المؤلفون: Michelle Kassner, J. Brek Eaton, Nanyun Tang, Joachim L. Petit, Nathalie Meurice, Hongwei Holly Yin, Paul Whiteaker

المصدر: SLAS Discovery, Vol 27, Iss 1, Pp 68-76 (2022)

مصطلحات موضوعية: Nicotinic acetylcholine receptor, Membrane potential assays, Cell-based screening, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555221000010; https://doaj.org/toc/2472-5552

URL الوصول: https://doaj.org/article/69bed0571f2b4e86ad58d7d3b8564877

المؤلفون: Lin Chen, Christopher R. Hughes, Henry A. Lester, Ronald J. Lukas, Aaron L. Nichols, Gaurav Advani, J. Brek Eaton, Kaori Noridomi, Richard W. Roberts, Farzad Jalali-Yazdi, Lan Huong Lai

المصدر: ACS Chem Biol

مصطلحات موضوعية: 0301 basic medicine, Xenopus, Receptors, Nicotinic, Ligands, Biochemistry, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, Point Mutation, Ion channel, Gene Library, Acetylcholine receptor, Chemistry, General Medicine, Bungarotoxin, Bungarotoxins, Recombinant Proteins, Fibronectins, Protein Subunits, Nicotinic acetylcholine receptor, 030104 developmental biology, Nicotinic agonist, nervous system, Biophysics, Thermodynamics, Molecular Medicine, lipids (amino acids, peptides, and proteins), Signal transduction, 030217 neurology & neurosurgery, Protein Binding, Protein ligand

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02d0b2ee1d50f827a1c6fd92e3c7f06
https://doi.org/10.1021/acschembio.8b00513

المؤلفون: Nicotinic Receptors, M. Imad Damaj, F. Ivy Carroll, J. Brek Eaton, Hernan A. Navarro, Bruce E. Blough, Sadiq Mirza, Ronald J. Lukas, Billy R. Martin

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://molpharm.aspetjournals.org/cgi/reprint/66/3/675.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.132.3024; http://molpharm.aspetjournals.org/cgi/reprint/66/3/675.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.132.3024
http://molpharm.aspetjournals.org/cgi/reprint/66/3/675.pdf

المؤلفون: J. Brek Eaton, Oluseye K. Onajole, Dani Brunner, Barbara J. Caldarone, Alan P. Kozikowski, Ronald J. Lukas, Gian Paolo Vallerini

المصدر: ACS Chemical Neuroscience. 7:811-822

مصطلحات موضوعية: Cyclopropanes, Male, 0301 basic medicine, Physiology, Stereochemistry, Cognitive Neuroscience, Motor Activity, Receptors, Nicotinic, Pharmacology, 01 natural sciences, Biochemistry, Partial agonist, Mice, Structure-Activity Relationship, 03 medical and health sciences, medicine, Animals, Potency, Nicotinic Agonists, EC50, Acetylcholine receptor, Sertraline, Behavior, Animal, 010405 organic chemistry, Chemistry, Cell Biology, General Medicine, Antidepressive Agents, 0104 chemical sciences, Nicotinic acetylcholine receptor, 030104 developmental biology, Antidepressant, medicine.drug, Behavioural despair test

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78a906ff17f686a33ebe0093dd6fa2d
https://doi.org/10.1021/acschemneuro.6b00050

المؤلفون: J. Brek Eaton, Ronald J. Lukas, Lucinda Thiede, Barbara J. Caldarone, Oluseye K. Onajole, Dani Brunner, Alan P. Kozikowski

المصدر: ACS Medicinal Chemistry Letters. 5:1196-1201

مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Ligand (biochemistry), Biochemistry, Cyclopropane, chemistry.chemical_compound, Nicotinic acetylcholine receptor, Enantiopure drug, nervous system, mental disorders, Drug Discovery, Pyridine, Side chain, sense organs, Selectivity, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68eda66f0330d674a22ad9b7379aa7c
https://doi.org/10.1021/ml500129k

المؤلفون: Li-Fang Yu, J. Brek Eaton, Alan P. Kozikowski, Han Kun Zhang, Ronald J. Lukas, Barbara J. Caldarone

