المؤلفون: Rodrigo Ricardo Sandoval Valencia

المصدر: Ecuador es Calidad, Vol 7, Iss 1 (2020)

مصطلحات موضوعية: anticuerpos, infecciones bacterianas, inmunoterapia, métodos antibacterianos, opsonización., Agriculture (General), S1-972, Animal culture, SF1-1100

وصف الملف: electronic resource

Relation: https://revistaecuadorescalidad.agrocalidad.gob.ec/revistaecuadorescalidad/index.php/revista/article/view/93; https://doaj.org/toc/1390-9223; https://doaj.org/toc/2528-7850

URL الوصول: https://doaj.org/article/5de11bbcd1a4426dbafa522a77a953da

المؤلفون: Alfaro Marenco, María Alejandra

المساهمون: Bernal Estévez, David Andres, Parra López, Carlos Alberto

مصطلحات موضوعية: 610 - Medicina y salud::616 - Enfermedades, 610 - Medicina y salud::612 - Fisiología humana, Inmunoterapia/métodos, Vacunas contra el Cáncer, Antígenos/uso terapéutico, Immunotherapy/methods, Cancer Vaccines, Antigens/therapeutic use, Linfocitos T CD8+, Muerte celular inmunogénica, Citometría de flujo, Células dendríticas derivadas de monocitos, Formulaciones del antígeno, Antígenos modelo, Monocyte-derived dendritic cells, Antigen formulations, Model antigens, CD8+ T cells, Tumor cell lines, immunogenic cell death, Flow cytometry

