-
1
المؤلفون: Periannan Kuppusamy, Christopher J Pelham, Sean D Smith, J. J. Gomm, Esha Madan, Louise J. Jones, Kevin Shee, Masaki Nagane, S. Kiparoidze, Yu Soon A. Park, Alan R. Fersht, M. Lakshmi Kuppusamy, Taylor M. Parker, Matthias R. Bauer, Alisha Dhiman, Kálmán Hideg, Laura A. Hansen, Matti Holmes, Karuppaiyah Selvendiran, Ana C. Cunha, Ana R. Tomás, Thomas R. Holmes, Rajan Gogna, Kranti Shaik
مصطلحات موضوعية: 0301 basic medicine, Curcumin, Mutant, Mice, Nude, Antineoplastic Agents, Apoptosis, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Neoplasms, medicine, Tumor Cells, Cultured, Cytotoxic T cell, Animals, Humans, Gene Regulation, Molecular Biology, Piperidones, Cell Proliferation, Drug discovery, Wild type, Cancer, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Mutation, Cancer research, Female, Mutant Proteins, Tumor Suppressor Protein p53
-
2Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
المؤلفون: Peter Stepper, John G. Gribben, Adrienne Morgan, J. Louise Jones, Gabriella Ficz, Michael D. Allen, Tomasz P. Jurkowski, J. J. Gomm, Emily A. Saunderson, Lily Hoa
المصدر: Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)مصطلحات موضوعية: Epigenomics, 0301 basic medicine, Senescence, Science, Kruppel-Like Transcription Factors, General Physics and Astronomy, Biology, DNA methyltransferase, Article, General Biochemistry, Genetics and Molecular Biology, DNA Methyltransferase 3A, 03 medical and health sciences, medicine, Cyclin-Dependent Kinase Inhibitor p18, Humans, Breast, DNA (Cytosine-5-)-Methyltransferases, Epigenetics, lcsh:Science, Promoter Regions, Genetic, Gene, Cells, Cultured, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Gene Editing, Genetics, Multidisciplinary, Tumor Suppressor Proteins, PTEN Phosphohydrolase, Cancer, Promoter, General Chemistry, DNA Methylation, medicine.disease, 3. Good health, Cell Transformation, Neoplastic, 030104 developmental biology, DNA methylation, Cancer research, lcsh:Q, Female, CRISPR-Cas Systems
وصف الملف: application/pdf
-
3
المؤلفون: Simak Ali, Sami Shousha, Claudia Busonero, Hetal Patel, Sally Smith, Luca Magnani, Balázs Győrffy, Laki Buluwela, Rezvan Abduljabbar, Chun-Fui Lai, Jennifer H. Steel, Dena A. Jerjees, Alison Harrod, Carolina Gemma, J. J. Gomm, Louise J. Jones, Ian O. Ellis, Manikandan Periyasamy, Naina Patel, Emad A. Rakha, Frances V. Fuller-Pace, Judit Remenyi, R. Charles Coombes
المساهمون: Cancer Research UK, Breast Cancer Now, National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, Cancer Research Technology Ltd
مصطلحات موضوعية: TRANSCRIPTION FACTOR TFIIH, 0301 basic medicine, Cancer Research, Cyclin H, Transcription, Genetic, Estrogen receptor, Gene Expression, Cell Cycle Proteins, 0302 clinical medicine, BINDING, Phosphorylation, Kinase, ANDROGEN RECEPTOR, Cell cycle, Middle Aged, Prognosis, Cyclin-Dependent Kinases, Oncology, Receptors, Estrogen, 030220 oncology & carcinogenesis, Female, Life Sciences & Biomedicine, Signal Transduction, Adult, medicine.medical_specialty, ER-ALPHA, Breast Neoplasms, Biology, Article, 03 medical and health sciences, Breast cancer, Cyclin-dependent kinase, Internal medicine, BIOMARKER ASSESSMENT, medicine, CELL-CYCLE, Humans, Oncology & Carcinogenesis, BIOLOGICAL SIGNIFICANCE, Science & Technology, ACTIVATING KINASE, medicine.disease, 4/6 INHIBITOR PALBOCICLIB, 030104 developmental biology, Endocrinology, Cancer research, biology.protein, Cyclin-dependent kinase 7, Carrier Proteins, 1112 Oncology And Carcinogenesis, Estrogen receptor alpha, Cyclin-Dependent Kinase-Activating Kinase, Transcription Factors
