المساهمون: Stephen Gottlieb, Professor of Medicine

المصدر: Single System Double Blinded Trial to Evaluate the Effect of Pre-operative Treatment With DigiFab to Prevent Post-operative Acute Kidney Injury (AKI) in Patients at High Risk for AKI Undergoing Cardiac Bypass Graft Surgery

المؤلفون: Isotope Technologies Munich (ITM) Oncologics, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

المصدر: A Phase I Trial to Determine the Maximum Tolerated Dose and Patient-specific Dosimetry of Fractionated Intracavitary Radioimmunotherapy With Lu-177 Labeled 6A10 Fab-fragments in Patients With Glioblastoma After Standard Treatment
Fiedler L, Kellner M, Gosewisch A, Oos R, Boning G, Lindner S, Albert N, Bartenstein P, Reulen HJ, Zeidler R, Gildehaus FJ. Evaluation of 177Lu[Lu]-CHX-A''-DTPA-6A10 Fab as a radioimmunotherapy agent targeting carbonic anhydrase XII. Nucl Med Biol. 2018 May;60:55-62. doi: 10.1016/j.nucmedbio.2018.02.004. Epub 2018 Mar 4.
Alterio V, Kellner M, Esposito D, Liesche-Starnecker F, Bua S, Supuran CT, Monti SM, Zeidler R, De Simone G. Biochemical and Structural Insights into Carbonic Anhydrase XII/Fab6A10 Complex. J Mol Biol. 2019 Dec 6;431(24):4910-4921. doi: 10.1016/j.jmb.2019.10.022. Epub 2019 Nov 1.
Battke C, Kremmer E, Mysliwietz J, Gondi G, Dumitru C, Brandau S, Lang S, Vullo D, Supuran C, Zeidler R. Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII. Cancer Immunol Immunother. 2011 May;60(5):649-58. doi: 10.1007/s00262-011-0980-z. Epub 2011 Feb 5.
Gondi G, Mysliwietz J, Hulikova A, Jen JP, Swietach P, Kremmer E, Zeidler R. Antitumor efficacy of a monoclonal antibody that inhibits the activity of cancer-associated carbonic anhydrase XII. Cancer Res. 2013 Nov 1;73(21):6494-503. doi: 10.1158/0008-5472.CAN-13-1110. Epub 2013 Sep 12.
Proescholdt MA, Mayer C, Kubitza M, Schubert T, Liao SY, Stanbridge EJ, Ivanov S, Oldfield EH, Brawanski A, Merrill MJ. Expression of hypoxia-inducible carbonic anhydrases in brain tumors. Neuro Oncol. 2005 Oct;7(4):465-75. doi: 10.1215/S1152851705000025.
Supuran CT. Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors. Expert Opin Investig Drugs. 2018 Dec;27(12):963-970. doi: 10.1080/13543784.2018.1548608. Epub 2018 Nov 22.

المؤلفون: Diwanji, Devan, Trenker, Raphael, Thaker, Tarjani M, Wang, Feng, Agard, David A, Verba, Kliment A, Jura, Natalia

المصدر: Nature. 600(7888)

مصطلحات موضوعية: Biochemistry and Cell Biology, Chemical Sciences, Biological Sciences, Women's Health, Cancer, Breast Cancer, Generic health relevance, Allosteric Regulation, Antibodies, Monoclonal, Humanized, Binding Sites, Cryoelectron Microscopy, Humans, Immunoglobulin Fab Fragments, Models, Molecular, Mutation, Neuregulin-1, Oncogenes, Protein Multimerization, Protein Stability, Receptor, ErbB-2, Receptor, ErbB-3, Trastuzumab, Receptor, erbB-2, Receptor, erbB-3, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5270602f
https://escholarship.org/content/qt5270602f/qt5270602f.pdf

المؤلفون: Wolfgang Roll, Michael Müther, Guido Böning, Astrid Delker, Nils Warneke, Franz-Josef Gildehaus, Michael Schäfers, Walter Stummer, Reinhard Zeidler, Hans-Jürgen Reulen, Lars Stegger

المصدر: EJNMMI Research, Vol 13, Iss 1, Pp 1-8 (2023)

مصطلحات موضوعية: Radioimmunotherapy, Carbonic anhydrase XII, Immunoglobulin Fab fragments, Glioblastoma, Lutetium-177, Medical physics. Medical radiology. Nuclear medicine, R895-920

