المؤلفون: Farzan Solimani, Katharina Meier, Kamran Ghoreschi

المصدر: Frontiers in Immunology, Vol 10 (2019)

مصطلحات موضوعية: inflammatory skin diseases, JAK (Janus kinase), JAK inhibition, pathophysiology, immunopathogenesis, autoimmune skin diseases, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02847/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/8200ff9572dc49c09c395208a69d4c79

المؤلفون: Hiroshi Yamanaka, Makoto Shiozaki, Satoru Noji, Tomoya Miura, Yoshinori Hara, 三浦 智也, 原 義典, 塩﨑 真, 山中 浩, 野路 悟

المصدر: MEDCHEM NEWS. 2021, 31(2):68

المؤلفون: Solimani, Farzan, Meier, Katharina, Ghoreschi, Kamran

مصطلحات موضوعية: JAK (Janus kinase), JAK inhibition, JAK/STAT pathway, autoimmune skin diseases, immunopathogenesis, inflammatory skin diseases, pathophysiology, ddc:610

وصف الملف: application/pdf

Relation: https://refubium.fu-berlin.de/handle/fub188/26308; http://dx.doi.org/10.17169/refubium-26067

الاتاحة: https://refubium.fu-berlin.de/handle/fub188/26308
https://doi.org/10.17169/refubium-26067
https://doi.org/10.3389/fimmu.2019.02847

المؤلفون: Amer Al-Musa, Brenna LaBere, Saddiq Habiballah, Alan A. Nguyen, Janet Chou

المصدر: The Journal of Allergy and Clinical Immunology

مصطلحات موضوعية: BMI, body mass index, RR, relative risk, Risk Factors, SOCS1, Suppressor of Cytokine Signaling, Immunology and Allergy, TNF-α, tumor necrosis factor alpha, COVID-19, Coronavirus disease 2019, Sulfonamides, LRBA, Lipopolysaccharide-Responsive Beige-Like Anchor Protein, Antibodies, Monoclonal, Prognosis, MCP, monocyte chemotactic protein, Treatment Outcome, CXCL, CXC motif chemokine ligand, JAK, Janus kinase, CVID, common variable immunodeficiency, TLR, Toll-like receptor, CYBB, beta subunit of cytochrome b, MIS-C, Multisystem Inflamatory Syndrome in Children, COVID-19 Vaccines, BAL, bronchial lavage fluid, Immunology, XIAP, X-linked Inhibitor of Apoptosis, primary immunodeficiency, ACE2, angiotensin-converting enzyme 2, Antiviral Agents, Article, EUA, emergency use authorization, PIDs, primary immunodeficiencies, MHC, major histocompatibility complex, Humans, biologics, IFN, interferon, CCL, C-C motif ligand, RCT, randomized control trial, PEG, polyethylene glycol, Biological Products, SARS-CoV-2, Interleukin-6, Immunologic Deficiency Syndromes, COVID-19, asthma, HR, hazard ratio, Survival Analysis, CI, confidence interval, OR, odds ratio, IVIG, intravenous immunoglobulin, Interleukin 1 Receptor Antagonist Protein, Purines, Azetidines, Pyrazoles, CTLA-4, Cytotoxic T-lymphocyte-Associated Protein 4, ECMO, extracorporeal membrane oxygenation, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078357d10622749990a0e5c126f1cecf
https://doi.org/10.1016/j.jaci.2021.12.775

المؤلفون: Andreas Zollner, Nicole Przysiecki, Sophie Macheiner, Vera Reinstadler, Barbara Jelusic, Simon J. Reider, Herbert Tilg, Christina Watschinger, Alexandra Pfister, Herbert Oberacher, Alexander R. Moschen, Bernhard Texler

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 383-404 (2022)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: JAKi, Janus kinase inhibitor, medicine.medical_treatment, PHA, phytohemagglutinin, Cell Communication, RC799-869, Pharmacology, CD8-Positive T-Lymphocytes, M-CSF, macrophage colony-stimulating factor, IEC, intestinal epithelial cell, Mice, DI, division index, Piperidines, TNF-α, tumor necrosis factor α, Original Research, tofacitinib, IBD, inflammatory bowel disease, Chemistry, LC-MS/MS, liquid chromatography–tandem mass spectrometry, Gastroenterology, PI, proliferation index, CFSE, carboxyfluorescein succinimidyl ester, ELISA, enzyme-linked immunosorbent assay, Diseases of the digestive system. Gastroenterology, Acquired immune system, mRNA, messenger RNA, Cytokine, medicine.anatomical_structure, Editorial, JAK inhibitor, LPS, lipopolysaccharide, medicine.symptom, JAK, Janus kinase, pharmacokinetics, IHC, immunohistochemistry, PBMC, peripheral blood mononuclear cell, ATP, adenosine triphosphate, FSC, forward scatter, Regulatory T cell, PBS, phosphate-buffered saline, IFNγ, interferon γ, Inflammation, STAT, signal transducers and activator of transcription, Immune system, inflammatory bowel disease, DSS, dextran sulfate sodium, 3D, 3-dimensional, medicine, CD, Crohn’s disease, Animals, Humans, Th, T helper, Innate immune system, Tofacitinib, Hepatology, mucosal inflammation, Immunity, Innate, IL, interleukin, UC, ulcerative colitis, Pyrimidines, Janus kinase, ENT, equilibrative nucleoside transporter, ASV, amplicon sequence variant

