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1Academic Journal
المؤلفون: Vukusic, Sandra, Bove, Riley, Dobson, Ruth, McElrath, Thomas, Oreja-Guevara, Celia, Pietrasanta, Carlo, Lin, Chien-Ju, Ferreira, Germano, Craveiro, Licinio, Zecevic, Dusanka, Pasquarelli, Noemi, Hellwig, Kerstin
المصدر: Neurology: Neuroimmunology & Neuroinflammation. 12(1)
مصطلحات موضوعية: Humans, Female, Pregnancy, Adult, Antibodies, Monoclonal, Humanized, Pregnancy Outcome, Infant, Newborn, Immunologic Factors, Pregnancy Complications, Multiple Sclerosis, Abortion, Spontaneous, Pharmacovigilance
وصف الملف: application/pdf
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2Academic Journal
المؤلفون: Bril, Vera, Berkowicz, Tomasz, Szczudlik, Andrzej, Nicolle, Michael, Bednarik, Josef, Hon, Petr, Vaitkus, Antanas, Vu, Tuan, Rozsa, Csilla, Magnus, Tim, Panczel, Gyula, Toomsoo, Toomas, Pasnoor, Mamatha, Mozaffar, Tahseen, Freimer, Miriam, Reuner, Ulrike, Vécsei, László, Souayah, Nizar, Levine, Todd, Pascuzzi, Robert, Dalakas, Marinos, Rivner, Michael, Griffin, Rhonda, Coll, Montse, Mondou, Elsa
المصدر: Muscle & Nerve. 71(1)
مصطلحات موضوعية: autoimmune disease, intravenous immunoglobulin, myasthenia gravis, neuromuscular disease, Humans, Myasthenia Gravis, Immunoglobulins, Intravenous, Male, Female, Double-Blind Method, Middle Aged, Adult, Receptors, Cholinergic, Aged, Treatment Outcome, Autoantibodies, Immunologic Factors, Activities of Daily Living, Prospective Studies
وصف الملف: application/pdf
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3Report
المؤلفون: Biocompatibles UK Ltd
المصدر: An Open-Label, Prospective, Multi-Center Clinical Trial to Evaluate the Efficacy and Safety of TheraSphere™ Followed by Durvalumab (Imfinzi®) With Tremelimumab (Imjudo®) for Hepatocellular Carcinoma (HCC)
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4Report
المؤلفون: Sun Yat-Sen Memorial Hospital Zhongshan University, Peking University Third Hospital, Fujian Provincial Hospital
المساهمون: Xuesong Li, Director of Department of Urology, Peking University First Hospital
المصدر: Hematoxylin-eosin Staining-based Tumor Microenvironment Subtype System Adjuvant Therapeutic Selection for Locally Advanced Upper Tract Urothelial Carcinoma After Radical Surgery:A Perspective Cohort Study
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5Report
المصدر: A Phase II, Multicentre, Non-Comparative, Randomised Controlled Trial of Stereotactic Ablative Body Radiotherapy and Immunotherapy Versus Immunotherapy Alone in Patients with Treatment Naïve Oligometastatic Extracranial Melanoma
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6Report
المصدر: Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy (OIT) in Food Allergic Children and Adults (CoFAR-11)
Sampson HA, Berin MC, Plaut M, Sicherer SH, Jones S, Burks AW, Lindblad R, Leung DYM, Wood RA. The Consortium for Food Allergy Research (CoFAR): The first generation. J Allergy Clin Immunol. 2019 Feb;143(2):486-493. doi: 10.1016/j.jaci.2018.12.989. Epub 2018 Dec 23.