وصف الملف: 156 páginas; application/pdf

Relation: Gierlich P, Lex V, Technau A, Keupp A, Morper L, Glunz A, et al. Prostaglandin E(2) in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8(+) T cells. Cancer Immunol Immunother. 2020;69(6):1029-42.; Chamucero-Millares JA, Bernal-Estevez DA, Parra-Lopez CA. Usefulness of IL-21, IL-7, and IL- 15 conditioned media for expansion of antigen-specific CD8+ T cells from healthy donor-PBMCs suitable for immunotherapy. Cell Immunol. 2021;360:104257.; Patente TA, Pinho MP, Oliveira AA, Evangelista GCM, Bergami-Santos PC, Barbuto JAM. Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy. Front Immunol. 2018;9:3176.; Granot T, Senda T, Carpenter DJ, Matsuoka N, Weiner J, Gordon CL, et al. Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life. Immunity. 2017;46(3):504-15.; Lamberti MJ, Nigro A, Mentucci FM, Rumie Vittar NB, Casolaro V, Dal Col J. Dendritic Cells and Immunogenic Cancer Cell Death: A Combination for Improving Antitumor Immunity. Pharmaceutics. 2020;12(3).; Bol KF, Schreibelt G, Gerritsen WR, de Vries IJ, Figdor CG. Dendritic Cell-Based Immunotherapy: State of the Art and Beyond. Clin Cancer Res. 2016;22(8):1897-906.; Sabado RL, Balan S, Bhardwaj N. Dendritic cell-based immunotherapy. Cell Res. 2017;27(1):74-95.; Hu Z, Ott PA, Wu CJ. Towards personalized, tumour-specific, therapeutic vaccines for cancer. Nat Rev Immunol. 2018;18(3):168-82.; Thomas R, Al-Khadairi G, Roelands J, Hendrickx W, Dermime S, Bedognetti D, et al. NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives. Front Immunol. 2018;9:947.; Mastelic-Gavillet B, Balint K, Boudousquie C, Gannon PO, Kandalaft LE. Personalized Dendritic Cell Vaccines-Recent Breakthroughs and Encouraging Clinical Results. Front Immunol. 2019;10:766.; Sarivalasis A, Boudousquie C, Balint K, Stevenson BJ, Gannon PO, Iancu EM, et al. A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian serous carcinoma. J Transl Med. 2019;17(1):391.; Prins RM, Wang X, Soto H, Young E, Lisiero DN, Fong B, et al. Comparison of gliomaassociated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients. J Immunother. 2013;36(2):152-7.; Castiello L, Sabatino M, Jin P, Clayberger C, Marincola FM, Krensky AM, et al. Monocytederived DC maturation strategies and related pathways: a transcriptional view. Cancer Immunol Immunother. 2011;60(4):457-66.; C DEW, M VDB, Hoefnagel M. Regulatory perspective on in vitro potency assays for human dendritic cells used in anti-tumor immunotherapy. Cytotherapy. 2018;20(11):1289-308.; Lee J, Breton G, Oliveira TY, Zhou YJ, Aljoufi A, Puhr S, et al. Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow. J Exp Med. 2015;212(3):385-99.; Gerlini G, Urso C, Mariotti G, Di Gennaro P, Palli D, Brandani P, et al. Plasmacytoid dendritic cells represent a major dendritic cell subset in sentinel lymph nodes of melanoma patients and accumulate in metastatic nodes. Clin Immunol. 2007;125(2):184-93.; Wylie B, Macri C, Mintern JD, Waithman J. Dendritic Cells and Cancer: From Biology to Therapeutic Intervention. Cancers (Basel). 2019;11(4).; Huysamen C, Willment JA, Dennehy KM, Brown GD. CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. J Biol Chem. 2008;283(24):16693-701.; Sancho D, Joffre OP, Keller AM, Rogers NC, Martinez D, Hernanz-Falcon P, et al. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature. 2009;458(7240):899-903.; Constantino J, Gomes C, Falcao A, Neves BM, Cruz MT. Dendritic cell-based immunotherapy: a basic review and recent advances. Immunol Res. 2017;65(4):798-810.; Calmeiro J, Mendes L, Duarte IF, Leitao C, Tavares AR, Ferreira DA, et al. In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy. Front Immunol. 2020;11:593363.; Munz C, Dao T, Ferlazzo G, de Cos MA, Goodman K, Young JW. Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells. Blood. 2005;105(1):266-73.; Luo XL, Dalod M. The quest for faithful in vitro models of human dendritic cells types. Mol Immunol. 2020;123:40-59.; Chiang CL, Kandalaft LE, Tanyi J, Hagemann AR, Motz GT, Svoronos N, et al. A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside. Clin Cancer Res. 2013;19(17):4801-15.; Mailliard RB, Wankowicz-Kalinska A, Cai Q, Wesa A, Hilkens CM, Kapsenberg ML, et al. alphatype-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activity. Cancer Res. 2004;64(17):5934-7.; Lee JJ, Foon KA, Mailliard RB, Muthuswamy R, Kalinski P. Type 1-polarized dendritic cells loaded with autologous tumor are a potent immunogen against chronic lymphocytic leukemia. J Leukoc Biol. 2008;84(1):319-25.; Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, et al. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-gamma and IL-12. Immunity. 2018;49(6):1148-61 e7.; Del Prete A, Sozio F, Barbazza I, Salvi V, Tiberio L, Laffranchi M, et al. Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications. Int J Mol Sci. 2020;21(11).; Cannon MJ, Schmid DS, Hyde TB. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol. 2010;20(4):202-13.; Terrazzini N, Kern F. Cell-mediated immunity to human CMV infection: a brief overview. F1000Prime Rep. 2014;6:28.; Schober K, Buchholz VR, Busch DH. TCR repertoire evolution during maintenance of CMVspecific T-cell populations. Immunol Rev. 2018;283(1):113-28.; O'Hara GA, Welten SP, Klenerman P, Arens R. Memory T cell inflation: understanding cause and effect. Trends Immunol. 2012;33(2):84-90.; Khan N, Best D, Bruton R, Nayak L, Rickinson AB, Moss PA. T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection. J Immunol. 2007;178(7):4455-65.; Wills MR, Carmichael AJ, Mynard K, Jin X, Weekes MP, Plachter B, et al. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol. 1996;70(11):7569-79.; Pittet MJ, Zippelius A, Valmori D, Speiser DE, Cerottini JC, Romero P. Melan-A/MART-1-specific CD8 T cells: from thymus to tumor. Trends Immunol. 2002;23(7):325-8.; Coulie PG, Brichard V, Van Pel A, Wolfel T, Schneider J, Traversari C, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994;180(1):35-42.; Pittet MJ, Valmori D, Dunbar PR, Speiser DE, Lienard D, Lejeune F, et al. High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals. J Exp Med. 1999;190(5):705-15.; Alanio C, Lemaitre F, Law HK, Hasan M, Albert ML. Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies. Blood. 2010;115(18):3718-25.; Valmori D, Fonteneau JF, Lizana CM, Gervois N, Lienard D, Rimoldi D, et al. Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues. J Immunol. 1998;160(4):1750-8.; van Elsas A, van der Burg SH, van der Minne CE, Borghi M, Mourer JS, Melief CJ, et al. Peptide-pulsed dendritic cells induce tumoricidal cytotoxic T lymphocytes from healthy donors against stably HLA-A*0201-binding peptides from the Melan-A/MART-1 self antigen. Eur J Immunol. 1996;26(8):1683-9.; Bakker AB, Marland G, de Boer AJ, Huijbens RJ, Danen EH, Adema GJ, et al. Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanomaassociated antigen-derived epitopes by dendritic cells in vitro. Cancer Res. 1995;55(22):5330-4.; Cebon J, Knights A, Ebert L, Jackson H, Chen W. Evaluation of cellular immune responses in cancer vaccine recipients: lessons from NY-ESO-1. Expert Rev Vaccines. 2010;9(6):617-29.; Chen YT, Scanlan MJ, Sahin U, Tureci O, Gure AO, Tsang S, et al. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci U S A. 1997;94(5):1914-8.; Sabbatini P, Tsuji T, Ferran L, Ritter E, Sedrak C, Tuballes K, et al. Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients. Clin Cancer Res. 2012;18(23):6497-508.; Raza A, Merhi M, Inchakalody VP, Krishnankutty R, Relecom A, Uddin S, et al. Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy. J Transl Med. 2020;18(1):140.; Slingluff CL, Jr. The present and future of peptide vaccines for cancer: single or multiple, long or short, alone or in combination? Cancer J. 2011;17(5):343-50.; Yamshchikov GV, Barnd DL, Eastham S, Galavotti H, Patterson JW, Deacon DH, et al. Evaluation of peptide vaccine immunogenicity in draining lymph nodes and peripheral blood of melanoma patients. Int J Cancer. 2001;92(5):703-11.; Rosenberg SA, Sherry RM, Morton KE, Scharfman WJ, Yang JC, Topalian SL, et al. Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma. J Immunol. 2005;175(9):6169-76.; Toes RE, Blom RJ, Offringa R, Kast WM, Melief CJ. Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors. J Immunol. 