المؤلفون: Kevin D. Freeman-Cook (2004784), Robert L. Hoffman (799027), Douglas C. Behenna (1334163), Britton Boras (10955067), Jordan Carelli (10955070), Wade Diehl (3104187), Rose Ann Ferre (2128093), You-Ai He (103797), Andrea Hui (10955073), Buwen Huang (2058541), Nanni Huser (2065525), Rhys Jones (1540795), Susan E. Kephart (4720167), John Lapek (10955076), Michele McTigue (1309425), Nichol Miller (4604398), Brion W. Murray (799034), Asako Nagata (2128075), Lisa Nguyen (89308), Sherry Niessen (395727), Sacha Ninkovic (2200828), Inish O’Doherty (2151259), Martha A. Ornelas (1309407), James Solowiej (3875254), Scott C. Sutton (2025337), Khanh Tran (2128105), Elaine Tseng (2025841), Ravi Visswanathan (7511996), Meirong Xu (773491), Luke Zehnder (2200813), Qin Zhang (58638), Cathy Zhang (4038041), Stephen Dann (10955079)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, broad-spectrum CDK inhibitors, phase 1, structure-based drug design, dynamics simulations, breast cancer, ADME profile, tumor types, PF -06873600, cell cycle, CDK 9, Cancer Control, cell cycle CDK isoforms, safety concerns

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_PF-06873600_a_CDK2_4_6_Inhibitor_for_the_Treatment_of_Cancer/14766330

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00159.s002

المؤلفون: Kevin D. Freeman-Cook (2004784), Robert L. Hoffman (799027), Douglas C. Behenna (1334163), Britton Boras (10955067), Jordan Carelli (10955070), Wade Diehl (3104187), Rose Ann Ferre (2128093), You-Ai He (103797), Andrea Hui (10955073), Buwen Huang (2058541), Nanni Huser (2065525), Rhys Jones (1540795), Susan E. Kephart (4720167), John Lapek (10955076), Michele McTigue (1309425), Nichol Miller (4604398), Brion W. Murray (799034), Asako Nagata (2128075), Lisa Nguyen (89308), Sherry Niessen (395727), Sacha Ninkovic (2200828), Inish O’Doherty (2151259), Martha A. Ornelas (1309407), James Solowiej (3875254), Scott C. Sutton (2025337), Khanh Tran (2128105), Elaine Tseng (2025841), Ravi Visswanathan (7511996), Meirong Xu (773491), Luke Zehnder (2200813), Qin Zhang (58638), Cathy Zhang (4038041), Stephen Dann (10955079)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, broad-spectrum CDK inhibitors, phase 1, structure-based drug design, dynamics simulations, breast cancer, ADME profile, tumor types, PF -06873600, cell cycle, CDK 9, Cancer Control, cell cycle CDK isoforms, safety concerns

Relation: https://figshare.com/articles/dataset/Discovery_of_PF-06873600_a_CDK2_4_6_Inhibitor_for_the_Treatment_of_Cancer/14766327

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00159.s001