المؤلفون: Amit Sharma, Alison Slaughter, Nivedita Jena, Lei Feng, Jacques J Kessl, Hind J Fadel, Nirav Malani, Frances Male, Li Wu, Eric Poeschla, Frederic D Bushman, James R Fuchs, Mamuka Kvaratskhelia

المصدر: PLoS Pathogens, Vol 10, Iss 5, p e1004171 (2014)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4038613?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/7ceda5ee2d6f497c8ecf7da87f9b4d83

المؤلفون: Radha P. Somarathne, Sandeep K. Misra, Chathuri S. Kariyawasam, Jacques J. Kessl, Joshua S. Sharp, Nicholas C. Fitzkee

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Biotechnology, Biological Sciences not elsewhere classified, used mass spectrometry, staphylococcus epidermidis <, data also highlight, “ corona ”, fast exchange rates, corona requires knowledge, characterizing complex protein, statistically significant changes, methylation ratios support, average exchange rates, r2ab protein interacts, partially structured regions, driving r2ab protein, nanoparticle interactions using, bacterial surface protein, nanoparticle corona, protein structure, protein behavior, significant interest, average behavior, nanoparticle surfaces, methylation patterns, lysine methylation, level interactions, hdx rates

Relation: https://figshare.com/articles/journal_contribution/Exploring_Residue-Level_Interactions_between_the_Biofilm-Driving_R2ab_Protein_and_Polystyrene_Nanoparticles/24942759

الاتاحة: https://doi.org/10.1021/acs.langmuir.3c02609.s001
https://figshare.com/articles/journal_contribution/Exploring_Residue-Level_Interactions_between_the_Biofilm-Driving_R2ab_Protein_and_Polystyrene_Nanoparticles/24942759

المؤلفون: Jian Sun, Jacques J. Kessl

المصدر: Viruses, Vol 16, Iss 2, p 200 (2024)

مصطلحات موضوعية: HIV, integrase, virus maturation, allosteric integrase inhibitor, ALLINI, quinoline, Microbiology, QR1-502

Relation: https://www.mdpi.com/1999-4915/16/2/200; https://doaj.org/toc/1999-4915; https://doaj.org/article/8be272e2c5b8483b93db95e9e02e3edb

الاتاحة: https://doi.org/10.3390/v16020200
https://doaj.org/article/8be272e2c5b8483b93db95e9e02e3edb

المؤلفون: Long Phi Dinh, Jian Sun, Courtney D. Glenn, Krunal Patel, Julie A. Pigza, Matthew G. Donahue, Larry Yet, Jacques J. Kessl

المصدر: Viruses; Volume 14; Issue 7; Pages: 1466

مصطلحات موضوعية: HIV-1, integrase, ALLINI, quinolines, multimerization

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: General Virology; https://dx.doi.org/10.3390/v14071466

الاتاحة: https://doi.org/10.3390/v14071466

المؤلفون: Nicholas G. Jentsch, Jared D. Hume, Emily B. Crull, Samer M. Beauti, Amy H. Pham, Julie A. Pigza, Jacques J. Kessl, Matthew G. Donahue

المصدر: Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2529-2536 (2018)

مصطلحات موضوعية: cyclodehydration, HIV integrase, isatoic anhydride, masked acyl cyanide, quinoline, Science, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1860-5397

URL الوصول: https://doaj.org/article/fbd91e864cd84c9da84a118b40063aa4

المؤلفون: Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques J. Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke

المصدر: Molecules; Volume 23; Issue 8; Pages: 1858

مصطلحات موضوعية: HIV-1 integrase, viral protein R, photoaffinity probe, inhibitor

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules23081858

الاتاحة: https://doi.org/10.3390/molecules23081858

المؤلفون: Mamuka Kvaratskhelia, Ari Katz, Nikolozi Shkriabai, Jocelyn O. Eidahl, Christopher J. McKee, Jacques J. Kessl

المصدر: Viruses, Vol 1, Iss 3, Pp 713-736 (2009)

مصطلحات موضوعية: HIV, retroviruses, DNA, integrase, crosslinking, footprinting, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1999-4915/1/3/713/; https://doaj.org/toc/1999-4915