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6e0dffe3ffcc5c8d849bd534a91dfc
http://www.sciencedirect.com/science/article/pii/S2352345X21001922

المؤلفون: Norito Katoh, Yukihiro Ohya, Hiroyuki Murota, Masanori Ikeda, Xiaofei Hu, Kimitoshi Ikeda, John Liu, Takuya Sasaki, Alvina D. Chu, Henrique D. Teixeira, Hidehisa Saeki

المصدر: JAAD International
JAAD International, Vol 6, Iss, Pp 27-36 (2022)

مصطلحات موضوعية: safety, Janus kinase inhibitors, SAE, serious adverse event, vIGA-AD, validated Investigator's Global Assessment for Atopic Dermatitis, atopic dermatitis, EASI, Eczema Area and Severity Index, EASI 90, ≥90% improvement in Eczema Area and Severity Index, fungi, TCS, topical corticosteroid, clinical trial, Dermatology, AD, atopic dermatitis, topical corticosteroids, upadacitinib, CPK, creatine phosphokinase, RL1-803, EASI 50, ≥50% improvement in eczema area and severity index, EASI 75, ≥75% improvement in Eczema Area and Severity Index, AESI, adverse event of special interest, Original Article, eczema, JAK, Janus kinase, AE, adverse event, TEAE, treatment-emergent adverse event

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dad6f61d4be10299f03e3bb56e5a83f
http://europepmc.org/articles/PMC8693619

المؤلفون: Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)

مصطلحات موضوعية: Genome instability, PD-L1, programmed death ligand 1, BRCA, breast cancer susceptibility gene, ICI, immune checkpoint inhibitor, medicine.medical_treatment, MUTYH, MutY homolog, cGAS, cyclic GMP–AMP synthase, Review, DNA damage response, Malignant transformation, ORR, objective response rate, PCR, polymerase chain reaction, 0302 clinical medicine, SCNAs, somatic copy number alterations, FDA, United State Food and Drug Administration, Cancer immunotherapy, MGMT, O6-methylguanine methyltransferase, PD-1, RB1, retinoblastoma 1, General Pharmacology, Toxicology and Pharmaceutics, BER, base excision repair, RAD51C, RAD51 homolog C, 0303 health sciences, TME, tumor microenvironment, TP53, tumor protein P53, cGAS–STING, MSI, microsatellite instability, TRIF, Toll-interleukin 1 receptor domain-containing adaptor inducing INF-β, PFS, progression-free survival, STAT, signal transducer and activator of transcription, NEK1, NIMA-related kinase 1, Tumor microenvironment, PALB2, partner and localizer of BRCA2, RSR, replication stress response, 030220 oncology & carcinogenesis, Immunotherapy, PARP, poly-ADP ribose polymerase, JAK, Janus kinase, IHC, immunohistochemistry, Genomic instability, PD-L1, DSBs, double-strand breaks, DNA repair, DNA damage, CHK1, checkpoint kinase 1, IRF1, interferon regulatory factor 1, MLH1, MutL homolog 1, RM1-950, MMR, mismatch repair, STING, stimulator of interferon genes, Biology, MNT, MAX network transcriptional repressor, DDR, DNA damage response, MSH2/6, MutS protein homologue-2/6, OS, overall survival, RPA, replication protein A, 03 medical and health sciences, GSK3β, glycogen synthase kinase 3β, NER, nucleotide excision repair, NSCLC, non-small cell lung cancer, MyD88, myeloid differentiation factor 88, ssDNA, single-stranded DNA, medicine, DAMP, damage-associated molecular patterns, DR, direct repair, 030304 developmental biology, BAP1, BRCA1-associated protein 1, BRAF, v-RAF murine sarcoma viral oncogene homologue B, TLR4, Toll-like receptor 4, Cancer, NGS, next generation sequencing, ATM, ataxia-telangiectasia mutated, NIMA, never-in-mitosis A, medicine.disease, CHEK, cell-cycle checkpoint kinase, PD-1, programmed death 1, MAD1, mitotic arrest deficient-like 1, body regions, IFNγ, interferon gamma, TILs, tumor-infiltrating lymphocytes, TBK1, TANK-binding kinase 1, ATR, ataxia telangiectasia and Rad3 related, Cancer research, NHEJ, nonhomologous end-joining, Therapeutics. Pharmacology, HMGB1, high mobility group box-1, HRR, homologous recombination repair, XRCC4, X-ray repair cross complementing protein 4, TMB, tumor mutational burden

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe73202674a833d134ec811bcbf7332
https://doi.org/10.1016/j.apsb.2021.01.003

