activity relationship, Animals, Enzyme Inhibitors, Molecular Biology, Hydroxamic acid, biology, Organic Chemistry, Biphenyl Compounds, Biological activity, Haplorhini, Neoplasms, Experimental, Rats, chemistry, Enzyme inhibitor, Area Under Curve, Injections, Intravenous, biology.protein, Molecular Medicine, Cell Division, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae58d179b83e3cac44f28dc88e780f48
https://pubmed.ncbi.nlm.nih.gov/11412980

المؤلفون: Robert B. Garland, Douglas H. Steinman, James H. Holms, Steven K. Davidsen, Douglas W. Morgan, Terry Magoc, Charles W. Hutchins, H. Robin Heyman, James B. Summers, Patrick A. Marcotte, Ildiko B. Nagy, Junling Li, Daniel H. Albert, Michael L. Curtin

المصدر: Bioorganicmedicinal chemistry letters. 8(16)

مصطلحات موضوعية: Models, Molecular, Molecular model, medicine.drug_class, Stereochemistry, Phenylalanine, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Thiophenes, Matrix metalloproteinase, Matrix Metalloproteinase Inhibitors, Crystallography, X-Ray, Hydroxamic Acids, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Humans, Protease Inhibitors, Collagenases, Molecular Biology, Hydroxamic acid, biology, Chemistry, Organic Chemistry, Succinates, Kinetics, Matrix Metalloproteinase 8, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Indicators and Reagents, Batimastat

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f337d14dcd7a34a7e8dd764d55b4820e
https://pubmed.ncbi.nlm.nih.gov/9873491

المؤلفون: Carol K. Wada, James H. Holms, Michael L. Curtin, Yujia Dai, Alan S. Florjancic, Robert B. Garl, Yan Guo, H. Robin Heyman, Jamie R. Stacey, Douglas H. Steinman, Daniel H. Albert, Jennifer J. Bouska, Ildiko N. Elmore, Carole L. Goodfellow, Patrick A. Marcotte, Paul Tapang, Douglas W. Morgan, Michael R. Michaelides, Steven K. Davidsen

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.enzim.hu/~lbarna/articles/11754593.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.505.8903; http://www.enzim.hu/~lbarna/articles/11754593.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.505.8903
http://www.enzim.hu/~lbarna/articles/11754593.pdf

المؤلفون: James H. Holms, Francis A. J. Kerdesky, Jennifer B. Bouska, Jimmie L. Moore, Hormoz Mazdiyasni, Patrick R. Young, James B. Summers, Karen E. Rodriques, Robert G. Maki, Jonathan G. Martin, Pramila Bhatia, C. Lanni, Teodozyj Kolasa, George W. Carter, Michael B. Martin, Andrew O. Stewart, Shari L. DeNinno, James D. Ratajczyk, Randy L. Bell, Clint D. W. Brooks, Richard A. Craig

المصدر: Journal of medicinal chemistry. 40(13)

مصطلحات موضوعية: Stereochemistry, Glucuronidation, Glucuronates, Thiophenes, Chemical synthesis, Structure-Activity Relationship, Oral administration, Drug Discovery, Potency, Animals, Humans, Hydroxyurea, Lipoxygenase Inhibitors, Enzyme Inhibitors, Furans, Cells, Cultured, chemistry.chemical_classification, biology, Templates, Genetic, Rats, Macaca fascicularis, Enzyme, chemistry, Models, Chemical, Enzyme inhibitor, Drug Design, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Stereoselectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d4b93829d9fc91fb87a116b9f2862a
https://pubmed.ncbi.nlm.nih.gov/9207936