-
4
المؤلفون: R C Coope, Eric Lam, Andrew Sunters, J J Gomm, M J Slade, R. C. Coombes, A Assadi-Sabet, M. J. O'Hare, D Roberts-Clark, Carlo Palmieri, A Hanby
المصدر: Journal of Endocrinology. 177:65-81
مصطلحات موضوعية: medicine.medical_specialty, Fibroblast Growth Factor 7, Stromal cell, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Blotting, Western, Breast Neoplasms, Enzyme-Linked Immunosorbent Assay, Biology, Fibroblast growth factor, Paracrine signalling, chemistry.chemical_compound, Endocrinology, Internal medicine, Paracrine Communication, Tumor Cells, Cultured, medicine, Humans, Breast, Receptor, Fibroblast Growth Factor, Type 2, skin and connective tissue diseases, Cells, Cultured, FGF10, Growth factor, Carcinoma, Ductal, Breast, Myoepithelial cell, Receptor Protein-Tyrosine Kinases, Epithelial Cells, Fibroblasts, Receptors, Fibroblast Growth Factor, Fibroblast Growth Factors, Carcinoma, Lobular, chemistry, Cancer research, Female, Keratinocyte growth factor, Fibroblast Growth Factor 10, Cell Division, Interleukin-1
-
5
المؤلفون: S Shousha, C L Johnston, R C Coombes, R Coope, J J Gomm, C Zammit
المصدر: British Journal of Cancer
مصطلحات موضوعية: Adult, medicine.medical_specialty, Cancer Research, Fibroblast Growth Factor 8, Colon, medicine.medical_treatment, Mammary gland, Breast Neoplasms, lactation, Biology, Fibroblast growth factor, Breast cancer, Internal medicine, Progesterone receptor, medicine, Biomarkers, Tumor, Humans, skin and connective tissue diseases, Fallopian Tubes, Aged, human breast cancer, Aged, 80 and over, Milk, Human, Growth factor, Uterus, Molecular and Cellular Pathology, Cancer, Epithelial Cells, Ductal carcinoma, Middle Aged, medicine.disease, Immunohistochemistry, Fibroblast Growth Factors, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Endocrinology, Oncology, Cancer research, Female, Cell Division
-
6
المؤلفون: J. J. Gomm, H C Cox, R. C. Coope, R. C. Coombes, R. Barnard, Sami Shousha, C. Yiangou, G. S. Bansal, N. Groome, J. Walters, C. L. Johnston
المصدر: British Journal of Cancer
مصطلحات موضوعية: musculoskeletal diseases, Cancer Research, Cell type, medicine.medical_specialty, animal structures, Molecular Sequence Data, Down-Regulation, Breast Neoplasms, Biology, Epitope, Isomerism, Internal medicine, Tumor Cells, Cultured, medicine, Humans, Amino Acid Sequence, Breast, RNA, Messenger, Receptor, Fibroblast Growth Factor, Type 1, Tyrosine, Receptor, Fibroblast growth factor receptor 1, Myoepithelial cell, Antibodies, Monoclonal, Receptor Protein-Tyrosine Kinases, Cancer, Epithelial Cells, Fibroblasts, medicine.disease, Immunohistochemistry, Receptors, Fibroblast Growth Factor, Molecular biology, Molecular Weight, Reverse transcription polymerase chain reaction, Endocrinology, Oncology, embryonic structures, Research Article
-
7
المؤلفون: J. J. Gomm, C Yiangou, Y. A. Luqmani, GS Bansal, R. C. Coombes, S K Marsh, C. L. Johnston, H C Cox
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Fibroblast Growth Factor 7, medicine.medical_treatment, Breast Neoplasms, Biology, Fibroblast growth factor, chemistry.chemical_compound, Breast cancer, Internal medicine, Tumor Cells, Cultured, medicine, Humans, Receptors, Growth Factor, Breast, RNA, Messenger, Receptor, Fibroblast Growth Factor, Type 2, Growth Substances, skin and connective tissue diseases, FGF10, Growth factor, Cancer, medicine.disease, Receptors, Fibroblast Growth Factor, Fibroblast Growth Factors, Endocrinology, Oncology, chemistry, Fibroblast growth factor receptor, Cancer research, Female, Keratinocyte growth factor, Fibroblast Growth Factor 10, Cell Division, Research Article