1996;156(10):3911-8.; Toes RE, Offringa R, Blom RJ, Melief CJ, Kast WM. Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction. Proc Natl Acad Sci U S A. 1996;93(15):7855-60.; Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, Ehst BD, et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature. 2005;434(7029):88-93.; Srinivasan M, Domanico SZ, Kaumaya PT, Pierce SK. Peptides of 23 residues or greater are required to stimulate a high affinity class II-restricted T cell response. Eur J Immunol. 1993;23(5):1011-6.; Zwaveling S, Ferreira Mota SC, Nouta J, Johnson M, Lipford GB, Offringa R, et al. Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides. J Immunol. 2002;169(1):350-8.; Ma Y, Adjemian S, Mattarollo SR, Yamazaki T, Aymeric L, Yang H, et al. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity. 2013;38(4):729-41.; Pathak SK, Skold AE, Mohanram V, Persson C, Johansson U, Spetz AL. Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cellspecific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and beta2 integrins. J Biol Chem. 2012;287(17):13731-42.; Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A. 2012;109(5):1607-12.; de Araujo-Souza PS, Hanschke SCH, Nardy A, Secca C, Oliveira-Vieira B, Silva KL, et al. Differential interferon-gamma production by naive and memory-like CD8 T cells. J Leukoc Biol. 2020;108(4):1329-37.; Bhat P, Leggatt G, Waterhouse N, Frazer IH. Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Cell Death Dis. 2017;8(6):e2836.; Lachmann R, Bajwa M, Vita S, Smith H, Cheek E, Akbar A, et al. Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses. J Virol. 2012;86(2):1001-9.; Gubser PM, Bantug GR, Razik L, Fischer M, Dimeloe S, Hoenger G, et al. Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nat Immunol. 2013;14(10):1064-72.; Sathaliyawala T, Kubota M, Yudanin N, Turner D, Camp P, Thome JJ, et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity. 2013;38(1):187-97.; Mehta AK, Gracias DT, Croft M. TNF activity and T cells. Cytokine. 2018;101:14-8.; Brehm MA, Daniels KA, Welsh RM. Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells. J Immunol. 2005;175(8):5043-9.; Harari A, Dutoit V, Cellerai C, Bart PA, Du Pasquier RA, Pantaleo G. Functional signatures of protective antiviral T-cell immunity in human virus infections. Immunol Rev. 2006;211:236-54.; Healy ZR, Weinhold KJ, Murdoch DM. Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells. Front Immunol. 2020;11:1859.; Imai N, Tawara I, Yamane M, Muraoka D, Shiku H, Ikeda H. CD4(+) T cells support polyfunctionality of cytotoxic CD8(+) T cells with memory potential in immunological control of tumor. Cancer Sci. 2020;111(6):1958-68.; Reddy M, Eirikis E, Davis C, Davis HM, Prabhakar U. Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: an in vitro model to monitor cellular immune function. J Immunol Methods. 2004;293(1-2):127-42.; Adamczyk M, Bartosinska J, Raczkiewicz D, Kowal M, Surdacka A, Krasowska D, et al. The Expression of Activation Markers CD25 and CD69 Increases during Biologic Treatment of Psoriasis. J Clin Med. 2023;12(20).; Cebrian M, Yague E, Rincon M, Lopez-Botet M, de Landazuri MO, Sanchez-Madrid F. Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J Exp Med. 1988;168(5):1621-37.; Risso A, Smilovich D, Capra MC, Baldissarro I, Yan G, Bargellesi A, et al. CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression. J Immunol. 1991;146(12):4105-14.; Cibrian D, Sanchez-Madrid F. CD69: from activation marker to metabolic gatekeeper. Eur J Immunol. 2017;47(6):946-53.; Ziegler SF, Ramsdell F, Alderson MR. The activation antigen CD69. Stem Cells. 1994;12(5):456-65.; Gonzalez-Amaro R, Cortes JR, Sanchez-Madrid F, Martin P. Is CD69 an effective brake to control inflammatory diseases? Trends Mol Med. 2013;19(10):625-32.; de la Fuente H, Cruz-Adalia A, Martinez Del Hoyo G, Cibrian-Vera D, Bonay P, Perez-Hernandez D, et al. The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1. Mol Cell Biol. 2014;34(13):2479-87.; Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155(3):1151-64.; Brusko TM, Wasserfall CH, Hulme MA, Cabrera R, Schatz D, Atkinson MA. Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation. PLoS One. 2009;4(11):e7980.; Green DR, Droin N, Pinkoski M. Activation-induced cell death in T cells. Immunol Rev. 2003;193:70-81.; Poulton TA, Gallagher A, Potts RC, Beck JS. Changes in activation markers and cell membrane receptors on human peripheral blood T lymphocytes during cell cycle progression after PHA stimulation. Immunology. 1988;64(3):419-25.; Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol. 2005;23:23-68.; Wolfl M, Kuball J, Eyrich M, Schlegel PG, Greenberg PD. Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities. Cytometry A. 2008;73(11):1043-9.; Wen T, Bukczynski J, Watts TH. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. J Immunol. 2002;168(10):4897-906.; Halstead ES, Mueller YM, Altman JD, Katsikis PD. In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses. Nat Immunol. 2002;3(6):536-41.; Vinay DS, Kwon BS. Role of 4-1BB in immune responses. Semin Immunol. 1998;10(6):481-9.; Etxeberria I, Glez-Vaz J, Teijeira A, Melero I. New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis. ESMO Open. 2020;4(Suppl 3):e000733.; Alosaimi MF, Hoenig M, Jaber F, Platt CD, Jones J, Wallace J, et al. Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency. J Allergy Clin Immunol. 2019;144(2):574-83 e5.; Zhu Y, Zhu G, Luo L, Flies AS, Chen L. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood. 2007;109(11):4882-9.; Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellstrom KE, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med. 1997;3(6):682-5.; Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol. 1998;16:111-35.; Caux C, Massacrier C, Vanbervliet B, Dubois B, Van Kooten C, Durand I, et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med. 1994;180(4):1263-72.; Bennett SR, Carbone FR, Karamalis F, Flavell RA, Miller JF, Heath WR. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 1998;393(6684):478-80.; Schoenberger SP, Toes RE, van der Voort EI, Offringa R, Melief CJ. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 1998;393(6684):480-3.; Tay NQ, Lee DCP, Chua YL, Prabhu N, Gascoigne NRJ, Kemeny DM. CD40L Expression Allows CD8(+) T Cells to Promote Their Own Expansion and Differentiation through Dendritic Cells. Front Immunol. 2017;8:1484.; Wong KL, Lew FC, MacAry PA, Kemeny DM. CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production. Eur J Immunol. 2008;38(8):2251-62.; Wong KL, Tang LF, Lew FC, Wong HS, Chua YL, MacAry PA, et al. CD44high memory CD8 T cells synergize with CpG DNA to activate dendritic cell IL-12p70 production. J Immunol. 2009;183(1):41-50.; Bourgeois C, Rocha B, Tanchot C. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science. 2002;297(5589):2060-3.; Hernandez MG, Shen L, Rock KL. CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help. J Immunol. 2007;178(5):2844-52.; Shugart JA, Bambina S, Alice AF, Montler R, Bahjat KS. A self-help program for memory CD8+ T cells: positive feedback via CD40-CD40L signaling as a critical determinant of secondary expansion. PLoS One. 2013;8(5):e64878.; Olson MR, Seah SG, Edenborough K, Doherty PC, Lew AM, Turner SJ. CD154+ CD4+ T-cell dependence for effective memory influenza virus-specific CD8+ T-cell responses. Immunol Cell Biol. 2014;92(7):605-11.; Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM. Centrosome polarization delivers secretory granules to the immunological synapse. Nature. 2006;443(7110):462-5.; Ballesteros-Tato A, Leon B, Lee BO, Lund FE, Randall TD. Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells. Immunity. 2014;41(1):127-40.; Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, et al. Defining 'T cell exhaustion'. Nat Rev Immunol. 2019;19(11):665-74.; Ahn E, Araki K, Hashimoto M, Li W, Riley JL, Cheung J, et al. Role of PD-1 during effector CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018;115(18):4749-54.; Wherry EJ. T cell exhaustion. Nat Immunol. 