المؤلفون: James A. Brannigan, Shirley M. Roberts, Andrew S. Bell, Jennie A. Hutton, Michael R. Hodgkinson, Edward W. Tate, Robin J. Leatherbarrow, Deborah F. Smith, Anthony J. Wilkinson

المصدر: IUCrJ, Vol 1, Iss 4, Pp 250-260 (2014)

مصطلحات موضوعية: N-myristoyltransferase, inhibitor, ligand binding, Leishmania, drug discovery, Crystallography, QD901-999

وصف الملف: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S2052252514013001; https://doaj.org/toc/2052-2525

URL الوصول: https://doaj.org/article/0ddbe1c7f7b94b29aa4a10083708bb2c

المؤلفون: William T. Ferreira, Jean L. Whittingham, James A. Brannigan, Simon M. Cutting, Shumpei Hanai, Johan P. Turkenburg, Anthony J. Wilkinson, Eleanor J. Dodson, Jared Cartwright

المصدر: Acta Crystallographica. Section F, Structural Biology Communications

مصطلحات موضوعية: Models, Molecular, Protein Conformation, spores, Peptidomimetic, Biophysics, Crystallography, X-Ray, glycosyl hydrolase, Biochemistry, Pentapeptide repeat, Research Communications, Microbiology, 03 medical and health sciences, Bacterial Proteins, CotE, Structural Biology, Genetics, Glycoside hydrolase, Amino Acid Sequence, Pathogen, Plant Proteins, 030304 developmental biology, 3D domain swapping, 0303 health sciences, biology, Obligate, Clostridioides difficile, 030306 microbiology, Chemistry, Chitinases, fungi, Peroxiredoxins, Clostridium difficile, Condensed Matter Physics, Chitinase, biology.protein, Peroxiredoxin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06df931b3a27f466b6aa023f4b6e5b00
https://doi.org/10.1107/s2053230x20006147

المؤلفون: Gavin H. Thomas, Roderick E. Hubbard, Marcus Fischer, Johan P. Turkenburg, Shirley M. Roberts, Adam P. Hopkins, James A. Brannigan, John F. Darby, Seishi Shimizu

المصدر: Journal of the American Chemical Society. 141:15818-15826

مصطلحات موضوعية: Binding Sites, Protein Conformation, Virulence Factors, Chemistry, Water, General Chemistry, Protein engineering, Ligands, 010402 general chemistry, Ligand (biochemistry), 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Transport protein, Solvent, Viral Proteins, Colloid and Surface Chemistry, Protein sequencing, Solvents, Thermodynamics, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7dff8fc3ae51a461a0aedb66a2bd14
https://doi.org/10.1021/jacs.9b06275

المؤلفون: Anthony J. Wilkinson, James A. Brannigan

المصدر: Biophysical Reviews

مصطلحات موضوعية: 0303 health sciences, Leishmaniasis inhibitor discovery, Chemistry, Drug discovery, 030302 biochemistry & molecular biology, Neglected tropical disease, Biophysics, Leishmaniasis, Review, medicine.disease, Protein lipidation, Virology, 3. Good health, 03 medical and health sciences, Structural Biology, medicine, Protein structure, Molecular Biology, N-myristoyltransferase, 030304 developmental biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898ce78090de2951a119c9a0734a35c5
https://pubmed.ncbi.nlm.nih.gov/35035594

المؤلفون: Z. Yu, Shirley M. Roberts, J.A. Hutton, James A. Brannigan, Andrew Simon Bell, Robin J. Leatherbarrow, Daniel Paape, Anthony J. Wilkinson, Megan H. Wright, Charlotte L. Sutherell, Edward W. Tate, Markus Ritzefeld, Deborah F. Smith

المساهمون: Wellcome Trust

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Medicinal & Biomolecular Chemistry, Antiprotozoal Agents, Protozoan Proteins, Leishmania donovani, Thiophenes, 01 natural sciences, 0305 Organic Chemistry, Article, Structure-Activity Relationship, 03 medical and health sciences, Parasitic Sensitivity Tests, Drug Discovery, parasitic diseases, Structure–activity relationship, Leishmania major, Enzyme Inhibitors, Amastigote, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Binding Sites, Molecular Structure, biology, 0304 Medicinal and Biomolecular Chemistry, Leishmania, biology.organism_classification, 3. Good health, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Biomarker, Pyrimidines, Enzyme, chemistry, Biochemistry, Molecular Medicine, 1115 Pharmacology and Pharmaceutical Sciences, Acyltransferases, Intracellular, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9f2666a304fae6a1cac6032c4a5f81
http://hdl.handle.net/10044/1/80204

المؤلفون: Helen P Price, Michael R Hodgkinson, Rachel S Curwen, Lorna M MacLean, James A Brannigan, Mark Carrington, Barbara A Smith, David A Ashford, Meg Stark, Deborah F Smith

المصدر: PLoS ONE, Vol 7, Iss 2, p e31842 (2012)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3282761?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/05e371e1ed47422a9b66e0883ba2a621

