المؤلفون: Harriet V Mears, George R Young, Theo Sanderson, Ruth Harvey, Jamie Barrett-Rodger, Rebecca Penn, Vanessa Cowton, Wilhelm Furnon, Giuditta De Lorenzo, Margaret Crawford, Daniel M Snell, Ashley S Fowler, Anob M Chakrabarti, Saira Hussain, Ciarán Gilbride, Edward Emmott, Katja Finsterbusch, Jakub Luptak, Thomas P Peacock, Jérôme Nicod, Arvind H Patel, Massimo Palmarini, Emma Wall, Bryan Williams, Sonia Gandhi, Charles Swanton, David L V Bauer

المصدر: PLoS Biology, Vol 23, Iss 1, p e3002982 (2025)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

URL الوصول: https://doaj.org/article/221751f24ca94b9485c64aed93b696a3

المؤلفون: Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F. Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L. Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C. James

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/9847497c03534f53b81f80ff92484d91

المؤلفون: Jakub Luptak, Donna L. Mallery, Aminu S. Jahun, Anna Albecka, Dean Clift, Osaid Ather, Greg Slodkowicz, Ian Goodfellow, Leo C. James

المصدر: Viruses, Vol 14, Iss 8, p 1610 (2022)

مصطلحات موضوعية: TRIM7, coxsackievirus, norovirus, 3C protease, 3Cpro, Mpro, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/8/1610; https://doaj.org/toc/1999-4915

URL الوصول: https://doaj.org/article/de751fb30f1643d5ae43609ef27a7402

المؤلفون: Guido Papa, Donna L Mallery, Anna Albecka, Lawrence G Welch, Jérôme Cattin-Ortolá, Jakub Luptak, David Paul, Harvey T McMahon, Ian G Goodfellow, Andrew Carter, Sean Munro, Leo C James

المصدر: PLoS Pathogens, Vol 17, Iss 1, p e1009246 (2021)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/e7f61576d1094208b86f915b6e68af06

المؤلفون: Suzanne Pickering, Gilberto Betancor, Rui Pedro Galão, Blair Merrick, Adrian W Signell, Harry D Wilson, Mark Tan Kia Ik, Jeffrey Seow, Carl Graham, Sam Acors, Neophytos Kouphou, Kathryn J A Steel, Oliver Hemmings, Amita Patel, Gaia Nebbia, Sam Douthwaite, Lorcan O'Connell, Jakub Luptak, Laura E McCoy, Philip Brouwer, Marit J van Gils, Rogier W Sanders, Rocio Martinez Nunez, Karen Bisnauthsing, Geraldine O'Hara, Eithne MacMahon, Rahul Batra, Michael H Malim, Stuart J D Neil, Katie J Doores, Jonathan D Edgeworth

المصدر: PLoS Pathogens, Vol 16, Iss 9, p e1008817 (2020)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/9e47f97b555e4d8f826354c685f40001

المؤلفون: George Carnell, James A. Nathan, Jessica Gronlund, Mina Paloniemi, Jakub Luptak, Paul Tonks, Sumita Pai, Soraya Ebrahimi, David A. Wells, Sara Lear, Leo C. James, Lourdes Ceron-Gutierrez, Rainer Döffinger, Helen Baxendale, Jonathan L. Heeney, John A. G. Briggs, Ashleigh Sayer, Angalee Nadesalingham, Guinevere L. Grice, Xiaoli Ziong

المصدر: The Journal of Critical Care Medicine
The Journal of Critical Care Medicine, Vol 7, Iss 3, Pp 199-210 (2021)

مصطلحات موضوعية: medicine.medical_specialty, seroprevalence, business.industry, RC86-88.9, SARS-CoV-2, Convalescence, media_common.quotation_subject, COVID-19, Medical emergencies. Critical care. Intensive care. First aid, General Medicine, medicine.disease, health care workers, critical care, Intensive care, Pandemic, Health care, Cohort, Emergency medicine, Hospital-acquired infection, medicine, Seroprevalence, Seroconversion, business, media_common, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d739dfeed0b0cac306b431a75c6246
http://europepmc.org/articles/PMC8519390

المؤلفون: Leo Kiss, Tyler Rhinesmith, Claire F Dickson, Jonas Weidenhausen, Shannon Smyly, Jakub Luptak, Ji-Chun Yang, Sarah L Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C James

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2ff087e88dc61ef593889cbe848b8038
https://doi.org/10.1101/2022.06.29.498105

المؤلفون: Harriet V Mears, George R Young, Theo Sanderson, Ruth Harvey, Margaret Crawford, Daniel M Snell, Ashley S Fowler, Saira Hussain, Jérôme Nicod, Thomas P Peacock, Edward Emmott, Katja Finsterbusch, Jakub Luptak, Emma Wall, Bryan Williams, Sonia Gandhi, Charles Swanton, David LV Bauer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2338afcfbde3f4f1b0a5b1348c124568
https://doi.org/10.1101/2022.04.20.488895

