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1Academic Journal
المؤلفون: Nikolova D, Yordanov A, Damyanova V, Radinov A, Toncheva D
المصدر: Balkan Journal of Medical Genetics, Vol 22, Iss 1, Pp 57-60 (2019)
مصطلحات موضوعية: jak2 (janus kinase 2) v617f mutation, myelofibrosis (mf), myeloproliferative neoplasms (mpn), Genetics, QH426-470
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1311-0160
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2
المؤلفون: Chuyao Liao, Di Wang, Ying Zhang, Zunjian Zhang, Fengguo Xu, Siyuan Qin, Yuxin Zhang, Danting Li, Yuan Tian, Jie Chen
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 763-780 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: CYP1A1, cytochrome P450 1A1, PF, PF-04859989, MOE, molecular operating environment, MTT, thiazolyl blue tetrazolium bromide, Kynurenine pathway, RPKM, reads per kilobase per million mapped reads, STAT3, signal transducer and activator of transcription 3, KAT, kynurenine aminotransferase, AHR, GPR35, G protein-coupled receptor 35, HRP, horseradish peroxi-dase, KA, kynurenic acid, RIPA, radioimmunoprecipitation, DMSO, dimethyl sulfoxide, ECL, enhanced chemiluminescence, Pharmacology, DPP-4, dipeptidyl peptidase-4, PDE5, phosphodiesterase type-5, RT-PCR, real-time polymerase chain reaction, CPT-11, irinotecan, AHR, aryl hydrocarbon receptor, chemistry.chemical_compound, DSS, dextran sulphate sodium, Intestinal toxicity, 0302 clinical medicine, Kynurenic acid, DRE, dioxin response elements, CH, CH223191, LC–MS, liquid chromatography–mass spectrometry, IS, internal standard, VCR, vincristine, General Pharmacology, Toxicology and Pharmaceutics, GE, gastric emptying, IL-6, interleukin-6, PDB, protein data bank, Receptor, GFP, green fluorescence protein, MOI, multiplicity of infection, 0303 health sciences, ESI, electrospray ionization, IBD, inflammatory bowel disease, HE, hematoxylin and eosin, ELISA, enzyme-linked immunosorbent assay, 030220 oncology & carcinogenesis, IDO1, indoleamine 2,3-dioxygenase 1, Original Article, 1-MT, 1-methyl-tryptophan, DAI, disease activity index, RPMI 1640, Roswell Park Memorial Institute 1640, medicine.symptom, GPR35, medicine.drug, PMA, phorbol 12-myristate 13-acetate, Linag, linagliptin, Trp, tryptophan, Dens-Cl, N-diethyl-amino naphthalene-1-sulfonyl chloride, Inflammation, AG, AG490, Linagliptin, Dns-Cl, N-dimethyl-amino naphthalene-1-sulfonyl chloride, 03 medical and health sciences, PBS, phosphate buffer saline, FBS, fetal bovine serum, Downregulation and upregulation, GI, gastrointestinal transit, Vard, vardenafil, Gradually sensing, medicine, 030304 developmental biology, MRM, multiple-reaction monitoring, lcsh:RM1-950, KYN, kynurenine, BCA, bicinchoninic acid, lcsh:Therapeutics. Pharmacology, PMSF, phenylmethylsulfonyl fluoride, chemistry, ARNT, aryl hydrocarbon receptor nuclear translocator, ERK1/2, extracellular regulated protein kinases 1/2, LPS, lipopolysaccharides, BSA, bovine serum albumin, JAK2, janus kinase 2, Homeostasis
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3
المؤلفون: Amany A. Azouz, Esraa Saleh, Ali Ahmed Abo-Saif
المصدر: Saudi Pharmaceutical Journal, Vol 28, Iss 9, Pp 1101-1111 (2020)
Saudi Pharmaceutical Journal : SPJمصطلحات موضوعية: 0301 basic medicine, STAT3, signal transducer and activator of transcription 3, GSH, reduced glutathione, PDE, phosphodiesterase, RA, rheumatoid arthritis, MPO, myeloperoxidase, Pharmaceutical Science, Arthritis, Pharmacology, chemistry.chemical_compound, 0302 clinical medicine, Medicine, IL-6, interleukin-6, JAK2, Janus kinase 2, MMP-3, biology, RANKL, eNOS, endothelial nitric oxide synthase, IL-10, interleukin-10, Nitric oxide synthase, Antirheumatic Agents, Rheumatoid arthritis, iNOS, inducible nitric oxide synthase, medicine.drug_class, MMP-3, matrix metalloproteinase-3, CFA-induced arthritis, IL-6/JAK2/STAT3 signaling, Renin inhibitor, Article, Nitric oxide, RAS, renin angiotensin system, 03 medical and health sciences, DMARD, disease-modifying antirheumatic drug, MDA, malondialdehyde, 030203 arthritis & rheumatology, NO, nitric oxide, business.industry, TNF-α, tumor necrosis factor-alpha, lcsh:RM1-950, RANKL, receptor activator of nuclear factor-kappa B ligand, CFA, complete Freund's adjuvant, Aliskiren, medicine.disease, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, chemistry, H&E, hematoxylin and eosin, biology.protein, business