2011;12(6):492-9.; Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol. 2007;8(3):239-45.; Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017;355(6332):1428-33.; Parry RV, Chemnitz JM, Frauwirth KA, Lanfranco AR, Braunstein I, Kobayashi SV, et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol. 2005;25(21):9543- 53.; Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates Tcell proliferation and interleukin-10 secretion. Nat Med. 1999;5(12):1365-9.; Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med. 2001;193(7):839-46.; Keir ME, Freeman GJ, Sharpe AH. PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol. 2007;179(8):5064-70.; Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455-65.; Meng X, Liu X, Guo X, Jiang S, Chen T, Hu Z, et al. FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Nature. 2018;564(7734):130-5.; Chan DV, Gibson HM, Aufiero BM, Wilson AJ, Hafner MS, Mi QS, et al. Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation. Genes Immun. 2014;15(1):25-32.; Dariavach P, Mattei MG, Golstein P, Lefranc MP. Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur J Immunol. 1988;18(12):1901-5.; Harper K, Balzano C, Rouvier E, Mattei MG, Luciani MF, Golstein P. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J Immunol. 1991;147(3):1037-44.; Auchincloss H, Turka LA. CTLA-4: not all costimulation is stimulatory. J Immunol. 2011;187(7):3457-8.; Lindsten T, Lee KP, Harris ES, Petryniak B, Craighead N, Reynolds PJ, et al. Characterization of CTLA-4 structure and expression on human T cells. J Immunol. 1993;151(7):3489-99.; Gajewski TF, Fallarino F, Fields PE, Rivas F, Alegre ML. Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase. J Immunol. 2001;166(6):3900-7.; Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994;1(5):405-13.; Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas-Pequignot E, et al. LAG-3, a novel lymphocyte activation gene closely related to CD4. J Exp Med. 1990;171(5):1393-405.; Workman CJ, Cauley LS, Kim IJ, Blackman MA, Woodland DL, Vignali DA. Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol. 2004;172(9):5450-5.; Hannier S, Tournier M, Bismuth G, Triebel F. CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling. J Immunol. 1998;161(8):4058-65.; Workman CJ, Dugger KJ, Vignali DA. Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J Immunol. 2002;169(10):5392-5.; Huard B, Tournier M, Hercend T, Triebel F, Faure F. Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes. Eur J Immunol. 1994;24(12):3216-21.; Goldberg MV, Drake CG. LAG-3 in Cancer Immunotherapy. Curr Top Microbiol Immunol. 2011;344:269-78.; Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009;10(1):29-37.; Bijker MS, van den Eeden SJ, Franken KL, Melief CJ, van der Burg SH, Offringa R. Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation. Eur J Immunol. 2008;38(4):1033-42.; Gutierrez-Martinez E, Planes R, Anselmi G, Reynolds M, Menezes S, Adiko AC, et al. Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets. Front Immunol. 2015;6:363.; Alloatti A, Kotsias F, Magalhaes JG, Amigorena S. Dendritic cell maturation and crosspresentation: timing matters! Immunol Rev. 2016;272(1):97-108.; Menager J, Ebstein F, Oger R, Hulin P, Nedellec S, Duverger E, et al. Cross-presentation of synthetic long peptides by human dendritic cells: a process dependent on ERAD component p97/VCP but Not sec61 and/or Derlin-1. PLoS One. 2014;9(2):e89897.; Tang-Huau TL, Gueguen P, Goudot C, Durand M, Bohec M, Baulande S, et al. Human in vivogenerated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway. Nat Commun. 2018;9(1):2570.; Fonteneau JF, Kavanagh DG, Lirvall M, Sanders C, Cover TL, Bhardwaj N, et al. Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. Blood. 2003;102(13):4448-55.; Du J MA, Widlund HR, Horstmann MA, Ramaswamy S, Fisher DE. MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol. 2003(Jul;163(1):333-43.).; Li J, Song JS, Bell RJ, Tran TN, Haq R, Liu H, et al. YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8(5):e1002688.; Vidard L. 4-1BB and cytokines trigger human NK, gammadelta T, and CD8(+) T cell proliferation and activation, but are not required for their effector functions. Immun Inflamm Dis. 2023;11(1):e749.; Almunia C, Bretaudeau M, Held G, Babon A, Marchetti C, Castelli FA, et al. Bee Venom Phospholipase A2, a Good "Chauffeur" for Delivering Tumor Antigen to the MHC I and MHC II Peptide-Loading Compartments of the Dendritic Cells: The Case of NY-ESO-1. PLoS One. 2013;8(6):e67645.; Levy F, Muehlethaler K, Salvi S, Peitrequin AL, Lindholm CK, Cerottini JC, et al. Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation. Mol Biol Cell. 2005;16(4):1777-87.; Sabbatino F, Wang Y, Scognamiglio G, Favoino E, Feldman SA, Villani V, et al. Antitumor Activity of BRAF Inhibitor and IFNalpha Combination in BRAF-Mutant Melanoma. J Natl Cancer Inst. 2016;108(7).; Suriano R, Rajoria S, A LG, Geliebter J, Wallack M, Tiwari RK. Ex vivo derived primary melanoma cells: implications for immunotherapeutic vaccines. J Cancer. 2013;4(5):371-82.; Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med. 1994;179(4):1109-18.; Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol. 1997;27(12):3135-42.; Martinuzzi E, Afonso G, Gagnerault MC, Naselli G, Mittag D, Combadiere B, et al. acDCs enhance human antigen-specific T-cell responses. Blood. 2011;118(8):2128-37.; Aspord C, Leloup C, Reche S, Plumas J. pDCs efficiently process synthetic long peptides to induce functional virus- and tumour-specific T-cell responses. Eur J Immunol. 2014;44(10):2880-92.; Wada H, Isobe M, Kakimi K, Mizote Y, Eikawa S, Sato E, et al. Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. J Immunother. 2014;37(2):84-92.; Martínez-Enríquez L. Identificación y caracterización de linfocitos T neoantígeno específicos de donantes sanos con fines de inmunoterapia en cáncer: Universidad Nacional de Colombia; 2022.; Weekes MP, Wills MR, Mynard K, Carmichael AJ, Sissons JG. The memory cytotoxic Tlymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo. J Virol. 1999;73(3):2099-108.; Solache A, Morgan CL, Dodi AI, Morte C, Scott I, Baboonian C, et al. Identification of three HLA-A*0201-restricted cytotoxic T cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus. J Immunol. 1999;163(10):5512-8.; Bruggner RV, Bodenmiller B, Dill DL, Tibshirani RJ, Nolan GP. Automated identification of stratifying signatures in cellular subpopulations. Proc Natl Acad Sci U S A. 2014;111(26):E2770-7.; Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of a tetrazoliumbased semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 1987;47(4):936-42.; Infante-Crúz A. Activación de respuesta inmune innata a partir de la inducción de muerte tumoral inmunogénica.: Universidad Nacional de Colombia; 2016.; Yadav B, Wennerberg K, Aittokallio T, Tang J. Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model. Comput Struct Biotechnol J. 2015;13:504-13.; Altomonte M, Gloghini A, Bertola G, Gasparollo A, Carbone A, Ferrone S, et al. Differential expression of cell adhesion molecules CD54/CD11a and CD58/CD2 by human melanoma cells and functional role in their interaction with cytotoxic cells. Cancer Res. 1993;53(14):3343-8.; Bernal Estévez D. Evaluación de la capacidad inmuno-estimulante de la terapia neoadyuvante con Doxorrubicina y Ciclofosfamida en pacientes con cáncer de mama: Universidad Nacional de Colombia Sede Bogotá 2017.; Mariotti S, Nisini R. Generation of human T cell clones. Methods Mol Biol. 2009;514:65-93.; Klapper JA, Thomasian AA, Smith DM, Gorgas GC, Wunderlich JR, Smith FO, et al. Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy. J Immunol Methods. 2009;345(1-2):90-9.; Rimoldi D, Muehlethaler K, Salvi S, Valmori D, Romero P, Cerottini JC, et al. Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope. J Biol Chem. 2001;276(46):43189-96.; Busam KJ JA. Melan-A, a new melanocytic differentiation marker. Adv Anat Pathol. 1999(Jan;6(1):12-8.).; Blass E, Ott PA. Advances in the development of personalized neoantigen-based therapeutic cancer vaccines. Nat Rev Clin Oncol. 2021;18(4):215-29.; Wahida A, Buschhorn L, Frohling S, Jost PJ, Schneeweiss A, Lichter P, et al. The coming decade in precision oncology: six riddles. Nat Rev Cancer. 2023;23(1):43-54.; Olivier T, Haslam A, Tuia J, Prasad V. Eligibility for Human Leukocyte Antigen-Based Therapeutics by Race and Ethnicity. JAMA Netw Open. 2023;6(10):e2338612.; Welten SPM, Baumann NS, Oxenius A. Fuel and brake of memory T cell inflation. Med Microbiol Immunol. 