المؤلفون: Jan P. Dutz, Evelyne Bonnardeaux

المصدر: JAAD Case Reports
JAAD Case Reports, Vol 20, Iss, Pp 61-64 (2022)

مصطلحات موضوعية: medicine.medical_specialty, Tofacitinib, tofacitinib, JAK inhibitors, business.industry, CLASI, cutaneous lupus erythematosus disease area and severity index, Dermatology, cutaneous lupus erythematosus, CLE, cutaneous lupus erythematosus, SLE, systemic lupus erythematosus, systemic lupus erythematosus, RL1-803, medicine, Cutaneous Lupus Erythematosus, Case Series, Janus kinase, business, JAK, Janus kinase, Cutaneous lupus, TOFACITINIB CITRATE

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a883f08e28cbbfa8f1a8e0355d68a5
http://europepmc.org/articles/PMC8792392

المؤلفون: David A. Frank, Isidora Tošić

المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)

مصطلحات موضوعية: Cancer Research, p53, tumor protein 53, MEF2D, Myocyte Enhancer Factor 2D, FASN, fatty acid synthase, OXPHOS, oxidative phosphorylation, ERH, enhancer of rudimentary homolog, PDGF, platelet-derived growth factor, PFK, phosphofructokinase, CREB, cyclic AMP response element-binding protein, HDL-C, high-density lipoprotein cholesterol, chemistry.chemical_compound, PC, phosphatidylcholine, GRIM-19, gene associated with retinoid-IFN-induced mortality, Neoplasms, Transcriptional regulation, TGFβ, transforming growth factor beta, AML, acute myeloid leukemia, RC254-282, CDK, cyclin-dependent kinase, FABP6, fatty acid binding protein 6, BCL, B-cell lymphoma, CLL, chronic lymphocytic leukemia, Chemistry, LIF, leukemia inhibitory factor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, VEGF, vascular endothelial growth factor, FBP1, fructose-bisphosphatase 1, GPI, glucose-6-phosphate isomerase, Cell biology, MMP, matrix metalloproteinase, STAT, signal transducer and activator of transcription, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, GP130, glycoprotein 130, Phosphorylation, NHL, non-Hodgkin's lymphoma, JAK, Janus kinase, Adenosine triphosphate, CNTF, ciliary neurotrophic factor, STAT3 Transcription Factor, ATP, adenosine triphosphate, TAG, triacylglycerol, Protein processing, Post-translational, PPARγ, peroxisome proliferator-activated receptor gamma, ETC, electron transport chain, TNFα, tumor necrosis factor alpha, RIME, rapid immunoprecipitation mass spectrometry of endogenous proteins, GLUT1, glucose transporter 1, PGK1, phosphoglycerate kinase, MPTP, mitochondrial permeability transition pore, Mediator, Review article, CML, chronic myeloid leukemia, HIF1α, hypoxia inducible factor 1α, PIAS, protein inhibitors of activated STATs, SOCS, suppressors of cytokine signaling, Animals, Humans, IFN, interferon, LDHA, lactate dehydrogenase A, Transcription factor, PKCδ, protein kinase C δ, TF, transcription factors, EGF, epidermal growth factor, SM, sphingomyelin, SREBP1, sterol regulatory element-binding protein 1, IAP, inhibitor of apoptosis, PTP, protein tyrosine phosphatases, Tyrosine phosphorylation, Lipid metabolism, BCSC, breast cancer stem cells, IL, interleukin, Metabolism, OSM, oncostatin M, Anaerobic glycolysis, NFκB, nuclear factor kappa B, TBK1, TANK-binding kinase 1, MCL, myeloid cell leukemia, LDL-C, low-density lipoprotein cholesterol, PBP, PPARγ binding protein, CPT1B, carnitine palmitoyltransferase 1B, FAO, fatty acid oxidation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1e221705a2edcb47149735290583
http://europepmc.org/articles/PMC8569436