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4
المؤلفون: Kenneth Walsh, Yoshimitsu Yura, Soichi Sano
المصدر: JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 196-207 (2020)
JACC: Basic to Translational Scienceمصطلحات موضوعية: 0301 basic medicine, MPN, myeloproliferative neoplasm, lcsh:Diseases of the circulatory (Cardiovascular) system, Il-1β inflammasome, Somatic cell, Cell, Inflammation, Disease, 030204 cardiovascular system & hematology, STATE-OF-THE-ART REVIEW, PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D, 03 medical and health sciences, TET2, ten-eleven translocation-2, 0302 clinical medicine, Immune system, Medicine, DNMT3A, DNA methyltransferase-3A, hsCRP, high-sensitivity C-reactive protein, TET2, TNF, tumor necrosis factor, business.industry, fungi, VAF, variant allele fraction, food and beverages, HSPCs, hematopoietic stem and progenitor cells, medicine.disease, Phenotype, IL, interleukin, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, JAK2, lcsh:RC666-701, TNF-α, Heart failure, Immunology, DNMT3A, ASXL1, additional sex combs like 1, TP53, tumor protein 53, JAK2, janus kinase 2, medicine.symptom, Cardiology and Cardiovascular Medicine, business
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5
المؤلفون: Sano, Soichi, Wang, Ying, Yura, Yoshimitsu, Sano, Miho, Oshima, Kosei, Yang, Yue, Katanasaka, Yasufumi, Min, Kyung-Duk, Matsuura, Shinobu, Ravid, Katya, Mohi, Golam, Walsh, Kenneth
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: BMT, bone marrow transplant, MPN, myeloproliferative neoplasm, AIM2, absence in melanoma 2, JAK2WT, wild-type Janus kinase 2, ARCH, age-related clonal hematopoiesis, LT-HSC, long-term hematopoietic stem cell, TAC, transverse aortic constriction surgery, CCL2, C-C motif chemokine ligand 2, left ventricular hypertrophy, IL, interleukin, STAT, signal transducer and activator of transcription, PRECLINICAL RESEARCH, myocardial infarction, JAK2V617F, mutant Janus kinase 2 (valine to phenylalanine at residue 617), HSC, hematopoietic stem cell, IFNGR1, interferon gamma receptor 1, clonal hematopoiesis, MI, myocardial infarction, LPS, lipopolysaccharide, CHIP, clonal hematopoiesis of indeterminate potential, HSPC, hematopoietic stem and progenitor cell, NET, neutrophil extracellular traps, JAK2, Janus kinase 2, ANOVA, analysis of variance, GFP, green fluorescent protein
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6
المؤلفون: A. Radinov, A. Yordanov, Draga Toncheva, Vera Damyanova, Dragomira Nikolova
المصدر: Balkan Journal of Medical Genetics, Vol 22, Iss 1, Pp 57-60 (2019)
Balkan Journal of Medical Genetics : BJMGمصطلحات موضوعية: medicine.medical_specialty, myeloproliferative neoplasms (mpn), QH426-470, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Polycythemia vera, Internal medicine, hemic and lymphatic diseases, Genotype, Genetics, Medicine, Myelofibrosis, Genetics (clinical), Myeloproliferative neoplasm, 030304 developmental biology, 0303 health sciences, Janus kinase 2, Hematology, biology, business.industry, Point mutation, myelofibrosis (mf), jak2 (janus kinase 2) v617f mutation, medicine.disease, 030220 oncology & carcinogenesis, biology.protein, Original Article, business
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7
المؤلفون: Jonel Trebicka, Yasuko Iwakiri
المصدر: JHEP Reports
