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1
المؤلفون: Siew Kiang Tan, Yee Wah Foong, Chrystie Wan Ning Quek, Mark Jean Aan Koh, Poh Lin Tan, Shui Yen Soh
المصدر: JAAD Case Reports, Vol 6, Iss 11, Pp 1138-1140 (2020)
JAAD Case Reportsمصطلحات موضوعية: JMML, juvenile myelomonocytic leukemia, medicine.medical_specialty, Juvenile myelomonocytic leukemia, business.industry, Sweet Syndrome, JXG, juvenile xanthogranulomas, Leukemia cutis, Case Report, Dermatology, lcsh:RL1-803, medicine.disease, juvenile myelomonocytic leukemia, leukemia cutis, Langerhans cell histiocytosis, Juvenile xanthogranulomas, multiple juvenile xanthogranulomas, medicine, lcsh:Dermatology, medicine.symptom, LCH, Langerhans cell histiocytosis, business
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2
المؤلفون: Brent Kelly, Adam V. Nguyen, Sharon S. Raimer, Michael P Ryan, Matthew J. Hay
المصدر: JAAD Case Reports, Vol 6, Iss 6, Pp 521-523 (2020)
JAAD Case Reportsمصطلحات موضوعية: Pathology, medicine.medical_specialty, nodule, Juvenile xanthogranuloma, unusual, Case Report, Dermatology, NF1, neurofibromatosis type 1, Juvenile xanthogranulomas, xanthogranuloma, medicine, lcsh:Dermatology, Juvenile, JXG, juvenile xanthogranuloma, JMML, juvenile myelomonocytic leukemia, Juvenile myelomonocytic leukemia, blue, business.industry, Nodule (medicine), lcsh:RL1-803, medicine.disease, infant, pediatric, juvenile, atypical, subcutaneous, Presentation (obstetrics), medicine.symptom, neonate, business
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3
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6125-6139 (2021)مصطلحات موضوعية: SHP2, Src homology 2 domain-containing phosphatase 2, CTLA-4, cytotoxic T lymphocyte-associated antigen 4, NSML, Noonan syndrome with multiple lentigines, Allosteric regulation, Phosphatase, Biophysics, Protein Data Bank (RCSB PDB), Protein tyrosine phosphatase, FRET, Förster resonance energy transfer, SH2 domain, Biochemistry, PD-1, programmed cell death protein 1, RMSF, root mean square fluctuation, RMSD, root mean square deviation, SAXS, small angle X-ray scattering, PMF, potential of mean force, Settore CHIM/02, Structural Biology, NS, Noonan syndrome, Genetics, Protein flexibility, pY, phosphorylated tyrosine, Binding site, PDB, protein data bank, ComputingMethodologies_COMPUTERGRAPHICS, JMML, juvenile myelomonocytic leukemia, biology, Chemistry, Wild type, Active site, SHP2 regulatory mechanism, REMD, replica exchange molecular dynamics, MD, molecular dynamics, SIRPalpha, signal regulatory protein alpha, Computer Science Applications, Inter-domain dynamics, Replica exchange molecular dynamics simulations, biology.protein, SASA, solvent accessible surface area, RTK, receptor tyrosine kinase, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, TP248.13-248.65, SH2, Src homology 2, Biotechnology, Research Article
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4
المصدر: JAAD Case Reports
مصطلحات موضوعية: Pathology, medicine.medical_specialty, CSHR, congenital self-healing reticulohistiocytoma, Juvenile xanthogranuloma, juvenile xanthogranuloma, Dermatology, erythema elevatum diutinum, xanthoma, Langerhans cell histiocytosis, medicine, Neurofibromatosis, JXG, juvenile xanthogranuloma, JMML, juvenile myelomonocytic leukemia, mastocytosis, Achilles tendon, Juvenile myelomonocytic leukemia, business.industry, NF, neurofibromatosis, Hyperpigmented nodule, Darier sign, EED, erythema elevatum diutinum, medicine.disease, juvenile myelomonocytic leukemia, ophthalmology, Histiocytosis, medicine.anatomical_structure, Erythema elevatum diutinum, Images in Dermatology, histiocytosis, business, MRI, magnetic resonance imaging