Wood RA, Togias A, Sicherer SH, Shreffler WG, Kim EH, Jones SM, Leung DYM, Vickery BP, Bird JA, Spergel JM, Iqbal A, Olsson J, Ligueros-Saylan M, Uddin A, Calatroni A, Huckabee CM, Rogers NH, Yovetich N, Dantzer J, Mudd K, Wang J, Groetch M, Pyle D, Keet CA, Kulis M, Sindher SB, Long A, Scurlock AM, Lanser BJ, Lee T, Parrish C, Brown-Whitehorn T, Spergel AKR, Veri M, Hamrah SD, Brittain E, Poyser J, Wheatley LM, Chinthrajah RS. Omalizumab for the Treatment of Multiple Food Allergies. N Engl J Med. 2024 Mar 7;390(10):889-899. doi: 10.1056/NEJMoa2312382. Epub 2024 Feb 25. -
7Report
المصدر: Neoadjuvant Chemoradiotherapy Combined With Sequential Perioperative PD-1 Inhibitor for Locally Advanced Esophageal Squamous Cell Carcinoma
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8Report
المؤلفون: United States Department of Defense
المصدر: A Multicenter Phase II Study of Vaccines to Prevent Recurrence in Patients With HER-2 Positive Breast Cancer
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9Academic Journal
المؤلفون: Hsu, Stephanie, Balan, Ayushi, Bove, Riley
المصدر: Multiple Sclerosis Journal. 30(13)
مصطلحات موضوعية: Lactation, amenorrhea, breastmilk, mother–infant dyad, reproductive safety, Humans, Female, Multiple Sclerosis, Lactation, Breast Feeding, Pregnancy, Immunologic Factors, Milk, Human, Pregnancy Complications
وصف الملف: application/pdf
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10ReportSafety Study of Sublingual Immunotherapy Tablets of House Dust Mite Allergen Extracts in Adolescents
المؤلفون: Syneos Health
المصدر: Investigation of the Safety and Tolerability of Sublingual Immunotherapy Tablets of House Dust Mite Allergen Extracts in Adolescents With House Dust Mite-associated Allergic Rhinitis
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11Report
المؤلفون: National Cancer Institute (NCI)
المصدر: Cryoablation Challenge Evaluated in Adaptive-Immune Resistance (CEDAR)
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12Report
المؤلفون: Children's Hospital Medical Center, Cincinnati, University of North Carolina, Chapel Hill, George Washington University, Emory University, University of Southampton, Imperial College London
المساهمون: Wanda Phipatanakul, Professor of Pediatrics
المصدر: Preventing Childhood Asthma Using Prophylactic House Dust Mite Allergen Immunotherapy
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13Report
المؤلفون: Merck KGaA, Darmstadt, Germany
المصدر: A Phase II, Randomized, Non-comparative Double Arm, Open-label, 2-stage, Multicenter Study to Evaluate the Efficacy and Safety of 2 Tetra-modality Bladder Preservation Strategies in Muscle-invasive Bladder Cancer with Maximum TURBT Followed by Induction Platinum-based Chemotherapy/Avelumab Followed by Radiation Therapy Then Maintenance Avelumab or Watch and Wait Approach
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14Report
المؤلفون: Merck Sharp & Dohme LLC
المصدر: A Multicenter, Open-Label, Randomized, Controlled Study to Assess the Antitumor Activity of LNS8801 with and Without Pembrolizumab in Patients with Treatment-Refractory, Unresectable Melanoma
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15Report
المؤلفون: Fujian Provincial Hospital
المصدر: Adebrelimab Combined with Non-platinum Chemotherapy and Fuzuloparib in the Treatment of Patients with Recurrent Platinum-resistant Ovarian Cancer (Sunrise Trial): a Single-Arm, Exploratory Study
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16Academic Journal
المؤلفون: Li, Zhaoyang, Roepcke, Stefan, Franke, Ryan, Yel, Leman
المصدر: Annals of Clinical and Translational Neurology. 11(8)
مصطلحات موضوعية: Humans, Immunoglobulins, Intravenous, Double-Blind Method, Middle Aged, Hand Strength, Male, Female, Adult, Aged, Cross-Over Studies, Polyneuropathies, Dose-Response Relationship, Drug, Immunologic Factors
وصف الملف: application/pdf
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17Academic Journal