-
8
المؤلفون: R. C. Coombes, Lakjaya Buluwela, J. J. Gomm
المصدر: Endocrine Related Cancer. 4:35-43
مصطلحات موضوعية: Cancer Research, Endocrinology, Oncology, business.industry, Endocrinology, Diabetes and Metabolism, Cancer research, Myoepithelial cell, Medicine, business, Human breast
-
9
المؤلفون: J. Louise Jones, Ion Andreu, Alberto Elosegui-Artola, Raimon Sunyer, Roger Oria, Xavier Trepat, Elsa Bazellières, Michael D. Allen, Pere Roca-Cusachs, John Marshall, J. J. Gomm
المساهمون: Institut de Biologie du Développement de Marseille-Luminy (IBDML), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Institució Catalana de Recerca i Estudis Avançats (ICREA)
المصدر: Nature Materials
Nature Materials, Nature Publishing Group, 2014, 13 (6), pp.631-637. ⟨10.1038/nmat3960⟩
Nature Materials, 2014, 13 (6), pp.631-637. ⟨10.1038/nmat3960⟩مصطلحات موضوعية: Integrins, Integrin, Nanotechnology, Cell behaviour, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], 02 engineering and technology, Mechanotransduction, Cellular, Models, Biological, Extracellular matrix, 03 medical and health sciences, Rigidity (electromagnetism), Antigens, Neoplasm, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Humans, General Materials Science, Receptors, Vitronectin, ComputingMilieux_MISCELLANEOUS, Cells, Cultured, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Mechanical Engineering, Myoepithelial cell, food and beverages, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Fibronectins, Cell biology, Mechanics of Materials, biology.protein, Antigens neoplasm, Adaptation, 0210 nano-technology
-
10
المؤلفون: Caroline J. Pennington, Sarah E Clark, J. J. Gomm, Dylan R. Edwards, Sarah Dickinson, J. Louise Jones, S. Dreger, Michael D. Allen, Ivana Sestak, Ian R. Hart, Sabrinath Vallath, Gareth J. Thomas, Jack Cuzick, S J L Payne, Marwa M. Dawoud, John Marshall
المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 20(2)
مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, Integrins, Breast Neoplasms, Biology, Cell Line, Mice, Breast cancer, Antigens, Neoplasm, Transforming Growth Factor beta, Cell Line, Tumor, medicine, Carcinoma, Tumor Microenvironment, Animals, Humans, Neoplasm Invasiveness, Tumor microenvironment, Mammary tumor, Myoepithelial cell, Epithelial Cells, Transforming growth factor beta, Ductal carcinoma, medicine.disease, Prognosis, Immunohistochemistry, Tumor Burden, Carcinoma, Intraductal, Noninfiltrating, Oncology, Matrix Metalloproteinase 9, Mink, Case-Control Studies, biology.protein, Disease Progression, Female, Neoplasm Grading, Neoplasm Recurrence, Local, Follow-Up Studies
-
11
المؤلفون: R. C. Coombes, Qiu Yan Liu, R. C. Coope, P. J. Browne, Lakjaya Buluwela, J. J. Gomm
المصدر: Analytical Biochemistry. 226:91-99
مصطلحات موضوعية: Cell type, DNA, Complementary, medicine.drug_class, Molecular Sequence Data, Biophysics, Gene Expression, Cell Separation, Biology, Monoclonal antibody, Immunomagnetic separation, Biochemistry, Dynabeads, Tissue culture, Organoid, medicine, Humans, Breast, Molecular Biology, Cells, Cultured, Electrophoresis, Agar Gel, Membrane Glycoproteins, Base Sequence, Immunomagnetic Separation, Mucin-1, Mucins, Myoepithelial cell, Antibodies, Monoclonal, Epithelial Cells, Cell Biology, Molecular biology, Chemically defined medium, Female, Neprilysin
-
12
المؤلفون: J J Gomm, C L Johnston, H C Cox, R C Coombes
المصدر: Biochemical Journal. 306:609-616