URL الوصول: https://doaj.org/article/f358cbf67f2c43f8aa48b368a2e64b13

المؤلفون: Jian Sun, Jacques J. Kessl, Kaitlin A McNeely, Julie A. Pigza, Nicholas G. Jentsch, Chiyang Lama, Jared D. Hume, Alison P Hart, Matthew Garrett Donahue

المصدر: ACS Medicinal Chemistry Letters. 9:1007-1012

مصطلحات موضوعية: 0301 basic medicine, biology, Stereochemistry, Aryl, 030106 microbiology, Organic Chemistry, Quinoline, Biochemistry, In vitro, Integrase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, ANTIRETROVIRAL AGENTS, chemistry, Viral replication, Drug Discovery, biology.protein, Hiv 1 integrase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ff79914f4d441c9d2d1e09908647b7
https://doi.org/10.1021/acsmedchemlett.8b00269

المؤلفون: Jacques J. Kessl, Christopher J. Mckee, Jocelyn O. Eidahl, Nikolozi Shkriabai, Ari Katz, Mamuka Kvaratskhelia

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/05/3f/Viruses_2009_Nov_5_1(3)_713-736.tar.gz

مصطلحات موضوعية: HIV, retroviruses, DNA, integrase, crosslinking, footprinting

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.1450

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.1450

المؤلفون: James R. Fuchs, Arthur J. Olson, Mamuka Kvaratskhelia, Stefano Forli, Lei Feng, Janet Antwi, D. Patel, Ronald M. Levy, Pratibha C. Koneru, Joseph D. Bauman, Erik Serrao, Nanjie Deng, Alan Engelman, Jacques J. Kessl, Eddy Arnold

المصدر: Journal of Biological Chemistry. 291:23569-23577

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Stereochemistry, Mutant, Allosteric regulation, Carboxylic Acids, HIV Infections, HIV Integrase, Thiophenes, Biology, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Catalytic Domain, Drug Discovery, Humans, HIV Integrase Inhibitors, Molecular Biology, 030102 biochemistry & molecular biology, Drug discovery, Quinoline, HEK 293 cells, Cell Biology, Integrase, Molecular Docking Simulation, Crystallography, HEK293 Cells, 030104 developmental biology, chemistry, Viral replication, Protein Structure and Folding, HIV-1, biology.protein, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9bfb32bbfe4818cb1bb991e7d9c8e8
https://doi.org/10.1074/jbc.m116.753384

المؤلفون: Erik Serrao, Frederic D. Bushman, Alan Engelman, Venkatasubramanian Dharmarajan, Ashley C. Hoyte, Alison Slaughter, Jacques J. Kessl, Patrick R. Griffin, James R. Fuchs, Matthew R. Plumb, Ross C. Larue, Mamuka Kvaratskhelia, Amit Sharma, Lei Feng

المصدر: ACS Chemical Biology. 11:1313-1321

مصطلحات موضوعية: 0301 basic medicine, Allosteric regulation, Integrase inhibitor, HIV Infections, HIV Integrase, Virus Replication, Biochemistry, Article, 03 medical and health sciences, Allosteric Regulation, Tetramer, Humans, HIV Integrase Inhibitors, Binding site, 030102 biochemistry & molecular biology, biology, HEK 293 cells, General Medicine, Molecular biology, In vitro, Integrase, HEK293 Cells, 030104 developmental biology, Viral replication, HIV-1, biology.protein, Intercellular Signaling Peptides and Proteins, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0909208d678fa8b0b74fc7dc0a20fb20
https://doi.org/10.1021/acschembio.6b00167

المؤلفون: Julie A. Pigza, Jared D. Hume, Jacques J. Kessl, Matthew Garrett Donahue, Jian Sun, Krunal Patel