المؤلفون: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

مصطلحات موضوعية: LOX1, lectin-like oxidized LDL receptor 1, BUN, blood urea nitrogen, TGBM, thickness of glomerular basement membrane, NQO1, NAD(P)H:quinone oxidoreductase 1, STAT, signal transducers and activators of transcription, N/O, not observed, p62, sequestosome 1 protein, p-IRS1, phospho-IRS1, Review, NOX-4, nicotinamide adenine dinucleotide phosphate-oxidase-4, OCP, oxidative carbonyl protein, Traditional Chinese medicine, AGEs, advanced glycation end-products, N/A, not applicable, TRAF5, tumor-necrosis factor receptor-associated factor 5, Health problems, 0302 clinical medicine, ESRD, end-stage renal disease, LDL, low-density lipoprotein, BMP-7, bone morphogenetic protein-7, TGFβR-I/II, TGF-β receptor I/II, Medicine, P70S6K, 70-kDa ribosomal protein S6 kinase, General Pharmacology, Toxicology and Pharmaceutics, SOCS, suppressor of cytokine signaling proteins, HO-1, heme oxygenase-1, 0303 health sciences, TG, triglyceride, BW, body weight, HDL-C, high density lipoprotein-cholesterol, RASI, renin-angiotensin system inhibitor, ATK, protein kinase B, TBARS, thiobarbituric acid-reactive substance, BCL-XL, B-cell lymphoma-extra large, Gαq, Gq protein alpha subunit, GCK, glucokinase, PI3K, phosphatidylinositol 3 kinases, Systematic review, TLR-2/4, toll-like receptor 2/4, IR, insulin receptor, PERK, protein kinase RNA-like eukaryotic initiation factor 2A kinase, 030220 oncology & carcinogenesis, CRP, C-reactive protein, IRS, insulin receptor substrate, AM, mesangial area, JAK, Janus kinase, FBG, fasting blood glucose, ETAR, endothelium A receptor, LDL-C, low density lipoprotein-cholesterol, CD2AP, CD2-associated protein, eIF2α, eukaryotic initiation factor 2α, RM1-950, mTOR, mammalian target of rapamycin, CHOP, C/EBP homologous protein, STZ, streptozotocin, 03 medical and health sciences, ADE, adverse event, PKC, protein kinase C, LC3, microtubule-associated protein light chain 3, ORP150, 150-kDa oxygen-regulated protein, PGE2, prostaglandin E2, IL-1β/6, interleukin 1β/6, Diabetic kidney disease, IGF-1, insulin-like growth factor 1, EP, E-prostanoid receptor, FN, fibronectin, eGFR, estimated GFR, MDA, malondialdehyde, Chinese medicine, MMP-2, matrix metallopeptidase 2, XBP-1, spliced X box-binding protein 1, TGF-β, tumor growth factor β, GRB 10, growth factor receptor-bound protein 10, medicine.disease, Clinical trial, GRP78, glucose-regulated protein 78, UP, urinary protein, IGF-1R, insulin-like growth factor 1 receptor, ACEI, angiotensin-converting enzyme inhibitor, BCL-2, B-cell lymphoma 2, EMT, epithelial-to-mesenchymal transition, MAPK, mitogen-activated protein kinase, MYD88, myeloid differentiation primary response 88, PBG, postprandial blood glucose, RCT, randomized clinical trial, N/R, not reported, COL-I/IV, collagen I/IV, PINK1, PTEN-induced putative kinase 1, UACR, urinary albumin to creatinine ratio, C, control group, Diabetic nephropathy, GPX, glutathione peroxidase, ICAM-1, intercellular adhesion molecule-1, Bioinformatics, VCAM-1, vascular cell adhesion molecule-1, AMPKα, adenosine monophosphate-activated protein kinase α, DM, diabetes mellitus, TFEB, transcription factor EB, TNF-α, tumor necrosis factor α, Molecular target, IKK-β, IκB kinase β, Signaling pathway, GLUT4, glucose transporter type 4, BAX, BCL-2-associated X protein, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, PARP, poly(ADP-Ribose) polymerase, SMURF-2, SMAD ubiquitination regulatory factor 2, AREs, antioxidant response elements, MD, mean difference, SMAD, small mothers against decapentaplegic, MCP-1, monocyte chemotactic protein-1, VEGF, vascular endothelial growth factor, cAMP, cyclic adenosine monophosphate, ARB, angiotensin receptor blocker, PAI-1, plasminogen activator inhibitor-1, SMD, standard mean difference, JNK, c-Jun N-terminal kinase, NRF2, nuclear factor erythroid 2-related factor 2, IκB-α, inhibitory protein α, Herbal medicine, TCM, traditional Chinese medicine, DG, glomerular diameter, GSK-3, glycogen synthase kinase 3, SIRT1, sirtuin 1, D, duration, HbA1c, glycosylated hemoglobin, WMD, weight mean difference, CTGF, connective tissue growth factor, ER, endoplasmic reticulum, DN, diabetic nephropathy, ROS, reactive oxygen species, CCR, creatinine clearance rate, SOD, superoxide dismutase, Diabetes mellitus, PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α, ET-1, endothelin-1, UMA, urinary microalbumin, SCr, serum creatinine, IRE-1α, inositol-requiring enzyme-1α, 030304 developmental biology, TII, tubulointerstitial injury index, RAGE, receptors of AGE, business.industry, GFR, glomerular filtration rate, PTEN, phosphatase and tensin homolog, CI, confidence interval, TC, total cholesterol, SD-rat, Sprague–Dawley rat, UAER, urinary albumin excretion rate, DKD, diabetic kidney disease, T, treatment group, Molecular targets, Therapeutics. Pharmacology, α-SMA, α smooth muscle actin, SD, standard deviation, business, DAG, diacylglycerol, GCLC, glutamate-cysteine ligase catalytic subunit, Kidney disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

المؤلفون: Konstantinos Leventogiannis, Vasiliki Lygoura, Anastasia Michail, Anna Samakidou, Nikolaos K. Gatselis, Evangelos J. Giamarellos-Bourboulis, Stella Gabeta, Efthymia Petinaki, Marianna Vlychou, Sarah P. Georgiadou, Aggelos Stefos, George N. Dalekos, George Ntaios, George Giannoulis