JHEP reports 3(4), 100316 (2021). doi:10.1016/j.jhepr.2021.100316مصطلحات موضوعية: Cirrhosis, Dll4, delta like canonical Notch ligand 4, HRS, hepatorenal syndrome, PDE, phosphodiesterase, medicine.medical_treatment, Portal venous pressure, PIGF, placental growth factor, Hsp90, heat shock protein 90, AT1R, angiotensin II type I receptor, PKG, cGMP-dependent protein kinase, Review, HSC, MLCP, myosin light-chain phosphatase, Chronic liver disease, Bioinformatics, PDGF, platelet-derived growth factor, angiogenesis, Hepatorenal syndrome, NET, neutrophil extracellular trap, CCl4, carbon tetrachloride, Immunology and Allergy, JAK2, Janus kinase 2, Gastroenterology, eNOS, endothelial nitric oxide synthase, VEGF, VEGF, vascular endothelial growth factor, ECM, extracellular matrix, β1-AR, β1-adrenergic receptor, CCL2, chemokine (C-C motif) ligand 2, FXR, VCAM1, vascular cell adhesion molecule 1, Portal hypertension, NSBB, TIPS, Transjugular intrahepatic portosystemic shunt, EUS, endoscopic ultrasound, HSCs, hepatic stellate cells, NSBBs, non-selective beta blockers, NO, statins, FXR, farnesoid X receptor, TIPS, transjugular intrahepatic portosystemic shunt, Internal Medicine, medicine, ddc:610, LSEC, Rho-kinase, HVPG, hepatic venous pressure gradient, NO, nitric oxide, KO, knockout, Hepatology, business.industry, fibrosis, β2-AR, β2-adrenergic receptor, LSEC, liver sinusoidal endothelial cells, medicine.disease, Review article, liver stiffness, ACE2, angiogenesis-converting enzyme 2, CSPH, clinically significant portal hypertension, ACLF, acute-on-chronic liver failure, CLD, chronic liver disease, Hepatic stellate cell, β-Arr2, β-arrestin 2, business, HCC, hepatocellular carcinoma
وصف الملف: application/octet-stream
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8
المؤلفون: David A. Goukassian, Lahouaria Hadri, Kenneth Fish, Malik Bisserier, Walid Hamouche, Abrisham Eskandari, Agnieszka Brojakowska
المصدر: Journal of Molecular and Cellular Cardiology
مصطلحات موضوعية: 0301 basic medicine, Lung Diseases, ARDS, AT1R, angiotensin II type 1 receptor, MRI, Magnetic resonance imaging, Physiopathology, 030204 cardiovascular system & hematology, medicine.disease_cause, Global Health, vWF, Von Willebrand factor, law.invention, HCoV, Human coronavirus, 0302 clinical medicine, law, Epidemiology, DIC, Disseminated intravascular coagulation, IL, Interleukin, JAK2, Janus kinase 2, COVID-19, Coronavirus disease 2019, TTE, Transthoracic echocardiography, HIV, Human immunodeficiency virus infection, IgG, Immunoglobulin G, Transmission (medicine), ECG, Electrocardiogram, PAR-1, Proteinase-activated receptor 1, RV, Right ventricle, Disease Management, Intensive care unit, CTD, C-terminal domain, Pulmonary embolism, IFN, Interferon, PKC, Protein kinase C, Cardiovascular Diseases, AC, Anticoagulation, S-protein, Spike protein, CMRI, Cardiovascular magnetic resonance, ECMO, Extracorporeal membrane oxygenation, CRP, C-reactive protein, CT, Computed tomography, Cardiology and Cardiovascular Medicine, MERS-CoV, Middle east respiratory syndrome-coronavirus, TMPRSS2, Transmembrane serine protease 2, medicine.medical_specialty, Middle East respiratory syndrome coronavirus, DPP4, Dipeptidyl peptidase IV, ICU, Intensive care Unit, JEV, Japanese encephalitis virus, STEMI, ST-segment elevated myocardial infarction, PE, Pulmonary embolism, LV, Left ventricle, Article, SARS-CoV, Severe acute respiratory syndrome coronavirus, WHO, World Health Organization, TTC, Takotsubo cardiomyopathy, 03 medical and health sciences, MRA, Mineralocorticoid receptor antagonists, PEEP, Positive end-expiratory pressure, ACE2, Angiotensin-converting enzyme 2, ARDS, Acute respiratory distress syndrome, medicine, STAT3, Signal transducer and activators of transcription 3, Humans, NTD, N-terminal domain, Intensive care medicine, Molecular Biology, BNP, B-type natriuretic peptide, RBM, Receptor-binding motif, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, EC, Endothelial cells, business.industry, SARS-CoV-2, RDV, Remdesivir, Public health, GGO, Ground-glass opacities, TNF, Tumor necrosis factor, COVID-19, Clinical features, AngI, Angiotensin I, ARB, AngII-type I receptor blockers, medicine.disease, United States, LVEF, Left ventricular ejection fraction, Clinical trial, Treatment, FDA, Food and drug administration, 030104 developmental biology, RAS, Renin-angiotensin system, RBD, Receptor-binding domain, DENV, Dengue virus, business
