المؤلفون: Yili Ding, Bo Yu, Shuzhen Zhou, Charles Ding, Zhiyuan Zhang, Shufeng Xu, Zhe Xu

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: icariin, inclusion complex, water solubility, in vitro and in vivo PK study, cyclodextrin, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1138686/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/f6228846809b4ce29e809bd033656f73

المؤلفون: Hongjuan WANG, Longfei ZHANG, Jianhe HU

المصدر: Kafkas Universitesi Veteriner Fakültesi Dergisi, Vol 28, Iss 2, Pp 281-289 (2022)

مصطلحات موضوعية: antibacterial drugs, pk/pd integration model, multi-drug resistance, dosage regimen optimization, in vivo pk/pd model, Veterinary medicine, SF600-1100

وصف الملف: electronic resource

Relation: https://vetdergikafkas.org/pdf.php?id=2889; https://doaj.org/toc/1309-2251

URL الوصول: https://doaj.org/article/7ac936f4dcd142fdb74586039a04b053

المؤلفون: Gebhard Thoma, Christian Markert, Rainer Lueoend, Wolfgang Miltz, Carsten Spanka, Birgit Bollbuck, Romain M. Wolf, Honnappa Srinivas, Carlos A. Penno, Michael Kiffe, Monika Gajewska, Dallas Bednarczyk, Grazyna Wieczorek, Amanda Evans, Christian Beerli, Till A. Röhn

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, orally efficacious inhibitors, leukotriene a4 hydrolase, exhibiting high selectivity, enabling toxicology studies, despite comparable stabilities, showed favorable profiles, hepatic blood flow, vivo pk properties, lys006 , 2 , showed distinct, whole blood, blood led, r <, >)-< b, week ind, polarity across, liver microsomes

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Amino_Alcohols_as_Highly_Potent_Selective_and_Orally_Efficacious_Inhibitors_of_Leukotriene_A4_Hydrolase/24649684

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01866.s001
https://figshare.com/articles/journal_contribution/Discovery_of_Amino_Alcohols_as_Highly_Potent_Selective_and_Orally_Efficacious_Inhibitors_of_Leukotriene_A4_Hydrolase/24649684

المؤلفون: Yili Ding, Zhiyuan Zhang, Charles Ding, Shufeng Xu, Zhe Xu

المصدر: Molecules, Vol 28, Iss 21, p 7295 (2023)

مصطلحات موضوعية: albendazole, methyl- β -cyclodextrin, inclusion complex, water solubility, in vitro and in vivo PK study, Organic chemistry, QD241-441

Relation: https://www.mdpi.com/1420-3049/28/21/7295; https://doaj.org/toc/1420-3049; https://doaj.org/article/70463f8c089f4dcc84e4b534f00bb1db

الاتاحة: https://doi.org/10.3390/molecules28217295
https://doaj.org/article/70463f8c089f4dcc84e4b534f00bb1db

المؤلفون: Yili Ding, Wutong Cui, Zhiyuan Zhang, Yanzhi Ma, Charles Ding, Yikai Lin, Zhe Xu

المصدر: Molecules, Vol 28, Iss 21, p 7360 (2023)

مصطلحات موضوعية: griseofulvin, HP- γ -cyclodextrin, inclusion complex, preparation, water solubility, in vitro and in vivo PK study, Organic chemistry, QD241-441

Relation: https://www.mdpi.com/1420-3049/28/21/7360; https://doaj.org/toc/1420-3049; https://doaj.org/article/ed28d14d06514dcebe58478c3be4a284

الاتاحة: https://doi.org/10.3390/molecules28217360
https://doaj.org/article/ed28d14d06514dcebe58478c3be4a284

المؤلفون: Xiao, Xia, Sun, Jian, Yang, Tao, Fang, Xi, Cheng, Jie, Xiong, Yan Q, Liu, Ya-Hong

المصدر: Frontiers in Veterinary Science. 3(SEP)

مصطلحات موضوعية: Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Infection, Good Health and Well Being, tiamulin, M. gallisepticum, in vivo PK/PD, chicken, Veterinary sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1js6h0xn
https://escholarship.org/content/qt1js6h0xn/qt1js6h0xn.pdf

المؤلفون: Ferlenghi F., Giorgio C., Incerti M., Guidetti L., Chiodelli P., Rusnati M., Tognolini M., Vacondio F., Mor M., Lodola A.

المساهمون: Ferlenghi F., Giorgio C., Incerti M., Guidetti L., Chiodelli P., Rusnati M., Tognolini M., Vacondio F., Mor M., Lodola A.