المؤلفون: Andrew S Bell, James E Mills, Gareth P Williams, James A Brannigan, Anthony J Wilkinson, Tanya Parkinson, Robin J Leatherbarrow, Edward W Tate, Anthony A Holder, Deborah F Smith

المصدر: PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1625 (2012)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3335879?pdf=render; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

URL الوصول: https://doaj.org/article/f9cdeabdf89e4f4f804ccc4da454aa0f

المؤلفون: Claudia Schnick, Spencer D. Polley, Quinton L. Fivelman, Lisa C. Ranford-cartwright, Shane R. Wilkinson, James A. Brannigan, Anthony J. Wilkinson, David A. Baker

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://eprints.gla.ac.uk/4842/1/structureandnonessential.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.514.2046; http://eprints.gla.ac.uk/4842/1/structureandnonessential.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.514.2046
http://eprints.gla.ac.uk/4842/1/structureandnonessential.pdf

المؤلفون: E. N. Baker, Z. Dauter, Lisa Wright, Elena Blagova, Vladimir M. Levdikov, James A. Brannigan, Rebecca J, Janet Chambers, Anthony J. Wilkinson, James A, Brannigan Rebecca J

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://eprints.whiterose.ac.uk/457/1/branniganja14.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.620.9382; http://eprints.whiterose.ac.uk/457/1/branniganja14.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.620.9382
http://eprints.whiterose.ac.uk/457/1/branniganja14.pdf

المؤلفون: Amrita Kumar, James A. Brannigan, Charles P. Moran

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jb.asm.org/content/186/4/1078.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.611.2715; http://jb.asm.org/content/186/4/1078.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.611.2715
http://jb.asm.org/content/186/4/1078.full.pdf

المؤلفون: Ngo T. Hoa, James A. Brannigan, Simon M. Cutting

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://eprints.whiterose.ac.uk/313/1/branniganja2.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.597.1063; http://eprints.whiterose.ac.uk/313/1/branniganja2.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.597.1063
http://eprints.whiterose.ac.uk/313/1/branniganja2.pdf

المؤلفون: Ngo T. Hoa, James A. Brannigan, Simon M. Cutting

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jb.asm.org/content/183/14/4364.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.336.5786; http://jb.asm.org/content/183/14/4364.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.336.5786
http://jb.asm.org/content/183/14/4364.full.pdf

المؤلفون: Marguerite A. Cervin, Richard J. Lewis, James A. Brannigan, George B. Spiegelman

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://nar.oxfordjournals.org/content/26/16/3806.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.3805; http://nar.oxfordjournals.org/content/26/16/3806.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.3805
http://nar.oxfordjournals.org/content/26/16/3806.full.pdf

المؤلفون: R.J. Spears, James A. Brannigan, Martin A. Fascione, A. Marek Brzozowski, Tessa Keenan, Sophie McKenna, Robin Brabham, Darshita Budhadev, Julia Walton, Michael J. Plevin, Anthony J. Wilkinson

مصطلحات موضوعية: chemistry.chemical_classification, Bioconjugation, Lysis, Tandem, 010405 organic chemistry, General Chemistry, 010402 general chemistry, Oxime, 01 natural sciences, Aldehyde, Small molecule, Combinatorial chemistry, 3. Good health, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Aldol reaction, Neutral ph

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f812031f09948e80a10316a61e59c408

المؤلفون: Sureshkumar Ramasamy, Cheravakkattu G. Suresh, Priyabrata Panigrahi, Nishant Kumar Varshney, Anthony J. Wilkinson, James A. Brannigan, Deepak Chand

المصدر: Protein Science. 24:1660-1670

مصطلحات موضوعية: chemistry.chemical_classification, biology, Stereochemistry, Mutant, Homoserine, Active site, Substrate (chemistry), Peptide, Biochemistry, Serine, chemistry.chemical_compound, Enzyme, chemistry, biology.protein, Molecular Biology, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4b7f190413caef093eb9feac61e3f02c
https://doi.org/10.1002/pro.2761

المؤلفون: Robin J. Leatherbarrow, Edward W. Tate, Kaveri Rangachari, Anthony A. Holder, Z. Yu, Anthony J. Wilkinson, William P. Heal, James A. Brannigan

المصدر: MedChemComm. 6:1767-1772

مصطلحات موضوعية: Stereochemistry, Pharmaceutical Science, Biology, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Potency, Transferase, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, Plasmodium falciparum, biology.organism_classification, Small molecule, 3. Good health, 0104 chemical sciences, Enzyme, chemistry, Lipophilicity, Molecular Medicine, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d2d2e65be66aa49e14fe70336105633a
https://doi.org/10.1039/c5md00242g

المؤلفون: Amin S. Asfor, Robin J. Leatherbarrow, Iva Hopkins-Navratilova, Aurelie Mousnier, Sean Robinson, Anabel Guedán, Inmaculada Pérez-Dorado, Andrew Simon Bell, Joseph Newman, Anthony J. Wilkinson, Markus Ritzefeld, Roberto Solari, Edward W. Tate, J.A. Hutton, Dawid Swieboda, Sebastian L. Johnston, Tobias J. Tuthill, James A. Brannigan, Julia Morales-Sanfrutos