المصدر: Journal of Medicinal Chemistry. 57:8204-8223

مصطلحات موضوعية: Drug, Chemistry, medicine.medical_treatment, media_common.quotation_subject, Pharmacology, 3. Good health, Nicotinic agonist, Drug Discovery, Cholinergic system, medicine, Molecular Medicine, Nicotinic Antagonist, Receptor, Depressive symptoms, Desensitization (medicine), media_common, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b3c32eb400ced5c1b7bce815abfedf0c
https://doi.org/10.1021/jm401937a

المؤلفون: J. Brek Eaton, Jon Lindstrom, Paul Whiteaker, Linda Lucero, Harrison Stratton, Yongchang Chang, John F. Cooper, Ronald J. Lukas

المصدر: Journal of Pharmacology and Experimental Therapeutics. 348:46-58

مصطلحات موضوعية: Pharmacology, Gene isoform, Agonist, biology, medicine.drug_class, Mutant, Xenopus, biology.organism_classification, Nicotinic agonist, medicine, Molecular Medicine, Binding site, Receptor, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::27c4dcf51971336162c90cd8e9c40833
https://doi.org/10.1124/jpet.113.208389

المؤلفون: Taleen Hanania, Han Kun Zhang, Ronald J. Lukas, Alan P. Kozikowski, J. Brek Eaton, Oluseye K. Onajole, Daniela Brunner, Li-Fang Yu, Paul Whiteaker

المصدر: Journal of Medicinal Chemistry. 56:5495-5504

مصطلحات موضوعية: Cyclopropanes, Male, Stereochemistry, Azetidine, Motor Activity, Receptors, Nicotinic, Pharmacology, Binding, Competitive, Partial agonist, Article, Cell Line, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Drug Stability, Cell Line, Tumor, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Structure–activity relationship, Nicotinic Agonists, Receptor, Swimming, Acetylcholine receptor, Mice, Inbred BALB C, Molecular Structure, Chemistry, Drug discovery, Stereoisomerism, Antidepressive Agents, Rats, Nicotinic acetylcholine receptor, Nicotinic agonist, Models, Chemical, Microsomes, Liver, Molecular Medicine, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e144a9ae7f5d7f2f0ca17d84b18cfbcb
https://doi.org/10.1021/jm400510u

المؤلفون: Oluseye K. Onajole, Dani Brunner, J. Brek Eaton, Li-Fang Yu, Allison Fedolak, Hendra Gunosewoyo, Han Kun Zhang, Ronald J. Lukas, Alan P. Kozikowski

مصطلحات موضوعية: 0301 basic medicine, Male, Stereochemistry, Ether, Receptors, Nicotinic, 01 natural sciences, Partial agonist, Article, Cyclopropane, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Drug Discovery, medicine, Animals, Nicotinic Agonists, Swimming, Pharmacology, Behavior, Molecular Structure, 010405 organic chemistry, Chemistry, Depression, Organic Chemistry, General Medicine, Affinities, 0104 chemical sciences, Mice, Inbred C57BL, Nicotinic acetylcholine receptor, 030104 developmental biology, Nicotinic agonist, Epibatidine, Varenicline, Selectivity, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3a9f05eefcc149a307e2923ae03bd8
https://europepmc.org/articles/PMC5097879/

المؤلفون: Dani Brunner, Barbara J. Caldarone, Allison Fedolak, Ronald J. Lukas, Taleen Hanania, J. Brek Eaton, Werner Tückmantel, Li-Fang Yu, Alan P. Kozikowski

المصدر: Journal of Medicinal Chemistry. 55:812-823

مصطلحات موضوعية: Male, ERG1 Potassium Channel, Receptors, Nicotinic, Pharmacology, Article, Mice, Radioligand Assay, Structure-Activity Relationship, Neurotransmitter receptor, Drug Discovery, Mecamylamine, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Nicotinic Agonists, Receptor, Mice, Inbred BALB C, Chemistry, Antagonist, Stereoisomerism, Blood Proteins, Isoxazoles, Antidepressive Agents, Ether-A-Go-Go Potassium Channels, Rats, Nicotinic acetylcholine receptor, HEK293 Cells, Nicotinic agonist, Microsomes, Liver, Molecular Medicine, Antidepressant, Protein Binding, Behavioural despair test, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ac15778e5639cd1126a8e8147d2cb9
https://doi.org/10.1021/jm201301h

المؤلفون: Katie Cavino, Afshin Ghavami, Barbara J. Caldarone, Jianhua Liu, Allison Fedolak, Li-Fang Yu, Ronald J. Lukas, Christina Ruiz, Alan P. Kozikowski, Matthew Terry, Daguang Wang, David Lowe, Dani Brunner, J. Brek Eaton