المؤلفون: Kurosaki, Takashi, Togashi, Yosuke, Fukuoka, Kazuya, Goto, Megumi, Chiba, Yasutaka, Tomida, Shuta, Ota, Takayo, Haratani, Koji, Takahama, Takayuki, Tanizaki, Junko, Yoshida, Takeshi, Iwasa, Tsutomu, Tanaka, Kaoru, Takeda, Masayuki, Hirano, Tomoko, Yoshida, Hironori, Ozasa, Hiroaki, Sakamori, Yuichi, Sakai, Kazuko, Higuchi, Keiko, Uga, Hitoshi, Suminaka, Chihiro, Hirai, Toyohiro, Nishio, Kazuto, Nakagawa, Kazuhiko, Honjo, Tasuku, Hayashi, Hidetoshi, Chamoto, Kenji, Hatae, Ryusuke
المصدر: The Journal of Clinical Investigation. 134(7)
مصطلحات موضوعية: Immunotherapy, Lung cancer, Oncology, T cells, Humans, B7-H1 Antigen, Carcinoma, Non-Small-Cell Lung, Immunologic Factors, Lung Neoplasms, Programmed Cell Death 1 Receptor, Immune Checkpoint Inhibitors
وصف الملف: application/pdf
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18Academic Journal
المؤلفون: Paules, Catharine, Wang, Jing, Tomashek, Kay, Bonnett, Tyler, Singh, Kanal, Marconi, Vincent, Davey, Richard, Lye, David, Dodd, Lori, Yang, Otto, Benson, Constance, Deye, Gregory, Doernberg, Sarah, Hynes, Noreen, Grossberg, Robert, Wolfe, Cameron, Nayak, Seema, Short, William, Voell, Jocelyn, Potter, Gail, Rapaka, Rekha
المصدر: ACP journal club. 177(3)
مصطلحات موضوعية: Adult, Humans, Antiviral Agents, Azetidines, COVID-19, COVID-19 Drug Treatment, Immunologic Factors, Purines, Pyrazoles, SARS-CoV-2, Sulfonamides, Treatment Outcome, Double-Blind Method
وصف الملف: application/pdf
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19Report
المؤلفون: The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Affiliated Hospital of Guangdong Medical University, First People's Hospital of Foshan
المساهمون: Wei Wei, Professor
المصدر: A Randomized Controlled Study of the Efficacy of Hepatic Arterial Perfusion Chemotherapy Concurrently Compared to Sequentially Combined With Targeted and Immunotherapy in Potentially Resectable Intermediate and Advanced HCC
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
Park JW, Chen M, Colombo M, Roberts LR, Schwartz M, Chen PJ, Kudo M, Johnson P, Wagner S, Orsini LS, Sherman M. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. Liver Int. 2015 Sep;35(9):2155-66. doi: 10.1111/liv.12818. Epub 2015 Mar 25.
Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018 Mar 31;391(10127):1301-1314. doi: 10.1016/S0140-6736(18)30010-2. Epub 2018 Jan 5.
Schwartz JD, Schwartz M, Mandeli J, Sung M. Neoadjuvant and adjuvant therapy for resectable hepatocellular carcinoma: review of the randomised clinical trials. Lancet Oncol. 2002 Oct;3(10):593-603. doi: 10.1016/s1470-2045(02)00873-2.
Shi HY, Wang SN, Wang SC, Chuang SC, Chen CM, Lee KT. Preoperative transarterial chemoembolization and resection for hepatocellular carcinoma: a nationwide Taiwan database analysis of long-term outcome predictors. J Surg Oncol. 2014 Apr;109(5):487-93. doi: 10.1002/jso.23521. Epub 2013 Nov 30.
He M, Li Q, Zou R, Shen J, Fang W, Tan G, Zhou Y, Wu X, Xu L, Wei W, Le Y, Zhou Z, Zhao M, Guo Y, Guo R, Chen M, Shi M. Sorafenib Plus Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin vs Sorafenib Alone for Hepatocellular Carcinoma With Portal Vein Invasion: A Randomized Clinical Trial. JAMA Oncol. 2019 Jul 1;5(7):953-960. doi: 10.1001/jamaoncol.2019.0250.
Lyu N, Kong Y, Mu L, Lin Y, Li J, Liu Y, Zhang Z, Zheng L, Deng H, Li S, Xie Q, Guo R, Shi M, Xu L, Cai X, Wu P, Zhao M. Hepatic arterial infusion of oxaliplatin plus fluorouracil/leucovorin vs. sorafenib for advanced hepatocellular carcinoma. J Hepatol. 2018 Jul;69(1):60-69. doi: 10.1016/j.jhep.2018.02.008. Epub 2018 Feb 20.
He MK, Le Y, Li QJ, Yu ZS, Li SH, Wei W, Guo RP, Shi M. Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma: a prospective non-randomized study. Chin J Cancer. 2017 Oct 23;36(1):83. doi: 10.1186/s40880-017-0251-2.
Li S, Mei J, Wang Q, Guo Z, Lu L, Ling Y, Xu L, Chen M, Zheng L, Lin W, Zou J, Wen Y, Wei W, Guo R. Postoperative Adjuvant Transarterial Infusion Chemotherapy with FOLFOX Could Improve Outcomes of Hepatocellular Carcinoma Patients with Microvascular Invasion: A Preliminary Report of a Phase III, Randomized Controlled Clinical Trial. Ann Surg Oncol. 2020 Dec;27(13):5183-5190. doi: 10.1245/s10434-020-08601-8. Epub 2020 May 16. Erratum In: Ann Surg Oncol. 2021 Dec;28(Suppl 3):874. doi: 10.1245/s10434-021-09813-2.
