المؤلفون: M. Kordes, L. Malgerud, J.-E. Frödin, J. Yachnin, C. Fernandez Moro, S. Ghazi, R. Pozzi Mucelli, N. Kartalis, P. Ghorbani, M. Del Chiaro, V. Wirta, M. Björnstedt, M.G. Liljefors, J.-M. Löhr

المصدر: ESMO Gastrointestinal Oncology, Vol 5, Iss , Pp 100070- (2024)

مصطلحات موضوعية: pancreatic cancer, precision oncology, clinical decision support system, molecular tumour board, cancer genomics, targeted therapies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2949819824000311; https://doaj.org/toc/2949-8198

URL الوصول: https://doaj.org/article/ecd9d7272a8447a19250dec73578fd2f

المؤلفون: Julia Koehler Leman, Sergey Lyskov, Steven M. Lewis, Jared Adolf-Bryfogle, Rebecca F. Alford, Kyle Barlow, Ziv Ben-Aharon, Daniel Farrell, Jason Fell, William A. Hansen, Ameya Harmalkar, Jeliazko Jeliazkov, Georg Kuenze, Justyna D. Krys, Ajasja Ljubetič, Amanda L. Loshbaugh, Jack Maguire, Rocco Moretti, Vikram Khipple Mulligan, Morgan L. Nance, Phuong T. Nguyen, Shane Ó Conchúir, Shourya S. Roy Burman, Rituparna Samanta, Shannon T. Smith, Frank Teets, Johanna K. S. Tiemann, Andrew Watkins, Hope Woods, Brahm J. Yachnin, Christopher D. Bahl, Chris Bailey-Kellogg, David Baker, Rhiju Das, Frank DiMaio, Sagar D. Khare, Tanja Kortemme, Jason W. Labonte, Kresten Lindorff-Larsen, Jens Meiler, William Schief, Ora Schueler-Furman, Justin B. Siegel, Amelie Stein, Vladimir Yarov-Yarovoy, Brian Kuhlman, Andrew Leaver-Fay, Dominik Gront, Jeffrey J. Gray, Richard Bonneau

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/7ccba8c202cd473d906c246ef7b2eb77

المؤلفون: Jacynthe L. Toulouse, Brahm J. Yachnin, Edward H. Ruediger, Daniel Deon, Marc Gagnon, Kévin Saint-Jacques, Maximilian C. C. J. C. Ebert, Delphine Forge, Dominic Bastien, Damien Y. Colin, Jean Jacques Vanden Eynde, Anne Marinier, Albert M. Berghuis, Joelle N. Pelletier

المصدر: ACS Omega, Vol 4, Iss 6, Pp 10056-10069 (2019)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/b6882ec44dce4affaf57abba4a81cf46

المؤلفون: Brahm J. Yachnin (1285692), Vikram Khipple Mulligan (3333285), Sagar D. Khare (216014), Chris Bailey-Kellogg (682345)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, T-cell epitopes, epitope predictors, design parameter choices, Rosetta design trajectory, optimized objective function, Rosetta protein design suite, deimmunized sequence space, Flexible Rosetta-Based Biotherapeut., drug efficacy, chemical qualities, design protocols, term, case study proteins, protein biotherapeutics, equivalent nondeimmunizing sequence.

Relation: https://figshare.com/articles/journal_contribution/MHCEpitopeEnergy_a_Flexible_Rosetta-Based_Biotherapeutic_Deimmunization_Platform/14485296

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00056.s001

المؤلفون: M. Hoejgaard, A. Drilon, J.J. Lin, S. Kummar, D.S.W. Tan, J. Patel, S. Leyvraz, V. Moreno Garcia, L.S. Rosen, B. Solomon, J. Yachnin, Y. Liu, M-S. Dai, R. Norenberg, D-I. Burcoveanu, L. Yun, G. Beckmann, C.E. Mussi, L. Shen

المصدر: Journal of Thoracic Oncology. 18:S48-S49

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c1a4789bf7b7268ba199c83e122d484d
https://doi.org/10.1016/s1556-0864(23)00269-1

