المؤلفون: Mariappan V. Chelliah, Tze-Ming Chan, Yan Xia, George Boykow, Madhu Chintala, Matthew Bryant, Ho-Sam Ahn, Keith Eagen, Jacqueline Agans-Fantuzzi, William J. Greenlee, Yunsheng Hsieh, Samuel Chackalamannil

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2544-2549

مصطلحات موضوعية: Blood Platelets, Platelet Aggregation, Metabolite, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Naphthalenes, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Alkaloids, Piperidines, In vivo, Drug Discovery, Thrombin receptor, medicine, Animals, Humans, Structure–activity relationship, Receptor, PAR-1, Furans, Molecular Biology, Vorapaxar, Drug discovery, Organic Chemistry, Thrombin, Rats, Macaca fascicularis, chemistry, Himbacine, Molecular Medicine, Platelet Aggregation Inhibitors, Ex vivo, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94036f493fa5d675af5fc8cc2d8746b
https://doi.org/10.1016/j.bmcl.2012.01.138

المؤلفون: Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, Matthew Bryant, Chan Tze-Ming, George Boykow, Yan Xia, Keith Eagen, David Hesk, Madhu Chintala, Mariappan V. Chelliah, Yunsheng Hsieh, Martin C. Clasby, Xiaobang Gao, Jairam Palamanda, William J. Greenlee, Samuel Chackalamannil

المصدر: Journal of Medicinal Chemistry. 50:5147-5160

مصطلحات موضوعية: Blood Platelets, Pyridines, Stereochemistry, Administration, Oral, Biological Availability, In Vitro Techniques, Naphthalenes, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Alkaloids, Piperidines, In vivo, Drug Discovery, Thrombin receptor, Animals, Humans, Receptor, PAR-1, Furans, chemistry.chemical_classification, Chemistry, Antagonist, Stereoisomerism, Biological activity, Isoquinolines, Rats, Macaca fascicularis, Himbacine, Microsomes, Liver, Molecular Medicine, Heterocyclic Compounds, 3-Ring, Platelet Aggregation Inhibitors, Ex vivo, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cc61ee2f05b48391d822d3acecca21
https://doi.org/10.1021/jm070704k

المؤلفون: Keith Eagen, Andrew T. McPhail, William J. Greenlee, Yunsheng Hsieh, Madhu Chintala, Samuel Chackalamannil, Yan Lin, Hsingan Tsai, Jayaram R. Tagat, Dario Doller, Ho-Sam Ahn, Yan Xia, George Boykow, Martin C. Clasby, Jacqueline Agans-Fantuzzi, Michael Czarniecki

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3647-3651

مصطلحات موضوعية: Platelet Aggregation, Chemistry, Pharmaceutical, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Naphthalenes, Ligands, Biochemistry, Inhibitory Concentration 50, chemistry.chemical_compound, Alkaloids, Thrombin, Piperidines, In vivo, Drug Discovery, Thrombin receptor, medicine, Animals, Furans, Molecular Biology, IC50, chemistry.chemical_classification, Chemistry, Organic Chemistry, Parasympatholytics, Biological activity, In vitro, Rats, Macaca fascicularis, Models, Chemical, Area Under Curve, Himbacine, Molecular Medicine, Receptors, Thrombin, Protein Binding, medicine.drug, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314b4325d14e742098e88c8f15d4faa6
https://doi.org/10.1016/j.bmcl.2007.04.061

المؤلفون: Samuel Chackalamannil, Yan Xia, Ho-Sam Ahn, Madhu Chintala, Zhiyong Hu, William J. Greenlee, George Boykow, Jairam Palamanda, Jacqueline Agans-Fantuzzi, Yuguang Wang, Yunsheng Hsieh, Stan Kurowski, Michael P. Graziano

المصدر: Journal of medicinal chemistry. 51(11)

مصطلحات موضوعية: Acute coronary syndrome, Pyridines, Administration, Oral, Pharmacology, In Vitro Techniques, Naphthalenes, chemistry.chemical_compound, Lactones, Structure-Activity Relationship, Alkaloids, Piperidines, Drug Discovery, Thrombin receptor, medicine, Animals, Humans, Myocardial infarction, Furans, Vorapaxar, Chemistry, Unstable angina, Antagonist, medicine.disease, Rats, Macaca fascicularis, Himbacine, Molecular Medicine, Platelet aggregation inhibitor, Receptors, Thrombin, Platelet Aggregation Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8283cae1689317bc0621d95ac186d5b4
https://pubmed.ncbi.nlm.nih.gov/18447380

المؤلفون: William J. Greenlee, Martin C. Clasby, Yan Xia, Charles A. Lunn, George Boykow, Madhu Chintala, Samuel Chackalamannil, Dario Doller, Ho-Sam Ahn, Hsingan Tsai, Yunsheng Hsieh, Keith Eagen, Jacqueline Agans-Fantuzzi

المصدر: Bioorganicmedicinal chemistry letters. 17(16)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Naphthalenes, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Alkaloids, Piperidines, Drug Discovery, Thrombin receptor, Pyridine, Structure–activity relationship, Animals, Receptor, PAR-1, Furans, Molecular Biology, Molecular Structure, Chemistry, Aryl, Organic Chemistry, Anticoagulants, Rats, Himbacine, Molecular Medicine, Platelet aggregation inhibitor, Platelet Aggregation Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6ec0e90cf0d03b83e02d4d5ec69c2b
https://pubmed.ncbi.nlm.nih.gov/17574850

المؤلفون: Jairam Palamanda, Yunsheng Hsieh, Kevin B. Alton, Carolyn Foster, Samuel Chackalamannil, Grace Kao, William J. Greenlee, Dario Doller, Ho-Sam Ahn, Hsingan Tsai, Martin C. Clasby, Matthew Bryant, George Boykow, April Smith-Torhan, Yan Xia, Michael Czarniecki, Janice Lau, Keith Eagen, Yan Lin, Jacqueline Agans-Fantuzzi, Madhu Chintala

المصدر: Journal of medicinal chemistry. 50(1)

مصطلحات موضوعية: Platelet Aggregation, Pyridines, Biological Availability, In Vitro Techniques, Radioligand Assay, Structure-Activity Relationship, Pharmacokinetics, Cytochrome P-450 Enzyme System, In vivo, Oral administration, Drug Discovery, Thrombin receptor, Potency, Animals, Humans, Enzyme inducer, Furans, biology, Chemistry, Antagonist, Stereoisomerism, In vitro, Rats, Macaca fascicularis, Biochemistry, biology.protein, Microsomes, Liver, Molecular Medicine, Receptors, Thrombin, Heterocyclic Compounds, 3-Ring, Platelet Aggregation Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd9d29b7d96274823e8704dbd569006
https://pubmed.ncbi.nlm.nih.gov/17201416

المؤلفون: Mariappan V. Chelliah, Samuel Chackalamannil, Yan Xia, Keith Eagen, Martin C. Clasby, Xiaobang Gao, William Greenlee, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Yunsheng Hsieh, Matthew Bryant, Jairam Palamanda, Tze-Ming Chan, David Hesk, Madhu Chintala

المصدر: Journal of Medicinal Chemistry; Oct2007, Vol. 50 Issue 21, p5147-5160, 14p

المؤلفون: Martin C. Clasby, Samuel Chackalamannil, Michael Czarniecki, Dario Doller, Keith Eagen, William Greenlee, Grace Kao, Yan Lin, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Madhu Chintala, Carolyn Foster, April Smith-Torhan, Kevin Alton, Matthew Bryant, Yunsheng Hsieh, Janice Lau

المصدر: Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 1, p129-138, 10p