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2191-219X

URL الوصول: https://doaj.org/article/4b7795c149c041df88ca457cecc3e060

المؤلفون: Kalagiri, Rajasree, Stanfield, Robyn, Meisenhelder, Jill, La Clair, James, Fuhs, Stephen, Wilson, Ian, Hunter, Tony

المصدر: Proceedings of the National Academy of Sciences. 118(6)

مصطلحات موضوعية: histidine phosphorylation, phosphohistidine antibodies, posttranslational modifications, Amino Acid Sequence, Animals, Antibodies, Monoclonal, Cross Reactions, Histidine, Immunoglobulin Fab Fragments, Isomerism, Kinetics, Peptides, Phosphates, Rabbits, Structure-Activity Relationship

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6ng7m0rq
https://escholarship.org/content/qt6ng7m0rq/qt6ng7m0rq.pdf

المؤلفون: Lim, Shion A, Gramespacher, Josef A, Pance, Katarina, Rettko, Nicholas J, Solomon, Paige, Jin, Jing, Lui, Irene, Elledge, Susanna K, Liu, Jia, Bracken, Colton J, Simmons, Graham, Zhou, Xin X, Leung, Kevin K, Wells, James A

المصدر: mAbs. 13(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Immunology, Lung, Clinical Research, Vaccine Related, Biotechnology, Immunization, Pneumonia, Pneumonia & Influenza, Prevention, Biodefense, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Good Health and Well Being, Antibodies, Bispecific, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Epitopes, HEK293 Cells, Humans, Immunoglobulin Fab Fragments, SARS-CoV-2, Spike Glycoprotein, Coronavirus, COVID-19 Drug Treatment, Bispecific, neutralizing antibody, knob-in-hole, Pharmacology and Pharmaceutical Sciences, Public Health and Health Services, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4v56594p
https://escholarship.org/content/qt4v56594p/qt4v56594p.pdf

المؤلفون: Sevillano, Natalia, Green, Evan M, Votteler, Jörg, Kim, Dong Young, Ren, Xuefeng, Yang, Bei, Liu, Xi, Lourenço, André Luiz, Hurley, James H, Farr-Jones, Shauna, Gross, John D, Cheng, Yifan, Craik, Charles S

المصدر: PLOS ONE. 16(5)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, HIV/AIDS, Prevention, Infectious Diseases, Sexually Transmitted Infections, Biotechnology, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Antibodies, Endosomal Sorting Complexes Required for Transport, HIV Infections, HIV-1, Humans, Immunoglobulin Fab Fragments, Multiprotein Complexes, Protein Binding, Recombinant Proteins, Virus Replication, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/05j700fv
https://escholarship.org/content/qt05j700fv/qt05j700fv.pdf

المؤلفون: Su, Qianling, Shi, Wei, Huang, Xianing, Yin, Shihua, Yang, Xiaomei, Lu, Xiaoling

المصدر: Medcomm: Biomaterials & Applications; Sep2023, Vol. 2 Issue 3, p1-28, 28p

مصطلحات موضوعية: IMMUNOGLOBULINS, PROTEIN expression, MEDICAL screening, IMMUNOGLOBULIN fab fragments, AMINO acids

المؤلفون: Naulin, Pamela A, Lozano, Benjamin, Fuentes, Christian, Liu, Yu, Schmidt, Carla, Contreras, Jorge E, Barrera, Nelson P

المصدر: Journal of Biological Chemistry. 295(49)

مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, 1.1 Normal biological development and functioning, Generic health relevance, Amino Acid Sequence, Connexin 26, Connexin 30, Cryoelectron Microscopy, Gap Junctions, HeLa Cells, Histidine, Humans, Immunoglobulin Fab Fragments, Microscopy, Atomic Force, Oligopeptides, Protein Multimerization, atomic force microscopy, Fab fragment, statistics, stoichiometry, subunit arrangement, membrane protein, connexin, heteromer, AFM, Hela Cells, Chemical Sciences, Biological Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7k93198v
https://escholarship.org/content/qt7k93198v/qt7k93198v.pdf

المؤلفون: Lecerf, Maxime¹, Kanyavuz, Alexia¹, Rossini, Sofia¹, Dimitrov, Jordan D.¹ jordan.dimitrov@sorbonne-universite.fr

المصدر: Communications Biology. 3/23/2021, Vol. 4 Issue 1, p1-13. 13p.