المصدر: Journal of Medicinal Chemistry. 54:7280-7288

مصطلحات موضوعية: medicine.medical_specialty, Pyridines, In Vitro Techniques, Receptors, Nicotinic, Pharmacology, Binding, Competitive, Partial agonist, Article, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Internal medicine, Drug Discovery, medicine, Animals, Humans, Nicotinic Agonists, Acetylcholine receptor, Sazetidine A, Behavior, Animal, Chemistry, Blood Proteins, Isoxazoles, Antidepressive Agents, Rats, Receptors, Neurotransmitter, Drug Partial Agonism, Nicotinic acetylcholine receptor, Endocrinology, Monoamine neurotransmitter, Nicotinic agonist, Microsomes, Liver, Azetidines, Molecular Medicine, Antidepressant, Serotonin, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129de2091cdbfddeda3218b1545813d3
https://doi.org/10.1021/jm200855b

المؤلفون: Han-Kun Zhang, J. Brek Eaton, Allison Fedolak, Hendra Gunosewoyo, Oluseye K. Onajole, Dani Brunner, Ronald J. Lukas, Li-Fang Yu, Alan P. Kozikowski

مصطلحات موضوعية: α4β2-nAChRs, Partial agonists, Hybrids, Antidepressant-like effects

Relation: http://hdl.handle.net/10027/21453; https://figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_novel_hybrids_of_highly_potent_and_selective_4_2-Nicotinic_acetylcholine_receptor_nAChR_partial_agonists/10776872

الاتاحة: http://hdl.handle.net/10027/21453
https://figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_novel_hybrids_of_highly_potent_and_selective_4_2-Nicotinic_acetylcholine_receptor_nAChR_partial_agonists/10776872

المؤلفون: Ronald J. Lukas, Bruce E. Blough, M. Imad Damaj, F. Ivy Carroll, S. Wayne Mascarella, Hernán A. Navarro, J. Brek Eaton

المصدر: Journal of Medicinal Chemistry. 53:8345-8353

مصطلحات موضوعية: Male, medicine.medical_treatment, Nicotinic Antagonists, Receptors, Nicotinic, Pharmacology, Article, Nicotine, Mice, chemistry.chemical_compound, Dopamine, Drug Discovery, medicine, Animals, Humans, Nicotinic Antagonist, Varenicline, Bupropion, Mice, Inbred ICR, Chemistry, Conditioned place preference, Nicotinic acetylcholine receptor, HEK293 Cells, Molecular Medicine, Smoking cessation, Tropanes, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8f4d145d89b52bd74bb5e266f524ae
https://doi.org/10.1021/jm100994w

المؤلفون: Bruce E. Blough, Sadiq Mirza, F. Ivy Carroll, Billy R. Martin, Hernán A. Navarro, Ronald J. Lukas, M. Imad Damaj, J. Brek Eaton

المصدر: Molecular Pharmacology. 66:675-682

مصطلحات موضوعية: Male, Metabolite, Pain, Nerve Tissue Proteins, Motor Activity, Receptors, Nicotinic, Pharmacology, Nicotine, Mice, chemistry.chemical_compound, Dopamine Uptake Inhibitors, Dopamine, mental disorders, medicine, Animals, Humans, Bupropion, Swimming, Dopamine Plasma Membrane Transport Proteins, Mice, Inbred ICR, Membrane Glycoproteins, Norepinephrine Plasma Membrane Transport Proteins, Behavior, Animal, Symporters, Membrane Transport Proteins, Hydroxybupropion, Disease Models, Animal, Nicotinic acetylcholine receptor, Monoamine neurotransmitter, chemistry, behavior and behavior mechanisms, Molecular Medicine, Antidepressant, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bfe40990ebd339c18baaed8de7d242
https://doi.org/10.1124/mol.104.001313

المؤلفون: Yong Chang Chang, Taleen Hanania, Paul Whiteaker, Guannan Li, Jie Wu, J. Brek Eaton, Ronald J. Lukas, Richard B. van Breemen, Alan P. Kozikowski, Emily Sabath, Han Kun Zhang, Qiang Liu, Li-Fang Yu, Dani Brunner