المؤلفون: Raheel Ahmad, Alexei M. Tyryshkin, Lingjun Xie, William A. Hansen, Brahm J. Yachnin, Thomas J. Emge, Ashraf Mashrai, Sagar D. Khare, Spencer Knapp

المصدر: Journal of Inorganic Biochemistry. 244:112206

مصطلحات موضوعية: Inorganic Chemistry, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1d401d705c920cb4c824ea5b46407c1d
https://doi.org/10.1016/j.jinorgbio.2023.112206

المؤلفون: Sagar D. Khare, Chris Bailey-Kellogg, Vikram Khipple Mulligan, Brahm J. Yachnin

المصدر: J Chem Inf Model

مصطلحات موضوعية: Computer science, General Chemical Engineering, Protein design, Epitopes, T-Lymphocyte, Computational biology, Library and Information Sciences, Protein Engineering, 01 natural sciences, Article, Epitope, 0103 physical sciences, Humans, Deimmunization, 010304 chemical physics, Sequence design, Computational Biology, Proteins, food and beverages, General Chemistry, Protein engineering, 0104 chemical sciences, Computer Science Applications, Term (time), 010404 medicinal & biomolecular chemistry, Benchmark (computing), Sequence space (evolution)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c782b568342e5b384ee89a5369293138
https://doi.org/10.1021/acs.jcim.1c00056

المؤلفون: Brahm J. Yachnin, Sai Kiran Naineni, Mehdi Amiri, Jutta Steinberger, Jerry Pelletier, Sarah A.E. Aboushawareb, Stephen J Kiniry, Francis Robert, Regina Cencic, Pavel V. Baranov, Nahum Sonenberg, Jennifer Chu, Leo Shen, Rayelle Itoua Maïga

المصدر: Nucleic Acids Research

مصطلحات موضوعية: AcademicSubjects/SCI00010, Hippuristanol, Biology, Ribosome, Helicase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Eukaryotic initiation factor, Small-molecule inhibition, Genetics, Protein biosynthesis, Humans, 030304 developmental biology, 0303 health sciences, Messenger RNA, Gene regulation, Chromatin and Epigenetics, RNA, Binding, RNA Helicase A, Eukaryotic translation initiation, Cell biology, Sterols, Therapeutic suppression, chemistry, Drug Resistance, Neoplasm, eIF4A, Eukaryotic Initiation Factor-4A, Mutation, CRISPR-Cas Systems, 5' Untranslated Regions, Ribosomes, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdcf49ca66e056ff882d0364ea18d02
https://doi.org/10.1093/nar/gkaa662

المؤلفون: Brahm J. Yachnin, Laura R. Azouz, Ralph E. White, Conceição A. S. A. Minetti, David P. Remeta, Victor M. Tan, Justin M. Drake, Sagar D. Khare

المصدر: Proceedings of the National Academy of Sciences. 119

مصطلحات موضوعية: Enzyme Precursors, Multidisciplinary, Catalytic Domain, Drug Design, PC-3 Cells, Computer-Aided Design, Humans, gamma-Glutamyl Hydrolase, Protein Engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0920c37310a6575d4da650a701305f02
https://doi.org/10.1073/pnas.2116097119

المؤلفون: V. Moreno, J.J. Lin, D.S.W. Tan, S. Kummar, M.-S. Dai, U.N. Lassen, S. Leyvraz, Y. Liu, J.D. Patel, L. Rosen, B. Solomon, J. Yachnin, R. Norenberg, M. Fellous, C.E. Mussi, L. Shen, A. Drilon

المصدر: Journal of Thoracic Oncology. 17:S473-S474

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::62bd758bdf8e46050c33964751145aae
https://doi.org/10.1016/j.jtho.2022.07.831