مصطلحات موضوعية: *IMMUNOGLOBULIN fab fragments, *MOLECULAR weights, *COFACTORS (Biochemistry), *PROTEIN expression, *HEME

المؤلفون: Campbell, Melody G, Cormier, Anthony, Ito, Saburo, Seed, Robert I, Bondesson, Andrew J, Lou, Jianlong, Marks, James D, Baron, Jody L, Cheng, Yifan, Nishimura, Stephen L

المصدر: Cell. 180(3)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Cancer, 1.1 Normal biological development and functioning, Animals, Antibodies, Binding Sites, Bronchi, CHO Cells, Cricetulus, Cryoelectron Microscopy, Female, Humans, Immunoglobulin Fab Fragments, Integrins, Latent TGF-beta Binding Proteins, Lymphocyte Activation, Male, Mink, Protein Binding, Protein Conformation, alpha-Helical, Protein Interaction Domains and Motifs, T-Lymphocytes, Regulatory, Transforming Growth Factor beta1, GARP, TGF-b signaling, TGF-beta, TGF-beta activation, cryo-electron microscopy, integrin, integrin conformation, structural biology, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/34p4015h
https://escholarship.org/content/qt34p4015h/qt34p4015h.pdf

المؤلفون: McKeating, Kristy S, Hinman, Samuel S, Rais, Nor Akmaliza, Zhou, Zhiguo, Cheng, Quan

المصدر: ACS Sensors. 4(7)

مصطلحات موضوعية: Analytical Chemistry, Chemical Sciences, Biotechnology, Generic health relevance, Good Health and Well Being, Animals, Antibodies, Immobilized, Cholera Toxin, Gold, Humans, Immunoassay, Immunoglobulin Fab Fragments, Immunoglobulin G, Membranes, Artificial, Mice, Phosphatidylcholines, Phosphatidylglycerols, Proof of Concept Study, Staphylococcal Protein A, antifouling, lipid membrane, surface-plasmon resonance, biosensing, human biofluid, Biomedical Engineering, Nanotechnology, Analytical chemistry, Electronics, sensors and digital hardware

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0t1267tk

المؤلفون: Trotta, Eleonora, Bessette, Paul H, Silveria, Stephanie L, Ely, Lauren K, Jude, Kevin M, Le, Duy T, Holst, Charles R, Coyle, Anthony, Potempa, Marc, Lanier, Lewis L, Garcia, K Christopher, Crellin, Natasha K, Rondon, Isaac J, Bluestone, Jeffrey A

المصدر: Nature Medicine. 24(7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Immunology, Transplantation, Autoimmune Disease, Immunization, Diabetes, Vaccine Related, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Aetiology, Inflammatory and immune system, Animals, Antibodies, CD8-Positive T-Lymphocytes, Cell Proliferation, Diabetes Mellitus, Type 1, Encephalomyelitis, Autoimmune, Experimental, Graft vs Host Disease, Humans, Immunoglobulin Fab Fragments, Immunotherapy, Interleukin-2, Kinetics, Mice, Inbred C57BL, Models, Molecular, Muromegalovirus, Phosphorylation, Protein Binding, STAT5 Transcription Factor, Signal Transduction, Structure-Activity Relationship, T-Lymphocytes, Regulatory, Up-Regulation, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1dn2c0jw

المؤلفون: Tian, Jingjing, Li, Cong, Shi, Bochang, Han, Hui, Liu, Yuan, Tan, Lingyun, Wang, Keyu, Yan, Fang, He, Wei, Li, Bo, Zheng, Naxin, Li, Huabin, Li, Xinyu, Tian, Chongyu, Zheng, Yuanqiang, Zhao, Zhongpeng, Fan, Ruiwen

المصدر: Zoonoses (2737-7466); 2023, Vol. 3 Issue 1, p1-8, 8p

مصطلحات موضوعية: RHESUS monkeys, RICIN, IMMUNOGLOBULIN fab fragments, IMMUNOGLOBULIN G, NEUTROPHILS

المؤلفون: Shi, Bochang, Han, Hui, Tan, Lingyun, Liu, Yuan, Yan, Fang, Li, Bo, Zheng, Naxin, Li, Min, Zhao, Liyan, Li, Huabin, Fan, Tietong, Zhang, Zhiping, Li, Xinyu, Tian, Chongyu, Zheng, Yuanqiang, He, Wei, Zhao, Zhongpeng