المؤلفون: Rainer Doffinger, Jonathan L. Heeney, S. Pai, J. Gronlund, Leo C. James, A. Sayer, John A. G. Briggs, Soraya Ebrahimi, Helen Baxendale, James A. Nathan, Lourdes Ceron-Gutierrez, Xiaoli Xiong, Jakub Luptak, Paul Tonks, M. Paloniemi, Angalee Nadesalingam, David A. Wells, Guinevere L. Grice, George Carnell

المساهمون: Carnell, George [0000-0001-8875-0989], Tonks, Paul [0000-0003-3512-5631], Nathan, James [0000-0002-0248-1632], Luptak, Jakub [0000-0002-9527-8755], Heeney, Jonathan [0000-0003-2702-1621], Apollo - University of Cambridge Repository

مصطلحات موضوعية: medicine.medical_specialty, seroprevalence, business.industry, SARS-CoV-2, Convalescence, media_common.quotation_subject, COVID-19, health care workers, critical care, Intensive care, Workforce, Emergency medicine, Health care, Cohort, Medicine, Seroprevalence, Anxiety, Seroconversion, medicine.symptom, business, media_common

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38569d413671ad0422358d6e87147fe0

المؤلفون: Liz Flavell, Jakub Luptak, David J. Hargreaves, Steven L. Kazmirski, Tina Howard, Kate F. Wickson, Ning Gao, David I Fisher, Michal Bista, Philip B. Rawlins

المصدر: Acta Crystallographica. Section D, Structural Biology

مصطلحات موضوعية: Programmed cell death, Myeloid, drug design, Cell, Apoptosis, CHO Cells, scFv, 03 medical and health sciences, Immunoglobulin Fab Fragments, 0302 clinical medicine, Cricetulus, Structural Biology, hemic and lymphatic diseases, Drug Discovery, medicine, Escherichia coli, Animals, Humans, Fab, Cloning, Molecular, 030304 developmental biology, 0303 health sciences, biology, Drug discovery, Chemistry, Cancer, Mcl-1, medicine.disease, Research Papers, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Myeloid Cell Leukemia Sequence 1 Protein, Antibody, Function (biology), Single-Chain Antibodies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f1ff2f5c281e68c59c2e4b03cee5ac
http://europepmc.org/articles/PMC6834078

المؤلفون: Leo C. James, Aamir S. Mukadam, David A. Jacques, Leo Kiss, William A. McEwan, Christopher M. Johnson, Nadine Renner, Ana Filipa Santos, Eurico Morais-de-Sá, Marina Vaysburd, Claire F. Dickson, Dean Clift, Jingwei Zeng, Jakub Luptak, Mariana Osswald, Stephen H. McLaughlin

المصدر: Nat Struct Mol Biol

مصطلحات موضوعية: Models, Molecular, Proteolysis, Ubiquitin-Protein Ligases, Plasma protein binding, Protein degradation, Article, Cell Line, 03 medical and health sciences, Mice, 0302 clinical medicine, Ubiquitin, Structural Biology, Antibody receptor, medicine, Huntingtin Protein, Animals, Humans, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, medicine.diagnostic_test, Chemistry, Ubiquitination, Ubiquitin ligase, Cell biology, Optogenetics, Cytosol, Drosophila melanogaster, Ribonucleoproteins, biology.protein, Biocatalysis, Protein Multimerization, Peptides, 030217 neurology & neurosurgery, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95319461771d8a5b6e3f5ff62e1a43c8
https://europepmc.org/articles/PMC7611929/

المؤلفون: Christopher M. Johnson, Claire F. Dickson, Nadine Renner, Marina Vaysburd, Jakub Luptak, Dean Clift, David A. Jacques, Leo C. James, Ana Filipa Santos, Eurico Morais-de-Sá, Jingwei Zeng, Aamir S. Mukadam, William A. McEwan, Mariana Osswald

مصطلحات موضوعية: chemistry.chemical_classification, Cytosol, DNA ligase, chemistry, Ubiquitin, biology, Mechanism (biology), Antibody receptor, biology.protein, Protein degradation, Ring (chemistry), Trim, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5330dfd9d8ebe28eec060f1b17030504
https://doi.org/10.1101/2020.07.28.225359