المصدر: European Journal of Internal Medicine

مصطلحات موضوعية: Male, BMI, body mass index, medicine.medical_treatment, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Intubation, 030212 general & internal medicine, Respiratory system, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2-related, COVID-19, coronavirus disease 2019, Respiratory Distress Syndrome, LDH, lactate dehydrogenase, Mortality rate, Middle Aged, Tocilizumab, IVIG, intravenous infusions of γ-globulins, Treatment Outcome, Anakinra, CRP, C-reactive protein, Female, Original Article, Respiratory Insufficiency, JAK, Janus kinase, medicine.drug, medicine.medical_specialty, Secondary infection, TNF-α, tumor necrosis factor-α, sHLH, haemophagocytic lymphohistiocytosis, 03 medical and health sciences, Internal medicine, Internal Medicine, medicine, Humans, RCTs, randomized controlled trials, Adverse effect, Aged, IL-6, SARS-CoV-2, IL-1, business.industry, COVID-19, HR, hazard ratio, IL, interleukin, MAS, macrophage activation syndrome, OR, odds ratio, Interleukin 1 Receptor Antagonist Protein, chemistry, Respiratory failure, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeb4d901f0603ee9f7a8f8a76a3ddcf
https://doi.org/10.1016/j.ejim.2021.03.026

المؤلفون: Matthew D. Vesely, Danielle Peterson

المصدر: JAAD Case Reports
JAAD Case Reports, Vol 10, Iss, Pp 4-7 (2021)

مصطلحات موضوعية: medicine.medical_specialty, BSA, body surface area, Case Report, Dermatology, JAK, janus kinase, Tofacitinib therapy, Rescue therapy, dupilumab, lcsh:Dermatology, medicine, Severe atopic dermatitis, severe atopic dermatitis, refractory atopic dermatitis, Janus kinase inhibitor, Body surface area, jak inhibitor, business.industry, Atopic dermatitis, lcsh:RL1-803, AD, atopic dermatitis, medicine.disease, Dupilumab, rescue therapy, janus kinase inhibitor, Janus kinase, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf68753f570b1e6a55ada387cc779c18
https://doi.org/10.1016/j.jdcr.2021.01.020

المؤلفون: Young Yun Jung, Jae-Young Um, Kwang Seok Ahn, In Jin Ha, Gautam Sethi

المصدر: Journal of Advanced Research
Journal of Advanced Research, Vol 35, Iss, Pp 245-257 (2022)

مصطلحات موضوعية: 0301 basic medicine, Medicine (General), IHC, Immunohistochemistry, Science (General), FCN, Fangchinoline, STAT3, signal transducer and activator of transcription 3, Pharmaceutical Science, P/S, Penicillin-streptomycin, Apoptosis, Fangchinoline, NT, Non treat, medicine.disease_cause, Stat3 Signaling Pathway, STAT3, Q1-390, Mice, 0302 clinical medicine, Multiple myeloma, Multidisciplinary, SHP-1, Src homology 2 domain-containing protein tyrosine phosphatase-1, biology, Chemistry, Protein Tyrosine Phosphatase, Non-Receptor Type 6, ROS, c/w, Cell per well, VEGF, vascular endothelial growth factor, Cell biology, 030220 oncology & carcinogenesis, JAK, Janus kinase, PARP, Poly (ADP-ribose) polymerase, DMEM, Dulbecco’s Modified Eagle Medium, HRP, Horseradish peroxidase, STAT3 Transcription Factor, Programmed cell death, MMP, Matrix metalloproteinase, Benzylisoquinolines, 03 medical and health sciences, R5-920, RTCA, Real-time cell analysis, medicine, GSH, Animals, Electrophoretic mobility shift assay, ComputingMethodologies_COMPUTERGRAPHICS, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, Cell growth, RT-PCR, Reverse transcription polymerase chain reaction, ICC, Immunocytochemistry, Oxidative Stress, 030104 developmental biology, ip, Intraperitoneal injection, Tumor progression, DAPI, 4′,6-Diamidino-2-Phenylindole, Dihydrochloride, biology.protein, STAT protein, FBS, Fetal bovine serum, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827fdb8a08fdd8e28ed3bcdc4a40ef6f
http://europepmc.org/articles/PMC8721253

