المؤلفون: Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi

المصدر: Journal of Medicinal Chemistry. 60:5521-5542

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Lactams, Stereochemistry, medicine.drug_class, Administration, Oral, Carboxamide, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Humans, Structure–activity relationship, Protein Kinase Inhibitors, ADME, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Chemistry, Active site, Isoquinolines, IRAK4, Combinatorial chemistry, Interleukin-1 Receptor-Associated Kinases, 030104 developmental biology, Lipophilic efficiency, Lipophilicity, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d71e108dde9e50f577dacbc8e3364e
https://doi.org/10.1021/acs.jmedchem.7b00231

المؤلفون: Steve Finegan, Jennifer L. Liras, John Schafer, Gregory G. Stone, Sarah K. Wade, Ann G. Connolly, Rhonda Monahan, Katherine E. Brighty, Joan Duignan, Steven J. Brickner, Phuong Le, Ivan J. Samardjiev, Richard P. Zaniewski, Dennis Girard, Jon Bordner, Meghan Maloney

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:276-279

مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Carboxamide, Ether, Dioxoles, Microbial Sensitivity Tests, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Ribose, medicine, Animals, Molecular Biology, Antibacterial agent, Organic Chemistry, Aminoglycoside, Haplorhini, Anti-Bacterial Agents, Rats, carbohydrates (lipids), chemistry, Cinnamates, Molecular Medicine, Hygromycin B, Hygromycin A

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31058e211b4e5cd78b92b592ecef72f
https://doi.org/10.1016/j.bmcl.2010.11.022

المؤلفون: Ashley A. Mills, Ivan J. Samardjiev, Amanda E. Riddle, David B. Damon, Brett L. Lucht, William B. Euler, Nadia Archambault, Devin Busse, Yu Wang, Allison M. Belcher

المصدر: Macromolecules. 41:7115-7121

مصطلحات موضوعية: chemistry.chemical_classification, Thermochromism, Materials science, Quenching (fluorescence), Polymers and Plastics, Organic Chemistry, Substituent, Mesophase, Polymer, Inorganic Chemistry, chemistry.chemical_compound, Differential scanning calorimetry, chemistry, Polymer chemistry, Materials Chemistry, Side chain, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::65902547512430b5f835b2937df18e85
https://doi.org/10.1021/ma801352f

المؤلفون: Makoto Kawai, Yoshinori Murata, Mio Sakai, Atsushi Omura, Kazunari Hattori, Shinichi Sakemi, Yoko Matsuoka, Ivan J. Samardjiev, Jon Bordner, Morimichi Sato, Takashi Kojima, Takashi Mano

المصدر: International Journal of Pharmaceutics. 355:337-340

مصطلحات موضوعية: Models, Molecular, Chemistry, Molecular Conformation, Antagonist, Pharmaceutical Science, Crystal structure, Quinolones, Dihedral angle, Receptors, N-Methyl-D-Aspartate, Dosage form, Crystallography, Differential scanning calorimetry, Isomerism, Piperidines, X-Ray Diffraction, Polymorphism (materials science), Microscopy, Electron, Scanning, NMDA receptor, Excitatory Amino Acid Antagonists, Single crystal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8050a9ed33b14d0a18ce1e4c46305dd
https://doi.org/10.1016/j.ijpharm.2007.11.060

المؤلفون: Hardwin O'dowd, Katherine E. Brighty, Michael W. Fichtner, Donn G. Wishka, Goss S. Kauffman, Mark C. Noe, Marion Bédard, Jason G. Lewis, Richard A. Buzon, Brian Samas, Jaap Kooistra, Ivan J. Samardjiev, Kathleen A. Farley, Geeta Yalamanchi

المصدر: The Journal of organic chemistry. 76(6)

مصطلحات موضوعية: Bicyclic molecule, Drug discovery, Organic Chemistry, Enantioselective synthesis, Nonene, Carboxylic Acids, Ketones, Bridged Bicyclo Compounds, Heterocyclic, Chemical synthesis, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Azepane, Drug Discovery, Stereoselectivity, Carboxylate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0679bee29b243873ab7356ff8fde330
https://pubmed.ncbi.nlm.nih.gov/21275376

المؤلفون: Ivan J. Samardjiev, Brian Samas

المصدر: Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E, Vol 64, Iss 8, Pp o1480-o1480 (2008)

مصطلحات موضوعية: Eclipsed conformation, Chemistry, General Chemistry, Condensed Matter Physics, Bioinformatics, Chloride, Organic Papers, lcsh:Chemistry, Crystallography, chemistry.chemical_compound, lcsh:QD1-999, medicine, General Materials Science, Twist, Anilinium chloride, Isopropyl, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f777f4de08c5c60d117f2c5522e6eaa
https://pubmed.ncbi.nlm.nih.gov/21203192

المؤلفون: Jane M. Withka, Christopher S. Jones, Michael John Munchhof, Yuriy A. Abramov, Rescek Diane Marie, Sandra P. McCurdy, Lawrence A. Reiter, Frank M. DiCapua, Jon Bordner, William H. Brissette, Ivan J. Samardjiev

المصدر: Bioorganicmedicinal chemistry letters. 18(9)

مصطلحات موضوعية: Agonist, Magnetic Resonance Spectroscopy, Molecular model, medicine.drug_class, Stereochemistry, Protein Conformation, Clinical Biochemistry, Pharmaceutical Science, Nuclear Overhauser effect, Crystallography, X-Ray, Biochemistry, Cell Line, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Computer Simulation, Receptor, Molecular Biology, Thrombopoietin, Thrombopoietin receptor, Chemistry, Organic Chemistry, Biological activity, Small molecule, Pyrimidines, Benzamides, Molecular Medicine, Receptors, Thrombopoietin, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760d0c1f270d3db21495d018daafea63
https://pubmed.ncbi.nlm.nih.gov/18396041

المؤلفون: Jon Bordner, Jotham Wadsworth Coe, Ivan J. Samardjiev, Crystal G. Bashore

المصدر: Journal of the American Chemical Society. 125(11)

مصطلحات موضوعية: chemistry.chemical_classification, Aza Compounds, Molecular Structure, Chemistry, Adamantane, Hydrazone, Amide reduction, General Chemistry, Crystallography, X-Ray, Biochemistry, Medicinal chemistry, Amides, Catalysis, Hydrolysis, chemistry.chemical_compound, Colloid and Surface Chemistry, Amide, Wolff–Kishner reduction, Organic chemistry, Organic synthesis, Ethylene glycol, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a410928ccba13b09e98ebf8ab95625c0
https://pubmed.ncbi.nlm.nih.gov/12630882

المؤلفون: Yu Wang, Nadia Archambault, Allison M. Belcher, Devin Busse, David B. Damon, Ashley Mills, Amanda E. Riddle, Ivan J. Samardjiev, Brett L. Lucht, William B. Euler

المصدر: Macromolecules; Sep2008, Vol. 41 Issue 19, p7115-7121, 7p