المؤلفون: Guido Papa (10031914), Donna L. Mallery (10031917), Anna Albecka (10031920), Lawrence G. Welch (10031923), Jérôme Cattin-Ortolá (2794252), Jakub Luptak (9415797), David Paul (659614), Harvey T. McMahon (10031926), Ian G. Goodfellow (8232648), Andrew Carter (62939), Sean Munro (33986), Leo C. James (9204820)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Immunology, Cancer, Hematology, Infectious Diseases, Virology, Acute Respiratory Syndrome coronavi., CRISPR-Cas 9 knockout, host cell receptor ACE 2, S 1-S boundary, S 1-S cleavage, mediates cell-cell fusion, SARS-CoV -2 virus, spread, multibasic site, TMPRSS 2-dependent cell-cell fusion, TMPRSS 2 processing, virus-host membrane fusion, multibasic site mutants, SARS-CoV -2 S protein, SARS-CoV -2 infectivity, SARS-CoV -2 Spike, furin knockout cells

Relation: https://figshare.com/articles/figure/TMPRSS2_protease_is_required_on_acceptor_cells_to_trigger_cell-cell_fusion_/13639999

الاتاحة: https://doi.org/10.1371/journal.ppat.1009246.g005

المؤلفون: Guido Papa (10031914), Donna L. Mallery (10031917), Anna Albecka (10031920), Lawrence G. Welch (10031923), Jérôme Cattin-Ortolá (2794252), Jakub Luptak (9415797), David Paul (659614), Harvey T. McMahon (10031926), Ian G. Goodfellow (8232648), Andrew Carter (62939), Sean Munro (33986), Leo C. James (9204820)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Immunology, Cancer, Hematology, Infectious Diseases, Virology, Acute Respiratory Syndrome coronavi., CRISPR-Cas 9 knockout, host cell receptor ACE 2, S 1-S boundary, S 1-S cleavage, mediates cell-cell fusion, SARS-CoV -2 virus, spread, multibasic site, TMPRSS 2-dependent cell-cell fusion, TMPRSS 2 processing, virus-host membrane fusion, multibasic site mutants, SARS-CoV -2 S protein, SARS-CoV -2 infectivity, SARS-CoV -2 Spike, furin knockout cells

Relation: https://figshare.com/articles/figure/Generation_of_stable_hACE2_and_TMPRSS2_overexpressing_293T_cell_lines_and_deletion_of_FURIN_in_293T_cells_by_CRISPR-Cas9_gene_editing_/13639975

الاتاحة: https://doi.org/10.1371/journal.ppat.1009246.s001

المؤلفون: Guido Papa (10031914), Donna L. Mallery (10031917), Anna Albecka (10031920), Lawrence G. Welch (10031923), Jérôme Cattin-Ortolá (2794252), Jakub Luptak (9415797), David Paul (659614), Harvey T. McMahon (10031926), Ian G. Goodfellow (8232648), Andrew Carter (62939), Sean Munro (33986), Leo C. James (9204820)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Immunology, Cancer, Hematology, Infectious Diseases, Virology, Acute Respiratory Syndrome coronavi., CRISPR-Cas 9 knockout, host cell receptor ACE 2, S 1-S boundary, S 1-S cleavage, mediates cell-cell fusion, SARS-CoV -2 virus, spread, multibasic site, TMPRSS 2-dependent cell-cell fusion, TMPRSS 2 processing, virus-host membrane fusion, multibasic site mutants, SARS-CoV -2 S protein, SARS-CoV -2 infectivity, SARS-CoV -2 Spike, furin knockout cells

Relation: https://figshare.com/articles/figure/Deletion_of_TMPRSS2_in_293T_cells_by_CRISPR-Cas9_gene_editing_/13639981

الاتاحة: https://doi.org/10.1371/journal.ppat.1009246.s003

المؤلفون: Guido Papa (10031914), Donna L. Mallery (10031917), Anna Albecka (10031920), Lawrence G. Welch (10031923), Jérôme Cattin-Ortolá (2794252), Jakub Luptak (9415797), David Paul (659614), Harvey T. McMahon (10031926), Ian G. Goodfellow (8232648), Andrew Carter (62939), Sean Munro (33986), Leo C. James (9204820)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Immunology, Cancer, Hematology, Infectious Diseases, Virology, Acute Respiratory Syndrome coronavi., CRISPR-Cas 9 knockout, host cell receptor ACE 2, S 1-S boundary, S 1-S cleavage, mediates cell-cell fusion, SARS-CoV -2 virus, spread, multibasic site, TMPRSS 2-dependent cell-cell fusion, TMPRSS 2 processing, virus-host membrane fusion, multibasic site mutants, SARS-CoV -2 S protein, SARS-CoV -2 infectivity, SARS-CoV -2 Spike, furin knockout cells

Relation: https://figshare.com/articles/figure/Deletion_of_FURIN_in_Vero_cells_did_not_impact_the_formation_of_multinucleated_cells_/13639978