المؤلفون: Hong-Min Liu, Ya-Hong Wu, Yihui Song, Min Zhao, Bin Yu

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 750-762 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PMSF, phenylmethanesulfonyl fluoride, LS, LEOPARD syndrome, Mutant, IC50, half maximal inhibitory concentration, Protein tyrosine phosphatase, HTS, high-throughput screening, chemistry.chemical_compound, 0302 clinical medicine, DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myelogenous leukemia, Tm, melting temperature, 0303 health sciences, LB, lysogeny broth, SDS-PAGE, sodium dodecyl sulphate polyacyrlamide gel electrophoresis, High-throughput screening, R2, coefficient of determination, S/B, signal over background, STAT, signal transducer and activator of transcription, SHP2, Src homology phosphotyrosyl phosphatase 2, Biochemistry, 030220 oncology & carcinogenesis, Original Article, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, SH2, Src homology 2, Proto-oncogene tyrosine-protein kinase Src, Thermal shift assay, Allosteric regulation, Phosphatase, JAK, janus kinase, AKT, protein kinase B, SHP2-WT, wild type Src homology phosphotyrosyl phosphatase 2, SHP2-PTP, protein tyrosine phosphatase domain of Src homology phosphotyrosyl phosphatase 2, 03 medical and health sciences, PI3K, phosphatidylinositol 3 kinase, NS, Noonan syndrome, RAS, rat sarcoma, FI, fluorescence intensity, NPC, no protein control, 030304 developmental biology, ΔTm, melting temperature change, DiFMU, 6,8-difluoro-4-methylumbelliferyl hydroxid, ALK, anaplastic lymphoma kinase, lcsh:RM1-950, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, MEK, extracellular regulated protein kinase kinases, JMML, juvenile myelomonocytic leukaemia, Enzyme assay, PD-1, programmed death 1, p-IRS1, phosphorylated insulin receptor substrate 1, Bis-tris, bis-(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, OD, optical density, lcsh:Therapeutics. Pharmacology, chemistry, DTT, dithiothreitol, SHP2, Allosteric inhibitors, Bioisostere, LOC, ligand only control, SD, standard deviation, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114cd1e4de1acb4de79002f71ffaa0be
https://doi.org/10.1016/j.apsb.2020.10.021

المؤلفون: Brian J. Nickoloff, Silvia Ottaviani, Jonathan T. Sims, Nicoletta Bivi, Richard E. Higgs, Ajay Nirula, Venkatesh Krishnan, George H. Rodgers, Giacomo Casalini, Robert J. Benschop, Anabela Cardoso, Justin Stebbing, Mario Corbellino, Sarah M. Engle, Ching Yun Chang, Robert J. Konrad, Stephanie de Bono

المساهمون: British Society for Antimicrobial Chemotherapy

المصدر: The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology

مصطلحات موضوعية: Male, Proteomics, SCF, Stem cell factor, 0301 basic medicine, Allergy, medicine.medical_treatment, Poly (ADP-Ribose) Polymerase-1, Disease, 030204 cardiovascular system & hematology, Cardiovascular, Pathogenesis, 0302 clinical medicine, Baricitinib, MCP, Monocyte chemoattractant protein, GDF-2, Growth/differentiation factor 2, Immunology and Allergy, IL, Interleukin, Endothelial dysfunction, COVID-19, Coronavirus disease 2019, IFN, Interferon, ICU, Intensive care unit, Cytokine, 1107 Immunology, Cytokines, Biomarker (medicine), CXCL9, Female, Cytokine Release Syndrome, JAK, Janus kinase, Adult, MMP, Matrix metalloproteinase, Ordinal Scale, Immunology, Article, 03 medical and health sciences, PEA, Proximity extension array, medicine, Humans, CXCL10, tSNE, T-distributed stochastic neighbor embedding, Inflammation, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, STAT, Signal transducer and activator of transcription, business.industry, PTX3, Pentraxin-related protein 3, COVID-19, medicine.disease, 030104 developmental biology, business, Cytokine storm, Biomarkers

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09fd77bcd0ea3c8be3c284be2af4e39
https://doi.org/10.1016/j.jaci.2020.08.031

المؤلفون: Akira Yamauchi, Masahiro Yamamura, Keisuke Hino, Kyo Sasaki, Yuichi Hara, Fukuda Kotaro, Sohji Nishina, Kensuke Egashira

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 739-762 (2021)