المؤلفون: Dominik Gront, Kresten Lindorff-Larsen, Jack Maguire, Jens Meiler, Christopher D. Bahl, Jason S. Fell, Chris Bailey-Kellogg, Andrew M. Watkins, Frank DiMaio, Daniel P. Farrell, Jared Adolf-Bryfogle, Julia Koehler Leman, Frank D. Teets, Vladimir Yarov-Yarovoy, Ajasja Ljubetič, Shannon T. Smith, William A. Hansen, Steven M. Lewis, Justyna Krys, Shourya S. Roy Burman, Amelie Stein, Rhiju Das, David Baker, Vikram Khipple Mulligan, Jason W. Labonte, Georg Kuenze, William R. Schief, Rebecca F. Alford, Shane Ó Conchúir, Hope Woods, Tanja Kortemme, Johanna K. S. Tiemann, Sagar D. Khare, Sergey Lyskov, Ziv Ben-Aharon, Ora Schueler-Furman, Amanda L. Loshbaugh, Richard Bonneau, Brahm J. Yachnin, Andrew Leaver-Fay, Kyle A. Barlow, Phuong T. Nguyen, Jeliazko R. Jeliazkov, Jeffrey J. Gray, Justin B. Siegel, Rocco Moretti, Ameya Harmalkar, Brian Kuhlman

مصطلحات موضوعية: Workflow, Documentation, SIMPLE (military communications protocol), business.industry, Computer science, Supercomputer, Software engineering, business, Protocol (object-oriented programming), Scientific software

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae3b538a88ca76a15e111345bd76765
https://doi.org/10.1101/2021.04.04.438423

المؤلفون: Brahm J. Yachnin, Justin M. Drake, David P. Remeta, Conceição A.S.A. Minetti, Victor M. Tan, Sagar D. Khare, Laura R. Azouz, Ralph White

مصطلحات موضوعية: chemistry.chemical_classification, Proteases, Methotrexate Toxicity, medicine.diagnostic_test, Chemistry, Proteolysis, Cell, Computational biology, medicine.anatomical_structure, Enzyme, medicine, Computational design, Massively parallel, Lower activity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f14579b53423aa50e59298dcb416c69b
https://doi.org/10.1101/2021.03.25.437042

المؤلفون: Richard Greil, Christiane Jungels, Luis Paz-Ares, E. Van Cutsem, Lars Thorsson, L. Østergaard Poulsen, Sebastian Ochsenreither, S. Cicenas, Dirk Arnold, J. Yachnin, M. Zematis, Joëlle Collignon, R.L. Eefsen, I. Garcia Ribas, Ahmad Awada, Per Pfeiffer

المصدر: Annals of Oncology. 32:S602-S603

مصطلحات موضوعية: Chemotherapy, Oncology, medicine.drug_class, business.industry, medicine.medical_treatment, Pancreatic cancer, medicine, Cancer research, non-small cell lung cancer (NSCLC), Hematology, medicine.disease, Monoclonal antibody, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3f2a3bf68a6c5126b04aead8dde2095c
https://doi.org/10.1016/j.annonc.2021.08.1060

المؤلفون: Ulka N. Vaishampayan, J.S. de Bono, Raanan Berger, Jeffrey C. Goh, Josep M. Piulats, Satoshi Fukasawa, Kristiina Ojamaa, R. de Wit, Cuizhen Niu, Aurelius Omlin, Susan Feyerabend, Marine Gross-Goupil, Ken-ichi Tabata, Christopher J. Hoimes, J. Yachnin, Emmanuel S. Antonarakis, A. Sezer, Charles Schloss, Tuomo Alanko, Christian Heinrich Poehlein

المصدر: Annals of Oncology. 32:S651-S652

مصطلحات موضوعية: Oncology, medicine.medical_specialty, business.industry, Hematology, Pembrolizumab, Castration resistant, medicine.disease, Prostate cancer, Docetaxel, Internal medicine, medicine, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ee35d7421ce607554a274938ca97ee32
https://doi.org/10.1016/j.annonc.2021.08.1124

المؤلفون: Laura R. Azouz, Justin M. Drake, Ralph W deVere White, Sagar D. Khare, Brahm J. Yachnin

المصدر: The FASEB Journal. 33

مصطلحات موضوعية: chemistry.chemical_classification, Chemotherapy, Computer science, medicine.medical_treatment, Protein design, Computational biology, Biochemistry, Enzyme, chemistry, Genetics, medicine, Molecular Biology, Massively parallel, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbbd1e80fbdf2abf852acc0dd982da18
https://doi.org/10.1096/fasebj.2019.33.1_supplement.472.13