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9
المؤلفون: Ergun Pinarbasi, Merve Nur Aydemir, Mahir Budak, Nilgun Cekin, Ertan Mahir Korkmaz, Habes Bilal Aydemir
المساهمون: Gaziosmanpaşa Üniversitesi, Fakülteler, Fen Edebiyat Fakültesi
المصدر: Gene Reports
مصطلحات موضوعية: STAT5B, HDAC2, histone deacetylase 2, SOCS4, suppressor of cytokine signaling 4, AKT1, AKT serine/threonine kinase 1, 0302 clinical medicine, RB1, RB transcriptional corepressor 1, JAK2, Janus kinase 2, Coronavirus, STAT6, IL17A, interleukin 17 A, MAPK3, mitogen-activated protein kinase 3, NOS3, nitric oxide synthase 3, HDAC1, histone deacetylase 1, CTNNB1, catenin beta 1, 030220 oncology & carcinogenesis, SUMO1, small ubiquitin like modifier 1, IL7, interleukin 7, TGFB, TNFRSF21, TNF receptor superfamily member 21, STAT4, signal transducer and activator of transcription 4, CXCL16, C-X-C motif chemokine ligand 16, CXCL11, C-X-C motif chemokine ligand 11, MAPK4, mitogen-activated protein kinase 4, TGFBR2, transforming growth factor beta receptor 2, KEGG, Kyoto Encyclopedia of Genes and Genomes, stat, Article, WHO, World Health Organization, JARID1A, lysine demethylase 5A, 03 medical and health sciences, SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1, microRNA, Genetics, E2F1, E2F transcription factor 1, IL33, interleukin 33, SOCS6, suppressor of cytokine signaling 6, COVID19, new type corona virus disease, SOCS5, suppressor of cytokine signaling 5, SP1, Sp1 transcription factor, TGFBR1, transforming growth factor beta receptor 1, PANTHER, protein analysis through evolutionary relationships, ICTV, International Committee on Taxonomy of Viruses, BCL2, BCL2 apoptosis regulator, 030104 developmental biology, SUMO2, small ubiquitin like modifier 2, NFKB1, nuclear factor kappa B subunit 1, 0301 basic medicine, STAT3, signal transducer and activator of transcription 3, viruses, IKBKE, inhibitor of nuclear factor kappa B kinase subunit epsilon, STAT5B, signal transducer and activator of transcription 5B, SARS-CoV-2, severe acute respiratory disease coronavirus type 2, NFKBIE, NFKB inhibitor epsilon, medicine.disease_cause, SMAD4, SMAD family member 4, IL2, interleukin 2, JARID1B, lysine demethylase 5B, SOCS1, suppressor of cytokine signaling 1, IL5, interleukin 5, SMAD3, SMAD family member 3, MAPK6, mitogen-activated protein kinase 6, IL10, interleukin 10, IL21, interleukin 21, SMAD2, SMAD family member 2, JAK-STAT signaling pathway, EIF4A1, eukaryotic translation initiation factor 4A1, STAT6, signal transducer and activator of transcription 6, JARID1C, lysine demethylase 5C, IL16, interleukin 16, IL24, interleukin 24, IL8, interleukin 8, IL13, interleukin 13, ACE-2, angiotensin-converting enzyme 2, IL22, interleukin 22, JAK1, Janus kinase 1, JARID2, Jumonji and AT-rich interaction domain containing 2, IL25, interleukin 25, Computational biology, Biology, MAPK7, mitogen-activated protein kinase 7, CXCL10, C-X-C motif chemokine ligand 10, CXCL9, C-X-C motif chemokine ligand 9, MAPK1, mitogen-activated protein kinase 1, medicine, HIF1A, hypoxia inducible factor 1 subunit alpha, TBP, TATA-box binding protein, GRB2, growth factor receptor bound protein 2, Epigenetics, CDK1, cyclin dependent kinase 1, CDKL2, cyclin dependent kinase like 2, PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, SOCS3, suppressor of cytokine signaling 3, miRNA, SARS-CoV-2, IL15, interleukin 15, HDAC3, histone deacetylase 3, IFNGR2, interferon gamma receptor 2, CXCL1, C-X-C motif chemokine ligand 1, NFKBIE, JAK/STAT, PTEN, phosphatase and tensin homolog, NFKB, RHOA, ras homolog family member A, TMPRSS4, transmembrane serine protease 4, TMPRSS11A, transmembrane serine protease 11A
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10
المؤلفون: Lu, Ping-Hsun, Tseng, Chien-Wei, Lee, Jing-Ling, Lee, En-Yu, Lin, Yu-Ping, Lin, I-Hsin, Yu, Min-Chien, Lu, Kuo-Cheng, Kuo, Ko-Lin
المصدر: Pharmacological Research-Modern Chinese Medicine