2019;208(3-4):329-38.; van der Leun AM, Thommen DS, Schumacher TN. CD8(+) T cell states in human cancer: insights from single-cell analysis. Nat Rev Cancer. 2020;20(4):218-32.; Rodriguez IJ, Bernal-Estevez DA, Llano-Leon M, Bonilla CE, Parra-Lopez CA. Neoadjuvant chemotherapy modulates exhaustion of T cells in breast cancer patients. PLoS One. 2023;18(2):e0280851.; Zhou LJ, Schwarting R, Smith HM, Tedder TF. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. J Immunol. 1992;149(2):735-42.; Zhou LJ, Tedder TF. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J Immunol. 1995;154(8):3821-35.; Lechmann M, Berchtold S, Hauber J, Steinkasserer A. CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol. 2002;23(6):273-5.; Li Z, Ju X, Silveira PA, Abadir E, Hsu WH, Hart DNJ, et al. CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential. Front Immunol. 2019;10:1312.; Trepiakas R, Pedersen AE, Met O, Hansen MH, Berntsen A, Svane IM. Comparison of alpha-Type-1 polarizing and standard dendritic cell cytokine cocktail for maturation of therapeutic monocyte-derived dendritic cell preparations from cancer patients. Vaccine. 2008;26(23):2824-32.; Li JG, Du YM, Yan ZD, Yan J, Zhuansun YX, Chen R, et al. CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice. Exp Ther Med. 2016;11(3):878-84.; Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferongamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986;137(1):245-54.; Carrasco YR, Fleire SJ, Cameron T, Dustin ML, Batista FD. LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity. 2004;20(5):589-99.; Sheikh NA, Jones LA. CD54 is a surrogate marker of antigen presenting cell activation. Cancer Immunol Immunother. 2008;57(9):1381-90.; Josephs TM, Grant EJ, Gras S. Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity. Biol Chem. 2017;398(9):1027-36.; Jimenez-Fernandez M, de la Fuente H, Martin P, Cibrian D, Sanchez-Madrid F. Unraveling CD69 signaling pathways, ligands and laterally associated molecules. EXCLI J. 2023;22:334-51.; Hosono M, de Boer OJ, van der Wal AC, van der Loos CM, Teeling P, Piek JJ, et al. Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction. Atherosclerosis. 2003;168(1):73-80.; Engelhard VH. Structure of peptides associated with class I and class II MHC molecules. Annu Rev Immunol. 1994;12:181-207.; Wang M, Larsen MV, Nielsen M, Harndahl M, Justesen S, Dziegiel MH, et al. HLA class I binding 9mer peptides from influenza A virus induce CD4 T cell responses. PLoS One. 2010;5(5):e10533.; Wang M, Tang ST, Stryhn A, Justesen S, Larsen MV, Dziegiel MH, et al. Identification of MHC class II restricted T-cell-mediated reactivity against MHC class I binding Mycobacterium tuberculosis peptides. Immunology. 2011;132(4):482-91.; Bioley G, Jandus C, Tuyaerts S, Rimoldi D, Kwok WW, Speiser DE, et al. Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers. J Immunol. 2006;177(10):6769-79.; Jandus C, Bioley G, Dojcinovic D, Derre L, Baitsch L, Wieckowski S, et al. Tumor antigenspecific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts. Cancer Res. 2009;69(20):8085-93.; Gross S, Lennerz V, Gallerani E, Mach N, Bohm S, Hess D, et al. Short Peptide Vaccine Induces CD4+ T Helper Cells in Patients with Different Solid Cancers. Cancer Immunol Res. 2016;4(1):18-25.; Hemmer B, Kondo T, Gran B, Pinilla C, Cortese I, Pascal J, et al. Minimal peptide length requirements for CD4(+) T cell clones--implications for molecular mimicry and T cell survival. Int Immunol. 2000;12(3):375-83.; Meeuwsen MH, Wouters AK, Hagedoorn RS, Kester MGD, Remst DFG, van der Steen DM, et al. Cutting Edge: Unconventional CD8(+) T Cell Recognition of a Naturally Occurring HLA-A*02:01- Restricted 20mer Epitope. J Immunol. 2022;208(8):1851-6.; Jimenez-Fernandez M, Rodriguez-Sinovas C, Canes L, Ballester-Servera C, Vara A, Requena S, et al. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4 + T lymphocytes. Cell Mol Life Sci. 2022;79(8):468.; Hu ZW, Sun W, Wen YH, Ma RQ, Chen L, Chen WQ, et al. CD69 and SBK1 as potential predictors of responses to PD-1/PD-L1 blockade cancer immunotherapy in lung cancer and melanoma. Front Immunol. 2022;13:952059.; Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, et al. LAG-3 inhibits the activation of CD4(+) T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII. Nat Immunol. 2018;19(12):1415-26.; MacLachlan BJ, Mason GH, Greenshields-Watson A, Triebel F, Gallimore A, Cole DK, et al. Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor. Eur J Immunol. 2021;51(2):331-41.; Liu W, Tang L, Zhang G, Wei H, Cui Y, Guo L, et al. Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. J Biol Chem. 2004;279(18):18748-58.; Kouo T, Huang L, Pucsek AB, Cao M, Solt S, Armstrong T, et al. Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells. Cancer Immunol Res. 2015;3(4):412-23.; Lichtenegger FS, Rothe M, Schnorfeil FM, Deiser K, Krupka C, Augsberger C, et al. Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells. Front Immunol. 2018;9:385.; Andreae S, Piras F, Burdin N, Triebel F. Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223). J Immunol. 2002;168(8):3874-80.; Tiago M, de Oliveira EM, Brohem CA, Pennacchi PC, Paes RD, Haga RB, et al. Fibroblasts protect melanoma cells from the cytotoxic effects of doxorubicin. Tissue Eng Part A. 2014;20(17-18):2412-21.; Mehraj U, Mir IA, Hussain MU, Alkhanani M, Wani NA, Mir MA. Adapalene and Doxorubicin Synergistically Promote Apoptosis of TNBC Cells by Hyperactivation of the ERK1/2 Pathway Through ROS Induction. Front Oncol. 2022;12:938052.; Licarete E, Rauca VF, Luput L, Drotar D, Stejerean I, Patras L, et al. Overcoming Intrinsic Doxorubicin Resistance in Melanoma by Anti-Angiogenic and Anti-Metastatic Effects of Liposomal Prednisolone Phosphate on Tumor Microenvironment. Int J Mol Sci. 2020;21(8).; Bernard S, Poon AC, Tam PM, Mutsaers AJ. Investigation of the effects of mTOR inhibitors rapamycin and everolimus in combination with carboplatin on canine malignant melanoma cells. BMC Vet Res. 2021;17(1):382.; Liebmann JE, Cook JA, Lipschultz C, Teague D, Fisher J, Mitchell JB. Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines. Br J Cancer. 1993;68(6):1104-9.; Fucikova J, Kepp O, Kasikova L, Petroni G, Yamazaki T, Liu P, et al. Detection of immunogenic cell death and its relevance for cancer therapy. Cell Death Dis. 2020;11(11):1013.; Kim DY, Pyo A, Yun M, Thangam R, You SH, Zhang Y, et al. Imaging Calreticulin for Early Detection of Immunogenic Cell Death During Anticancer Treatment. J Nucl Med. 2021;62(7):956-60.; Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med. 2007;13(1):54-61.; Liu P, Zhao L, Kepp O, Kroemer G. Quantitation of calreticulin exposure associated with immunogenic cell death. Methods Enzymol. 2020;632:1-13.; Mistarz A, Graczyk M, Winkler M, Singh PK, Cortes E, Miliotto A, et al. Induction of cell death in ovarian cancer cells by doxorubicin and oncolytic vaccinia virus is associated with CREB3L1 activation. Mol Ther Oncolytics. 2021;23:38-50.; Golden EB, Frances D, Pellicciotta I, Demaria S, Helen Barcellos-Hoff M, Formenti SC. Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Oncoimmunology. 2014;3:e28518.; Schaer DA, Geeganage S, Amaladas N, Lu ZH, Rasmussen ER, Sonyi A, et al. The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy. Clin Cancer Res. 2019;25(23):7175-88.; Lau TS, Chan LKY, Man GCW, Wong CH, Lee JHS, Yim SF, et al. Paclitaxel Induces Immunogenic Cell Death in Ovarian Cancer via TLR4/IKK2/SNARE-Dependent Exocytosis. Cancer Immunol Res. 2020;8(8):1099-111.; Arandjelovic S, Ravichandran KS. Phagocytosis of apoptotic cells in homeostasis. Nat Immunol. 2015;16(9):907-17.; Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, et al. Cellsurface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell. 2005;123(2):321-34.; Liu X, Li J, Liu Y, Ding J, Tong Z, Liu Y, et al. Calreticulin acts as an adjuvant to promote dendritic cell maturation and enhances antigen-specific cytotoxic T lymphocyte responses against non-small cell lung cancer cells. Cell Immunol. 2016;300:46-53.; Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 2014;3(9):e955691.; https://repositorio.unal.edu.co/handle/unal/86203; Universidad Nacional de Colombia; Repositorio Institucional Universidad Nacional de Colombia; https://repositorio.unal.edu.co/

