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1
المؤلفون: David Wilson, Bindhu V. Karanam, Mona Purcell, Maria Madeira, Gary G. Chicchi, Jianming Bao, Liza Gantert, Robert J. DeVita, Huagang Lu, Wai-Si Eng, Sander G. Mills, Richard G. Ball, Andrew J. Kassick, Peter Lin, Sanjeev Kumar, Jaime Lynn Bunda, George A. Doss, Kwei-Lan C. Tsao, Jacquelyn J. Cook, Xinchun Tong, Richard Tschirret-Guth, Jinlong Jiang, Koppara Samuel, Richard Hargreaves, Hong Wang, Donald F. Hora
المصدر: Journal of Medicinal Chemistry. 56:5940-5948
مصطلحات موضوعية: Trifluoromethyl, CYP3A4, Chemistry, Stereochemistry, Glucuronidation, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Medicine, Potency, NK1 receptor antagonist, Once daily dosing, Short duration, Aprepitant, medicine.drug
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2
المؤلفون: Rominder Singh, K.J. Stauffer, S. Dale Lewis, Marie A. Holahan, Daniel R. McMasters, Youwei Yan, Harold G. Selnick, Rebecca B. White, Matthew M. Zrada, Peter D. Williams, Audrey A. Wallace, Joseph J. Lynch, Maria Stranieri-Michener, Beth Pietrak, Cynthia Miller-Stein, Bradley K. Wong, Yvonne M. Leonard, Julie A. Krueger, G. R. Sitko, Philippe G. Nantermet, Bobby J. Lucas, Jacquelyn J. Cook, Carl F. Homnick, Elizabeth A. Lyle, Christina L. Newton
المصدر: Journal of medicinal chemistry. 48(7)
مصطلحات موضوعية: Male, Models, Molecular, Proline, Stereochemistry, Administration, Oral, Biological Availability, In Vitro Techniques, Crystallography, X-Ray, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, Thrombin, Dogs, Pharmacokinetics, Oral administration, In vivo, Drug Discovery, medicine, Potency, Animals, Humans, Fluorenes, biology, Chemistry, Stereoisomerism, Blood Proteins, Macaca mulatta, Rats, Enzyme inhibitor, biology.protein, Microsomes, Liver, Molecular Medicine, medicine.drug, Discovery and development of direct thrombin inhibitors, Half-Life, Protein Binding