مصطلحات موضوعية: Male, 0301 basic medicine, Chemokine, Glucose uptake, Cell Culture Techniques, PLGA, poly(lactic-co-glycolic acid), 2-NDBG, 2-(N-[nitrobenz-2-oxa1,3-diazol-4-yl]amino)-2-deoxyglucose, CD8-Positive T-Lymphocytes, TNF-α, tumor necrosis factor-α, 2DG, 2-Deoxy-D-glucose, Mice, chemistry.chemical_compound, Liver Neoplasms, Experimental, 0302 clinical medicine, Polylactic Acid-Polyglycolic Acid Copolymer, Antineoplastic Combined Chemotherapy Protocols, Warburg Effect, Oncologic, GSH, glutathione, Cytotoxic T cell, IFN-γ, interferon-γ, Cytotoxicity, Immune Checkpoint Inhibitors, IFN-γ, Original Research, biology, Chemistry, Programmed Death 1, Liver Neoplasms, EZH2, enhancer of zeste homologue 2, Gastroenterology, PLGA, Drug Synergism, CCL, C-C motif chemokine, mRNA, messenger RNA, 030211 gastroenterology & hepatology, FITC, fluorescein isothiocyanate, JAK, Janus kinase, Carcinoma, Hepatocellular, ATP, adenosine triphosphate, CCR, C-C chemokine receptor type 4, ICG, indocyanine green, Treg, regulatory T cell, mTOR, mammalian target of rapamycin, macromolecular substances, Deoxyglucose, H3K27me3, H3 lysine 27 trimethylation, STAM, stelic animal model, STAT, signal transducers and activator of transcription, ER, endoplasmic reticulum, Interferon-gamma, homologue, 2, 03 medical and health sciences, ROS, reactive oxygen species, FBS, fetal bovine serum, Cell Line, Tumor, Animals, Humans, CXCL10, lcsh:RC799-869, PD1, programmed death 1, 18F-FDG, 18F-2-fluoro-2-deoxyglucose, Hepatology, technology, industry, and agriculture, Xenograft Model Antitumor Assays, Coculture Techniques, AMPK, AMP-activated protein kinase, PD-L1, programmed death-ligand 1, 030104 developmental biology, Drug Resistance, Neoplasm, Cancer cell, Cancer research, biology.protein, Lactate, lcsh:Diseases of the digestive system. Gastroenterology, Tumor Escape, NP, nanoparticles, Nanoparticle Drug Delivery System, HCC, hepatocellular carcinoma, 2-Deoxy-D-glucose, CD8, DAPI, 4′,6-diamidino-2-phenylindole, DEN, diethylnitrosamine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010d385be012e5b858cf3e9cba28a067
https://doi.org/10.1016/j.jcmgh.2020.10.010

المؤلفون: Mingyang Shao, Qing Xu, Menglin Chen, Xiaoyue Cao, Chuan Li, Hong Bu, Yuwei Chen, Yuke Shu, Zhenru Wu, Gang Guo, Yuping Gong, Yongjie Zhou, Yujun Shi

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 633-651 (2021)

مصطلحات موضوعية: Male, 0301 basic medicine, Adenosine, FoxM1, forkhead box M1, IRE1α, inositol requiring enzyme 1 alpha, XBP1, X-box-binding protein 1, STAT, signal transducers and activators of transcription, RNA Stability, Mettl3, methyltransferase-like 3, Alkbh5, ALKB family member 5 protein, Apoptosis, RC799-869, AST, aspartate aminotransferase, WTAP, Wilms’ tumor 1-associated protein, Endoplasmic Reticulum, UPR, unfolded protein response, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, Homeostasis, TUDCA, tauroursodeoxycholate, BrdU, 5-bromo-2-deoxyuridine, eIF2α, eukaryotic translation initiator factor 2α, Original Research, Mice, Knockout, N6-methyladenosine, Chemistry, Gastroenterology, PI3K, phosphatidylinositol 3-kinase, Methylation, Diseases of the digestive system. Gastroenterology, Cell cycle, Endoplasmic Reticulum Stress, Liver regeneration, Cell biology, UTR, untranslated region, medicine.anatomical_structure, Liver, PHx, partial hepatectomy, Organ Specificity, Hepatocyte, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, FTO, fat mass and obesity-associated protein, ATF6, activating transcription factor 6, AMPK, adenosine 5′-monophosphate-activated protein kinase, JAK, janus kinase, ER, endoplasmic reticulum, Taurochenodeoxycholic Acid, PAS, periodic acid–Schiff, Necrosis, 03 medical and health sciences, ALT, alanine aminotransferase, TM, tunicamycin, medicine, Act D, actinomycin, Animals, Hepatectomy, RNA, Messenger, Cell Proliferation, Messenger RNA, Hepatology, Endoplasmic reticulum, CDS, coding sequence, Mettl14, Methyltransferases, FC, fold change, m6A, N6-methyladenosine, WT, wild-type, Liver Regeneration, m6A-seq, m6A sequencing, 030104 developmental biology, MRNA Sequencing, Hepatocytes, Unfolded protein response, EIF3A, eukaryotic translation initiation factor 3 subunit A, HCC, hepatocellular carcinoma, Peptides, Transcriptome, PERK, protein kinase R-like endoplasmic reticulum kinase, Chop, C/EBP-homologous protein, MAPK, mitogen-activated protein kinase, Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07948b84c6263e6b798b7056d5735a81
https://doi.org/10.1016/j.jcmgh.2021.04.001