مصطلحات موضوعية: ALI, acute lung injury, PrsDMe, prosapogenin D methyl ester, ASC, C-terminal caspase recruitment domain, AT1R, angiotensin II type I receptor, RNP, ribonucleoprotein, CCR, CC chemokine receptor, MPO, myeloperoxidase, Review Article, GC-MS, gas chromatography-mass spectrometry, Nrf2, nuclear factor erythroid-related factor 2, PLE, perilla leaf extract, AKT1, AKT serine/threonine kinase 1, CoVs, coronaviruses, TNF-α, tumor necrosis factor-α, GSK3β, glycogen synthase kinase beta, HIV-1, human immunodeficiency virus type 1, VCAM-1, vascular cell adhesion molecule 1, PRRs, pattern recognition receptors, ADRP, ADP ribose phosphatase, BALF, bronchoalveolar lavage fluid, ILC3, type 3 innate lymphoid cells, DIC, disseminated intravascular coagulation, RCT, randomized controlled trial, JAK2, Janus kinase 2, NF-κB, nuclear factor kappa B, ICAM-1, intercellular adhesion molecule 1, antivirus, PLpro, papain-like protease, Jing Si Herbal Drink, NO, nitrogen monoxide, RBD, receptor-binding domain, VEGF, vascular endothelial growth factor, STAT, signal transducer and activator of transcription, MMP-9, matrix metallopeptidase 9, Ang-II, angiotensin-II, LC–MS, liquid chromatography-mass spectrometry, COX-2, cyclooxygenase-2, iNOS, inducible nitric oxide synthase, LPS, lipopolysaccharide, TCM, traditional Chinese medicine, GM-CSF, granulocyte-macrophage colony-stimulating factor, NK, natural killer, PI3K, phosphoinositide 3-kinase, CPE, cytopathogenic effect, TLR, Toll-like receptor, ATF2, activating transcription factor 2, NETs, neutrophil extracellular traps, RA, rosmarinic acid, JSHD, Jing Si herbal drink, NEK7, NIMA-related kinase 7, RdRP, RNA-dependent RNA polymerase, HLH, hemophagocytic lymphohistiocytosis, mechanism, ACE2, angiotensin-converting enzyme 2, complex mixtures, NLRP3, NLR family pyrin domain-containing 3, WHO, World Health Organization, ROS, reactive oxygen species, 3CLpro, 3-chymotrypsin-like cysteine protease, SOD, superoxide dismutase, TGF-β, transforming growth factor-β, RORγ, RAR-related orphan receptor γ, NE, neutrophil elastase, PD, platycodin D, IFN, interferon, CSFR, colony-stimulating factor receptor, TXA2, thromboxane A2, VOC, variants of concern, ARDS, acute respiratory distress syndrome, citH3, citrullinated H3, PG, Platycodon grandiflorum, COVID-19, herbs, DA, dehydromatricarin A, HSP70, heat shock protein 70, SM, Seomae mugwort, anti-inflammation, HIF-1, hypoxia-inducible factor 1, HMGB1, high mobility group box 1, AA, Artemisia argyi, Mpro, main protease, COPD, chronic obstructive pulmonary disease, CSF, colony-stimulating factor, DAMPs, damage-associated molecular patterns, Nsps, nonstructural proteins, TMPRSS2, transmembrane serine protease 2, MAPK, mitogen-activated protein kinase
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11
المؤلفون: Martin Bidlingmaier, Birgit Rathkolb, Martin Hrabĕ de Angelis, Arne Hinrichs, Werner F. Blum, Sebastian Bultmann, Heinrich Leonhardt, Maik Dahlhoff, Simone Renner, Andreas Blutke, Eckhard Wolf, Barbara Kessler, Andreas Hoeflich, Hiroshi Nagashima, Maren Bernau, Mayuko Kurome, Rüdiger Wanke, Elisabeth Kemter, Armin M. Scholz
المصدر: Molecular Metabolism, Vol 11, Iss, Pp 113-128 (2018)
Molecular Metabolism
Mol. Metab. 11, 113-128 (2018)
Molecular metabolism, 11: 113-128مصطلحات موضوعية: 0301 basic medicine, Insulin-like growth factor 1, Swine, INSR, insulin receptor, medicine.medical_treatment, 4EBP1, eukaryotic initiation factor 4E binding protein 1, IGFBP3, Dwarfism, IGF1, insulin-like growth factor 1, Growth hormone receptor, PCR, polymerase chain reaction, LDL, low-density lipoprotein, Laron syndrome, STAT5 Transcription Factor, Insulin-Like Growth Factor I, LSM, least squares mean, CRISPR/Cas, clustered regularly interspaced short palindromic repeats/CRISPR-associated, JAK2, Janus kinase 2, Adiposity, mTOR, mechanistic target of rapamycin, HOMA, homeostatic model assessment, DXA, dual-energy X-ray absorptiometry, ELISA, enzyme-linked immunosorbent assay, Pig model, eIF4E, eukaryotic translation initiation factor 4E, AKT, serine-threonine protein kinase, PPARG, peroxisome proliferator-activated receptor gamma, STAT, signal