Li SH, Mei J, Cheng Y, Li Q, Wang QX, Fang CK, Lei QC, Huang HK, Cao MR, Luo R, Deng JD, Jiang YC, Zhao RC, Lu LH, Zou JW, Deng M, Lin WP, Guan RG, Wen YH, Li JB, Zheng L, Guo ZX, Ling YH, Chen HW, Zhong C, Wei W, Guo RP. Postoperative Adjuvant Hepatic Arterial Infusion Chemotherapy With FOLFOX in Hepatocellular Carcinoma With Microvascular Invasion: A Multicenter, Phase III, Randomized Study. J Clin Oncol. 2023 Apr 1;41(10):1898-1908. doi: 10.1200/JCO.22.01142. Epub 2022 Dec 16. -
20Report
المساهمون: Xu Yu, Professor, Chief Physician
المصدر: A Study on the Efficacy and Safety of Intratonsillar Immunotherapy for Allergic Rhinitis
Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N; 23andMe Research Team; AAGC collaborators; Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Anto JM, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt CEM, Bleecker ER, Bonas-Guarch S, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Dmitrieva J, Duijts L, Ege MJ, Gauderman WJ, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Jonsdottir I, Kabesch M, Kaprio J, Kumar A, Lee YA, Levin AM, Li X, Lorenzo-Diaz F, Melen E, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pershagen G, Pino-Yanes M, Probst-Hensch NM, Ruschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Bonnelykke K. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 Aug;50(8):1072-1080. doi: 10.1038/s41588-018-0157-1. Epub 2018 Jul 16. Erratum In: Nat Genet. 2018 Sep;50(9):1343. doi: 10.1038/s41588-018-0197-6.
Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001 Jul;108(1 Suppl):S2-8. doi: 10.1067/mai.2001.115569.
Smith JM, Pizarro YA. Hyposensitization with extracts of Dermatophagoides pteronyssinus and house dust. Clin Allergy. 1972 Sep;2(3):281-3. doi: 10.1111/j.1365-2222.1972.tb01291.x. No abstract available.
James C, Bernstein DI. Allergen immunotherapy: an updated review of safety. Curr Opin Allergy Clin Immunol. 2017 Feb;17(1):55-59. doi: 10.1097/ACI.0000000000000335.
Senti G, Prinz Vavricka BM, Erdmann I, Diaz MI, Markus R, McCormack SJ, Simard JJ, Wuthrich B, Crameri R, Graf N, Johansen P, Kundig TM. Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17908-12. doi: 10.1073/pnas.0803725105. Epub 2008 Nov 10.
Zimmer A, Bouley J, Le Mignon M, Pliquet E, Horiot S, Turfkruyer M, Baron-Bodo V, Horak F, Nony E, Louise A, Moussu H, Mascarell L, Moingeon P. A regulatory dendritic cell signature correlates with the clinical efficacy of allergen-specific sublingual immunotherapy. J Allergy Clin Immunol. 2012 Apr;129(4):1020-30. doi: 10.1016/j.jaci.2012.02.014.
Swamy RS, Reshamwala N, Hunter T, Vissamsetti S, Santos CB, Baroody FM, Hwang PH, Hoyte EG, Garcia MA, Nadeau KC. Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. J Allergy Clin Immunol. 2012 Jul;130(1):215-24.e7. doi: 10.1016/j.jaci.2012.04.021. Epub 2012 Jun 5. Erratum In: J Allergy Clin Immunol. 2012 Nov;130(5):1224.
Rosskopf S, Jahn-Schmid B, Schmetterer KG, Zlabinger GJ, Steinberger P. PD-1 has a unique capacity to inhibit allergen-specific human CD4+ T cell responses. Sci Rep. 2018 Sep 10;8(1):13543. doi: 10.1038/s41598-018-31757-z.
Shamji MH, Larson D, Eifan A, Scadding GW, Qin T, Lawson K, Sever ML, Macfarlane E, Layhadi JA, Wurtzen PA, Parkin RV, Sanda S, Harris KM, Nepom GT, Togias A, Durham SR. Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy. J Allergy Clin Immunol. 2021 Oct;148(4):1061-1071.e11. doi: 10.1016/j.jaci.2021.03.030. Epub 2021 Apr 2.