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Integrase inhibitor, HIV Integrase, Virus Replication, Biochemistry, HIV-1, human immunodeficiency virus type 1, quinoline, HTRF, homogeneous time resolved fluorescence, human immunodeficiency virus, biology, Chemistry, CTD, C-terminal domain, DMSAO, dimethyl sulfoxide, Chromatin, Integrase, Cell biology, Quinolines, Intercellular Signaling Peptides and Proteins, CCD, catalytic core domain, I N, integrase, Research Article, Protein Binding, drug design, Virus Integration, Protein subunit, Allosteric regulation, ALLINI, allosteric IN inhibitors, Antiviral Agents, oligomerization, Protein–protein interaction, antiviral agent, 03 medical and health sciences, Allosteric Regulation, Humans, NTD, N-terminal domain, HIV Integrase Inhibitors, Binding site, Molecular Biology, RNP, ribonucleoprotein complex, 030102 biochemistry & molecular biology, Cell Biology, protein–protein interaction, HEK293 Cells, 030104 developmental biology, vDNA, viral cDNA, Viral replication, HIV-1, biology.protein, ALLINI, integrase, Protein Multimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812afed44ebca78da55c911ffeaba508
https://doi.org/10.1016/j.jbc.2021.100363

المؤلفون: Emily B. Crull, Samer M. Beauti, Jared D. Hume, Amy H. Pham, Jacques J. Kessl, Nicholas G. Jentsch, Matthew Garrett Donahue, Julie A. Pigza

المصدر: Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2529-2536 (2018)

مصطلحات موضوعية: Sodium, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Full Research Paper, lcsh:QD241-441, chemistry.chemical_compound, Residue (chemistry), lcsh:Organic chemistry, quinoline, Organic chemistry, isatoic anhydride, Carboxylate, lcsh:Science, HIV integrase, masked acyl cyanide, Triphosgene, 010405 organic chemistry, Quinoline, Organic Chemistry, 0104 chemical sciences, Chemistry, chemistry, Sodium hydroxide, Ethyl acetoacetate, Electrophile, cyclodehydration, lcsh:Q

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ae380e1f278bb6b26e9c640fdc1393
https://pubmed.ncbi.nlm.nih.gov/30344776

المؤلفون: Yasuhiro Koh, Mamuka Kvaratskhelia, Alison Slaughter, Lei Feng, Alan Engelman, Nikolozi Shkriabai, Jacques J. Kessl, Hiroaki Mitsuya, Nivedita Jena, Ross C. Larue, Pratiq A. Patel, Amit Sharma, James R. Fuchs

المصدر: Journal of Biological Chemistry. 288:15813-15820

مصطلحات موضوعية: Allosteric regulation, Mutation, Missense, HIV Integrase, Plasma protein binding, Biology, Virus Replication, Biochemistry, Protein–protein interaction, Allosteric Regulation, Drug Resistance, Viral, medicine, Humans, HIV Integrase Inhibitors, Molecular Biology, HEK 293 cells, Molecular Bases of Disease, Cell Biology, Resistance mutation, Integrase, Cell biology, HEK293 Cells, Amino Acid Substitution, Mechanism of action, Structural biology, HIV-1, biology.protein, Intercellular Signaling Peptides and Proteins, Protein Multimerization, medicine.symptom, HeLa Cells, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054379f725cd8dce41d456506c662a57
https://doi.org/10.1074/jbc.m112.443390

المؤلفون: Hao Wang, Lei Feng, Yasuhiro Koh, Alan Engelman, Weifeng Wang, Alison Slaughter, Pratiq A. Patel, Kellie A. Jurado, Jacques J. Kessl, Allison Ballandras-Colas, James R. Fuchs, Mamuka Kvaratskhelia

المصدر: Proceedings of the National Academy of Sciences. 110:8690-8695

مصطلحات موضوعية: Multidisciplinary, biology, viruses, Allosteric regulation, Integrase inhibitor, Small molecule, Reverse transcriptase, Integrase, Cell biology, Viral replication, Biochemistry, biology.protein, Binding site, Transcription factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f36e37db9d90e3a6cff1c99bc4a29f2b
https://doi.org/10.1073/pnas.1300703110

المؤلفون: Pratibha C. Koneru, Nivedita Jena, Pratiq A. Patel, Janet Antwi, Mosaad S. Mohamed, Matthew J. Kobe, Guqin Shi, Jacques J. Kessl, Lei Feng, Chenglong Li, James R. Fuchs, Nina Kvaratskhelia, Yara E. Mansour

مصطلحات موضوعية: 0301 basic medicine, Indoles, Stereochemistry, Dimer, Clinical Biochemistry, Allosteric regulation, Mutant, Pharmaceutical Science, HIV Integrase, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, Structure–activity relationship, HIV Integrase Inhibitors, Molecular Biology, Indole test, biology, 010405 organic chemistry, Hydrogen bond, Organic Chemistry, Quinoline, Hydrogen Bonding, 0104 chemical sciences, Integrase, 030104 developmental biology, chemistry, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295e070ab652040d73122f41f53fbf44
https://europepmc.org/articles/PMC5018460/