transducer and activator of transcription, GHR, growth hormone receptor, LPL, lipoprotein lipase, Liver, mTORC, mTOR complex, S6K, protein S6 kinase 1, Original Article, IRS1, insulin receptor substrate 1, Growth Hormone Receptor, Laron Syndrome, Pig Model, Hypoglycemia, Insulin-like Growth Factor 1, Signaling, HSL, hormone-sensitive lipase, PI3K, phosphoinositide 3 kinase, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, medicine.medical_specialty, lcsh:Internal medicine, aa, amino acid, HDL, high-density lipoprotein, IgG, immunoglobulin G, Mechanistic Target of Rapamycin Complex 2, Biology, 03 medical and health sciences, GSK3B, glycogen synthase 3 beta, Internal medicine, medicine, Animals, LS, Laron syndrome, lcsh:RC31-1245, Molecular Biology, Leptin receptor, DAB, 3,3′-diaminobenzidine, SE, standard error, Growth factor, Body Weight, sgRNA, single guide RNA, Cell Biology, Receptors, Somatotropin, Janus Kinase 2, medicine.disease, IRS1, GH, growth hormone, TBS, Tris-buffered saline, Insulin receptor, Insulin-Like Growth Factor Binding Protein 2, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, Insulin-Like Growth Factor Binding Protein 3, IGFBP, IGF-binding protein, LEPR, leptin receptor, Growth Hormone, biology.protein, RIA, radioimmunoassay, MRI, magnetic resonance imaging, MAPK, mitogen-activated protein kinase
وصف الملف: application/pdf
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12
المؤلفون: Xin Tong, Lei Yin, Ram K. Menon, Colin L. Stewart, Min-Jung Park, Makayla J. Brunt, M. Bishr Omary, Raymond Kwan, Maria Brzozowski, Graham F. Brady, Sujith V.W. Weerasinghe, Hope Martin
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 3, Pp 365-383 (2017)مصطلحات موضوعية: WT, wild type, 0301 basic medicine, Premature aging, HFD, high-fat diet, Stat, signal transducer and activator of transcription, Nonalcoholic Fatty Liver Disease, Lipodystrophy, Laminopathy, Growth Hormone Signaling, % liver weight, liver percentage of body mass, PBS, phosphate-buffered saline, Igf1, insulin-like growth factor 1, Biology, FPLD2, Dunnigan familial partial lipodystrophy, Het, heterozygous, Erk, extracellular signal–regulated kinase, LMNA, 03 medical and health sciences, Hepatocyte homeostasis, Jak2, Janus kinase 2, medicine, lcsh:RC799-869, STAT5, Original Research, KO, knockout, Hepatology, ND, normal diet, Gastroenterology, medicine.disease, Fibrosis, GH, growth hormone, 3. Good health, Cell biology, 030104 developmental biology, Cancer research, biology.protein, qPCR, quantitative polymerase chain reaction, Nuclear lamina, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, Steatohepatitis, Lamin
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13Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor☆
المؤلفون: Kendra K. Bence, Derek J. Zimmer, Kimberly Rak, Ryan C. Tsou
المصدر: Molecular Metabolism
مصطلحات موضوعية: Leptin, WAT, White adipose tissue, White adipose tissue, SHP2, Src homology 2 domain-containing protein tyrosine phosphatase, GTT, Glucose tolerance test, 0302 clinical medicine, Prdm16, PR domain containing 16, PTP1B, Protein tyrosine phosphatase 1B, Glucose homeostasis, JAK2, Janus kinase 2, PRDM16, 0303 health sciences, Glucose tolerance test, medicine.diagnostic_test, digestive, oral, and skin physiology, POMC, Proopiomelanocortin, UCP1, Uncoupling protein 1, Hypothalamus, Original Article, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, HFD, High-fat diet, Biology, PI3K, Phosphatidylinositol 3-kinase, 03 medical and health sciences, Proopiomelanocortin, Internal medicine, BAT, Brown adipose tissue, LepRb, Leptin receptor long form, Phosphatase, medicine, Obesity, IL-6, Interleukin-6, Molecular Biology, 030304 developmental biology, Leptin receptor, Nkx2.1, NK2 homeobox 1 protein or thyroid transcription factor-1, ob/ob, leptin-deficient mice, Cell Biology, HPA, hypothalamus–pituitary–adrenal, STAT3, Signal transducer and activator of transcription 3, Endocrinology, ITT, Insulin tolerance test, biology.protein, CNTF, Ciliary neurotrophic factor, db/db, Leptin receptor-deficient mice, 030217 neurology & neurosurgery, Cre, Cre recombinase, PTPs, Protein tyrosine phosphatases
