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1Academic Journal
المؤلفون: Scott H Henderson, Fiona Sorrell, James Bennett, Oleg Fedorov, Marcus T Hanley, Paulo H Godoi, Roberta Ruela De Sousa, Sean Robinson, Alexander Ashall-Kelly, Iva Hopkins Navratilova, Daryl S Walter, Jonathan M Elkins, Simon E Ward
مصطلحات موضوعية: Dose-Response Relationship, Drug, Drug Discovery, HEK293 Cells, Humans, Ligands, Molecular Structure, Protein Kinase Inhibitors, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Solubility, Structure-Activity Relationship
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2Academic Journal
المؤلفون: Scott H. Henderson (5315468), Fiona Sorrell (9095199), James Bennett (154826), Oleg Fedorov (244326), Marcus T. Hanley (9095202), Paulo H. Godoi (6400943), Roberta Ruela de Sousa (11224367), Sean Robinson (832893), Alexander Ashall-Kelly (11224370), Iva Hopkins Navratilova (9095205), Daryl S. Walter (2355013), Jonathan M. Elkins (1288767), Simon E. Ward (2237998)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, regulated kinase 1a, ray crystallography leads, pyrazolo [ 1, neuronal progenitor cells, good physicochemical properties, exhibited good permeability, >] pyridazine inhibitors, viable lead series, including alzheimer ’, excellent ligand efficiencies, 11 , >] pyridazines, vivo <, b <, specificity tyrosine, resolution x, oncologic indications, new therapies, neurodegenerative diseases, glycoprotein liability
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المؤلفون: Claire Shepherd, Sean Robinson, Alice Berizzi, Laura E. J. Thompson, Louise Bird, Simone Culurgioni, Simon Varzandeh, Philip B. Rawlins, Reid H. J. Olsen, Iva Hopkins Navratilova
المصدر: ACS Medicinal Chemistry Letters. 13:1172-1181
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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المؤلفون: Jürgen Brem, Tharindi Panduwawala, Jon Ulf Hansen, Joanne Hewitt, Edgars Liepins, Pawel Donets, Laura Espina, Alistair J. M. Farley, Kirill Shubin, Gonzalo Gomez Campillos, Paula Kiuru, Shifali Shishodia, Daniel Krahn, Robert K. Leśniak, Juliane Schmidt, Karina Calvopiña, María-Carmen Turrientes, Madeline E. Kavanagh, Dmitrijs Lubriks, Philip Hinchliffe, Gareth W. Langley, Ali F. Aboklaish, Anders Eneroth, Maria Backlund, Andrei G. Baran, Elisabet I. Nielsen, Michael Speake, Janis Kuka, John Robinson, Solveiga Grinberga, Lindsay Robinson, Michael A. McDonough, Anna M. Rydzik, Thomas M. Leissing, Juan Carlos Jimenez-Castellanos, Matthew B. Avison, Solange Da Silva Pinto, Andrew D. Pannifer, Marina Martjuga, Emma Widlake, Martins Priede, Iva Hopkins Navratilova, Marek Gniadkowski, Anna Karin Belfrage, Peter Brandt, Jari Yli-Kauhaluoma, Eric Bacque, Malcolm G. P. Page, Fredrik Björkling, Jonathan M. Tyrrell, James Spencer, Pauline A. Lang, Pawel Baranczewski, Rafael Cantón, Stuart P. McElroy, Philip S. Jones, Fernando Baquero, Edgars Suna, Angus Morrison, Timothy R. Walsh, Christopher J. Schofield
المساهمون: Staff Services, Pharmaceutical Design and Discovery group, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Jari Yli-Kauhaluoma / Principal Investigator, University Management
المصدر: Brem, J, Panduwawala, T, Hansen, J U, Hewitt, J, Liepins, E, Donets, P, Espina, L, Farley, A J M, Shubin, K, Campillos, G G, Kiuru, P, Shishodia, S, Krahn, D, Leśniak, R K, Schmidt Adrian, J, Calvopiña, K, Turrientes, M-C, Kavanagh, M E, Lubriks, D, Hinchliffe, P, Langley, G W, Aboklaish, A F, Eneroth, A, Backlund, M, Baran, A G, Nielsen, E I, Speake, M, Kuka, J, Robinson, J, Grinberga, S, Robinson, L, McDonough, M A, Rydzik, A M, Leissing, T M, Jimenez-Castellanos, J C, Avison, M B, Da Silva Pinto, S, Pannifer, A D, Martjuga, M, Widlake, E, Priede, M, Hopkins Navratilova, I, Gniadkowski, M, Belfrage, A K, Brandt, P, Yli-Kauhaluoma, J, Bacque, E, Page, M G P, Björkling, F, Tyrrell, J M, Spencer, J, Lang, P A, Baranczewski, P, Cantón, R, McElroy, S P, Jones, P S, Baquero, F, Suna, E, Morrison, A, Walsh, T R & Schofield, C J 2022, ' Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors ', Nature Chemistry, vol. 14, pp. 15-24 . https://doi.org/10.1038/s41557-021-00831-x
