المؤلفون: Gianni Chessari (1541785), Ian R. Hardcastle (129314), Jong Sook Ahn (5614631), Burcu Anil (2530831), Elizabeth Anscombe (1859752), Ruth H. Bawn (2884739), Luke D. Bevan (10429825), Timothy J. Blackburn (129305), Ildiko Buck (10429828), Celine Cano (1859773), Benoit Carbain (1859755), Juan Castro (3448166), Ben Cons (10429831), Sarah J. Cully (10429834), Jane A. Endicott (1286214), Lynsey Fazal (1269375), Bernard T. Golding (129309), Roger J. Griffin (129311), Karen Haggerty (1859770), Suzannah J. Harnor (10429837), Keisha Hearn (1668085), Stephen Hobson (10429840), Rhian S. Holvey (10429843), Steven Howard (760049), Claire E. Jennings (3068733), Christopher N. Johnson (157130), John Lunec (2224543), Duncan C. Miller (6509135), David R. Newell (129326), Martin E. M. Noble (10429846), Judith Reeks (3068739), Charlotte H. Revill (2224558), Christiane Riedinger (2224555), Jeffrey D. St. Denis (10429849), Emiliano Tamanini (1541818), Huw Thomas (431643), Neil T. Thompson (5322431), Mladen Vinković (2396401), Stephen R. Wedge (2493652), Pamela A. Williams (572408), Nicola E. Wilsher (1541797), Bian Zhang (10429852), Yan Zhao (58882)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, osteosarcoma xenograft model, vivo inhibitors, quantum mechanics ligand-based design, MDM 2 X-ray crystallography, SJSA, metabolite identification, Isoindolinone Inhibitors, Structure-Based Design, minute 2, reactivate p 53, representative compounds, MDM 2-p interaction, novel isoindolinone-based MDM 2 inh., tumor growth

Relation: https://figshare.com/articles/journal_contribution/Structure-Based_Design_of_Potent_and_Orally_Active_Isoindolinone_Inhibitors_of_MDM2-p53_Protein_Protein_Interaction/14298511

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02188.s004

المؤلفون: Gianni Chessari (1541785), Ian R. Hardcastle (129314), Jong Sook Ahn (5614631), Burcu Anil (2530831), Elizabeth Anscombe (1859752), Ruth H. Bawn (2884739), Luke D. Bevan (10429825), Timothy J. Blackburn (129305), Ildiko Buck (10429828), Celine Cano (1859773), Benoit Carbain (1859755), Juan Castro (3448166), Ben Cons (10429831), Sarah J. Cully (10429834), Jane A. Endicott (1286214), Lynsey Fazal (1269375), Bernard T. Golding (129309), Roger J. Griffin (129311), Karen Haggerty (1859770), Suzannah J. Harnor (10429837), Keisha Hearn (1668085), Stephen Hobson (10429840), Rhian S. Holvey (10429843), Steven Howard (760049), Claire E. Jennings (3068733), Christopher N. Johnson (157130), John Lunec (2224543), Duncan C. Miller (6509135), David R. Newell (129326), Martin E. M. Noble (10429846), Judith Reeks (3068739), Charlotte H. Revill (2224558), Christiane Riedinger (2224555), Jeffrey D. St. Denis (10429849), Emiliano Tamanini (1541818), Huw Thomas (431643), Neil T. Thompson (5322431), Mladen Vinković (2396401), Stephen R. Wedge (2493652), Pamela A. Williams (572408), Nicola E. Wilsher (1541797), Bian Zhang (10429852), Yan Zhao (58882)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, osteosarcoma xenograft model, vivo inhibitors, quantum mechanics ligand-based design, MDM 2 X-ray crystallography, SJSA, metabolite identification, Isoindolinone Inhibitors, Structure-Based Design, minute 2, reactivate p 53, representative compounds, MDM 2-p interaction, novel isoindolinone-based MDM 2 inh., tumor growth

Relation: https://figshare.com/articles/dataset/Structure-Based_Design_of_Potent_and_Orally_Active_Isoindolinone_Inhibitors_of_MDM2-p53_Protein_Protein_Interaction/14298502