الاتاحة: https://repositorio.unal.edu.co/handle/unal/86203
https://repositorio.unal.edu.co/

المؤلفون: Villota Alava, María Alejandra

المساهمون: Parra López, Carlos Alberto, Clavijo Ramirez, Carlos Arturo, Inmunología y Medicina Traslacional, Patarroyo Gutiérrez, Manuel Alfonso, Villota Alava, María Alejandra https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001786060

مصطلحات موضوعية: 610 - Medicina y salud::615 - Farmacología y terapéutica, Antígenos de Neoplasias, Antígenos Virales/análisis, Inmunoterapia/métodos, Antigens, Neoplasm, Viral/analysis, Immunotherapy/methods, Minigenes, Neoantígenos, Células presentadoras de antígeno artificiales, Transfección, Transducción, Citometría de Flujo, Inmunoterapia, Minigene, Neoantigens, Artificial Antigen Presenting Cells, Transfection, Flow Cytometry, Transduction, Immunotherapy

وصف الملف: 164 páginas; application/pdf

Relation: Bireme; Tan, S., D. Li, and X. Zhu, Cancer immunotherapy: Pros, cons and beyond. Biomed Pharmacother, 2020. 124: p. 109821.; Dagher, O.K., et al., Advances in cancer immunotherapies. Cell, 2023. 186(8): p. 1814-1814.e1.; Zhang, Y. and Z. Zhang, The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cell Mol Immunol, 2020. 17(8): p. 807-821.; Lollini, P.L., et al., Vaccines for tumour prevention. Nat Rev Cancer, 2006. 6(3): p. 204-16.; Fu, C., et al., DC-Based Vaccines for Cancer Immunotherapy. Vaccines (Basel), 2020. 8(4).; Devi, G.R. and S. Nath, Delivery of Synthetic mRNA Encoding FOXP3 Antigen into Dendritic Cells for Inflammatory Breast Cancer Immunotherapy. Methods Mol Biol, 2016. 1428: p. 231-43.; Sahin, U., et al., Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature, 2017. 547(7662): p. 222-226.; Carreno, B.M., et al., Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells. Science, 2015. 348(6236): p. 803-8.; Patente, T.A., et al., Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy. Front Immunol, 2018. 9: p. 3176.; Lesterhuis, W.J., et al., Immunogenicity of dendritic cells pulsed with CEA peptide or transfected with CEA mRNA for vaccination of colorectal cancer patients. Anticancer Res, 2010. 30(12): p. 5091-7.; Cafri, G., et al., mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer. The Journal of clinical investigation, 2020. 130(11).; Aurisicchio, L., et al., A novel minigene scaffold for therapeutic cancer vaccines. Oncoimmunology, 2014. 3(1).; Tateshita, N., et al., Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine. Journal of controlled release : official journal of the Controlled Release Society, 2019. 310.; Lu, Y., et al., Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014. 20(13).; Gelband, H., et al., Cancer: Disease Control Priorities, Third Edition (Volume 3). 2015.; Bray, F., et al., Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018. 68(6): p. 394-424.; Kennedy, L.B. and A.K.S. Salama, A review of cancer immunotherapy toxicity. CA Cancer J Clin, 2020. 70(2): p. 86-104.; Igarashi, Y. and T. Sasada, Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy. J Immunol Res, 2020. 2020: p. 5825401.; Maus, M.V., et al., Adoptive immunotherapy for cancer or viruses. Annu Rev Immunol, 2014. 32: p. 189-225.; Bernal-Estévez, D.A., et al., Monitoring the responsiveness of T and antigen presenting cell compartments in breast cancer patients is useful to predict clinical tumor response to neoadjuvant chemotherapy. BMC Cancer, 2018. 18(1): p. 77.; Karpanen, T. and J. Olweus, The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy. Front Immunol, 2017. 8: p. 1718.; Wells, D.K., et al., Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction. Cell, 2020. 183(3): p. 818-834.e13.; Bradley, P. and P.G. Thomas, Using T Cell Receptor Repertoires to Understand the Principles of Adaptive Immune Recognition. Annu Rev Immunol, 2019. 37: p. 547-570.; E, S., et al., Targeting of cancer neoantigens with donor-derived T cell receptor repertoires. Science (New York, N.Y.), 2016. 352(6291).; Ali, M., et al., Induction of neoantigen-reactive T cells from healthy donors. Nat Protoc, 2019. 14(6): p. 1926-1943.; Aurisicchio, L., et al., Poly-specific neoantigen-targeted cancer vaccines delay patient derived tumor growth. J Exp Clin Cancer Res, 2019. 38(1): p. 78.; Farkona, S., E.P. Diamandis, and I.M. Blasutig, Cancer immunotherapy: the beginning of the end of cancer? BMC Med, 2016. 14: p. 73.; van der Bruggen, P., et al., A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science, 1991. 254(5038): p. 1643-7.; Gaugler, B., et al., Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. J Exp Med, 1994. 179(3): p. 921-30.; Banchereau, J. and R.M. Steinman, Dendritic cells and the control of immunity. Nature, 1998. 392(6673): p. 245-52.; Kawakami, Y., et al., Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc Natl Acad Sci U S A, 1994. 91(14): p. 6458-62.; Kantoff, P.W., et al., Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med, 2010. 363(5): p. 411-22.; Mou, Z., Y. He, and Y. Wu, Immunoproteomics to identify tumor-associated antigens eliciting humoral response. Cancer Lett, 2009. 278(2): p. 123-129.; Di Oto, E., et al., Prognostic impact of HER-2 Subclonal Amplification in breast cancer. Virchows Arch, 2017. 471(3): p. 313-319.; Brinkman, J.A., et al., Peptide-based vaccines for cancer immunotherapy. Expert Opin Biol Ther, 2004. 4(2): p. 181-98.; Disis, M.L., et al., Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines. J Clin Oncol, 2002. 20(11): p. 2624-32.; Rivoltini, L., et al., Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1. J Immunol, 1995. 154(5): p. 2257-65.; Simpson, A.J., et al., Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer, 2005. 5(8): p. 615-25.; Thomas, R., et al., NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives. Front Immunol, 2018. 9: p. 947.; Kakimi, K., et al., A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. Int J Cancer, 2011. 129(12): p. 2836-46.; Chamucero-Millares, J.A., D.A. Bernal-Estévez, and C.A. Parra-López, Usefulness of IL-21, IL-7, and IL-15 conditioned media for expansion of antigen-specific CD8+ T cells from healthy donor-PBMCs suitable for immunotherapy. Cell Immunol, 2021. 360: p. 104257.; Spaete, R.R., R.C. Gehrz, and M.P. Landini, Human cytomegalovirus structural proteins. J Gen Virol, 1994. 75 ( Pt 12): p. 3287-308.; Solache, A., et al., Identification of three HLA-A*0201-restricted cytotoxic T cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus. J Immunol, 1999. 163(10): p. 5512-8.; Wloch, M.K., et al., Safety and immunogenicity of a bivalent cytomegalovirus DNA vaccine in healthy adult subjects. J Infect Dis, 2008. 197(12): p. 1634-42.; Bouvier, N.M. and P. Palese, The biology of influenza viruses. Vaccine, 2008. 26 Suppl 4(Suppl 4): p. D49-53.; Choo, J.A., et al., The immunodominant influenza A virus M158-66 cytotoxic T lymphocyte epitope exhibits degenerate class I major histocompatibility complex restriction in humans. J Virol, 2014. 88(18): p. 10613-23.; Lillie, P.J., et al., Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans. Clin Infect Dis, 2012. 55(1): p. 19-25.; Dörrie, J., et al., Therapeutic Cancer Vaccination with Ex Vivo RNA-Transfected Dendritic Cells-An Update. Pharmaceutics, 2020. 12(2).; Chen, Y.Z., et al., Gene carriers and transfection systems used in the recombination of dendritic cells for effective cancer immunotherapy. Clin Dev Immunol, 2010. 2010: p. 565643.; Li, G.B. and G.X. Lu, Gene delivery efficiency in bone marrow-derived dendritic cells: comparison of four methods and optimization for lentivirus transduction. Mol Biotechnol, 2009. 43(3): p. 250-6.; Mack, C.A., et al., Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype. Hum Gene Ther, 1997. 8(1): p. 99-109.; Foged, C., et al., Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition. Vaccine, 2004. 22(15-16): p. 1903-13.; Yamada, M., et al., Tissue and intrahepatic distribution and subcellular localization of a mannosylated lipoplex after intravenous administration in mice. J Control Release, 2004. 98(1): p. 157-67.; Lu, Y., et al., Development of an antigen-presenting cell-targeted DNA vaccine against melanoma by mannosylated liposomes. Biomaterials, 2007. 28(21): p. 3255-62.; Kim, T.H., et al., Receptor-mediated gene delivery into antigen presenting cells using mannosylated chitosan/DNA nanoparticles. J Nanosci Nanotechnol, 2006. 6(9-10): p. 2796-803.; Ali, O.A. and D.J. Mooney, Sustained GM-CSF and PEI condensed pDNA presentation increases the level and duration of gene expression in dendritic cells. J Control Release, 2008. 132(3): p. 273-8.; Potter, H. and R. Heller, Transfection by Electroporation. Curr Protoc Mol Biol, 2018. 121: p. 9.3.1-9.3.13.; Schwartz, R.H., T cell anergy. Annu Rev Immunol, 2003. 21: p. 305-34.; Butler, M.O. and N. Hirano, Human cell-based artificial antigen-presenting cells for cancer immunotherapy. Immunol Rev, 2014. 257(1): p. 191-209.; Kim, J.V., et al., The ABCs of artificial antigen presentation. Nat Biotechnol, 2004. 22(4): p. 403-10.; Neal, L.R., et al., The Basics of Artificial Antigen Presenting Cells in T Cell-Based Cancer Immunotherapies. J Immunol Res Ther, 2017. 2(1): p. 68-79.; Klein, E., et al., Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia. Int J Cancer, 1976. 18(4): p. 421-31.; Butler, M.O., et al., A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles. Int Immunol, 2010. 22(11): p. 863-73.; Stepanenko, A.A. and V.V. Dmitrenko, HEK293 in cell biology and cancer research: phenotype, karyotype, tumorigenicity, and stress-induced genome-phenotype evolution. Gene, 2015. 569(2): p. 182-90.; Hong, C.H., et al., Antigen Presentation by Individually Transferred HLA Class I Genes in HLA-A, HLA-B, HLA-C Null Human Cell Line Generated Using the Multiplex CRISPR-Cas9 System. J Immunother, 2017. 40(6): p. 201-210.; Lee, M.N. and M. Meyerson, Antigen identification for HLA class I- and HLA class II-restricted T cell receptors using cytokine-capturing antigen-presenting cells. Sci Immunol, 2021. 6(55).; Prasher, D.C., Using GFP to see the light. Trends Genet, 1995. 11(8): p. 320-3.; Schmidt, A., et al., lacZ transgenic mice to monitor gene expression in embryo and adult. Brain Res Brain Res Protoc, 1998. 3(1): p. 54-60.; Hoffman, R.M., Green fluorescent protein imaging of tumor cells in mice. Lab Anim (NY), 2002. 31(4): p. 34-41.; Okabe, M., et al., 'Green mice' as a source of ubiquitous green cells. FEBS Lett, 1997. 407(3): p. 313-9.; Yang, M., et al., Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci U S A, 2000. 97(3): p. 1206-11.; Han, Q., et al., Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A, 2012. 109(5): p. 1607-12.; Peng, S., et al., Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell Rep, 2019. 