الاتاحة: https://doi.org/10.1371/journal.ppat.1009246.s002

المؤلفون: Guido Papa (10031914), Donna L. Mallery (10031917), Anna Albecka (10031920), Lawrence G. Welch (10031923), Jérôme Cattin-Ortolá (2794252), Jakub Luptak (9415797), David Paul (659614), Harvey T. McMahon (10031926), Ian G. Goodfellow (8232648), Andrew Carter (62939), Sean Munro (33986), Leo C. James (9204820)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Immunology, Cancer, Hematology, Infectious Diseases, Virology, Acute Respiratory Syndrome coronavi., CRISPR-Cas 9 knockout, host cell receptor ACE 2, S 1-S boundary, S 1-S cleavage, mediates cell-cell fusion, SARS-CoV -2 virus, spread, multibasic site, TMPRSS 2-dependent cell-cell fusion, TMPRSS 2 processing, virus-host membrane fusion, multibasic site mutants, SARS-CoV -2 S protein, SARS-CoV -2 infectivity, SARS-CoV -2 Spike, furin knockout cells

Relation: https://figshare.com/articles/figure/SARS-CoV-2_S_protein_mediates_cell-cell_fusion_between_different_cell_types_/13639987

الاتاحة: https://doi.org/10.1371/journal.ppat.1009246.g001

المؤلفون: Guido Papa (10031914), Donna L. Mallery (10031917), Anna Albecka (10031920), Lawrence G. Welch (10031923), Jérôme Cattin-Ortolá (2794252), Jakub Luptak (9415797), David Paul (659614), Harvey T. McMahon (10031926), Ian G. Goodfellow (8232648), Andrew Carter (62939), Sean Munro (33986), Leo C. James (9204820)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Immunology, Cancer, Hematology, Infectious Diseases, Virology, Acute Respiratory Syndrome coronavi., CRISPR-Cas 9 knockout, host cell receptor ACE 2, S 1-S boundary, S 1-S cleavage, mediates cell-cell fusion, SARS-CoV -2 virus, spread, multibasic site, TMPRSS 2-dependent cell-cell fusion, TMPRSS 2 processing, virus-host membrane fusion, multibasic site mutants, SARS-CoV -2 S protein, SARS-CoV -2 infectivity, SARS-CoV -2 Spike, furin knockout cells

Relation: https://figshare.com/articles/figure/Furin_enhances_SARS-CoV-2_replication_but_is_not_essential_for_S-pseudovirus_entry_/13639996

الاتاحة: https://doi.org/10.1371/journal.ppat.1009246.g004

المؤلفون: Guido Papa (10031914), Donna L. Mallery (10031917), Anna Albecka (10031920), Lawrence G. Welch (10031923), Jérôme Cattin-Ortolá (2794252), Jakub Luptak (9415797), David Paul (659614), Harvey T. McMahon (10031926), Ian G. Goodfellow (8232648), Andrew Carter (62939), Sean Munro (33986), Leo C. James (9204820)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Immunology, Cancer, Hematology, Infectious Diseases, Virology, Acute Respiratory Syndrome coronavi., CRISPR-Cas 9 knockout, host cell receptor ACE 2, S 1-S boundary, S 1-S cleavage, mediates cell-cell fusion, SARS-CoV -2 virus, spread, multibasic site, TMPRSS 2-dependent cell-cell fusion, TMPRSS 2 processing, virus-host membrane fusion, multibasic site mutants, SARS-CoV -2 S protein, SARS-CoV -2 infectivity, SARS-CoV -2 Spike, furin knockout cells

Relation: https://figshare.com/articles/figure/Furin_is_not_essential_for_the_cleavage_of_S_protein_but_enhances_its_processing_/13639990

الاتاحة: https://doi.org/10.1371/journal.ppat.1009246.g002

المؤلفون: Guido Papa (10031914), Donna L. Mallery (10031917), Anna Albecka (10031920), Lawrence G. Welch (10031923), Jérôme Cattin-Ortolá (2794252), Jakub Luptak (9415797), David Paul (659614), Harvey T. McMahon (10031926), Ian G. Goodfellow (8232648), Andrew Carter (62939), Sean Munro (33986), Leo C. James (9204820)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Immunology, Cancer, Hematology, Infectious Diseases, Virology, Acute Respiratory Syndrome coronavi., CRISPR-Cas 9 knockout, host cell receptor ACE 2, S 1-S boundary, S 1-S cleavage, mediates cell-cell fusion, SARS-CoV -2 virus, spread, multibasic site, TMPRSS 2-dependent cell-cell fusion, TMPRSS 2 processing, virus-host membrane fusion, multibasic site mutants, SARS-CoV -2 S protein, SARS-CoV -2 infectivity, SARS-CoV -2 Spike, furin knockout cells

Relation: https://figshare.com/articles/figure/Processing_of_the_S_protein_multibasic_site_is_essential_for_cell-cell_fusion_but_furin_is_dispensable_/13639993

الاتاحة: https://doi.org/10.1371/journal.ppat.1009246.g003