المؤلفون: Peng Yang, Xiao Wang, Kai Yuan, Haojie Dong, Wenjian Min, Haiping Hao

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 30-54 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: ER, estrogen receptor, Review, PI3K, phosphatidylinositol 3-hydroxy kinase, 0302 clinical medicine, PROTAC, proteolysis targeting chimera, Medicine, HER2, human epidermal growth factor receptor 2, Selectivity, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myeloid leukemia, Cancer, 0303 health sciences, integumentary system, biology, Kinase, CRPC, castration-resistant prostate cancer, CDKs, cyclin-dependent kinases, MM, multiple myeloma, ORR, overall response rates, Cell cycle, CPU, China Pharmaceutical University, PFS, progression-free survival, FLT, fms-like tyrosine kinase, 030220 oncology & carcinogenesis, STATs, signal transducers and activators of transcription, PDK1, 3-phosphoinositide-dependent protein kinase 1, biological phenomena, cell phenomena, and immunity, JAK, janus kinase, AKT, protein kinase B, PROTAC, 03 medical and health sciences, Cyclin-dependent kinase, NSCLC, non-small cell lung cancer, MCL, mantle cell lymphoma, CDK4/6, 030304 developmental biology, SPH, Shanghai Pharmaceuticals Holding Co., Ltd, Cell growth, business.industry, ERK, extracellular regulated protein kinases, RB, retinoblastoma protein, lcsh:RM1-950, Proteolysis targeting chimera, CIP/KIP, cyclin-dependent kinase inhibitor 1/kinase inhibitory protein, CKIs, cyclin-dependent kinase inhibitors, PR, progesterone receptor, INK4, inhibitors of CDK4, medicine.disease, Clinical trial, FDA, U.S. Food and Drug Administration, enzymes and coenzymes (carbohydrates), lcsh:Therapeutics. Pharmacology, UNISA, University of South Australia, Drug resistance, Cancer cell, biology.protein, Cancer research, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159c763465a8f81e7796102401f7aa90
https://doi.org/10.1016/j.apsb.2020.05.001

المؤلفون: Tariq Ahmad, Nihar R. Desai, Bani M. Azari, Mohsin Chowdhury

المصدر: JACC Case Reports
JACC: Case Reports, Vol 2, Iss 10, Pp 1461-1465 (2020)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Myocarditis, medicine.medical_treatment, TTE, transthoracic echocardiogram, Cardiomyopathy, shock, 030105 genetics & heredity, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, LVEF, left ventricular ejection fraction, Diseases of the circulatory (Cardiovascular) system, Medicine, Eosinophilia, tofacitinib, Tofacitinib, business.industry, Mortality rate, Cardiogenic shock, Mini-Focus Issue: Heart Failure, medicine.disease, IABP, intra-aortic balloon pump, DRESS, drug rash with eosinophilia and systemic symptoms, RC666-701, Shock (circulatory), Cardiology, NT-proBNP, N-terminal pro–B-type natriuretic peptide, Case Report: Clinical Case, myocarditis, medicine.symptom, DRESS, JAK, Janus kinase, Cardiology and Cardiovascular Medicine, business, cardiomyopathy, eosinophilia, 030217 neurology & neurosurgery, cTNT, cardiac troponin T

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bdd77907105fd974d9957d34944068
https://doi.org/10.1016/j.jaccas.2020.02.004

المؤلفون: Grange, Lucile, Guilpain, Philippe, Truchetet, Marie-Elise, Cracowski, Jean-Luc, Pharmacology And Therapeutics, French Society Of

المساهمون: Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), CCSD, Accord Elsevier, Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Bordeaux [Bordeaux], Université de Bordeaux (UB), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2)

المصدر: Therapies
Thérapie
Thérapie, EDP Sciences, 2020, 75, pp.335-342. ⟨10.1016/j.therap.2020.06.013⟩
Thérapie, 2020, 75, pp.335-342. ⟨10.1016/j.therap.2020.06.013⟩
Therapie

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], RA, rheumatoid arthritis, Disease, Pharmacologie, 030226 pharmacology & pharmacy, Dexamethasone, SLE, systemic lupus erythematosus, 0302 clinical medicine, Chloroquine, Pandemic, COVID-19, novel coronavirus disease 2019, Pharmacology (medical), ANCA, anti-neutrophil cytoplasmic antibodies, bDMARDS, biological disease-modifiyng antirheumatic drugs, NSAIDs, non steroidal anti-inflammatory drugs, TNF, tumor necrosis factor, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, tsDMARDS, targeted synthetic disease modifying antirheumatic drugs, Incidence, TCZ, tocilizumab, Anti-Inflammatory Agents, Non-Steroidal, Dexaméthasone, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, ICU, intensive care unit, 3. Good health, Polyarthrite rhumatoïde, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Rhumatologie, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Antirheumatic Agents, Rheumatoid arthritis, Coronavirus Infections, csDMARDS, conventional synthetic disease modifying antirheumatic drugs, Hydroxychloroquine, medicine.drug, medicine.medical_specialty, IL6, interleukin 6, Pneumonia, Viral, Article, WHO, World Health Organization, Autoimmune Diseases, 03 medical and health sciences, Immune system, Rheumatology, Rheumatic Diseases, Internal medicine, medicine, Humans, IL1, interleukin 1, Intensive care medicine, Pandemics, ARDS, acute respiratory distress syndrome, MERS-COV, middle East respiratory syndrome coronavirus, Pharmacology, SSc, systemic sclerosis, business.industry, COVID-19, HCQ, hydroxychloroquine, medicine.disease, JAK, Janus kinase (inhibitors), RNA, ribonucleic acid, SARS-COV2, severe acute respiratory syndrome coronavirus 2, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd162387881604cb7c764fc28f541e4c
https://doi.org/10.1016/j.therap.2020.06.013