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14
المؤلفون: Nahid Aboutaleb, Faramarz Souri, Solmaz Nasseri Maleki
المصدر: Journal of Chemical Neuroanatomy
مصطلحات موضوعية: 0301 basic medicine, Male, Berberine, STAT3, signal transducer and activator of transcription 3, Anti-Inflammatory Agents, Pharmacology, medicine.disease_cause, Antioxidants, Brain Ischemia, chemistry.chemical_compound, 0302 clinical medicine, Medicine, p-AKT, phosphorylated Protein kinase B, TTC, 23,5-triphenyltetrazolium chloride, Alkaloid, Brain, Inflammatory cytokines, Neuroprotection, Interleukin 10, MMP-9, matrix metallopeptidase 9, Neuroprotective Agents, COX-2, prostaglandin-endoperoxide synthase 2, Anesthesia, iNOS, inducible nitric oxide synthase, PI3K, phosphoinositide 3-kinase, IL-1β, interleukin-1β, PPARγ, peroxisome proliferator-activated receptor-γ, pGSK, phosphorylated Glycogen synthase kinase, Ischemia, NF-κB, nuclear factor-κB, TNFα, tumor necrosis factor alpha, Article, Proinflammatory cytokine, 03 medical and health sciences, Cellular and Molecular Neuroscience, Downregulation and upregulation, MCAO model, Animals, cardiovascular diseases, JAK2, Janus Kinase 2, Rats, Wistar, MCAO, middle cerebral artery occlusion, MAPK or MAP kinase, A mitogen-activated protein kinase, business.industry, medicine.disease, Rats, JNKs, c-Jun N-terminal kinases, AMPK, AMP-activated protein kinase, 030104 developmental biology, chemistry, pCREB, phosphorylated cAMP response element-binding protein, IL-10, interleukin 10, business, 030217 neurology & neurosurgery, Oxidative stress
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15
المؤلفون: Zhiping P. Pang, Weiping Han
المصدر: Bioscience Reports
Bioscience Reports, Vol 32, Iss 5 (2012)مصطلحات موضوعية: cognition, Central Nervous System, Leptin, STAT3, signal transducer and activator of transcription 3, lcsh:Life, lcsh:QR1-502, Review Article, Biochemistry, Synaptic Transmission, lcsh:Microbiology, NMDAR, NMDA receptor, LTP, long-term potentiation, Postsynaptic potential, MSH, melanocyte stimulating hormone, Homeostasis, Insulin, NAc, nucleus accumbens, JAK2, Janus kinase 2, AgRP, agouti-related peptide, Neuronal Plasticity, diabetes, neurodegeneration, DA, dopaminergic, PBN, parabrachial nucleus, Ghrelin, LepRb, leptin receptor long isoform, medicine.anatomical_structure, Hypothalamus, IR, insulin receptor, neural circuitry, GHSR, growth hormone secretagogue receptor, MC3R, melanocortin 3 receptor, NMDA receptor, KA, kainic acid, GABAA, γ-aminobutyric acid A, PI3K, phosphoinositide 3-kinase, medicine.medical_specialty, LTD, long-term depression, energy homoeostasis, TH, tyrosine hydroxylase, Central nervous system, hormone, Biophysics, NPY, neuropeptide Y, Endocrine System, AMPA receptor, POMC, pro-opiomelanocortin, Biology, Neurotransmission, CNS, central nervous system, VTA, ventral tegmental area, Receptors, N-Methyl-D-Aspartate, S4, ARC, arcuate nucleus, Receptors, GABA, Internal medicine, Neuroplasticity, medicine, Animals, Humans, Receptors, AMPA, Molecular Biology, GluR, glutamate receptor, AMPAR, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor, NMDA, N-methyl-D-aspartate, IPSC, inhibitory postsynaptic current, VMH, ventromedial hypothalamus, Cell Biology, LHA, lateral hypothalamic area, Axons, Hormones, EPSC, excitatory postsynaptic current, lcsh:QH501-531, Endocrinology, MC, melanocortin, Synaptic plasticity, Synapses, Energy Metabolism, Neuroscience, GABA, γ-aminobutyric acid, MAPK, mitogen-activated protein kinase
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16Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy
المؤلفون: Toos Daemen, Joyce M Lubbers, Hans W. Nijman, Oana Draghiciu
المصدر: Oncoimmunology