28(10): p. 2728-2738.e7.; Bentzen, A.K. and S.R. Hadrup, Evolution of MHC-based technologies used for detection of antigen-responsive T cells. Cancer Immunol Immunother, 2017. 66(5): p. 657-666.; Zappasodi, R., et al., In vitro assays for effector T cell functions and activity of immunomodulatory antibodies. Methods Enzymol, 2020. 631: p. 43-59.; Rochman, Y., R. Spolski, and W.J. Leonard, New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol, 2009. 9(7): p. 480-90.; Jicha, D.L., J.J. Mulé, and S.A. Rosenberg, Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy. J Exp Med, 1991. 174(6): p. 1511-5.; Shevach, E.M., Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity, 2009. 30(5): p. 636-45.; Boyman, O., et al., Cytokines and T-cell homeostasis. Curr Opin Immunol, 2007. 19(3): p. 320-6.; Ettinger, R., et al., IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol, 2005. 175(12): p. 7867-79.; van den Broek, T., J.A.M. Borghans, and F. van Wijk, The full spectrum of human naive T cells. Nat Rev Immunol, 2018. 18(6): p. 363-373.; Melichar, B., et al., Expression of costimulatory molecules CD80 and CD86 and their receptors CD28, CTLA-4 on malignant ascites CD3+ tumour-infiltrating lymphocytes (TIL) from patients with ovarian and other types of peritoneal carcinomatosis. Clin Exp Immunol, 2000. 119(1): p. 19-27.; Young, J.W., et al., The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro. J Clin Invest, 1992. 90(1): p. 229-37.; Li, Z., et al., CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential. Front Immunol, 2019. 10: p. 1312.; Hirano, N., et al., Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity. Blood, 2006. 107(4): p. 1528-36.; Wallet, M.A., P. Sen, and R. Tisch, Immunoregulation of dendritic cells. Clin Med Res, 2005. 3(3): p. 166-75.; Shuford, W.W., et al., 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med, 1997. 186(1): p. 47-55.; Martinez-Perez, A.G., et al., 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer. Int J Mol Sci, 2021. 22(12).; Díaz, Á., et al., CD40-CD154: A perspective from type 2 immunity. Semin Immunol, 2021. 53: p. 101528.; Alunno, A., et al., Novel Therapeutic Strategies in Primary Sjögren's Syndrome. Isr Med Assoc J, 2017. 19(9): p. 576-580.; Hassan, G.S., J. Stagg, and W. Mourad, Role of CD154 in cancer pathogenesis and immunotherapy. Cancer Treat Rev, 2015. 41(5): p. 431-40.; Bacher, P. and A. Scheffold, Flow-cytometric analysis of rare antigen-specific T cells. Cytometry A, 2013. 83(8): p. 692-701.; Dawicki, W. and T.H. Watts, Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Eur J Immunol, 2004. 34(3): p. 743-751.; Otano, I., et al., CD137 (4-1BB) costimulation of CD8. Nat Commun, 2021. 12(1): p. 7296.; Bajnok, A., et al., The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia. Mediators Inflamm, 2017. 2017: p. 8045161.; Spetz, J., A.G. Presser, and K.A. Sarosiek, T Cells and Regulated Cell Death: Kill or Be Killed. Int Rev Cell Mol Biol, 2019. 342: p. 27-71.; Reddy, M., et al., Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: an in vitro model to monitor cellular immune function. J Immunol Methods, 2004. 293(1-2): p. 127-42.; Marzio, R., J. Mauël, and S. Betz-Corradin, CD69 and regulation of the immune function. Immunopharmacol Immunotoxicol, 1999. 21(3): p. 565-82.; González-Amaro, R., et al., Is CD69 an effective brake to control inflammatory diseases? Trends Mol Med, 2013. 19(10): p. 625-32.; Lim, L.C., et al., A whole-blood assay for qualitative and semiquantitative measurements of CD69 surface expression on CD4 and CD8 T lymphocytes using flow cytometry. Clin Diagn Lab Immunol, 1998. 5(3): p. 392-8.; Gorabi, A.M., et al., The pivotal role of CD69 in autoimmunity. J Autoimmun, 2020. 111: p. 102453.; Mallett, S., S. Fossum, and A.N. Barclay, Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor. EMBO J, 1990. 9(4): p. 1063-8.; Croft, M., et al., The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev, 2009. 229(1): p. 173-91.; Rogers, P.R., et al., OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity, 2001. 15(3): p. 445-55.; Walker, L.S., et al., Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J Exp Med, 1999. 190(8): p. 1115-22.; Jubel, J.M., et al., The Role of PD-1 in Acute and Chronic Infection. Front Immunol, 2020. 11: p. 487.; Keir, M.E., et al., PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol, 2008. 26: p. 677-704.; Pentcheva-Hoang, T., et al., B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity, 2004. 21(3): p. 401-13.; Walunas, T.L., et al., CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J Immunol, 1996. 156(3): p. 1006-13.; Buchbinder, E.I. and A. Desai, CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Am J Clin Oncol, 2016. 39(1): p. 98-106.; Sharpe, A.H. and G.J. Freeman, The B7-CD28 superfamily. Nat Rev Immunol, 2002. 2(2): p. 116-26.; Workman, C.J., et al., Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol, 2004. 172(9): p. 5450-5.; Ménager, J., et al., Cross-presentation of synthetic long peptides by human dendritic cells: a process dependent on ERAD component p97/VCP but Not sec61 and/or Derlin-1. PLoS One, 2014. 9(2): p. e89897.; Aspord, C., et al., pDCs efficiently process synthetic long peptides to induce functional virus- and tumour-specific T-cell responses. Eur J Immunol, 2014. 44(10): p. 2880-92.; Wang, M., et al., Identification of MHC class II restricted T-cell-mediated reactivity against MHC class I binding Mycobacterium tuberculosis peptides. Immunology, 2011. 132(4): p. 482-91.; Dhanda, S.K., et al., IEDB-AR: immune epitope database-analysis resource in 2019. Nucleic Acids Res, 2019. 47(W1): p. W502-W506.; Czerniecki, B.J., et al., Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion. Cancer Res, 2007. 67(4): p. 1842-52.; Jain, R.K., et al., Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells. Biochem J, 2001. 360(Pt 3): p. 645-9.; Arnaud, M., et al., Sensitive identification of neoantigens and cognate TCRs in human solid tumors. Nat Biotechnol, 2022. 40(5): p. 656-660.; Liu, Y., et al., Tumor microenvironment-mediated immune tolerance in development and treatment of gastric cancer. Front Immunol, 2022. 13: p. 1016817.; Phetsouphanh, C., J.J. Zaunders, and A.D. Kelleher, Detecting Antigen-Specific T Cell Responses: From Bulk Populations to Single Cells. Int J Mol Sci, 2015. 16(8): p. 18878-93.; Azuma, M., Co-signal Molecules in T-Cell Activation : Historical Overview and Perspective. Adv Exp Med Biol, 2019. 1189: p. 3-23.; Curtsinger, J.M., et al., Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol, 1999. 162(6): p. 3256-62.; Tanimoto, K., et al., Genetically engineered fixed K562 cells: potent "off-the-shelf" antigen-presenting cells for generating virus-specific T cells. Cytotherapy, 2014. 16(1): p. 135-46.; Riedhammer, C., D. Halbritter, and R. Weissert, Peripheral Blood Mononuclear Cells: Isolation, Freezing, Thawing, and Culture. Methods Mol Biol, 2016. 1304: p. 53-61.; Van Camp, K., et al., Efficient mRNA electroporation of peripheral blood mononuclear cells to detect memory T cell responses for immunomonitoring purposes. J Immunol Methods, 2010. 354(1-2): p. 1-10.; Chong, Z.X., S.K. Yeap, and W.Y. Ho, Transfection types, methods and strategies: a technical review. PeerJ, 2021. 9: p. e11165.; Nastasi, C., L. Mannarino, and M. D'Incalci, DNA Damage Response and Immune Defense. Int J Mol Sci, 2020. 21(20).; Mortara, L., et al., Therapy-induced antitumor vaccination by targeting tumor necrosis factor alpha to tumor vessels in combination with melphalan. Eur J Immunol, 2007. 37(12): p. 3381-92.; Lejeune, F.J., et al., Efficiency of recombinant human TNF in human cancer therapy. Cancer Immun, 2006. 6: p. 6.; Kang, S., H.M. Brown, and S. Hwang, Direct Antiviral Mechanisms of Interferon-Gamma. Immune Netw, 2018. 18(5): p. e33.; Jouanguy, E., et al., A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat Genet, 1999. 21(4): p. 370-8.; Ikeda, H., L.J. Old, and R.D. Schreiber, The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev, 2002. 13(2): p. 95-109.; Ikeda, H, R.R., A.M. Ghoneim, and N. El-Mashad, TNF-α gene polymorphisms and expression. Springerplus, 2016. 5(1): p. 1508.; Trapani, J.A. and V.R. Sutton, Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr Opin Immunol, 2003. 15(5): p. 533-43.; de Jong, R., et al., Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors. J Immunol, 1991. 146(8): p. 2488-94.; Walker, L.S., et al., Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol Today, 2000. 21(7): p. 333-7.; Acuto, O. and F. Michel, CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat Rev Immunol, 2003. 3(12): p. 939-51.; Kaminski, D.A., et al., CD28 and inducible costimulator (ICOS) signalling can sustain CD154 expression on activated T cells. Immunology, 2009. 127(3): p. 373-85.; Wolfl, M., et al., Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. Blood, 2007. 110(1): p. 201-10.; Ahn, E., et al., Role of PD-1 during effector CD8 T cell differentiation. Proc Natl Acad Sci U S A, 2018. 115(18): p. 4749-4754.; Waterhouse, P., et al., Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science, 1995. 270(5238): p. 985-8.; Steiner, K., et al., Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection. Clin Exp Immunol, 1999. 115(3): p. 451-7.; Goldberg, M.V. and C.G. Drake, LAG-3 in Cancer Immunotherapy. Curr Top Microbiol Immunol, 2011. 344: p. 269-78.; Fuertes Marraco, S.A., et al., Inhibitory Receptors Beyond T Cell Exhaustion. Front Immunol, 2015. 6: p. 310.; Wang, W., et al., PD-L1/PD-1 signal deficiency promotes allogeneic immune responses and accelerates heart allograft rejection. Transplantation, 2008. 86(6): p. 836-44.; Bernal-Estévez, D., et al., Chemotherapy and radiation therapy elicits tumor specific T cell responses in a breast cancer patient. BMC Cancer, 2016. 16: p. 591.; Kaech, S.M., E.J. Wherry, and R. Ahmed, Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol, 2002. 2(4): p. 251-62.; Hsiue, E.H., et al., Targeting a neoantigen derived from a common. Science, 2021. 371(6533).; Maus, M.V., et al., Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB. Nat Biotechnol, 2002. 20(2): p. 143-8.; Zeng, W., et al., Artificial antigen-presenting cells expressing CD80, CD70, and 4-1BB ligand efficiently expand functional T cells specific to tumor-associated antigens. Immunobiology, 2014. 219(8): p. 583-92.; Shao, J., et al., Artificial antigen-presenting cells are superior to dendritic cells at inducing antigen-specific cytotoxic T lymphocytes. Cell Immunol, 2018. 334: p. 78-86.; Butler, M.O., et al., Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell. Clin Cancer Res, 2007. 13(6): p. 1857-67.; https://repositorio.unal.edu.co/handle/unal/86062; Universidad Nacional de Colombia; Repositorio Institucional Universidad Nacional de Colombia; https://repositorio.unal.edu.co/