مصطلحات موضوعية: medicine.medical_specialty, Membrane ruffling, Motility, Breast Neoplasms, Biology, Transfection, Fibroblast growth factor, Biochemistry, Epithelium, Mice, Breast cancer, GTP-Binding Proteins, Internal medicine, medicine, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 3, Receptor, Fibroblast Growth Factor, Type 4, Breast, Receptor, Molecular Biology, Cell Membrane, Cancer, 3T3 Cells, Cell Biology, Protein-Tyrosine Kinases, medicine.disease, Receptors, Fibroblast Growth Factor, rac GTP-Binding Proteins, Endocrinology, Microscopy, Fluorescence, Fibroblast growth factor receptor, Cell culture, Mutagenesis, Site-Directed, Cancer research, Fibroblast Growth Factor 1, Fibroblast Growth Factor 2, Research Article
-
13
المؤلفون: A. G. B. Lansdown, S. K. Chander, R. C. Coombes, R. C. Coope, J. J. Gomm, Y. A. Luqmani, N. Gould
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, PROTEINS, Monoterpene, Mammary gland, INHIBITION, Biology, Formestane, Terpene, chemistry.chemical_compound, Internal medicine, REGRESSION, Antineoplastic Combined Chemotherapy Protocols, Cyclohexenes, medicine, Animals, Oncology & Carcinogenesis, Anticarcinogen, Carcinogen, Limonene, Science & Technology, Terpenes, CARCINOGENESIS, Androstenedione, Mammary Neoplasms, Experimental, Methylnitrosourea, Rats, Inbred Strains, CANCER, TUMORS, Rats, MICE, Endocrinology, medicine.anatomical_structure, Oncology, chemistry, Toxicity, Female, Drug Screening Assays, Antitumor, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis, Research Article, medicine.drug
-
14
المؤلفون: R C Coope, R. C. Coombes, J J Gomm, M J Slade
المصدر: Experimental cell research. 247(1)
مصطلحات موضوعية: Mammary gland, Integrin, Molecular Sequence Data, Breast Neoplasms, Cell Communication, Biology, Basement Membrane, Cell Line, Focal adhesion, Laminin, medicine, Tumor Cells, Cultured, Humans, Amino Acid Sequence, Breast, Cells, Cultured, Epithelial polarity, Basement membrane, Myoepithelial cell, Cell Polarity, Epithelial Cells, Cell Biology, Cell biology, medicine.anatomical_structure, Cell culture, biology.protein, Female
-
15
المؤلفون: G S Bansal, J J Gomm, S K Marsh, D Roberts-Clarke, Richard C. Barnard, Caroline L. Johnston, C Zammit, R. C. Coombes, R C Coope
المصدر: Oncogene. 18(4)
مصطلحات موضوعية: Adult, Cancer Research, medicine.medical_specialty, animal structures, Fibroblast Growth Factor 8, Breast Neoplasms, Biology, Fibroblast growth factor, medicine.disease_cause, Breast cancer, Internal medicine, Genetics, medicine, Tumor Cells, Cultured, Humans, Receptor, Fibroblast Growth Factor, Type 3, Receptor, Fibroblast Growth Factor, Type 4, Breast, RNA, Messenger, Receptor, Fibroblast Growth Factor, Type 1, Autocrine signalling, Molecular Biology, In Situ Hybridization, Aged, Reverse Transcriptase Polymerase Chain Reaction, Fibroblast growth factor receptor 1, Myoepithelial cell, Cancer, Receptor Protein-Tyrosine Kinases, Epithelial Cells, Middle Aged, Protein-Tyrosine Kinases, medicine.disease, Receptors, Fibroblast Growth Factor, Neoplasm Proteins, Fibroblast Growth Factors, stomatognathic diseases, Endocrinology, Fibroblast growth factor receptor, embryonic structures, Cancer research, Female, Carcinogenesis
-
16Academic Journal
المؤلفون: C Palmieri, D Roberts-clark, A Assadi-sabet, R C Coope, A Sunters, A Hanby, M J Slade, J J Gomm, E W-f Lam, R C Coombes
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.581.9516; http://joe.endocrinology-journals.org/content/177/1/65.full.pdf
-
17
المؤلفون: C L Johnston, R C Coope, C. Yiangou, J J Gomm, P. J. Browne, R. C. Coombes, R Mason, G. S. Bansal