المؤلفون: Brahm J. Yachnin, Peter C. K. Lau, Albert M. Berghuis

المصدر: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1864:1641-1648

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Stereochemistry, Mutant, Biophysics, Calorimetry, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, Biochemistry, Mixed Function Oxygenases, Analytical Chemistry, Enzyme catalysis, 03 medical and health sciences, Residue (chemistry), Bacterial Proteins, X-Ray Diffraction, Catalytic Domain, Enzyme Stability, Scattering, Small Angle, Rhodococcus, Molecular Biology, chemistry.chemical_classification, Acinetobacter, biology, Active site, Monooxygenase, Enzyme structure, 0104 chemical sciences, Loop (topology), Kinetics, 030104 developmental biology, Enzyme, chemistry, Biocatalysis, Mutagenesis, Site-Directed, Oxygenases, biology.protein, NADP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce461b52a858bb3a9316e630a33bde22
https://doi.org/10.1016/j.bbapap.2016.08.015

المؤلفون: Brahm J. Yachnin, Sagar D. Khare

المصدر: Protein engineering, designselection : PEDS. 30(4)

مصطلحات موضوعية: 0301 basic medicine, Enzyme Precursors, medicine.medical_treatment, Bioengineering, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Zymogen, Carboxypeptidase-G2, Enzyme Stability, medicine, Molecular Biology, chemistry.chemical_classification, Protease, biology, Chemistry, Active site, gamma-Glutamyl Hydrolase, Circular permutation in proteins, Prodrug, 030104 developmental biology, Enzyme, 030220 oncology & carcinogenesis, Mutation, biology.protein, Original Article, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6aa4a002d9c12bc78da0be9194862e
https://pubmed.ncbi.nlm.nih.gov/28160000

المؤلفون: Brahm J. Yachnin, Tara Sprules, Albert M. Berghuis, Michelle B. McEvoy, Peter C. K. Lau

المصدر: Journal of the American Chemical Society

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Cyclohexanone, Flavoprotein, Flavin group, 010402 general chemistry, cyclohexanones, 01 natural sciences, Biochemistry, Article, Catalysis, Cofactor, Substrate Specificity, Baeyer Villiger oxidation, substrate-bound, 03 medical and health sciences, chemistry.chemical_compound, conformational change, Colloid and Surface Chemistry, cyclic ketones, Oxidoreductase, Criegee intermediate, cofactors, Rhodococcus, bound structure, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Active site, Substrate (chemistry), General Chemistry, Oxygen atom, 0104 chemical sciences, cyclohexanon monooxygenase, chemistry, Mutation, Oxygenases, Baeyer-Villiger monooxygenases, biology.protein, enantiospecificity, Rhodococcus sp, NADP, Carbonyl groups, cosubstrates, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfac3656f77469bc3efb853c89bf599
https://doi.org/10.1021/ja211876p

المؤلفون: Gunnar Nilsson, J Yachnin, Henrik Lindman, S Al-Musawi

المصدر: Cancer Research. 71:P5-13

مصطلحات موضوعية: Oncology, CA15-3, Cancer Research, medicine.medical_specialty, business.industry, medicine.drug_class, Cancer, CA 15-3, Retrospective cohort study, medicine.disease, Metastatic breast cancer, Breast cancer, Estrogen, Internal medicine, Medicine, business, Tumor marker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6ae6468c269e341ad29dd7e1217d8f51
https://doi.org/10.1158/0008-5472.sabcs11-p5-13-18

المؤلفون: Arne Östman, Matthias Löhr, M. Karimi, J. E. Frodin, Maria Gustafsson-Liljefors, Stephan Brock, J. Yachnin, Rainer Heuchel, Linnéa Malgerud, Sam Ghazi, Katrin Stecker, Sajo Kaduthanam, Valtteri Wirta, Carolin Hülsewig, Lars Engstrand, M Del Chiaro, C. Fernadez Moro, Maximilian Kordes

المصدر: Annals of Oncology. 29:vi31

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Second line treatment, business.industry, Internal medicine, medicine, Adenocarcinoma, Hematology, medicine.disease, business, Stratification (mathematics)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::29b064e9800e2634c3ed66c48430d625
https://doi.org/10.1093/annonc/mdy314.038