الاتاحة: https://repositorio.unal.edu.co/handle/unal/86062
https://repositorio.unal.edu.co/

المؤلفون: Skrie, Victor Claudio

المساهمون: Copioli, Juan Carlos

المصدر: Repositorio Digital Universitario (UNC)
Universidad Nacional de Córdoba
instacron:UNC

مصطلحات موضوعية: Preescolar, Pediatria, Asma, Inmunoterapia, Desensibilización Inmunológica, Alergenos, Niños, Asma, Inmunoterapia, Métodos

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المؤلفون: Reyes Osorio, Diego Sergio A.

المساهمون: Salazar Onfray, Flavio, Huidobro A., Christian

مصطلحات موضوعية: Neoplasias de la próstata resistentes a la castración - Terapia, Células presentadoras de antígenos - Inmunología, Inmunoterapia - Métodos

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Relation: https://repositorio.uchile.cl/handle/2250/183545

الاتاحة: https://repositorio.uchile.cl/handle/2250/183545

المؤلفون: Barrera, Nelly Teresita del Valle

المساهمون: Copioli, Juan Carlos

المصدر: Repositorio Digital Universitario (UNC)
Universidad Nacional de Córdoba
instacron:UNC

مصطلحات موضوعية: Asma, Inmunología, Pruebas de Provocacion Bronquial, Normas, Hiperractividad Bronquial, Diagnostico, Pruebas de Provocacion Bronquial, Métodos, Mucosa Nazal, Inmunología, Hiperractividad Bronquial, Complicaciones, Asma, Diagnostico, Rinitis Alérgica Estacional, Diagnostico, Rinitis, Inmunoterapia, Métodos, Hiperractividad Bronquial, Etiología

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