مصطلحات موضوعية: Eph–ephrin system, High-resolution mass spectrometry (HR-MS), In vivo PK, Metabolite ID, UniPR129, UniPR500

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000747021000001; volume:15; issue:1; firstpage:41; journal:PHARMACEUTICALS; http://hdl.handle.net/11379/551918; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85122156108

الاتاحة: http://hdl.handle.net/11379/551918
https://doi.org/10.3390/ph15010041

المؤلفون: Longfei Zhang, Hongbing Xie, Hongjuan Wang, Huanzhong Ding, Gaiping Zhang, Jianhe Hu

المصدر: Frontiers in Veterinary Science, Vol 8 (2021)

مصطلحات موضوعية: kill rate, ex vivo PK/PD integration, cefquinome, Actinobacillus pleuropneumoniae, tissue cage model, Veterinary medicine, SF600-1100

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fvets.2021.751957/full; https://doaj.org/toc/2297-1769

URL الوصول: https://doaj.org/article/36d1395e26714cf0a82dfb6949f865eb

المؤلفون: Douglas S. Williamson (2188903), Garrick P. Smith (3023454), Gitte K. Mikkelsen (2231557), Thomas Jensen (92927), Pamela Acheson-Dossang (4540645), Lassina Badolo (827449), Simon T. Bedford (4540642), Victoria Chell (3749047), I-Jen Chen (2297146), Pawel Dokurno (2188936), Morten Hentzer (2210332), Samantha Newland (4540639), Stuart C. Ray (9620234), Terry Shaw (2188924), Allan E. Surgenor (2188933), Lindsey Terry (2188939), Yikang Wang (2188945), Kenneth V. Christensen (4540633)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Chemical Sciences not elsewhere classified, vivo PK profile, LRRK 2 inhibition, LRRK 2 kinase domain surrogates, 2- methyl substituent, Compounds 44, Ala 2016, pyrimidine-Derived Leucine-Rich Rep., kinase 2, X-ray structures, LRRK 2, structure-guided elaboration, Ala 147, Checkpoint Kinase 1, chemical probes, species disconnects, CHK 1 10- point, PK profile, X-ray structure, LRRK 2 G 2019S c K i 0.7 nM, mouse model, pyrazol -4-yl, Surrogate Inhibitors

Relation: https://figshare.com/articles/journal_contribution/Design_and_Synthesis_of_Pyrrolo_2_3_i_d_i_pyrimidine-Derived_Leucine-Rich_Repeat_Kinase_2_LRRK2_Inhibitors_Using_a_Checkpoint_Kinase_1_CHK1_-Derived_Crystallographic_Surrogate/14877656

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00720.s001

المؤلفون: Dana M. Klug (6194387), Eftychia M. Mavrogiannaki (11009156), Katherine C. Forbes (5725409), Lisseth Silva (11009159), Rosario Diaz-Gonzalez (345689), Guiomar Pérez-Moreno (1744951), Gloria Ceballos-Pérez (8262147), Raquel Garcia-Hernández (11009162), Cristina Bosch-Navarrete (740114), Carlos Cordón-Obras (11009165), Claudia Gómez-Liñán (11009168), Andreu Saura (10309889), Jeremiah D. Momper (5697437), Maria Santos Martinez-Martinez (3935165), Pilar Manzano (650253), Ali Syed (9586857), Nelly El-Sakkary (184701), Conor R. Caffrey (113916), Francisco Gamarro (292598), Luis Miguel Ruiz-Perez (8262153), Dolores Gonzalez Pacanowska (8262156), Lori Ferrins (1365060), Miguel Navarro (176103), Michael P. Pollastri (345704)

مصطلحات موضوعية: Medicine, Pharmacology, Ecology, Sociology, Cancer, Environmental Sciences not elsewhere classified, Physical Sciences not elsewhere classified, vivo PK studies, series, Trypanosoma brucei, Trypanosomiasis Neglected, African trypanosomiasis, causes HAT, hit-to-lead optimization, BBB, antitrypanosomal compound, growth inhibitors, high-throughput screen, Lead Optimization, stage 2 HAT treatments, therapeutic

Relation: https://figshare.com/articles/journal_contribution/Lead_Optimization_of_3_5-Disubstituted-7-Azaindoles_for_the_Treatment_of_Human_African_Trypanosomiasis/14825027