مصطلحات موضوعية: MECHANISM, Medicin och hälsovetenskap, General Chemical Engineering, Microbial Sensitivity Tests, beta-Lactams, Medical and Health Sciences, 03 medical and health sciences, Mice, Structure-Activity Relationship, AVIBACTAM, Gram-Negative Bacteria, polycyclic compounds, metallo-beta-lactamase, Animals, Humans, 030304 developmental biology, 0303 health sciences, 030306 microbiology, General Chemistry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, 3. Good health, 317 Pharmacy, beta-Lactamase Inhibitors, ANTIBIOTICS, RESISTANCE, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Daniel Mariappa, Andrew T. Ferenbach, Daan M. F. van Aalten, Tonia Aristotelous, Matthias Trost, Nithya Selvan, Ritchie Williamson, David G. Campbell, Robert Gourlay, Iva Hopkins-Navratilova
المصدر: Nat Chem Biol
مصطلحات موضوعية: 0301 basic medicine, Mutation, biology, ved/biology, Mutant, ved/biology.organism_classification_rank.species, Cell Biology, biology.organism_classification, medicine.disease_cause, beta-N-Acetylhexosaminidases, Article, Cell biology, 03 medical and health sciences, Drosophila melanogaster, 030104 developmental biology, Proteome, medicine, Animals, Hox gene, Homeotic gene, Model organism, Molecular Biology, Gene
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المؤلفون: Amin S. Asfor, Robin J. Leatherbarrow, Iva Hopkins-Navratilova, Aurelie Mousnier, Sean Robinson, Anabel Guedán, Inmaculada Pérez-Dorado, Andrew Simon Bell, Joseph Newman, Anthony J. Wilkinson, Markus Ritzefeld, Roberto Solari, Edward W. Tate, J.A. Hutton, Dawid Swieboda, Sebastian L. Johnston, Tobias J. Tuthill, James A. Brannigan, Julia Morales-Sanfrutos
المساهمون: Medical Research Council (MRC), Wellcome Trust, Asthma UK, GlaxoSmithKline Services Unlimited, Cancer Research UK
المصدر: Nature chemistry
Mousnier, A, Bell, A S, Swieboda, D P, Morales-Sanfrutos, J, Pérez-Dorado, I, Brannigan, J A, Newman, J, Ritzefeld, M, Hutton, J A, Guedán, A, Asfor, A S, Robinson, S W, Hopkins-Navratilova, I, Wilkinson, A J, Johnston, S L, Leatherbarrow, R J, Tuthill, T J, Solari, R & Tate, E W 2018, ' Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus ', Nature chemistry, vol. 10, no. 6, pp. 599-606 . https://doi.org/10.1038/s41557-018-0039-2مصطلحات موضوعية: 0301 basic medicine, Viral capsid assembly, Rhinovirus, Chemistry, Multidisciplinary, General Chemical Engineering, viruses, PREVENTS, medicine.disease_cause, Virus Replication, 01 natural sciences, INFECTION, Enzyme Inhibitors, Cytotoxicity, Molecular Structure, Chemistry, Poliovirus, NMT2, MYRISTOYLATION, 3. Good health, Capsid, Physical Sciences, PROTEOMICS, 03 Chemical Sciences, Antiviral Agents, Virus, Article, 03 medical and health sciences, Inhibitory Concentration 50, SDG 3 - Good Health and Well-being, medicine, Humans, Myristoylation, Science & Technology, CYSTIC-FIBROSIS, 010405 organic chemistry, Virus Assembly, Organic Chemistry, General Chemistry, Virology, 0104 chemical sciences, 030104 developmental biology, CELLS, ASTHMA, Linker, Acyltransferases, HeLa Cells
وصف الملف: application/pdf
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المؤلفون: Stephanie Versluys, Pierre Fons, Michael R. Paillasse, Celia bergeaud, Federica Ferigo, Andrew Simon Bell, Richard Cox, Jérémy Besnard, Eric Cogo, Simone Culurgioni, Sean Robinson, Frederic Machet, Sabrina Pagliarusco, Emilie Pelissier, Craig Johnstone, Iva Hopkins-Navratilova, Jerome Menegotto, Emilie Mirey, Michael Esquerre, Joanna Lisztwan, Florie Bertrand, Virgile Visentin, Celine Poussereau-Pomie, Andrew Payne, Adrian Schreyer, Andrew L. Hopkins, Mark Whittaker
المصدر: Cancer Research. 79:519-519
مصطلحات موضوعية: Cancer Research, chemistry.chemical_compound, Oncology, Drug development, Cancer immunotherapy, chemistry, Drug discovery, medicine.medical_treatment, Philosophy, medicine, Cancer research, Penetrant (biochemical)
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المؤلفون: Michael Esquerre, Florie Bertrand, Celia bergeaud, Andrew Simon Bell, Ghislaine Marchand, Simone Culurgioni, Michael R. Paillasse, Peter N. Ray, Emilie Pelissier, Craig Johnstone, Iva Hopkins-Navratilova, Leonardo-Silvestre Hernani, Jérémy Besnard, Sean Robinson, Mark Whittaker, Joanna Lisztwan, Stephanie Versluys, Andrew L. Hopkins, Andrew Payne, Pierre Fons, Adrian Schreyer, Celine Poussereau-Pomie, Richard S. Cox
المصدر: Cancer Research. 79:507-507
مصطلحات موضوعية: Cancer Research, business.industry, Drug discovery, medicine.medical_treatment, Cancer, Biological activity, medicine.disease, Adenosine, Adenosine receptor, Small molecule, Immune checkpoint, Oncology, Cancer immunotherapy, Cancer research, Medicine, business, medicine.drug