المؤلفون: Nikolozi Shkriabai, Gregory D. Van Duyne, Mark P. Foster, Jacques J. Kessl, Kushol Gupta, Frauke Christ, Eric M. Danhart, Christiane Wuensch, Zeger Debyser, Oliver Taltynov, Ross C. Larue, Lei Feng, Mamuka Kvaratskhelia

المصدر: Journal of Biological Chemistry. 287:34044-34058

مصطلحات موضوعية: HIV Integrase, Computational biology, Plasma protein binding, Virus Replication, Biochemistry, Mass Spectrometry, Protein–protein interaction, Protein structure, X-Ray Diffraction, Scattering, Small Angle, Humans, Homology modeling, Molecular Biology, biology, Protein footprinting, Circular Dichroism, virus diseases, Molecular Bases of Disease, Cell Biology, beta Karyopherins, Molecular biology, Protein Structure, Tertiary, Integrase, DNA, Viral, HIV-1, biology.protein, Beta Karyopherins, Protein Binding, Binding domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cc224655f4aa68f5726ac36e38fa99
https://doi.org/10.1074/jbc.m112.384669

المؤلفون: James R. Fuchs, Alan Engelman, Alison Slaughter, Nivedita Jena, Jacques J. Kessl, Stuart F. J. Le Grice, Yasuhiro Koh, Suresh de Silva, Mamuka Kvaratskhelia, Lei Feng, Humeyra Taskent-Sezgin, Li Wu

المصدر: Journal of Biological Chemistry. 287:16801-16811

مصطلحات موضوعية: Allosteric regulation, Integrase inhibitor, HIV Infections, Integrase Inhibitors, Cooperativity, HIV Integrase, Virus Replication, Biochemistry, chemistry.chemical_compound, Allosteric Regulation, Humans, Protein–DNA interaction, Molecular Biology, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, Indoleacetic Acids, biology, Molecular Bases of Disease, Cell Biology, Integrase, HEK293 Cells, Enzyme, chemistry, Viral replication, DNA, Viral, HIV-1, biology.protein, DNA, Protein Binding, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989ec4e0cc4cf89358afad3df54c6a72
https://doi.org/10.1074/jbc.m112.354373

المؤلفون: Christopher McKee, Jacques J. Kessl, Jocelyn O. Norris, Nikolozi Shkriabai, Mamuka Kvaratskhelia

المصدر: Methods. 47:304-307

مصطلحات موضوعية: chemistry.chemical_classification, biology, DNA Footprinting, DNA footprinting, Mass spectrometry, Combinatorial chemistry, Mass Spectrometry, Protein Structure, Secondary, Article, General Biochemistry, Genetics and Molecular Biology, Footprinting, Amino acid, Protein–protein interaction, Integrase, Protein structure, chemistry, Biochemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, biology.protein, Humans, Protein Interaction Domains and Motifs, Protein–protein interaction prediction, Molecular Biology, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc565d7b185809b23bda464b14d985d
https://doi.org/10.1016/j.ymeth.2008.10.023

المؤلفون: Janet E. Daigle, Webster L. Santos, Jacques J. Kessl, Christopher McKee, Zhuojun Zhao, Mamuka Kvaratskhelia, Gregory L. Verdine, Alan Engelman

المصدر: Journal of Biological Chemistry. 283:5632-5641

مصطلحات موضوعية: Conformational change, HMG-box, Protein subunit, HIV Infections, HIV Integrase, Computational biology, Peptide Mapping, Biochemistry, Article, Cell Line, law.invention, law, Humans, Protein Structure, Quaternary, Molecular Biology, Genetics, biology, Mutagenesis, Cell Biology, Footprinting, Protein Structure, Tertiary, Integrase, Nucleoprotein, Amino Acid Substitution, DNA, Viral, HIV-1, Mutagenesis, Site-Directed, biology.protein, Recombinant DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e879d282c207e068ef19923bb045f834
https://doi.org/10.1074/jbc.m705241200