مصطلحات موضوعية: CD62L, L-selectin, TUMOR-BEARING MICE, MDSCs, myeloid-derived suppressor cells, STAT3, signal transducer and activator of transcription 3, medicine.medical_treatment, ARG1, arginase-1, ATRA, all-trans retinoic acid, PDE-5, phosphodiesterase type 5, Review, IMCs, immature myeloid cells, HNSCC, head and neck squamous cell carcinoma, law.invention, APCs, antigen presenting cells, CARCINOMA PATIENTS, iNOS2, inducible nitric oxid synthase 2, law, GM-CSF/CSF2, granulocyte monocyte colony stimulating factor, ANTITUMOR IMMUNITY, GSH, glutathione, TGFβ, transforming growth factor β, Immunology and Allergy, Cytotoxic T cell, JAK2, Janus kinase 2, IN-VIVO, TCR, T cell receptor, gemcitabine, IL-1β, interleukin 1 β, NSAID, nonsteroidal anti-inflammatory drugs, c-kit, Mast/stem cell growth factor receptor, all-trans retinoic acid, TNFα, tumor necrosis factor α, IL-6, interleukin 6, mRCC, metastatic renal cell carcinoma, CCL2, chemokine (C-C motif) ligand 2, Oncology, VEGFR, vascular endothelial growth factor receptor, Tregs, regulatory T cells, CDDO-Me, bardoxolone methyl, ESTABLISHED TUMORS, DCs, dendritic cells, WITHANIA-SOMNIFERA, medicine.drug, MMPs, metalloproteinases (e.g., MMP9), CTLs, cytotoxic T lymphocytes, ERK1/2, extracellular signal-regulated kinases, FoxP3, forkhead box P3, 5-Fluorouracil, Immunology, sunitinib therapeutic vaccination, IFNγ, interferon γ, CANCER-PATIENTS, CD8(+) T-CELLS, Biology, ODN, oligodeoxynucleotides, RNS, reactive nitrogen species, ROS, reactive oxygen species, In vivo, IL-4, interleukin 4, TAMs, tumor-associated macrophages, medicine, PGE2, prostaglandin E2, WA, withaferin A, GITR, anti-glucocorticoid tumor necrosis factor receptor, bisphosphonates, CXCL15, chemokine (C-X-C motif) ligand 15, Flt3, Fms-like tyrosine kinase 3, WRE, Withaferin somnifera, NO, nitric oxide, immune suppressive mechanisms, HLA, human leukocyte antigen, SCF, stem cell factor, IMMUNOSUPPRESSIVE ACTIVITY, HSCs, hematopoietic stem cells, Cancer, COX2, cyclooxygenase 2, Immunotherapy, NADPH, nicotinamide adenine dinucleotide phosphate-oxidase NK cells, natural killer cells, medicine.disease, myeloid-derived suppressor cells, HPV-16, human papillomavirus 16, ADAM17, metalloproteinase domain-containing protein 17, Gemcitabine, Blockade, TRANS-RETINOIC ACID, NOHA, N-hydroxy-L-Arginine, NAC, N-acetyl cysteine, Myeloid-derived Suppressor Cell, Suppressor, CXCL12, chemokine (C-X-C motif) ligand 12, 5-FU, 5-fluorouracil, HIF-1α, hypoxia inducible factor 1α, IL-10, interleukin 10, Myd88, myeloid differentiation primary response protein 88, ICT, 3, 5, 7-trihydroxy-4′-emthoxy-8-(3-hydroxy-3-methylbutyl)-flavone, IL-13, interleukin 13
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17Academic Journal
المؤلفون: Yu,Hua E
المساهمون: CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA DUARTE
مصطلحات موضوعية: Medicine and Medical Research, Pharmacology, drug resistance, Neuroblastoma, neoplasms, tumor microenvironment, JAK2(Janus kinase 2), STAT3(Signal transducer and activator of transcription 3), monocytes, tumor cells, cell monocyte, chemotherapy
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18
المؤلفون: Wolfgang Vogel, Melanie Schranz, William J.H. Griffiths, Andreas R. Janecke, Antonello Pietrangelo, Roman Mayr, Heinz Zoller
المصدر: Università degli studi di Modena e Reggio Emilia-IRIS
Journal of Hepatologyمصطلحات موضوعية: Pathology, medicine.medical_specialty, Hemochromatosis type IV, IREG1, Iron, FPN1, Ferroportin, Elevated transferrin saturation, Biology, PolyPhen, ER, endoplasmic reticulum, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, medicine, SLC40A1, Bio-informatics, SLC11A3, JAK2, Janus Kinase 2, Hemochromatosis, PolyPhen, polymorphism phenotyping, 030304 developmental biology, chemistry.chemical_classification, AUROC, area under the receiver operator curve, 0303 health sciences, Hepatology, Transferrin saturation, Genetic heterogeneity, ROC, receiver operator curve, SIFT, sorting intolerant from tolerant, HIC, hepatic iron concentration, medicine.disease, Penetrance, 3. Good health, chemistry, Transferrin, 030220 oncology & carcinogenesis, Immunology, biology.protein, MRI, magnetic resonance imaging, Research Article
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