JUILLARD G, BUBBERS J E. Experimental intra-lymphatic immunotherapy (ILI) of canine allergic disease[C/OL]. 1983[2023-02-12]. https://www.semanticscholar.org/paper/Experimental-intra-lymphatic-immunotherapy-(ILI)-of-Juillard-Bubbers/3d454bcc0cb13e5375ac58a9f415672a0c6b609c.
Sigel MB, Sinha YN, VanderLaan WP. Production of antibodies by inoculation into lymph nodes. Methods Enzymol. 1983;93:3-12. doi: 10.1016/s0076-6879(83)93031-8.
Maloy KJ, Erdmann I, Basch V, Sierro S, Kramps TA, Zinkernagel RM, Oehen S, Kundig TM. Intralymphatic immunization enhances DNA vaccination. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3299-303. doi: 10.1073/pnas.051630798. Epub 2001 Feb 27.
Johansen P, Haffner AC, Koch F, Zepter K, Erdmann I, Maloy K, Simard JJ, Storni T, Senti G, Bot A, Wuthrich B, Kundig TM. Direct intralymphatic injection of peptide vaccines enhances immunogenicity. Eur J Immunol. 2005 Feb;35(2):568-74. doi: 10.1002/eji.200425599.
Martinez-Gomez JM, Johansen P, Erdmann I, Senti G, Crameri R, Kundig TM. Intralymphatic injections as a new administration route for allergen-specific immunotherapy. Int Arch Allergy Immunol. 2009;150(1):59-65. doi: 10.1159/000210381. Epub 2009 Apr 2.
Kreiter S, Selmi A, Diken M, Koslowski M, Britten CM, Huber C, Tureci O, Sahin U. Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity. Cancer Res. 2010 Nov 15;70(22):9031-40. doi: 10.1158/0008-5472.CAN-10-0699. Epub 2010 Nov 2.
Kim EH, Kim JH, Samivel R, Bae JS, Chung YJ, Chung PS, Lee SE, Mo JH. Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis. Allergy. 2016 May;71(5):629-39. doi: 10.1111/all.12839. Epub 2016 Feb 12.
Fischer N, Rostaher A, Favrot C. [Intralymphatic immunotherapy: An effective and safe alternative route for canine atopic dermatitis]. Schweiz Arch Tierheilkd. 2016 Sep;158(9):646-652. doi: 10.17236/sat00085. German.
Landolt GA, Hussey SB, Kreutzer K, Quintana A, Lunn DP. Low-dose DNA vaccination into the submandibular lymph nodes in ponies. Vet Rec. 2010 Aug 21;167(8):302-3. doi: 10.1136/vr.c3891. No abstract available.
Juillard GJ, Boyer PJ, Yamashiro CH. A phase I study of active specific intralymphatic immunotherapy (ASILI). Cancer. 1978 Jun;41(6):2215-25. doi: 10.1002/1097-0142(197806)41:63.0.co;2-x.
Draube A, Klein-Gonzalez N, Mattheus S, Brillant C, Hellmich M, Engert A, von Bergwelt-Baildon M. Dendritic cell based tumor vaccination in prostate and renal cell cancer: a systematic review and meta-analysis. PLoS One. 2011 Apr 20;6(4):e18801. doi: 10.1371/journal.pone.0018801.
Schmid JM, Nezam H, Madsen HH, Schmitz A, Hoffmann HJ. Intralymphatic immunotherapy induces allergen specific plasmablasts and increases tolerance to skin prick testing in a pilot study. Clin Transl Allergy. 2016 May 25;6:19. doi: 10.1186/s13601-016-0107-x. eCollection 2016.
Patterson AM, Bonny AE, Shiels WE 2nd, Erwin EA. Three-injection intralymphatic immunotherapy in adolescents and young adults with grass pollen rhinoconjunctivitis. Ann Allergy Asthma Immunol. 2016 Feb;116(2):168-70. doi: 10.1016/j.anai.2015.11.010. Epub 2015 Dec 17. No abstract available.
Lee SP, Choi SJ, Joe E, Lee SM, Lee MW, Shim JW, Kim YJ, Kyung SY, Park JW, Jeong SH, Jung JH. A Pilot Study of Intralymphatic Immunotherapy for House Dust Mite, Cat, and Dog Allergies. Allergy Asthma Immunol Res. 2017 May;9(3):272-277. doi: 10.4168/aair.2017.9.3.272.Other URLs: http://edc-cloud.medsci.cn/