المصدر: Experimental cell research. 234(1)
مصطلحات موضوعية: medicine.medical_specialty, Cell type, Basic fibroblast growth factor, Cell, Blotting, Western, Tetrazolium Salts, Biology, Fibroblast growth factor, Tritium, Epithelium, chemistry.chemical_compound, Paracrine signalling, Internal medicine, medicine, Humans, Breast, Receptor, Fibroblast Growth Factor, Type 2, Cells, Cultured, Chromatography, High Pressure Liquid, DNA Primers, Glucosamine, integumentary system, Fibroblast growth factor receptor 1, Myoepithelial cell, Receptor Protein-Tyrosine Kinases, Epithelial Cells, Cell Biology, Immunohistochemistry, Receptors, Fibroblast Growth Factor, Cell biology, Extracellular Matrix, Blotting, Southern, Endocrinology, medicine.anatomical_structure, chemistry, embryonic structures, Female, Fibroblast Growth Factor 2, biological phenomena, cell phenomena, and immunity, Mitogens, Cell Division, Subcellular Fractions
-
18
المؤلفون: G. S. Bansal, C Yiangou, Sami Shousha, J. J. Gomm, R. C. Coombes, R. C. Coope, C. L. Johnston, P. J. Browne, N. Groome, J. Walters
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Proteases, medicine.medical_treatment, Immunoblotting, Breast Neoplasms, Biology, HUMAN MAMMARY-GLAND, Fibroblast growth factor, MOUSE, Polymerase Chain Reaction, Paracrine signalling, Mice, breast cancer, Internal medicine, Endopeptidases, medicine, EXTRACELLULAR-MATRIX, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 4, Receptor, Fibroblast Growth Factor, Type 1, Oncology & Carcinogenesis, Autocrine signalling, fibroblast growth factor 1, GENE-EXPRESSION, FACTOR RECEPTOR-1, Science & Technology, CARCINOMA CELLS, Growth factor, SIGNAL TRANSDUCTION, Myoepithelial cell, Receptor Protein-Tyrosine Kinases, protease, LOCALIZATION, Fibroblast growth factor receptor 4, ONCOLOGY, FACTOR MESSENGER-RNA, Molecular biology, Immunohistochemistry, Receptors, Fibroblast Growth Factor, Endocrinology, Female, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis, Immunostaining, FACTOR FAMILY, Research Article
-
19
المؤلفون: Sami Shousha, C. N. Rees, B. Dagg, R. C. Coope, J. J. Gomm, A. J. Desai, V. Thirunavukkarasu, Paul E. Pace, N. Groome, J. Walters, R. C. Coombes, Simak Ali, YA Luqmani
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, polymerase chain reaction, BINDING DOMAINS, Exon, Mice, Tumor Cells, Cultured, exon, GLUCOCORTICOID RECEPTORS, Sequence Deletion, Aged, 80 and over, Mice, Inbred BALB C, biology, DELETION VARIANT, Antibodies, Monoclonal, Exons, Middle Aged, oestrogen receptor, Gene Expression Regulation, Neoplastic, Receptors, Estrogen, COS Cells, Immunohistochemistry, Female, Antibody, transcription, MESSENGER-RNA, Receptors, Progesterone, Life Sciences & Biomedicine, Research Article, EXPRESSION, Adult, Breast Neoplasms, Enzyme-Linked Immunosorbent Assay, Transfection, Breast cancer, breast neoplasm, Progesterone receptor, medicine, Animals, Humans, RNA, Messenger, Oncology & Carcinogenesis, Aged, DNA Primers, Messenger RNA, Science & Technology, IDENTIFICATION, Cancer, medicine.disease, ONCOLOGY, Molecular biology, GENE, Survival Analysis, Reverse transcriptase, HUMAN ESTROGEN-RECEPTOR, biology.protein, TRANSCRIPTIONAL ACTIVATION, 1112 Oncology And Carcinogenesis, RESISTANCE
-
20
المؤلفون: J J, Gomm, R C, Coope, P J, Browne, R C, Coombes
المصدر: Journal of cellular physiology. 171(1)
مصطلحات موضوعية: Epidermal Growth Factor, Animals, Humans, Cell Differentiation, Epithelial Cells, Female, Fibroblast Growth Factor 2, Breast, Cell Separation, Cell Division, Cells, Cultured, Rats