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00674.s001

المؤلفون: Michael G. Yang (2123170), Myra Beaudoin-Bertrand (4067701), Zili Xiao (2123182), David Marcoux (2182586), Carolyn A. Weigelt (2276455), Shiuhang Yip (1402564), Dauh-Rurng Wu (1402558), Max Ruzanov (5877002), John S. Sack (2375029), Jinhong Wang (34550), Melissa Yarde (1745002), Sha Li (145229), David J. Shuster (2459569), Jenny H. Xie (3385667), Tara Sherry (9610086), Mary T. Obermeier (1436389), Aberra Fura (1436362), Kevin Stefanski (1551436), Georgia Cornelius (1429912), Purnima Khandelwal (4724169), Ananta Karmakar (2236600), Mushkin Basha (7597451), Venkatesh Babu (10151570), Arun Kumar Gupta (7597448), Arvind Mathur (144120), Luisa Salter-Cid (1429873), Rex Denton (2012920), Qihong Zhao (517396), T. G. Murali Dhar (7542971)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Immunology, Cancer, Infectious Diseases, Computational Biology, X-ray co-crystal structure, ROR γt, vivo PK profiles, efficacy, BMS -986313 SAR efforts, IL -23-induced acanthosis model, ligand binding domain

Relation: https://figshare.com/articles/journal_contribution/Tricyclic-Carbocyclic_ROR_t_Inverse_Agonists_Discovery_of_BMS-986313/14043458

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01992.s002

المؤلفون: Qiaoyi Zhou, Guijun Zhang, Qin Wang, Wenguang Liu, Yan Huang, Pengling Yu, Yanqin Li, Huanzhong Ding, Binghu Fang

المصدر: Frontiers in Pharmacology, Vol 8 (2017)

مصطلحات موضوعية: tulathromycin, Pasteurella multocida, ex vivo PK/PD, tissue cage model, PK/PD parameters, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphar.2017.00392/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/fd1a7e1c238d4f6aac40596b1edaf4ef

المؤلفون: Francesca Ferlenghi, Carmine Giorgio, Matteo Incerti, Lorenzo Guidetti, Paola Chiodelli, Marco Rusnati, Massimiliano Tognolini, Federica Vacondio, Marco Mor, Alessio Lodola

المصدر: Pharmaceuticals, Vol 15, Iss 41, p 41 (2022)
Pharmaceuticals; Volume 15; Issue 1; Pages: 41
Pharmaceuticals

مصطلحات موضوعية: Eph–ephrin system, High-resolution mass spectrometry (HR-MS), In vivo PK, Metabolite ID, UniPR129, UniPR500, Settore BIO/14 - FARMACOLOGIA, Pharmaceutical Science, Article, RS1-441, Pharmacy and materia medica, Drug Discovery, Molecular Medicine, Medicine, metabolite ID, in vivo PK, high-resolution mass spectrometry (HR-MS)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb49ea604f8f59ddc3ead2b68b2c1b9
http://hdl.handle.net/11379/551918

المؤلفون: Gu, Mengxiao, Zhang, Nan, Zhang, Longfei, Xiong, Mingpeng, Yang, Yuanyuan, Gu, Xiaoyan, Shen, Xiangguang, Ding, Huanzhong

مصطلحات موضوعية: Tissue-cage model, in vivo PK/PD, Cefquinome, A clinical Escherichia coli strain, Piglets

Relation: http://www.biomedcentral.com/1746-6148/11/169

الاتاحة: http://www.biomedcentral.com/1746-6148/11/169

المؤلفون: Francesca Ferlenghi, Antonella Brizzi, Federica Vacondio, Rafaela Mostallino, Giancarlo Colombo, Paola Maccioni, Claudia Mugnaini, Marco Mor, Federica Fara, M. Paola Castelli, Federico Corelli

مصطلحات موضوعية: Allosteric modulator, Metabolite, medicine.medical_treatment, Pharmaceutical Science, GABAB PAM, Metabolite ID, In vivo PK, Metabolic protection, Alcohol and chocolate self-administration, Sardinian alcohol-preferring rats, 02 engineering and technology, Pharmacology, GABAB receptor, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Metabolite ID, medicine, Receptor, Chemistry, In vivo PK, 021001 nanoscience & nanotechnology, Sardinian alcohol-preferring rats, In vitro, GABAB PAM, Metabolic protection, Alcohol and chocolate self-administration, Cannabinoid, 0210 nano-technology, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9e1a735cd3ea062fbb2c3c726f1efa
http://hdl.handle.net/11365/1138721

المؤلفون: Sanja Koštrun (2064985), Andrea Fajdetić (2115007), Dijana Pešić (2093464), Karmen Brajša (2065021), Vlatka Bencetić Mihaljević (10941240), Dubravko Jelić (2065006), Adriana Petrinić Grba (10941243), Ivaylo Elenkov (391501), Renata Rupčić (2115004), Samra Kapić (2064979), Ivana Ozimec Landek (10941246), Kristina Butković (2231761), Ana Grgičević (10941249), Dinko Žiher (1400686), Ana Čikoš (1400689), Jasna Padovan (2064982), Gordon Saxty (1668052), Kevin Dack (2148385), Haakan Bladh (10941252), Tine Skak-Nielsen (2728693), Simon Feldbaek Nielsen (10941255), Maja Lambert (2516587), Martin Stahlhut (5158313)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, ring sizes, psoriatic patients, chemical space, vivo PK properties, ADME, drug discovery, phenotypic assays, non-lesion parts, IL -17A modulators, Macrocycle, IL -17A Interaction Interleukin 17, bowel disease, IL -17A, nM range, IL -17