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02188.s001

المؤلفون: Gianni Chessari (1541785), Ian R. Hardcastle (129314), Jong Sook Ahn (5614631), Burcu Anil (2530831), Elizabeth Anscombe (1859752), Ruth H. Bawn (2884739), Luke D. Bevan (10429825), Timothy J. Blackburn (129305), Ildiko Buck (10429828), Celine Cano (1859773), Benoit Carbain (1859755), Juan Castro (3448166), Ben Cons (10429831), Sarah J. Cully (10429834), Jane A. Endicott (1286214), Lynsey Fazal (1269375), Bernard T. Golding (129309), Roger J. Griffin (129311), Karen Haggerty (1859770), Suzannah J. Harnor (10429837), Keisha Hearn (1668085), Stephen Hobson (10429840), Rhian S. Holvey (10429843), Steven Howard (760049), Claire E. Jennings (3068733), Christopher N. Johnson (157130), John Lunec (2224543), Duncan C. Miller (6509135), David R. Newell (129326), Martin E. M. Noble (10429846), Judith Reeks (3068739), Charlotte H. Revill (2224558), Christiane Riedinger (2224555), Jeffrey D. St. Denis (10429849), Emiliano Tamanini (1541818), Huw Thomas (431643), Neil T. Thompson (5322431), Mladen Vinković (2396401), Stephen R. Wedge (2493652), Pamela A. Williams (572408), Nicola E. Wilsher (1541797), Bian Zhang (10429852), Yan Zhao (58882)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, osteosarcoma xenograft model, vivo inhibitors, quantum mechanics ligand-based design, MDM 2 X-ray crystallography, SJSA, metabolite identification, Isoindolinone Inhibitors, Structure-Based Design, minute 2, reactivate p 53, representative compounds, MDM 2-p interaction, novel isoindolinone-based MDM 2 inh., tumor growth

Relation: https://figshare.com/articles/dataset/Structure-Based_Design_of_Potent_and_Orally_Active_Isoindolinone_Inhibitors_of_MDM2-p53_Protein_Protein_Interaction/14298505

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02188.s002

المؤلفون: Gianni Chessari (1541785), Ian R. Hardcastle (129314), Jong Sook Ahn (5614631), Burcu Anil (2530831), Elizabeth Anscombe (1859752), Ruth H. Bawn (2884739), Luke D. Bevan (10429825), Timothy J. Blackburn (129305), Ildiko Buck (10429828), Celine Cano (1859773), Benoit Carbain (1859755), Juan Castro (3448166), Ben Cons (10429831), Sarah J. Cully (10429834), Jane A. Endicott (1286214), Lynsey Fazal (1269375), Bernard T. Golding (129309), Roger J. Griffin (129311), Karen Haggerty (1859770), Suzannah J. Harnor (10429837), Keisha Hearn (1668085), Stephen Hobson (10429840), Rhian S. Holvey (10429843), Steven Howard (760049), Claire E. Jennings (3068733), Christopher N. Johnson (157130), John Lunec (2224543), Duncan C. Miller (6509135), David R. Newell (129326), Martin E. M. Noble (10429846), Judith Reeks (3068739), Charlotte H. Revill (2224558), Christiane Riedinger (2224555), Jeffrey D. St. Denis (10429849), Emiliano Tamanini (1541818), Huw Thomas (431643), Neil T. Thompson (5322431), Mladen Vinković (2396401), Stephen R. Wedge (2493652), Pamela A. Williams (572408), Nicola E. Wilsher (1541797), Bian Zhang (10429852), Yan Zhao (58882)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, osteosarcoma xenograft model, vivo inhibitors, quantum mechanics ligand-based design, MDM 2 X-ray crystallography, SJSA, metabolite identification, Isoindolinone Inhibitors, Structure-Based Design, minute 2, reactivate p 53, representative compounds, MDM 2-p interaction, novel isoindolinone-based MDM 2 inh., tumor growth

Relation: https://figshare.com/articles/dataset/Structure-Based_Design_of_Potent_and_Orally_Active_Isoindolinone_Inhibitors_of_MDM2-p53_Protein_Protein_Interaction/14298508

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02188.s003