المساهمون: Medical Research Council (MRC), Wellcome Trust, Asthma UK, GlaxoSmithKline Services Unlimited, Cancer Research UK

المصدر: Nature chemistry
Mousnier, A, Bell, A S, Swieboda, D P, Morales-Sanfrutos, J, Pérez-Dorado, I, Brannigan, J A, Newman, J, Ritzefeld, M, Hutton, J A, Guedán, A, Asfor, A S, Robinson, S W, Hopkins-Navratilova, I, Wilkinson, A J, Johnston, S L, Leatherbarrow, R J, Tuthill, T J, Solari, R & Tate, E W 2018, ' Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus ', Nature chemistry, vol. 10, no. 6, pp. 599-606 . https://doi.org/10.1038/s41557-018-0039-2

مصطلحات موضوعية: 0301 basic medicine, Viral capsid assembly, Rhinovirus, Chemistry, Multidisciplinary, General Chemical Engineering, viruses, PREVENTS, medicine.disease_cause, Virus Replication, 01 natural sciences, INFECTION, Enzyme Inhibitors, Cytotoxicity, Molecular Structure, Chemistry, Poliovirus, NMT2, MYRISTOYLATION, 3. Good health, Capsid, Physical Sciences, PROTEOMICS, 03 Chemical Sciences, Antiviral Agents, Virus, Article, 03 medical and health sciences, Inhibitory Concentration 50, SDG 3 - Good Health and Well-being, medicine, Humans, Myristoylation, Science & Technology, CYSTIC-FIBROSIS, 010405 organic chemistry, Virus Assembly, Organic Chemistry, General Chemistry, Virology, 0104 chemical sciences, 030104 developmental biology, CELLS, ASTHMA, Linker, Acyltransferases, HeLa Cells

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48995809560d4e285bfb8d4e0d3fcd39
https://pubmed.ncbi.nlm.nih.gov/29760414

المؤلفون: Neil J. Rzechorzek, L. G. Carter, Karl Harlos, Keith S. Wilson, David I. Stuart, Axel Müller, Olga V. Moroz, Robert Kaptein, T. Dierks, Ian W. Boucher, Raymond J. Owens, Rosa Grenha, Robert Esnouf, Elena Blagova, Thomas S. Walter, M. P. Boyle, Nathan R. Zaccai, Vladimir M. Levdikov, Gert E. Folkers, Nick S. Berrow, Mark J. Fogg, N. Milioti, Sarah Sainsbury, Kin Fai Au, Anthony J. Wilkinson, David G. Waterman, Anne K. Kalliomaa, Christoph Meier, James A. Brannigan

مصطلحات موضوعية: DNA, Bacterial, Proteomics, TRNA modification, Magnetic Resonance Spectroscopy, Genetic Vectors, Target analysis, Computational biology, Crystallography, X-Ray, Structural genomics, Protein structure, Bacillus cereus, Bacterial Proteins, RNA, Transfer, Structural Biology, Escherichia coli, Cloning, Molecular, SPINE (molecular biology), Spores, Bacterial, biology, Reverse Transcriptase Polymerase Chain Reaction, Ligation-independent cloning, Computational Biology, General Medicine, Robotics, biology.organism_classification, Bacillus anthracis, Biochemistry, Sulfurtransferases, Crystallization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ecc1e6775977e5fbe2992297572c20
https://doi.org/10.1107/s0907444906033555

المؤلفون: James A. Brannigan, Anthony J. Wilkinson

المصدر: Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery

مصطلحات موضوعية: Cycloguanil, Drug discovery, Sulfadoxine, medicine.medical_treatment, Biology, medicine.disease, biology.organism_classification, Virology, Plasmodium, Pyrimethamine, medicine, N-myristoyltransferase, Malaria, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::291dea8106c2dd1aef4bd2010f780a34
https://doi.org/10.1002/9783527694082.ch12

المؤلفون: Anthony A. Holder, Z. Yu, Edward W. Tate, D.K. Moss, Mark David Rackham, James A. Brannigan, Robin J. Leatherbarrow, Anthony J. Wilkinson

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, Brief Article, Stereochemistry, Antiparasitic, medicine.drug_class, Plasmodium falciparum, Plasmodium vivax, Thiophenes, Plasma protein binding, Crystallography, X-Ray, Ligands, Antimalarials, Structure-Activity Relationship, chemistry.chemical_compound, Parasitic Sensitivity Tests, parasitic diseases, Drug Discovery, medicine, Structure–activity relationship, Ligand efficiency, Molecular Structure, biology, Ligand, Benzothiophene, biology.organism_classification, chemistry, Biochemistry, Molecular Medicine, Acyltransferases, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361c68b577585774d496872664c00caf
https://doi.org/10.1021/jm301474t