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5Academic Journal
المؤلفون: Shannon, Kevin
المساهمون: CALIFORNIA UNIV SAN FRANCISCO
المصدر: DTIC
مصطلحات موضوعية: Genetic Engineering and Molecular Biology, Biology, Medicine and Medical Research, Pharmacology, CANCER, DRUGS, GENE EXPRESSION, RESISTANCE(BIOLOGY), ACTIVATION, CELLS(BIOLOGY), CHEMOTHERAPY, GENES, IN VIVO ANALYSIS, INHIBITION, INHIBITORS, LEUKEMIA, MICE, MUTATIONS, NEOPLASMS, PROTEINS, THERAPY, AML CELLS, AML(ACUTE MYELOID LEUKEMIA), COMBINATION TREATMENT, CONVENTIONAL ANTICANCER DRUGS, DRUG RESISTANCE, GAP(GTPASE ACTIVATING PROTEIN), HYPERACTIVE RAS SIGNALING, JMML(JUVENILE MYELOMONOCYTIC LEUKEMIA), MEK INHIBITORS
وصف الملف: text/html
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6Academic Journal
المؤلفون: Shannon, Kevin
المساهمون: CALIFORNIA UNIV SAN FRANCISCO
المصدر: DTIC
مصطلحات موضوعية: Medicine and Medical Research, LEUKEMIA, CLINICAL MEDICINE, CLONES, DOSAGE, DRUGS, GENES, GENETICS, IN VIVO ANALYSIS, INACTIVATION, MODULATION, MUTATIONS, NEOPLASMS, PATIENTS, RESISTANCE, RESPONSE, SURVIVAL(PERSONNEL), NEUROFIBROMATOSIS, JMML(JUVENILE MYELOMONOCYTIC LEUKEMIA), MOUSE MODELS, MPN(MYELOPROLIFERATIVE NEOPLASMS), NF1(NEUROFIBROMATOSIS 1) PEDIATRIC CANCER, TARGETED THERAPEUTICS
وصف الملف: text/html
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7
المؤلفون: Geneviève Coulombe, Nathalie Rivard
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 1, Pp 11-21 (2016)مصطلحات موضوعية: 0301 basic medicine, animal structures, gastrointestinal cancer, ERK, extracellular signal-regulated kinases, NF-κB, nuclear factor-κB, chemical and pharmacologic phenomena, Protein tyrosine phosphatase, Review, PTPN11, Receptor tyrosine kinase, IEC, intestinal epithelial cell, 03 medical and health sciences, lcsh:RC799-869, Protein kinase B, PI3K/AKT/mTOR pathway, JMML, juvenile myelomonocytic leukemia, KO, knockout, Hepatology, biology, IBD, inflammatory bowel disease, Gastroenterology, Wnt signaling pathway, hemic and immune systems, PI3K, phosphatidyl-inositol 3-kinase, GI, gastrointestinal, 3. Good health, FGF, fibroblast growth factor, 030104 developmental biology, inflammation, embryonic structures, biology.protein, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, CagA, cytotoxin-associated gene A, Signal transduction, biological phenomena, cell phenomena, and immunity, Janus kinase, HCC, hepatocellular carcinoma, epithelium, PTP, protein tyrosine phosphatase, RAS, rat sarcoma viral oncogene, MAPK, mitogen-activated protein kinase, Proto-oncogene tyrosine-protein kinase Src
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8Electronic Resource
المؤلفون: CALIFORNIA UNIV SAN FRANCISCO, Shannon, Kevin
المصدر: DTIC
مصطلحات الفهرس: Medicine and Medical Research, LEUKEMIA, CLINICAL MEDICINE, CLONES, DOSAGE, DRUGS, GENES, GENETICS, IN VIVO ANALYSIS, INACTIVATION, MODULATION, MUTATIONS, NEOPLASMS, PATIENTS, RESISTANCE, RESPONSE, SURVIVAL(PERSONNEL), NEUROFIBROMATOSIS, JMML(JUVENILE MYELOMONOCYTIC LEUKEMIA), MOUSE MODELS, MPN(MYELOPROLIFERATIVE NEOPLASMS), NF1(NEUROFIBROMATOSIS 1) PEDIATRIC CANCER, TARGETED THERAPEUTICS, Text