يعرض 1 - 14 نتائج من 14 نتيجة بحث عن '"Incorporating 3 D properties"', وقت الاستعلام: 0.48s تنقيح النتائج
  1. 1
    Academic Journal
    MTOR Missense Variants Subjected to in vitro Functional Assessment.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/journal_contribution/_i_MTOR_i_Missense_Variants_Subjected_to_i_in_vitro_i_Functional_Assessment_/14895962

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.s004

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  2. 2
    Image
    TSC1 and 2 Double Knockout Results in Reduced AKT Activation.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/figure/TSC1_and_2_Double_Knockout_Results_in_Reduced_AKT_Activation_/14895953

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.s001

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  3. 3
    Data from Immunoblotting Experiments for MTORC1-S6K Activation (Fig 1).

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/dataset/Data_from_Immunoblotting_Experiments_for_MTORC1-S6K_Activation_Fig_1_/14895965

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.s005

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  4. 4
    Image
    Novel Smith-Kingsmore Syndrome Variants Activate MTORC1 and MTORC2 in Stimulated and Serum-starved Human Embryonic Kidney Cells.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/figure/Novel_Smith-Kingsmore_Syndrome_Variants_Activate_MTORC1_and_MTORC2_in_Stimulated_and_Serum-starved_Human_Embryonic_Kidney_Cells_/14895974

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.g001

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  5. 5
    Image
    A Comparison of Active, Inactive, Consensus, and Differential RSA Measures Between Population-, Cancer- and NDD-associated MTOR Variants.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/figure/A_Comparison_of_Active_Inactive_Consensus_and_Differential_RSA_Measures_Between_Population-_Cancer-_and_NDD-associated_MTOR_Variants_/14895959

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.s003

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  6. 6
    Image
    NDD- and cancer-associated MTOR variants form distinct clusters in which disease-associated variants face neighboring helices, while population variants face into solvent.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/figure/NDD-_and_cancer-associated_MTOR_variants_form_distinct_clusters_in_which_disease-associated_variants_face_neighboring_helices_while_population_variants_face_into_solvent_/14895956

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.s002

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  7. 7
    Data from Immunoblotting Experiments for MTORC2-AKT Activation (Fig 1).

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/dataset/Data_from_Immunoblotting_Experiments_for_MTORC2-AKT_Activation_Fig_1_/14895968

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.s006

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  8. 8
    Data for Relative Accessible Surface Area Analyses (Figs 4 and 5).

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/dataset/Data_for_Relative_Accessible_Surface_Area_Analyses_Figs_4_and_5_/14895971

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.s007

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  9. 9
    Image
    Cryogenic Electron Microscopy Structure of MTOR with Mapped Novel Variants.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/figure/Cryogenic_Electron_Microscopy_Structure_of_MTOR_with_Mapped_Novel_Variants_/14895977

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.g002

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  10. 10
    Image
    Disease-associated MTOR Variants Have Lower Relative Accessible Surface Area Than Proximal Population Variants Based on Domain Location.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/figure/Disease-associated_MTOR_Variants_Have_Lower_Relative_Accessible_Surface_Area_Than_Proximal_Population_Variants_Based_on_Domain_Location_/14895983

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.g004

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  11. 11
    Image
    Pathogenic MTOR Variants Cluster in Key Tertiary Protein Structures and Lie on Internally Facing Helical Surfaces.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/figure/Pathogenic_MTOR_Variants_Cluster_in_Key_Tertiary_Protein_Structures_and_Lie_on_Internally_Facing_Helical_Surfaces_/14895980

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.g003

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  12. 12
    Image
    ROC Curve for Relative Accessible Surface Area as a Predictor of MTOR Variant Pathogenicity in Neurodevelopmental Disorders and Cancer.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/figure/ROC_Curve_for_Relative_Accessible_Surface_Area_as_a_Predictor_of_i_MTOR_i_Variant_Pathogenicity_in_Neurodevelopmental_Disorders_and_Cancer_/14895986

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.g005

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  13. 13
    Summary of NDD-associated MTOR Variants.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/dataset/Summary_of_NDD-associated_i_MTOR_i_Variants_/14895992

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.t002

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  14. 14
    Summary of Clinical Features of Smith-Kingsmore Syndrome in Patients with Novel Variants.

    المؤلفون: Aaron D. Besterman (11061044), Thorsten Althoff (10846022), Peter Elfferich (3508580), Irma Gutierrez-Mejia (11061047), Joshua Sadik (11061050), Jonathan A. Bernstein (9353526), Yvette van Ierland (524465), Anja A. Kattentidt-Mouravieva (11061053), Mark Nellist (549064), Jeff Abramson (3737131), Julian A. Martinez-Agosto (10329686)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Biotechnology, Sociology, Cancer, Chemical Sciences not elsewhere classified, surface area, acid side-chain accessibility, SKS, novel Smith-Kingsmore Syndrome-Asso., 3 D properties, variants cause disease, 4 novel MTOR variants, mechanism, MTOR variant pathogenicity, pathogenicity Smith-Kingsmore syndrome, acid side chains, MTOR variants, report 7 patients, MTOR Complex 2 activation, Incorporating 3 D properties, MTOR Complex 1 activation

    Relation: https://figshare.com/articles/dataset/Summary_of_Clinical_Features_of_Smith-Kingsmore_Syndrome_in_Patients_with_Novel_Variants_/14895989

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009651.t001

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