المصدر: Pharmacology Research & Perspectives. 2

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Pharmacology, Partial agonist, 3. Good health, Nicotinic acetylcholine receptor, Nicotinic agonist, Endocrinology, Neurology, Internal medicine, Medicine, Antidepressant, Cholinergic, General Pharmacology, Toxicology and Pharmaceutics, Nicotinic Antagonist, business, ADME, Behavioural despair test

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cf884747297e2fede9079e6b41fa9839
https://doi.org/10.1002/prp2.26

المؤلفون: Michelle Kassner, Holly Yin, Paul Whiteaker, J. Brek Eaton, Joachim Petit, Nathalie Meurice

المصدر: Biochemical Pharmacology. 97:622-623

مصطلحات موضوعية: Pharmacology, Nicotinic acetylcholine receptor, Chemistry, High-throughput screening, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::217b8c91ef6b71a3c6ee52522cd27fb6
https://doi.org/10.1016/j.bcp.2015.08.009

المؤلفون: J Brek, Eaton, Linda M, Lucero, Harrison, Stratton, Yongchang, Chang, John F, Cooper, Jon M, Lindstrom, Ronald J, Lukas, Paul, Whiteaker

المصدر: The Journal of pharmacology and experimental therapeutics. 348(1)

مصطلحات موضوعية: Protein Subunits, Xenopus laevis, Binding Sites, Neuropharmacology, Dose-Response Relationship, Drug, Oocytes, Animals, Humans, Female, Nicotinic Agonists, Receptors, Nicotinic, Crystallography, X-Ray, Cell Line

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e53446c55ae794b70b070df39cdcc831
https://pubmed.ncbi.nlm.nih.gov/24190916

المؤلفون: Li-Fang, Yu, J, Brek Eaton, Han-Kun, Zhang, Emily, Sabath, Taleen, Hanania, Guan-Nan, Li, Richard B, van Breemen, Paul, Whiteaker, Qiang, Liu, Jie, Wu, Yong-Chang, Chang, Ronald J, Lukas, Dani, Brunner, Alan P, Kozikowski

المصدر: Pharmacology Research & Perspectives

مصطلحات موضوعية: Antidepressive-like behavior, selectivity, partial agonist, Original Articles, nicotinic acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e91e7966687b0a771dac894883529c13
https://pubmed.ncbi.nlm.nih.gov/25505580

المؤلفون: Han Kun Zhang, Taleen Hanania, Ronald J. Lukas, J. Brek Eaton, Alan P. Kozikowski, Li-Fang Yu, Allison Fedolak, Dani Brunner

المصدر: Journal of medicinal chemistry. 55(22)

مصطلحات موضوعية: Male, Stereochemistry, Azetidine, Ether, Motor Activity, Receptors, Nicotinic, Article, chemistry.chemical_compound, Mice, Neuroblastoma, Radioligand Assay, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Nicotinic Agonists, Swimming, Acetylcholine receptor, Mice, Inbred BALB C, Stereoisomerism, Isoxazoles, Antidepressive Agents, Nicotinic acetylcholine receptor, Nicotinic agonist, chemistry, Mechanism of action, Epibatidine, Molecular Medicine, medicine.symptom, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8798aa190026fe665cd03898be3e3853
https://pubmed.ncbi.nlm.nih.gov/23092294

المؤلفون: Daniela Brunner, Allison Fedolak, Afshin Ghavami, Ronald J. Lukas, Werner Tückmantel, J. Brek Eaton, Hankun Zhang, Daguang Wang, Barbara J. Caldarone, Po Wai Yuen, Alan P. Kozikowski, Li-Fang Yu, Krishna Mohan Bajjuri, David Lowe, Neil E. Paterson

مصطلحات موضوعية: Molecular Conformation, Pharmacology, Receptors, Nicotinic, Crystallography, X-Ray, Ligands, Partial agonist, Article, Cell Line, chemistry.chemical_compound, Mice, Radioligand Assay, Structure-Activity Relationship, Neurotransmitter receptor, Drug Discovery, Animals, Humans, Drug Partial Agonism, Nicotinic Agonists, Receptor, Varenicline, Acetylcholine receptor, Mice, Inbred BALB C, Behavior, Animal, Chemistry, Stereoisomerism, Antidepressive Agents, Rats, Nicotinic acetylcholine receptor, Nicotinic agonist, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0febabfd3f451f81f0d67e0c3ba76c6
https://europepmc.org/articles/PMC3292870/