المصدر: Zoonoses (2737-7466); 2023, Vol. 3 Issue 1, p1-7, 7p

مصطلحات موضوعية: SMALLPOX, IMMUNOGLOBULINS, TRANSMISSION electron microscopy, IMMUNOGLOBULIN fab fragments, HIGH performance liquid chromatography

المؤلفون: Eronen, Veikko, Tullila, Antti, Iljin, Kristiina, Rouvinen, Juha, Nevanen, Tarja K., Hakulinen, Nina

المصدر: Eronen , V , Tullila , A , Iljin , K , Rouvinen , J , Nevanen , T K & Hakulinen , N 2023 , ' Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids ' , Journal of Structural Biology , vol. 215 , no. 2 , 107966 . https://doi.org/10.1016/j.jsb.2023.107966

مصطلحات موضوعية: Binding specificity, Cortisol, Fab, Glucocorticoid, Hapten, Amino Acid Sequence, Glucocorticoids, Immunoglobulin Fab Fragments/chemistry, Models, Molecular, Crystallography, X-Ray, Protein Conformation, Hydrocortisone

الاتاحة: https://cris.vtt.fi/en/publications/06e4ad63-7650-458e-a656-421f311cea9d
https://doi.org/10.1016/j.jsb.2023.107966
http://www.scopus.com/inward/record.url?scp=85154546238&partnerID=8YFLogxK

المؤلفون: Tang, Jiazhi, Zhang, Cheng, Castillo, Nuria Codina, Lalaurie, Christophe J, Gao, Xin, Dalby, Paul A, Kozielski, Frank

المصدر: Scientific Reports , 13 , Article 16281. (2023)

مصطلحات موضوعية: Humans, Molecular Dynamics Simulation, X-Ray Diffraction, Protein Conformation, Scattering, Small Angle, Immunoglobulin Fab Fragments

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10178293/1/s41598-023-42698-7.pdf; https://discovery.ucl.ac.uk/id/eprint/10178293/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10178293/1/s41598-023-42698-7.pdf
https://discovery.ucl.ac.uk/id/eprint/10178293/

المؤلفون: Zhang, Cheng, Dalby, Paul Anthony

المصدر: Methods in Molecular Biology , 2552 pp. 165-197. (2023)

مصطلحات موضوعية: Antibodies, Antibody Affinity, Immunoglobulin Fab Fragments, Molecular Conformation, Protein Engineering, Protein Stability, Aggregation, Antibody, B-factor, Entropy, Fab, Molecular dynamics (Gromacs), Rosetta, Tm

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10159884/1/2020-05-23%20version.pdf; https://discovery.ucl.ac.uk/id/eprint/10159884/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10159884/1/2020-05-23%20version.pdf
https://discovery.ucl.ac.uk/id/eprint/10159884/

المؤلفون: Binning, Jennifer M, Smith, Amber M, Hultquist, Judd F, Craik, Charles S, Caretta Cartozo, Nathalie, Campbell, Melody G, Burton, Lily, La Greca, Florencia, McGregor, Michael J, Ta, Hai M, Bartholomeeusen, Koen, Peterlin, B Matija, Krogan, Nevan J, Sevillano, Natalia, Cheng, Yifan, Gross, John D

المصدر: PLoS pathogens. 14(1)

مصطلحات موضوعية: Humans, HIV-1, HIV Infections, Cytidine Deaminase, Cytosine Deaminase, Cullin Proteins, Ubiquitin, Antiviral Agents, Virus Assembly, Immunoglobulin Fab Fragments, vif Gene Products, Human Immunodeficiency Virus, Ubiquitination, HEK293 Cells, Microbiology, Immunology, Medical Microbiology, Virology

URL الوصول: https://escholarship.org/uc/item/4wf805h6

المؤلفون: Kim, Oleg V, Litvinov, Rustem I, Alber, Mark S, Weisel, John W

المصدر: Nature communications. 8(1)

مصطلحات موضوعية: Blood Platelets, Pseudopodia, Humans, Thrombosis, Fibrin, Actomyosin, Platelet Glycoprotein GPIIb-IIIa Complex, Platelet Aggregation Inhibitors, Antibodies, Monoclonal, Microscopy, Confocal, Microscopy, Fluorescence, Cell Adhesion, Image Processing, Computer-Assisted, Immunoglobulin Fab Fragments, Biomechanical Phenomena, Abciximab, Antibodies, Monoclonal, Image Processing, Computer-Assisted, Microscopy, Confocal, Fluorescence

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0pt6t40q