Relation: https://figshare.com/articles/dataset/Macrolide_Inspired_Macrocycles_as_Modulators_of_the_IL-17A_IL-17RA_Interaction/14748996

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00327.s003

المؤلفون: Pengling Yu, Yanqin Li, Qin Wang, Yan Huang, Binghu Fang, Qiaoyi Zhou, Guijun Zhang, Wenguang Liu, Huanzhong Ding

المصدر: Frontiers in Pharmacology, Vol 8 (2017)

مصطلحات موضوعية: 0301 basic medicine, Pasteurella multocida, ex vivo PK/PD, 040301 veterinary sciences, medicine.drug_class, Antibiotics, Microbiology, 0403 veterinary science, 03 medical and health sciences, Minimum inhibitory concentration, Pharmacokinetics, medicine, Pharmacology (medical), Tulathromycin, Pharmacology, biology, lcsh:RM1-950, 04 agricultural and veterinary sciences, biology.organism_classification, Transudate, tulathromycin, PK/PD parameters, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, Pharmacodynamics, tissue cage model, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ba5efd3978e2670375f1c8cae25dbf
http://journal.frontiersin.org/article/10.3389/fphar.2017.00392/full

المؤلفون: Xia Xiao, Jian Sun, Tao Yang, Xi Fang, Jie Cheng, Yan Q. Xiong, Ya-Hong Liu

المصدر: Frontiers in Veterinary Science, Vol 3 (2016)
Frontiers in veterinary science, vol 3, iss SEP
Frontiers in Veterinary Science

مصطلحات موضوعية: 0301 basic medicine, Mycoplasma gallisepticum, tiamulin, medicine.drug_class, chicken, 030106 microbiology, Antibiotics, Tiamulin, Biology, Microbiology, in vivo PK/PD, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, In vivo, medicine, Veterinary Sciences, M. gallisepticum, Pathogen, Original Research, PKPD modeling, lcsh:Veterinary medicine, General Veterinary, biology.organism_classification, in vivo, Good Health and Well Being, 030104 developmental biology, chemistry, Pharmacodynamics, lcsh:SF600-1100, Veterinary Science, Infection, Chickens, Pleuromutilin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0342c32c1d2ed4e7e0d19a8c689305c6
https://doi.org/10.3389/fvets.2016.00075

المؤلفون: Nilsson, Magnus, Belfrage, Anna Karin, Lindstrom, Stefan, Wahling, Horst, Lindquist, Charlotta, Ayesa, Susana, Kahnberg, Pia, Pelcman, Mikael, Benkestock, Kurt, Agback, Tatiana, Vrang, Lotta, Terelius, Ylva, Wikstrom, Kristina, Hamelink, Elizabeth, Rydergard, Christina, Edlund, Michael, Eneroth, Anders, Raboisson, Pierre, Lin, Tse-I, de Kock, Herman, Wigerinck, Piet, Simmen, Kenneth, Samuelsson, Bertil, Rosenquist, Asa

المصدر: Bioorganic & Medicinal Chemistry Letters. 20(14):4004-4011

مصطلحات موضوعية: HCV, NS3/4A protease, Inhibitors, P2 substituent, Quinazoline, Replicon assay, In vitro, DMPK, In vivo PK, PHARMACY, FARMACI

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136039

المؤلفون: Xiangguang Shen, Mengxiao Gu, Yuanyuan Yang, Huanzhong Ding, Xiaoyan Gu, Longfei Zhang, Nan Zhang, Mingpeng Xiong

المصدر: BMC Veterinary Research

مصطلحات موضوعية: Male, Veterinary medicine, Swine, Cmax, Cefquinome, Microbial Sensitivity Tests, Biology, Microbiology, in vivo PK/PD, Random Allocation, Minimum inhibitory concentration, Pharmacokinetics, Tissue-cage model, In vivo, medicine, Animals, Escherichia coli Infections, Swine Diseases, Dose-Response Relationship, Drug, General Veterinary, General Medicine, veterinary(all), Anti-Bacterial Agents, Cephalosporins, Dose–response relationship, Piglets, Pharmacodynamics, Diffusion Chambers, Culture, A clinical Escherichia coli strain, Intramuscular injection, Research Article, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfe5e9bab6f2b132ef321c5787b5f46